Gene: Pbx3

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Phenotype System Allele Zyg Sex Life Stage P Value
decreased circulating creatinine level Pbx3tm1b(EUCOMM)Wtsi HET postnatal 9.29×10-05
increased bone mineral density Pbx3tm1a(EUCOMM)Wtsi HOM postnatal 4.61×10-06
absent ovary Pbx3tm1b(EUCOMM)Wtsi HET postnatal 0.00
decreased circulating cholesterol level Pbx3tm1a(EUCOMM)Wtsi HOM postnatal 2.03×10-05
increased lean body mass Pbx3tm1a(EUCOMM)Wtsi HOM postnatal 7.77×10-09
decreased bone mineral density Pbx3tm1a(EUCOMM)Wtsi HOM postnatal 4.61×10-06
increased circulating cholesterol level Pbx3tm1a(EUCOMM)Wtsi HOM postnatal 2.03×10-05
abnormal response to new environment Pbx3tm1a(EUCOMM)Wtsi HET postnatal 7.94×10-05
preweaning lethality, complete penetrance Pbx3tm1b(EUCOMM)Wtsi HOM n/a 0.00
abnormal tooth morphology Pbx3tm1b(EUCOMM)Wtsi HET postnatal 1.11×10-07
prolonged PR interval Pbx3tm1b(EUCOMM)Wtsi HET postnatal 1.24×10-06
decreased blood urea nitrogen level Pbx3tm1b(EUCOMM)Wtsi HET postnatal 9.78×10-05
decreased total body fat amount Pbx3tm1b(EUCOMM)Wtsi HET postnatal 2.44×10-06

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (1/2)  Wholemount images
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No N/A
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No N/A
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (1/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 3  (6/485)  (3/4) N/A
Ear 3  (1/485) N/A
Embryo 3  (1/485)  (4/4) N/A
Eye 3  (1/485)  (3/4) N/A
Foot 3  (1/485)  (1/4) N/A
Forebrain 3  (1/485)  (3/4) N/A
Forelimb 3  (1/485)  (1/4) N/A
Hand 3  (1/485)  (1/4) N/A
Head 3  (5/485)  (3/4) N/A
Heart 3  (1/485)  (1/4) N/A
Hindbrain 3  (6/485)  (3/4) N/A
Hindlimb 3  (1/485)  (1/4) N/A
Liver 3  (1/485) N/A
Lung 3  (1/485) N/A
Mandibular process 3  (1/485) N/A
Maxillary process 3  (1/485) N/A
Midbrain 3  (1/485)  (1/4) N/A
Oral cavity 3  (1/485) N/A
Skin 3  (1/485) N/A
Tail 3  (1/485) N/A
Tail somite 3  (1/485) N/A

 Associated Images

Echo: M-Mode Images
28 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Lateral Orientation
11 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
Adult LacZ: LacZ Images Wholemount
16 Images
X-ray: XRay Images Dorso Ventral
11 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Pbx3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Pbx3tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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