Pbx3 | pre B cell leukemia homeobox 3
GeneMGI:97496
Physiological systems
22 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Adipose tissue Growth/size/body region Behavior/neurological Skeleton Craniofacial Mortality/aging
13 No significant impact
2 Not tested
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
absent ovary | 1 supporting dataset | Pbx3tm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
abnormal response to new environment | 1 supporting dataset | Pbx3tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 7.94x10-5 | ||
abnormal tooth morphology | 1 supporting dataset | Pbx3tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.5x10-7 | ||
increased total body fat amount | 1 supporting dataset | Pbx3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.06x10-6 | ||
decreased blood urea nitrogen level | 1 supporting dataset | Pbx3tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.7x10-5 | ||
increased bone mineral content | 1 supporting dataset | Pbx3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.27x10-8 | ||
increased bone mineral density | 1 supporting dataset | Pbx3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.02x10-5 | ||
abnormal bone mineralization | 1 supporting dataset | Pbx3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.78x10-5 | ||
decreased total body fat amount | 1 supporting dataset | Pbx3tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.19x10-5 | ||
preweaning lethality, complete penetrance | 1 supporting dataset | Pbx3tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | |
adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
cerebellum | heterozygote | n/a | 50% (1/2) | 0.56% (3/532) |
cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
External links
No external links available for Pbx3.
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Pbx3tm1(EGFP/cre/ERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
Pbx3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Pbx3tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Pbx3tm2(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |