Gene: Pcsk5

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Name
proprotein convertase subtilisin/kexin type 5
MGI ID
MGI:97515
Synonyms
PC6 SPC6 PC5A PC5/6A b2b585Clo b2b1549Clo
Viability
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased circulating HDL cholesterol level Pcsk5tm1b(KOMP)Mbp HET Early adult 1.31×10-05
preweaning lethality, complete penetrance Pcsk5tm1b(KOMP)Mbp HOM   Early adult 0.00
abnormal limb bud morphology Pcsk5tm1b(KOMP)Mbp HOM E12.5 0.00
abnormal limb morphology Pcsk5tm1b(KOMP)Mbp HOM E15.5 0.00
abnormal limb morphology Pcsk5tm1b(KOMP)Mbp HOM E18.5 0.00
decreased circulating cholesterol level Pcsk5tm1b(KOMP)Mbp HET Early adult 2.86×10-07
decreased circulating calcium level Pcsk5tm1b(KOMP)Mbp HET Early adult 8.74×10-05
cleft palate Pcsk5tm1b(KOMP)Mbp HOM E18.5 0.00
embryonic growth retardation Pcsk5tm1b(KOMP)Mbp HOM E12.5 0.00
abnormal body wall morphology Pcsk5tm1b(KOMP)Mbp HOM E18.5 0.00
hemorrhage Pcsk5tm1b(KOMP)Mbp HOM E15.5 0.00
abnormal neural tube closure Pcsk5tm1b(KOMP)Mbp HOM E12.5 0.00
abnormal embryo size Pcsk5tm1b(KOMP)Mbp HOM E12.5 0.00
abnormal embryo size Pcsk5tm1b(KOMP)Mbp HOM E15.5 0.00
abnormal embryo size Pcsk5tm1b(KOMP)Mbp HOM E18.5 0.00
abnormal tail morphology Pcsk5tm1b(KOMP)Mbp HOM E18.5 0.00
abnormal tail morphology Pcsk5tm1b(KOMP)Mbp HOM E12.5 0.00
hemorrhage Pcsk5tm1b(KOMP)Mbp HOM E18.5 0.00
decreased circulating triglyceride level Pcsk5tm1b(KOMP)Mbp HET Early adult 7.31×10-05
abnormal facial morphology Pcsk5tm1b(KOMP)Mbp HOM E18.5 0.00
abnormal tail morphology Pcsk5tm1b(KOMP)Mbp HOM E15.5 0.00

Download data as:  TSV  XLS

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
2 No  (4/583)  (2/2)  Section images
2 No  (1/583)  (2/2)  Section images
2 No  (4/583)  (2/2)  Section images
2 No  (2/583) N/A
2 No N/A
2 No  (1/583) N/A
2 No  (3/583) N/A
2 No  (2/583)  (2/2)  Section images
2 No  (18/132)  (1/2)  Section images
2 No  (7/407)  (2/2)  Section images
2 No  (2/2)  Section images
2 No  (2/583)  (2/2)  Section images
2 No  (3/583) N/A
2 No  (2/583)  (2/2)  Section images
2 No  (21/583)  (2/2)  Section images
2 No  (10/583)  (2/2)  Section images
2 No  (1/2)  Section images
2 No  (1/583) N/A
2 No  (2/583)  (2/2)  Section images
2 No  (1/583) N/A
2 No N/A
2 No N/A
2 No  (2/583) N/A
2 No  (1/583)  (1/2)  Section images
2 No  (1/2)  Section images
2 No  (5/583)  (2/2)  Section images
2 No  (2/583)  (2/2)  Section images
2 No N/A
2 No  (1/583) N/A
2 No  (12/583) N/A
2 No N/A
2 No  (1/583)  (1/2)  Section images
2 No  (9/583)  (2/2)  Section images
2 No  (3/583)  (2/2)  Section images
2 No  (3/583)  (2/2)  Section images
2 No  (13/583)  (2/2)  Section images
2 No  (3/583) N/A
2 No  (2/130)  (2/2)  Section images
2 No  (6/583)  (1/2)  Section images
2 No N/A
2 No  (1/583)  (2/2)  Section images
2 No  (17/583) N/A
2 No  (3/583)  (1/2)  Section images
2 No  (2/2)  Section images
2 No  (1/2)  Section images
2 No  (2/2)  Section images
2 No N/A
2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
2  (6/505)  (2/3) N/A
1  (1/60) N/A
2  (1/505) N/A
2  (1/506)  (2/3)  Wholemount images
2  (1/505)  (1/3) N/A
2  (1/505)  (2/3) N/A
2  (1/505)  (2/3) N/A
2  (1/505)  (2/3) N/A
1  (1/61) Image Only N/A
2  (1/505)  (2/3) N/A
2  (5/505)  (2/3) N/A
2  (1/505)  (2/3) N/A
2  (6/505)  (1/3) N/A
2  (1/505)  (2/3) N/A
2  (1/503) N/A
2  (1/503) Image Only N/A
2  (1/505)  (2/3) N/A
2  (1/505)  (2/3) N/A
2  (1/505)  (1/3) N/A
1  (1/75)  (1/1) N/A
2  (1/503)  (1/3) N/A
2  (1/505)  (2/3) N/A
1  (1/72)  (1/1) N/A
2  (1/505)  (2/3) N/A
2  (1/505)  (1/3) N/A

 Associated Images

X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Embryo LacZ: LacZ images wholemount
12 Images
Gross Morphology Embryo E12.5
4 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Original Image
Adult LacZ: LacZ Images Section
29 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Forepaw
10 Images
Gross Morphology Embryo E14.5-E15.5
4 Images
Eye Morphology: Images Slit Lamp
1 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Pcsk5tm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre) Mice
Pcsk5tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells