Gene: Pde6b

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Name
phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
MGI ID
MGI:97525
Synonyms
Pdeb r rd rd10 rd1
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased circulating amylase level Pde6bPde6b HOM Early adult 2.14×10-07
hypoactivity Pde6bPde6b HOM Early adult 9.17×10-07
increased circulating total protein level Pde6btm1b(KOMP)Wtsi HOM   Early adult 8.07×10-05
decreased circulating triglyceride level Pde6bPde6b HOM Early adult 2.50×10-08
increased tidal volume Pde6bPde6b HOM   Early adult 7.13×10-05
increased circulating potassium level Pde6bPde6b HOM Early adult 2.28×10-06
abnormal heart morphology Pde6btm1b(KOMP)Wtsi HOM Early adult 0.00
increased blood uric acid level Pde6bPde6b HOM Early adult 2.61×10-09
increased cellular hemoglobin content Pde6bPde6b HOM Early adult 5.73×10-06
increased mean corpuscular volume Pde6bPde6b HOM Early adult 2.72×10-07
decreased body weight Pde6bPde6b HOM Early adult 3.56×10-06
increased mean corpuscular hemoglobin concentration Pde6bPde6b HOM Early adult 9.07×10-05
abnormal whole-body plethysmography Pde6bPde6b HOM   Early adult 1.00×10-05
enlarged heart Pde6btm1b(KOMP)Wtsi HOM Early adult 0.00
hyperactivity Pde6btm1b(KOMP)Wtsi HOM   Early adult 2.68×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590) N/A
Aorta 2 No  (1/590) N/A
Blood 2 No N/A
Bone marrow 2 No N/A
Brain 2 No  (3/590) N/A
Brainstem 2 No  (2/590) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cecum 2 No  (12/377) N/A
Cerebellum 2 No  (3/590) N/A
Cerebral cortex 2 No  (2/590) N/A
Chest bone 2 No N/A
Colon 2 No  (12/127) N/A
Diaphragm 2 No N/A
Duodenum 2 No  (2/127) N/A
Epididymis 2 No  (18/134)  (1/2)  Section images
Esophagus 2 No  (7/415)  (1/2)  Section images
Eye 2 No  (2/2)  Section images
Gall bladder 2 No N/A
Gonadal fat pad 2 No N/A
Harderian gland 2 No N/A
Heart 2 No  (1/590) N/A
Hindlimb 2 No N/A
Hippocampus 2 No  (3/590) N/A
Hypothalamus 2 No  (2/590) N/A
Ileum 2 No  (14/127) N/A
Jejunum 2 No  (6/127) N/A
Kidney 2 No  (20/590) N/A
Large intestine 2 No  (10/590) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/590) N/A
Lung 2 No  (1/590) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Mesenteric adipose tissue 2 No N/A
Mesenteric lymph node 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No  (2/590) N/A
Ovary 2 No  (1/590) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/590) N/A
Parathyroid gland 2 No N/A
Parotid gland 2 No N/A
Penis 2 No N/A
Peripheral nervous system 2 No  (1/590) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/590) N/A
Prostate gland 2 No  (12/590) N/A
Quadriceps 2 No N/A
Sciatic nerve 2 No N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/590) N/A
Spinal cord 2 No  (2/590) N/A
Spleen 2 No  (2/590) N/A
Stomach 2 No  (13/590) N/A
Stomach pyloric region 2 No N/A
Striatum 2 No  (3/590) N/A
Sublingual gland 2 No N/A
Submandibular gland 2 No  (2/132) N/A
Testis 2 No  (5/590)  (1/2)  Section images
Thymus 2 No N/A
Thyroid gland 2 No  (16/590) N/A
Tongue 2 No  (5/127) N/A
Trachea 2 No  (2/590) N/A
Trigeminal V nerve 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vagina 2 No N/A
Vas deferens 2 No  (15/388)  (1/2)  Section images
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

Adult LacZ: LacZ Images Section
9 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images

 Disease Models

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MGI Allele Allele Type Produced
Pde6btm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Pde6btm44764(L1L2_gt0) Targeting vectors
Pde6btm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells