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Gene: Oprk1 MGI:97439

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
opioid receptor, kappa 1
Synonyms:
Oprk2,  R21,  KOR-1

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Oprk1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Oprk1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
7q11.23 duplication syndrome
Short attention span DECIPHER:43
Presenile Dementia, Kraepelin Type
Dementia OMIM:176600
Monoamine Oxidase A Deficiency
Cognitive impairment ORPHA:3057
Progressive Supranuclear Palsy-Pure Akinesia With Gait Freezing Syndrome
Short stepped shuffling gait, Falls, Akinesia, Gait imbalance, Freezing of gait, Loss of ambulati... ORPHA:240094
Spinocerebellar Ataxia Type 27
Difficulty walking, Akinesia, Limb ataxia, Gait ataxia, Gait disturbance, Truncal ataxia ORPHA:98764
Spinocerebellar Ataxia Type 21
Akinesia, Gait ataxia, Progressive cerebellar ataxia ORPHA:98773
Parkinson Disease 17
Akinesia OMIM:614203
Atypical Juvenile Parkinsonism
Short stepped shuffling gait, Shuffling gait, Inability to walk, Akinesia, Gait ataxia ORPHA:391411
Spinocerebellar Ataxia 21
Akinesia, Limb ataxia, Gait ataxia, Ataxia, Progressive cerebellar ataxia OMIM:607454
Congenital Myopathy 9A
Akinesia OMIM:618822
Sporadic Adult-Onset Ataxia Of Unknown Etiology
Shuffling gait, Akinesia, Gait ataxia, Ataxia, Abnormal vestibulo-ocular reflex, Dysdiadochokinesis ORPHA:247234
Intellectual Developmental Disorder With Language Impairment And Early-Onset Dopa-Responsive Dystonia-Parkinsonism
Akinesia, Freezing of gait OMIM:619911
Corticobasal Syndrome
Akinesia, Gait disturbance ORPHA:454887
Arthrogryposis Multiplex Congenita 6
Akinesia OMIM:619334
Complex Regional Pain Syndrome
Pedal edema, Edema of the upper limbs, Allodynia ORPHA:83452
Lethal Congenital Contracture Syndrome 2
Akinesia OMIM:607598
Perry Syndrome
Short stepped shuffling gait, Akinesia OMIM:168605
Kufor-Rakeb Syndrome
Akinesia, Gait disturbance, Ataxia OMIM:606693
Manganese Poisoning
Akinesia, Gait disturbance ORPHA:306682
Neurodegeneration With Brain Iron Accumulation 5
Akinesia OMIM:300894
Mitochondrial Complex I Deficiency, Nuclear Type 28
Truncal ataxia, Akinesia, Choreoathetosis OMIM:618249
Classic Progressive Supranuclear Palsy Syndrome
Akinesia, Gait imbalance, Falls ORPHA:240071
Pudendal Neuralgia
Dyspareunia, Erectile dysfunction, Allodynia ORPHA:60039
Congenital Myopathy 12
Akinesia OMIM:612540
Fetal Akinesia Deformation Sequence
Akinesia ORPHA:994
Aceruloplasminemia
Akinesia, Limb ataxia, Gait ataxia, Ataxia ORPHA:48818
Anterior Cutaneous Nerve Entrapment Syndrome
Nausea, Hyperhidrosis, Allodynia ORPHA:51890
Erythermalgia, Primary
Diarrhea, Xerostomia, Hyperhidrosis, Constipation OMIM:133020
Multiple Pterygium Syndrome, Lethal Type
Akinesia OMIM:253290
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Akinesia OMIM:225790
Parkinson Disease 23, Autosomal Recessive Early-Onset
Akinesia OMIM:616840
Postencephalitic Parkinsonism
Akinesia ORPHA:97349
Leukoencephalopathy, Progressive, Infantile-Onset, With Or Without Deafness
Akinesia OMIM:619147
Achalasia, Familial Esophageal
Xerostomia, Achalasia OMIM:200400
Gaucher Disease, Perinatal Lethal
Akinesia OMIM:608013
Postorgasmic Illness Syndrome
Xerostomia, Hyperhidrosis ORPHA:279947
Intestinal Botulism
Diarrhea, Xerostomia, Dysphagia ORPHA:178481
Neurotrophic Keratopathy
Corneal stromal edema, Allodynia ORPHA:137596
Hereditary Late-Onset Parkinson Disease
Shuffling gait, Akinesia ORPHA:411602
Ichthyotic Keratoderma, Spasticity, Hypomyelination, And Dysmorphic Facial Features
Xerostomia, Dysmetria, Ataxia OMIM:618527
Spinal Cord Injury
Paralytic ileus, Allodynia ORPHA:90058
Iatrogenic Botulism
Constipation, Xerostomia, Dysphagia ORPHA:254509
Sjogren Syndrome
Xerostomia OMIM:270150
Inhalational Botulism
Diarrhea, Xerostomia, Constipation ORPHA:254504
Botulism
Diarrhea, Xerostomia, Dysphagia, Constipation ORPHA:1267
Trigeminal Neuralgia
Allodynia ORPHA:221091
Supranuclear Palsy, Progressive, 2
Akinesia, Gait imbalance, Falls OMIM:609454
Mitochondrial Dna Depletion Syndrome 1 (Mngie Type)
Vomiting, Diarrhea, Gastroparesis, Constipation, Intermittent diarrhea, Dysphagia, Allodynia OMIM:603041
Foodborne Botulism
Diarrhea, Xerostomia, Dysphagia, Constipation ORPHA:228371
Arthrogryposis Multiplex Congenita 5
Akinesia OMIM:618947
Lambert-Eaton Myasthenic Syndrome
Impotence, Hypohidrosis, Xerostomia, Constipation ORPHA:43393
Supranuclear Palsy, Progressive, 1
Akinesia, Gait imbalance, Falls OMIM:601104
Neurodegeneration With Brain Iron Accumulation 1
Akinesia, Gait disturbance, Choreoathetosis, Ataxia OMIM:234200
Dpagt1-Cdg
Inability to walk, Akinesia, Ataxia ORPHA:86309
Helix Syndrome
Hyperparathyroidism, Hypohidrosis, Xerostomia, Anhidrosis OMIM:617671
Benign Schwannoma
Allodynia ORPHA:252164
Aplasia Of Lacrimal And Salivary Glands
Xerostomia OMIM:180920
African Trypanosomiasis
Difficulty walking, Akinesia, Gait disturbance, Choreoathetosis ORPHA:3385

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Oprk1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Oprk1.

No publications found that use IMPC mice or data for Oprk1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Oprk1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Oprk1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Oprk1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Oprk1em1(IMPC)Ccpcz Exon Deletion Mice

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