Genes Phenotypes

Gene: Notch1

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Name
notch 1
MGI ID
MGI:97363
Synonyms
Tan1 lin-12 N1 Motch A 9930111A19Rik Mis6
Viability
Homozygous - Lethal
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (2) Measurements chart (230) All data table (447)
Expression & images (46) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal vertebrae morphology Notch1tm1b(EUCOMM)Hmgu HET Early adult 3.57×10-05
preweaning lethality, complete penetrance Notch1tm1b(EUCOMM)Hmgu HOM Early adult 0.00

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (1/2)  Wholemount images
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No  (1/2)  Wholemount images
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/584) N/A
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584)  (2/2)  Wholemount images
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (15/584)  (2/2)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (3)
Aorta expression
MA:0000062
digestive system (5)
Gall Bladder expression
MA:0000356
endocrine system (2)
Adrenal gland expression
MA:0000116
exocrine system (2)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
immune system (3)
Lymph Node expression
MA:0000139
integumental system (2)
Mammary gland expression
MA:0000145
musculoskeletal system (1)
Cartilage tissue expression
Vascular System expression
Bone expression
MA:0000104
MA:0002718
MA:0001459
nervous system (5)
Cerebral Cortex expression
Striatum expression
Hippocampus expression
Brain expression
MA:0000185
MA:0000891
MA:0000191
MA:0000168
postnatal mouse (27)
Adrenal gland expression
MA:0000116
reproductive system (3)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
respiratory system (3)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
set of connective tissues (1)
Cartilage tissue expression
Vascular System expression
Bone expression
MA:0000104
MA:0002718
MA:0001459
trunk (16)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
No Embryo expression data was found for this gene.

 Associated Images

Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
Adult LacZ: LacZ Images Wholemount
27 Images
X-ray: XRay Images Whole Body Lateral Orientation
12 Images
X-ray: XRay Images Whole Body Dorso Ventral
12 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
Echo: M-Mode Images
32 Images
X-ray: XRay Images Skull Lateral Orientation
1 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Notch1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Notch1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Notch1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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