Gene: Pcsk5

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Name
proprotein convertase subtilisin/kexin type 5
MGI ID
MGI:97515
Synonyms
b2b1549Clo b2b585Clo PC5A PC6 PC5/6A SPC6
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
embryonic growth retardation Pcsk5tm1b(KOMP)Mbp HOM E12.5 0.00
hemorrhage Pcsk5tm1b(KOMP)Mbp HOM E15.5 0.00
decreased circulating cholesterol level Pcsk5tm1b(KOMP)Mbp HET Early adult 8.80×10-05
abnormal embryo size Pcsk5tm1b(KOMP)Mbp HOM E12.5 0.00
abnormal neural tube closure Pcsk5tm1b(KOMP)Mbp HOM E12.5 0.00
abnormal body wall morphology Pcsk5tm1b(KOMP)Mbp HOM E18.5 0.00
abnormal limb morphology Pcsk5tm1b(KOMP)Mbp HOM E18.5 0.00
abnormal limb morphology Pcsk5tm1b(KOMP)Mbp HOM E15.5 0.00
abnormal tail morphology Pcsk5tm1b(KOMP)Mbp HOM E15.5 0.00
hemorrhage Pcsk5tm1b(KOMP)Mbp HOM E18.5 0.00
abnormal tail morphology Pcsk5tm1b(KOMP)Mbp HOM E12.5 0.00
abnormal tail morphology Pcsk5tm1b(KOMP)Mbp HOM E18.5 0.00
preweaning lethality, complete penetrance Pcsk5tm1b(KOMP)Mbp HOM Early adult 0.00
abnormal facial morphology Pcsk5tm1b(KOMP)Mbp HOM E18.5 0.00
abnormal limb bud morphology Pcsk5tm1b(KOMP)Mbp HOM E12.5 0.00
abnormal embryo size Pcsk5tm1b(KOMP)Mbp HOM E18.5 0.00
abnormal embryo size Pcsk5tm1b(KOMP)Mbp HOM E15.5 0.00
cleft palate Pcsk5tm1b(KOMP)Mbp HOM E18.5 0.00
decreased circulating HDL cholesterol level Pcsk5tm1b(KOMP)Mbp HET Early adult 6.93×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No  (2/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No  (2/2) N/A
Epididymis 2 No  (18/134)  (1/2) N/A
Esophagus 2 No  (7/415)  (2/2) N/A
Eye 2 No  (2/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No N/A
Hypothalamus 2 No  (2/2) N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No  (1/2) N/A
Lower urinary tract 2 No N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2) N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No N/A
Submandibular gland 2 No  (2/132)  (2/2) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thalamus 2 No N/A
Thymus 2 No  (2/2) N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No  (1/2) N/A
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
Vascular system 2 No  (2/2) N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504)  (2/3) N/A
Dorsal root ganglion 1  (1/57) N/A
Ear 2  (1/504) N/A
Embryo 2  (1/505)  (2/3)  Wholemount images
Eye 2  (1/504)  (1/3) N/A
Foot 2  (1/504)  (2/3) N/A
Forebrain 2  (1/504)  (2/3) N/A
Forelimb 2  (1/504)  (2/3) N/A
Fronto-nasal process 1  (1/58) Image Only N/A
Hand 2  (1/503)  (2/3) N/A
Head 2  (5/504)  (2/3) N/A
Heart 2  (1/504)  (2/3) N/A
Hindbrain 2  (6/504)  (1/3) N/A
Hindlimb 2  (1/503)  (2/3) N/A
Liver 2  (1/504) N/A
Lung 2  (1/500) Image Only N/A
Mandibular process 2  (1/504)  (2/3) N/A
Maxillary process 2  (1/504)  (2/3) N/A
Midbrain 2  (1/504)  (1/3) N/A
Nose 1  (1/70)  (1/1) N/A
Oral cavity 2  (1/504)  (1/3) N/A
Skin 2  (1/504)  (2/3) N/A
Spinal cord 1  (1/69)  (1/1) N/A
Tail 2  (1/504)  (2/3) N/A
Tail somite 2  (1/504)  (1/3) N/A

 Associated Images

Embryo LacZ: LacZ images wholemount
12 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Gross Morphology Embryo E14.5-E15.5
2 Images
Gross Morphology Embryo E12.5
4 Images
Eye Morphology: Images Ophthalmoscopy
2 Images
X-ray: XRay Images Forepaw
10 Images
Combined SHIRPA and Dysmorphology
3 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Pcsk5tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Pcsk5tm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre) Mice