Gene: Cdk17 MGI:97517
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The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal embryo size | Cdk17em1(IMPC)J | HOM | E18.5 | 0.00 | ||
abnormal snout morphology | Cdk17em1(IMPC)J | HOM | Early adult | 7.57×10-05 | ||
increased vertical activity | Cdk17em1(IMPC)J | HOM | Early adult | 4.83×10-06 | ||
preweaning lethality, incomplete penetrance | Cdk17em1(IMPC)J | HOM | Early adult | 0.00 | ||
hyperactivity | Cdk17em1(IMPC)J | HET | Early adult | 5.05×10-06 |
Human diseases caused by Cdk17 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Cdk17 by phenotypic similarity.
IMPC related publications
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cdk17.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
The Role of CDKs and CDKIs in Murine Development. | International journal of molecular sciences (July 2020) | Cdk17em1(IMPC)J | PMC7432401 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Cdk17tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Cdk17tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Cdk17tm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Targeting vectors, ES Cells |
Cdk17tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Cdk17em1(IMPC)J | Exon Deletion | Mice |
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