Pbx3 | pre B cell leukemia homeobox 3

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Adipose tissue Growth/size/body region Behavior/neurological Skeleton Craniofacial Mortality/aging

13 No significant impact

2 Not tested

Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues

Phenotypes

absent ovary1 supporting datasetPbx3tm1b(EUCOMM)WtsiheterozygoteEarly adultN/A * 
abnormal response to new environment1 supporting datasetPbx3tm1a(EUCOMM)WtsiheterozygoteEarly adult7.94x10-5 
abnormal tooth morphology1 supporting datasetPbx3tm1b(EUCOMM)WtsiheterozygoteEarly adult1.5x10-7 
increased total body fat amount1 supporting datasetPbx3tm1a(EUCOMM)WtsihomozygoteEarly adult2.06x10-6 
decreased blood urea nitrogen level1 supporting datasetPbx3tm1b(EUCOMM)WtsiheterozygoteEarly adult5.7x10-5 
increased bone mineral content1 supporting datasetPbx3tm1a(EUCOMM)WtsihomozygoteEarly adult5.27x10-8 
increased bone mineral density1 supporting datasetPbx3tm1a(EUCOMM)WtsihomozygoteEarly adult1.02x10-5 
abnormal bone mineralization1 supporting datasetPbx3tm1a(EUCOMM)WtsihomozygoteEarly adult4.78x10-5 
decreased total body fat amount1 supporting datasetPbx3tm1b(EUCOMM)WtsiheterozygoteEarly adult5.19x10-5 
preweaning lethality, complete penetrance1 supporting datasetPbx3tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a100% (2/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
boneheterozygoten/a0% (0/2)0% (0/394)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/a100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a50% (1/2)0.56% (3/532)
cerebral cortexheterozygoten/a0% (0/2)0.41% (2/491)
esophagusheterozygoten/a100% (2/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Pbx3tm1(EGFP/cre/ERT2)WtsiReporter-tagged deletion allele (with selection cassette)ES Cell
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Pbx3tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
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Pbx3tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Pbx3tm2(EGFP_CreERT2)WtsiReporter-tagged deletion allele (with selection cassette)ES Cell

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