Gene: Nodal

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Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating HDL cholesterol level Nodaltm1b(EUCOMM)Wtsi HET Early adult 5.36×10-07
abnormal startle reflex Nodaltm1Rob HET Early adult 8.58×10-05
preweaning lethality, complete penetrance Nodaltm1b(EUCOMM)Wtsi HOM Early adult 0.00
increased grip strength Nodaltm1b(EUCOMM)Wtsi HET Early adult 3.22×10-07
embryonic lethality prior to tooth bud stage Nodaltm1b(EUCOMM)Wtsi HOM E12.5 0.00
increased circulating cholesterol level Nodaltm1b(EUCOMM)Wtsi HET Early adult 2.15×10-06
decreased B cell number Nodaltm1Rob HET Early adult 6.35×10-05
corneal vascularization Nodaltm1b(EUCOMM)Wtsi HET Early adult 6.30×10-06

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Adult LacZ: LacZ Images Wholemount
1 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
2 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Nodaltm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Nodaltm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Nodaltm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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