Genes Phenotypes

Gene: Notch1

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Name
notch 1
MGI ID
MGI:97363
Synonyms
lin-12 Tan1 Mis6 9930111A19Rik Motch A N1
Viability
Homozygous - Lethal
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (2) Measurements chart (231) All data table (501)
Expression & images (67) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Notch1tm1b(EUCOMM)Hmgu HOM Early adult 0.00
abnormal vertebrae morphology Notch1tm1b(EUCOMM)Hmgu HET Early adult 3.55×10-05

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/589)  (1/2)  Wholemount images
Aorta 2 No  (1/589)  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (3/589)  (2/2)  Wholemount images
Brainstem 2 No  (2/589)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (3/589)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/589)  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (1/589) N/A
Hippocampus 2 No  (3/589)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/589)  (2/2)  Wholemount images
Kidney 2 No  (20/589)  (2/2)  Wholemount images
Large intestine 2 No  (10/589)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/589)  (2/2)  Wholemount images
Lung 2 No  (1/589)  (2/2)  Wholemount images
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No  (1/2)  Wholemount images
Olfactory lobe 2 No  (2/589)  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/589) N/A
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/589)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (1/589)  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/589) N/A
Prostate gland 2 No  (12/589)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/589)  (2/2)  Wholemount images
Spinal cord 2 No  (2/589)  (2/2)  Wholemount images
Spleen 2 No  (2/589)  (2/2)  Wholemount images
Stomach 2 No  (13/589)  (2/2)  Wholemount images
Striatum 2 No  (3/589)  (2/2)  Wholemount images
Testis 2 No  (5/589)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (16/589)  (2/2)  Wholemount images
Trachea 2 No  (2/589)  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
Unassigned Top Level MA (32)
Esophagus expression
Stomach
cardiovascular system (2)
Aorta expression
MA:0000062
digestive system (4)
Gall Bladder expression
MA:0000356
endocrine system (1)
Adrenal gland expression
MA:0000116
exocrine system (1)
Mammary gland expression
MA:0000145
immune system (3)
Lymph Node expression
MA:0000139
integumental system (2)
Mammary gland expression
MA:0000145
nervous system (2)
Peripheral Nervous System expression
MA:0000218
postnatal mouse (19)
Adrenal gland expression
MA:0000116
reproductive system (1)
Testis expression
MA:0000411
respiratory system (2)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
trunk (12)
Adrenal gland expression
MA:0000116
urinary system (1)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/506) Image Only N/A
Ear 1  (1/506) Image Only N/A
Embryo 1  (1/507) Image Only N/A
Eye 1  (1/506) Image Only N/A
Foot 1  (1/506) Image Only N/A
Forebrain 1  (1/506) Image Only N/A
Forelimb 1  (1/506) Image Only N/A
Hand 1  (1/505) Image Only N/A
Head 1  (5/506) Image Only N/A
Heart 1  (1/506) Image Only N/A
Hindbrain 1  (6/506) Image Only N/A
Hindlimb 1  (1/505) Image Only N/A
Liver 1  (1/506) Image Only N/A
Lung 1  (1/502) Image Only N/A
Mandibular process 1  (1/506) Image Only N/A
Maxillary process 1  (1/506) Image Only N/A
Midbrain 1  (1/506) Image Only N/A
Oral cavity 1  (1/506) Image Only N/A
Skin 1  (1/506) Image Only N/A
Tail 1  (1/506) Image Only N/A
Tail somite 1  (1/506) Image Only N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
51 Images
X-ray: XRay Images Whole Body Dorso Ventral
12 Images
X-ray: XRay Images Whole Body Lateral Orientation
12 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
X-ray: XRay Images Skull Lateral Orientation
1 Images
Echo: M-Mode Images
32 Images
Embryo LacZ: LacZ images wholemount
8 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Notch1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Notch1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Notch1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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