The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
| Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
|---|---|---|---|---|---|---|
| decreased lean body mass | Pcxtm1b(EUCOMM)Wtsi | HET | Early adult | 4.92×10-09 | ||
| decreased bone mineral content | Pcxtm1b(EUCOMM)Wtsi | HET | Early adult | 8.70×10-05 | ||
| decreased respiratory quotient | Pcxtm1b(EUCOMM)Wtsi | HET | Early adult | 9.71×10-05 | ||
| preweaning lethality, complete penetrance | Pcxtm1b(EUCOMM)Wtsi | HOM | Early adult | 0.00 | ||
| increased total body fat amount | Pcxtm1b(EUCOMM)Wtsi | HET | Early adult | 1.09×10-09 | ||
| increased grip strength | Pcxtm1b(EUCOMM)Wtsi | HET | Early adult | 5.01×10-09 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
| Anatomy | Images | Zygosity | Mutant Expr |
|---|---|---|---|
| Adrenal gland | Wholemount images | heterozygote | 50% (2 of 4) |
| Brain | Wholemount images | heterozygote | 100% (4 of 4) |
| Brainstem | Wholemount images | heterozygote | 50% (2 of 4) |
| Brown adipose tissue | Wholemount images | heterozygote | 100% (4 of 4) |
| Cerebellum | Wholemount images | heterozygote | 50% (2 of 4) |
| Cerebral cortex | Wholemount images | heterozygote | 0.0% (0 of 4) |
| Chest bone | Wholemount images | heterozygote | 100% (2 of 2) |
| Esophagus | Wholemount images | heterozygote | 0.0% (0 of 4) |
| Gall bladder | Wholemount images | heterozygote | 25% (1 of 4) |
| Hippocampus | Wholemount images | heterozygote | 50% (2 of 4) |
| Hypothalamus | Wholemount images | heterozygote | 50% (2 of 4) |
| Kidney | Wholemount images | heterozygote | 100% (4 of 4) |
| Liver | Wholemount images | heterozygote | 50% (2 of 4) |
| Lower urinary tract | Wholemount images | heterozygote | 50% (2 of 4) |
| Lung | Wholemount images | heterozygote | 75% (3 of 4) |
| Lymph node | Wholemount images | heterozygote | 25% (1 of 4) |
| Mammary gland | Wholemount images | heterozygote | 25% (1 of 4) |
| Olfactory lobe | Wholemount images | heterozygote | 50% (2 of 4) |
| Ovary | Wholemount images | heterozygote | 25% (1 of 4) |
| Oviduct | Wholemount images | heterozygote | 25% (1 of 4) |
| Pancreas | Wholemount images | heterozygote | 75% (3 of 4) |
| Parathyroid gland | Wholemount images | heterozygote | 50% (2 of 4) |
| Peripheral nervous system | Wholemount images | heterozygote | 50% (2 of 4) |
| Skeletal muscle | Wholemount images | heterozygote | 50% (2 of 4) |
| Skin | Wholemount images | heterozygote | 100% (4 of 4) |
| Spinal cord | Wholemount images | heterozygote | 50% (2 of 4) |
| Stomach | Wholemount images | heterozygote | 100% (4 of 4) |
| Testis | Wholemount images | heterozygote | 50% (2 of 4) |
| Thymus | Wholemount images | heterozygote | 50% (2 of 4) |
| Thyroid gland | Wholemount images | heterozygote | 50% (2 of 4) |
| White adipose tissue | Wholemount images | heterozygote | 75% (3 of 4) |
| Aorta | N/A | heterozygote | 0.0% (0 of 4) |
| Blood | N/A | heterozygote | 0.0% (0 of 2) |
| Bone marrow | N/A | heterozygote | 0.0% (0 of 2) |
| Bone | N/A | heterozygote | 0.0% (0 of 4) |
| Cartilage tissue | N/A | heterozygote | 0.0% (0 of 4) |
| Cecum | N/A | heterozygote | 0.0% (0 of 2) |
| Colon | N/A | heterozygote | 0.0% (0 of 2) |
| Cranium | N/A | heterozygote | 0.0% (0 of 2) |
| Diaphragm | N/A | heterozygote | 0.0% (0 of 2) |
| Epididymis | N/A | heterozygote | Not available |
| Eye | N/A | heterozygote | 0.0% (0 of 4) |
| Harderian gland | N/A | heterozygote | 0.0% (0 of 2) |
| Heart | N/A | heterozygote | 0.0% (0 of 4) |
| Hindlimb | N/A | heterozygote | 0.0% (0 of 2) |
| Large intestine | N/A | heterozygote | 0.0% (0 of 4) |
| Main olfactory bulb | N/A | heterozygote | 0.0% (0 of 2) |
| Mesenteric lymph node | N/A | heterozygote | 0.0% (0 of 2) |
| Oral epithelium | N/A | heterozygote | 0.0% (0 of 4) |
| Parotid gland | N/A | heterozygote | 0.0% (0 of 2) |
| Penis | N/A | heterozygote | Not available |
| Peyer's patch | N/A | heterozygote | 0.0% (0 of 4) |
| Pituitary gland | N/A | heterozygote | 0.0% (0 of 4) |
| Prostate gland | N/A | heterozygote | 0.0% (0 of 4) |
| Sciatic nerve | N/A | heterozygote | 0.0% (0 of 2) |
| Small intestine | N/A | heterozygote | 0.0% (0 of 4) |
| Spleen | N/A | heterozygote | 0.0% (0 of 4) |
| Stomach pyloric region | N/A | heterozygote | 0.0% (0 of 2) |
| Striatum | N/A | heterozygote | 0.0% (0 of 4) |
| Sublingual gland | N/A | heterozygote | 0.0% (0 of 2) |
| Submandibular gland | N/A | heterozygote | 0.0% (0 of 2) |
| Tongue | N/A | heterozygote | 0.0% (0 of 2) |
| Trachea | N/A | heterozygote | 0.0% (0 of 4) |
| Trigeminal V nerve | N/A | heterozygote | 0.0% (0 of 2) |
| Urinary bladder | N/A | heterozygote | 0.0% (0 of 2) |
| Uterus | N/A | heterozygote | 0.0% (0 of 4) |
| Vagina | N/A | heterozygote | Not available |
| Vas deferens | N/A | heterozygote | 0.0% (0 of 2) |
| Vascular system | N/A | heterozygote | 0.0% (0 of 4) |
| Vesicular gland | N/A | heterozygote | Not available |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
| Anatomy | Images | Zygosity | Mutant Expr |
|---|---|---|---|
| Brain | N/A | heterozygote | 0.0% (0 of 2) |
| Brain | N/A | homozygote | 50% (1 of 2) |
| Ear | N/A | heterozygote | 0.0% (0 of 2) |
| Ear | N/A | homozygote | 0.0% (0 of 2) |
| Embryo | N/A | heterozygote | 50% (1 of 2) |
| Embryo | N/A | homozygote | 100% (2 of 2) |
| Eye | N/A | heterozygote | 0.0% (0 of 2) |
| Eye | N/A | homozygote | 50% (1 of 2) |
| Footplate | N/A | heterozygote | 0.0% (0 of 2) |
| Footplate | N/A | homozygote | 0.0% (0 of 2) |
| Forebrain | N/A | heterozygote | 0.0% (0 of 2) |
| Forebrain | N/A | homozygote | 50% (1 of 2) |
| Forelimb | N/A | heterozygote | 0.0% (0 of 2) |
| Forelimb | N/A | homozygote | 0.0% (0 of 2) |
| Handplate | N/A | heterozygote | 0.0% (0 of 2) |
| Handplate | N/A | homozygote | 0.0% (0 of 2) |
| Head | N/A | heterozygote | 50% (1 of 2) |
| Head | N/A | homozygote | 100% (2 of 2) |
| Heart | N/A | heterozygote | 50% (1 of 2) |
| Heart | N/A | homozygote | Not available |
| Hindbrain | N/A | heterozygote | 0.0% (0 of 2) |
| Hindbrain | N/A | homozygote | 50% (1 of 2) |
| Hindlimb | N/A | heterozygote | 0.0% (0 of 2) |
| Hindlimb | N/A | homozygote | 0.0% (0 of 2) |
| Liver | N/A | heterozygote | 0.0% (0 of 2) |
| Liver | N/A | homozygote | 0.0% (0 of 2) |
| Lung | N/A | heterozygote | 0.0% (0 of 2) |
| Lung | N/A | homozygote | 0.0% (0 of 2) |
| Mandibular process | N/A | heterozygote | 0.0% (0 of 2) |
| Mandibular process | N/A | homozygote | 0.0% (0 of 2) |
| Maxillary process | N/A | heterozygote | 0.0% (0 of 2) |
| Maxillary process | N/A | homozygote | 0.0% (0 of 2) |
| Midbrain | N/A | heterozygote | 0.0% (0 of 2) |
| Midbrain | N/A | homozygote | 50% (1 of 2) |
| Oral cavity | N/A | heterozygote | 0.0% (0 of 2) |
| Oral cavity | N/A | homozygote | 0.0% (0 of 2) |
| Skin | N/A | heterozygote | 0.0% (0 of 2) |
| Skin | N/A | homozygote | 0.0% (0 of 2) |
| Tail somite | N/A | heterozygote | 0.0% (0 of 2) |
| Tail somite | N/A | homozygote | 0.0% (0 of 2) |
| Tail | N/A | heterozygote | 0.0% (0 of 2) |
| Tail | N/A | homozygote | 50% (1 of 2) |
Background staining occurs in wild type mice and embryos at an incidental rate.
| Anatomy | Background staining in controls (WT) |
|---|---|
| adrenal gland | 0.67% (4 of 598) |
| aorta | 0.17% (1 of 598) |
| blood | 0.0% |
| bone | 0.0% |
| bone marrow | 0.0% |
| brain | 0.84% (5 of 598) |
| brainstem | 0.33% (2 of 598) |
| brown adipose tissue | 0.0% |
| cartilage tissue | 0.17% (1 of 598) |
| cecum | 5.73% (22 of 384) |
| cerebellum | 0.5% (3 of 598) |
| cerebral cortex | 0.33% (2 of 598) |
| chest bone | Unavailable |
| colon | 15.71% (22 of 140) |
| cranium | |
| diaphragm | 0.0% |
| epididymis | 14.29% (21 of 147) |
| esophagus | 1.66% (7 of 422) |
| eye | 0.0% |
| gall bladder | 0.0% |
| harderian gland | 0.71% (1 of 140) |
| heart | 0.33% (2 of 598) |
| hindlimb | 0.0% |
| hippocampus | 0.5% (3 of 598) |
| hypothalamus | 0.33% (2 of 598) |
| kidney | 4.52% (27 of 598) |
| large intestine | 5.35% (32 of 598) |
| liver | 0.0% |
| lower urinary tract | 0.17% (1 of 598) |
| lung | 0.33% (2 of 598) |
| lymph node | 0.17% (1 of 598) |
| main olfactory bulb | 0.0% |
| mammary gland | 0.0% |
| mesenteric lymph node | 0.31% (1 of 323) |
| olfactory lobe | 0.33% (2 of 598) |
| oral epithelium | 0.0% |
| ovary | 0.17% (1 of 598) |
| oviduct | 0.0% |
| pancreas | 0.84% (5 of 598) |
| parathyroid gland | 0.17% (1 of 576) |
| parotid gland | 0.0% |
| penis | 0.0% |
| peripheral nervous system | 0.33% (2 of 598) |
| peyers patch | 0.0% |
| pituitary gland | 0.17% (1 of 598) |
| prostate gland | 2.17% (13 of 598) |
| sciatic nerve | 0.0% |
| skeletal muscle | 0.0% |
| skin | 0.17% (1 of 598) |
| small intestine | 5.35% (32 of 598) |
| spinal cord | 0.5% (3 of 598) |
| spleen | 0.5% (3 of 598) |
| stomach | 3.68% (22 of 598) |
| stomach pyloric region | 0.0% |
| striatum | 0.5% (3 of 598) |
| sublingual gland | 0.0% |
| submandibular gland | 1.38% (2 of 145) |
| testis | 1% (6 of 598) |
| thymus | 0.17% (1 of 598) |
| thyroid gland | 3.01% (18 of 598) |
| tongue | 3.57% (5 of 140) |
| trachea | 0.5% (3 of 598) |
| trigeminal v nerve | 0.0% |
| urinary bladder | 0.0% |
| uterus | 0.33% (2 of 598) |
| vagina | 0.0% |
| vas deferens | 4.56% (18 of 395) |
| vascular system | 0.0% |
| vesicular gland | 0.0% |
| white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
| Anatomy | Background staining in controls(WT) |
|---|---|
| brain | 1.17% (6 of 511) |
| ear | 0.2% (1 of 511) |
| embryo | 0.39% (2 of 512) |
| eye | 0.2% (1 of 511) |
| footplate | 0.2% (1 of 511) |
| forebrain | 0.2% (1 of 511) |
| forelimb | 0.2% (1 of 511) |
| handplate | 0.2% (1 of 511) |
| head | 0.98% (5 of 511) |
| heart | 0.2% (1 of 511) |
| hindbrain | 1.17% (6 of 511) |
| hindlimb | 0.2% (1 of 511) |
| liver | 0.2% (1 of 506) |
| lung | 0.2% (1 of 506) |
| mandibular process | 0.2% (1 of 511) |
| maxillary process | 0.2% (1 of 511) |
| midbrain | 0.2% (1 of 511) |
| oral cavity | 0.2% (1 of 506) |
| skin | 0.2% (1 of 511) |
| tail | 0.2% (1 of 511) |
| tail somite group | 0.2% (1 of 511) |
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
LacZ Images Wholemount
38 Images
XRay Images Whole Body Dorso Ventral
20 Images
XRay Images Whole Body Lateral Orientation
20 Images
XRay Images Skull Dorso Ventral Orientation
10 Images
M-Mode Images
32 Images
LacZ images wholemount
8 Images
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Pcx by orthology or direct annotation.
| Disease | Similarity of phenotypes |
Matching phenotypes | Source |
|---|---|---|---|
| Pyruvate Carboxylase Deficiency | OMIM:266150 |
The table below shows human diseases predicted to be associated to Pcx by phenotypic similarity.
| Disease | Similarity of phenotypes |
Matching phenotypes | Source |
|---|---|---|---|
| Pyruvate Carboxylase Deficiency | OMIM:266150 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Pcx.
There are 2 publications which use IMPC produced mice or data.
| Title | Journal | IMPC Allele | PubMed ID |
|---|---|---|---|
| Requirement of hepatic pyruvate carboxylase during fasting, high fat, and ketogenic diet. | The Journal of biological chemistry (October 2022) | Pcxtm1c(EUCOMM)Wtsi Pcxtm1a(EUCOMM)Wtsi | PMC9694104 |
| Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver. | Cell metabolism (April 2019) | Pcxtm1c(EUCOMM)Wtsi | 31006591 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
This service may be affected by the Covid-19 pandemic. See how
| MGI Allele | Allele Type | Produced |
|---|---|---|
| Pcxtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
| Pcxtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
| Pcxtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice |
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