Gene: Pcsk1

proprotein convertase subtilisin/kexin type 1
Nec-1 Nec1 PC3 prohormone convertase 1/3 SPC3 Phpp-1 PC1
Homozygous - Subviable
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View data by physiological system
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal retinal vasculature morphology Pcsk1tm1b(EUCOMM)Wtsi HET postnatal 3.17×10-05
hypoactivity Pcsk1tm1b(EUCOMM)Wtsi HET postnatal 7.46×10-05
preweaning lethality, incomplete penetrance Pcsk1tm1b(EUCOMM)Wtsi HOM n/a 0.00
abnormal vitreous body morphology Pcsk1tm1b(EUCOMM)Wtsi HET postnatal 3.09×10-07
persistence of hyaloid vascular system Pcsk1tm1b(EUCOMM)Wtsi HET postnatal 4.16×10-08
decreased food intake Pcsk1tm1b(EUCOMM)Wtsi HET postnatal 4.10×10-06
abnormal retinal blood vessel morphology Pcsk1tm1b(EUCOMM)Wtsi HET postnatal 3.07×10-05

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Filtered by: all phenotypes


Expression data not available

 Associated Images

X-ray: XRay Images Dorso Ventral
12 Images
X-ray: XRay Images Lateral Orientation
12 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Pcsk1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Pcsk1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Pcsk1tm44480(L1L2_st0) Targeting vectors

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