Genes Phenotypes

Gene: Furin

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Name
furin (paired basic amino acid cleaving enzyme)
MGI ID
MGI:97513
Synonyms
Fur SPC1 PACE Pcsk3 9130404I01Rik
Viability
Homozygous - Lethal
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (4) Measurements chart (260) All data table (460)
Expression & images (67) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to tooth bud stage Furintm1b(EUCOMM)Wtsi HOM E12.5 0.00
brachydactyly Furintm1b(EUCOMM)Wtsi HET Early adult 2.57×10-08
abnormal vibrissa morphology Furintm1b(EUCOMM)Wtsi HET Early adult 4.89×10-11
preweaning lethality, complete penetrance Furintm1b(EUCOMM)Wtsi HOM Early adult 0.00

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Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (3/589)  (4/4)  Wholemount images
Aorta 4 No  (1/589)  (4/4) N/A
Bone 4 No  (4/4)  Wholemount images
Brain 4 No  (3/589)  (4/4)  Wholemount images
Brainstem 4 No  (2/589)  (4/4)  Wholemount images
Brown adipose tissue 4 No  (4/4)  Wholemount images
Cartilage tissue 4 No  (4/4)  Wholemount images
Cerebellum 4 No  (3/589)  (4/4)  Wholemount images
Cerebral cortex 4 No  (2/589)  (4/4)  Wholemount images
Esophagus 4 No  (7/415)  (4/4)  Wholemount images
Eye 4 No  (4/4)  Wholemount images
Gall bladder 4 No  (4/4)  Wholemount images
Heart 4 No  (1/589)  (4/4)  Wholemount images
Hippocampus 4 No  (3/589)  (4/4)  Wholemount images
Hypothalamus 4 No  (2/589)  (4/4)  Wholemount images
Kidney 4 No  (20/589)  (4/4)  Wholemount images
Large intestine 4 No  (10/589)  (4/4)  Wholemount images
Liver 4 No  (4/4)  Wholemount images
Lower urinary tract 4 No  (1/589)  (4/4)  Wholemount images
Lung 4 No  (1/589)  (4/4)  Wholemount images
Lymph node 4 No  (4/4)  Wholemount images
Mammary gland 4 No  (2/4)  Wholemount images
Olfactory lobe 4 No  (2/589)  (4/4)  Wholemount images
Oral epithelium 4 No  (3/4)  Wholemount images
Ovary 4 No  (1/589)  (1/4)  Wholemount images
Oviduct 4 No  (2/4)  Wholemount images
Pancreas 4 No  (5/589)  (4/4)  Wholemount images
Parathyroid gland 4 No  (4/4)  Wholemount images
Peripheral nervous system 4 No  (1/589)  (4/4)  Wholemount images
Peyer's patch 4 No  (4/4)  Wholemount images
Pituitary gland 4 No  (1/589)  (4/4)  Wholemount images
Prostate gland 4 No  (12/589)  (2/4)  Wholemount images
Skeletal muscle 4 No N/A
Skin 4 No  (4/4)  Wholemount images
Small intestine 4 No  (9/589)  (4/4)  Wholemount images
Spinal cord 4 No  (2/589)  (4/4)  Wholemount images
Spleen 4 No  (2/589)  (1/4) N/A
Stomach 4 No  (13/589)  (4/4)  Wholemount images
Striatum 4 No  (3/589)  (4/4)  Wholemount images
Testis 4 No  (5/589)  (2/4)  Wholemount images
Thymus 4 No  (4/4)  Wholemount images
Thyroid gland 4 No  (16/589)  (4/4)  Wholemount images
Trachea 4 No  (2/589)  (4/4)  Wholemount images
Uterus 4 No  (2/4)  Wholemount images
Vascular system 4 No  (4/4)  Wholemount images
White adipose tissue 4 No N/A
LacZ Wholemount Images
Unassigned Top Level MA (45)
Bone expression
Skin
adipose tissue (1)
Brown adipose tissue expression
MA:0000057
cardiovascular system (1)
Heart expression
MA:0000072
digestive system (2)
Large Intestine expression
MA:0000333
endocrine system (1)
Adrenal gland expression
MA:0000116
exocrine system (2)
Mammary gland expression
MA:0000145
immune system (2)
Lymph Node expression
MA:0000139
integumental system (4)
Mammary gland expression
MA:0000145
nervous system (1)
Spinal cord expression
MA:0000216
postnatal mouse (17)
Adrenal gland expression
MA:0000116
reproductive system (1)
Testis expression
MA:0000411
respiratory system (2)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
set of connective tissues (1)
Brown adipose tissue expression
MA:0000057
trunk (9)
Adrenal gland expression
MA:0000116
urinary system (1)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/506)  (1/1) N/A
Ear 1  (1/506) N/A
Embryo 1  (1/507)  (1/1) N/A
Eye 1  (1/506)  (1/1) N/A
Foot 1  (1/506)  (1/1) N/A
Forebrain 1  (1/506)  (1/1) N/A
Forelimb 1  (1/506)  (1/1) N/A
Hand 1  (1/505)  (1/1) N/A
Head 1  (5/506)  (1/1) N/A
Heart 1  (1/506) N/A
Hindbrain 1  (6/506)  (1/1) N/A
Hindlimb 1  (1/505)  (1/1) N/A
Liver 1  (1/506) N/A
Lung 1  (1/502) N/A
Mandibular process 1  (1/506) N/A
Maxillary process 1  (1/506) N/A
Midbrain 1  (1/506)  (1/1) N/A
Oral cavity 1  (1/506) N/A
Skin 1  (1/506) N/A
Tail 1  (1/506)  (1/1) N/A
Tail somite 1  (1/506)  (1/1) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
62 Images
X-ray: XRay Images Whole Body Lateral Orientation
11 Images
X-ray: XRay Images Whole Body Dorso Ventral
12 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
Echo: M-Mode Images
64 Images
Embryo LacZ: LacZ images wholemount
4 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Furintm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Furintm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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