Furin | furin, paired basic amino acid cleaving enzyme
Physiological systems
21 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Integument Limbs/digits/tail Mortality/aging
18 No significant impact
3 Not tested
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
21Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Furintm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal vibrissa morphology | 1 supporting dataset | Furintm1b(EUCOMM)Wtsi | heterozygote | Early adult | 9.94x10-12 | ||
| brachydactyly | 1 supporting dataset | Furintm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.02x10-8 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Furintm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * |
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External links
No external links available for Furin.
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| Furintm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Furintm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Furintm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |