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Gene: Nkx3-1 MGI:97352

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
NK3 homeobox 1
Synonyms:
bagpipe,  Nkx-3.1,  NKX3.1,  Bax,  NKX3A

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Nkx3-1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Nkx3-1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cancer, Familial, With In Vitro Radioresistance
Neoplasm OMIM:114450
Multiple Self-Healing Squamous Epithelioma, Susceptibility To
Neoplasm OMIM:132800
Drug Metabolism, Poor, Cyp2D6-Related
Neoplasm OMIM:608902
Nasopharyngeal Carcinoma, Susceptibility To, 2
Neoplasm OMIM:161550
Adamantinoma Of Long Bones
Neoplasm OMIM:102660
Salivary Gland Adenoma, Pleomorphic
Salivary gland neoplasm OMIM:181030
Cheilitis Glandularis
Abnormal salivary gland morphology, Thick lower lip vermilion ORPHA:1221
Hearing Loss-Familial Salivary Gland Insensitivity To Aldosterone Syndrome
Abnormal salivary gland morphology ORPHA:3225
Kimura Disease
Abnormal salivary gland morphology ORPHA:482
Van Der Woude Syndrome
Lip pit, Cleft upper lip, Lower lip pit, Cleft palate, Hypodontia, Abnormal salivary gland morpho... ORPHA:888
Breast-Ovarian Cancer, Familial, Susceptibility To, 2
Breast carcinoma, Ovarian neoplasm OMIM:612555
Breast-Ovarian Cancer, Familial, Susceptibility To, 1
Breast carcinoma, Ovarian neoplasm OMIM:604370
Breast-Ovarian Cancer, Familial, Susceptibility To, 3
Ovarian carcinoma, Breast carcinoma OMIM:613399
Ovarian Cancer
Dysgerminoma, Ovarian papillary adenocarcinoma, Breast carcinoma OMIM:167000
Brooke-Spiegler Syndrome
Abnormality of the sublingual glands, Abnormality of the submandibular glands, Salivary gland neo... ORPHA:79493
Ovarian Fibromata
Ovarian fibroma OMIM:166970
Variant Abeta2M Amyloidosis
Intestinal perforation, Abnormal salivary gland morphology, Abnormality of the tongue ORPHA:314652
Oxoglutaric Aciduria
Abnormal salivary gland morphology ORPHA:31
Reticulum Cell Sarcoma
Neoplasm, Sarcoma OMIM:267730
Pancreatic Cancer, Susceptibility To, 5
Melanoma, Pancreatic adenocarcinoma OMIM:618680
Pancreatic Cancer, Susceptibility To, 1
Pancreatic adenocarcinoma OMIM:606856
Pancreatic Cancer, Susceptibility To, 2
Neoplasm of the pancreas OMIM:613347
Leiomyoma, Uterine
Uterine leiomyoma OMIM:150699
Igg4-Related Submandibular Gland Disease
Facial edema, Periorbital edema, Prostatitis, Enlarged lacrimal glands, Abnormal pancreas morphol... ORPHA:449432
Thyroid Cancer, Nonmedullary, 4
Ovarian neoplasm, Basal cell carcinoma, Papillary thyroid carcinoma, Prostate cancer, Goiter OMIM:616534
Muir-Torre Syndrome
Endometrial carcinoma, Neoplasm of the stomach, Salivary gland neoplasm, Colon cancer, Adenoma se... ORPHA:587
Hereditary Breast And/Or Ovarian Cancer Syndrome
Neoplasm of the pancreas, Breast carcinoma, Ovarian neoplasm, Melanoma, Prostate cancer, Abnormal... ORPHA:145
Igg4-Related Thyroid Disease
Pancreatic fibrosis, Thyrotoxicosis with diffuse goiter, Abnormal pituitary gland morphology, Gra... ORPHA:64744
Melioidosis
Prostatitis, Parotitis, Abnormal parotid gland morphology ORPHA:31202
Melanoma-Pancreatic Cancer Syndrome
Pancreatic adenocarcinoma, Oropharyngeal squamous cell carcinoma, Squamous cell carcinoma, Melano... OMIM:606719
Al Amyloidosis
Gastrointestinal hemorrhage, Gastroparesis, Xerostomia, Macroglossia, Peripheral edema, Dysphagia... ORPHA:85443
Cowden-Like syndrome
Endometrial carcinoma, Uterine leiomyoma, Papillary thyroid carcinoma, Breast carcinoma OMIM:612359
Parotid Salivary Glands, Polycystic Dysgenetic Disease Of
Enlargement of parotid gland OMIM:600343
Darier-White Disease
Enlargement of parotid gland OMIM:124200
Lynch Syndrome 5
Neoplasm of the pancreas, Endometrial carcinoma, Ovarian neoplasm OMIM:614350
Igg4-Related Dacryoadenitis And Sialadenitis
Palpebral edema, Facial edema, Enlarged lacrimal glands, Xerostomia, Thyroiditis, Enlargement of ... ORPHA:79078
Treacher Collins Syndrome 1
Cleft soft palate, Cryptorchidism, Cleft palate, Wide mouth, Abnormal parotid gland morphology, N... OMIM:154500
Lynch Syndrome 4
Endometrial carcinoma, Ovarian neoplasm OMIM:614337
Pancreatic Cancer
Neoplasm of the pancreas OMIM:260350
Benign Schwannoma
Intestinal polyposis, Abnormal parotid gland morphology, Abnormal esophagus morphology ORPHA:252164
Insulin-Resistance Syndrome Type B
Enlarged ovaries, Abnormal salivary gland morphology, Enlarged polycystic ovaries, Polycystic ova... ORPHA:2298
Igg4-Related Ophthalmic Disease
Palpebral edema, Orchitis, Periorbital edema, Abnormality of the anterior pituitary, Enlarged lac... ORPHA:449563
Lacrimoauriculodentodigital Syndrome
Abnormal dental enamel morphology, Abnormality of the dentition, Carious teeth, Cryptorchidism, E... ORPHA:2363
Nut Midline Carcinoma
Oropharyngeal squamous cell carcinoma, Pancreatoblastoma, Squamous cell carcinoma, Neoplasm, Panc... ORPHA:443167
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3
Anal stenosis, Absence of Stensen duct, Decreased response to growth hormone stimulation test, Hy... OMIM:604292
Prune Belly Syndrome
Cryptorchidism, Xerostomia, Anal atresia, Oligohydramnios OMIM:100100
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Absence of Stensen duct, Decreased response to growth hormone stimulation test, Hypogonadotropic ... OMIM:129900
Sarcoidosis, Susceptibility To, 1
Pericardial effusion, Enlarged lacrimal glands, Inflammation of the large intestine, Abnormal sal... OMIM:181000
Neurofibroma
Enlargement of parotid gland, Multiple intestinal neurofibromatosis, Intestinal bleeding ORPHA:252183
Blau Syndrome
Joint swelling, Abnormal salivary gland morphology, Xerostomia ORPHA:90340
Teratoma, Ovarian
Ovarian teratoma OMIM:166950
Endometrial Cancer
Endometrial carcinoma OMIM:608089
Lacrimoauriculodentodigital Syndrome 1
Absence of Stensen duct, Delayed eruption of primary teeth, Carious teeth, Coronal hypospadias, X... OMIM:149730
Igg4-Related Kidney Disease
Abnormality of the anterior pituitary, Thyroiditis, Pedal edema, Sialadenitis, Prostatitis, Pancr... ORPHA:449395
Ectodermal Dysplasia 11B, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive
Anhidrosis, Absent nipple, Conical tooth, Xerostomia, Everted lower lip vermilion, Hypoplastic ni... OMIM:614941
Sim1-Related Prader-Willi-Like Syndrome
Thin upper lip vermilion, Small scrotum, Hypogonadotropic hypogonadism, External genital hypoplas... ORPHA:398079
Burning Mouth Syndrome
Abnormality of taste sensation, Parageusia, Abnormality of the gingiva, Strawberry tongue, Xerost... ORPHA:353253
Familial Multinodular Goiter
Alveolar rhabdomyosarcoma, Pleuropulmonary blastoma, Pilomatrixoma, Multinodular goiter, Ovarian ... ORPHA:276399
Hypohidrotic Ectodermal Dysplasia
Abnormal dental morphology, Abnormality of the dentition, Xerostomia, Hypohidrosis, Tooth agenesi... ORPHA:238468
Prader-Willi Syndrome
Small scrotum, Decreased response to growth hormone stimulation test, External genital hypoplasia... ORPHA:739
Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia
Epididymitis, Prostatitis, Decreased response to growth hormone stimulation test OMIM:307200
Aplasia Of Lacrimal And Salivary Glands
Carious teeth, Lacrimal gland hypoplasia, Xerostomia, Lacrimal gland aplasia OMIM:180920
Magel2-Related Prader-Willi-Like Syndrome
Thin upper lip vermilion, Small scrotum, External genital hypoplasia, Precocious puberty, Cryptor... ORPHA:398069
Kikuchi-Fujimoto Disease
Enlargement of parotid gland, Pleural effusion, Palpebral edema, Oral ulcer ORPHA:50918
Hereditary Acrokeratotic Poikiloderma
Premature loss of primary teeth, Abnormal preputium morphology, Open bite, Abnormality of the den... ORPHA:2907
Erythermalgia, Primary
Diarrhea, Constipation, Xerostomia, Hyperhidrosis OMIM:133020
Cryptococcosis
Lymphoid leukemia, Neoplasm, Prostatitis ORPHA:1546
Sarcoidosis
Hyperthyroidism, Abnormal reproductive system morphology, Enlarged lacrimal glands, Enlargement o... ORPHA:797
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes
Malabsorption, Diarrhea, Xerostomia, Hamartomatous polyposis, Hematochezia, Protein-losing entero... OMIM:175500
Helix Syndrome
Anhidrosis, Hyperparathyroidism, Xerostomia, Hypohidrosis OMIM:617671
Whim Syndrome
Cervix cancer, Abnormal small intestine morphology, Severe periodontitis, Parotitis ORPHA:51636
Eec Syndrome
Hypospadias, Decreased response to growth hormone stimulation test, Abnormal dental enamel morpho... ORPHA:1896
Yao Syndrome
Diarrhea, Xerostomia, Oral ulcer OMIM:617321
Agammaglobulinemia, X-Linked
Epididymitis, Prostatitis OMIM:300755
Alkaptonuria
Prostatitis ORPHA:56
Postorgasmic Illness Syndrome
Xerostomia, Hyperhidrosis ORPHA:279947
Intestinal Botulism
Diarrhea, Xerostomia, Dysphagia ORPHA:178481
Kilquist Syndrome
Intestinal malrotation, Midgut malrotation, Xerostomia, Hypoplasia of teeth, Wide mouth, Chronic ... OMIM:619080
Adiposis Dolorosa
Hypothyroidism, Constipation, Xerostomia, Diarrhea ORPHA:36397
Iatrogenic Botulism
Constipation, Xerostomia, Dysphagia ORPHA:254509
Autoimmune Polyendocrinopathy Type 3
Atrophic gastritis, Hypergonadotropic hypogonadism, Autoimmune hypoparathyroidism, Celiac disease... ORPHA:227982
Botulism
Diarrhea, Xerostomia, Dysphagia, Constipation ORPHA:1267
Autoimmune Polyendocrinopathy Type 4
Atrophic gastritis, Hypergonadotropic hypogonadism, Celiac disease, Xerostomia, Primary adrenal i... ORPHA:227990
Foodborne Botulism
Diarrhea, Xerostomia, Dysphagia, Constipation ORPHA:228371
Microsporidiosis
Abnormality of the parathyroid gland, Abnormal endometrium morphology, Thyroiditis, Abnormal fall... ORPHA:2552
Inhalational Botulism
Diarrhea, Xerostomia, Constipation ORPHA:254504
Reynolds Syndrome
Abnormal gastric mucosa morphology, Xerostomia, Gastroesophageal reflux, Dysphagia, Ascites ORPHA:779
Achalasia, Familial Esophageal
Achalasia, Xerostomia OMIM:200400
Lacrimoauriculodentodigital Syndrome 3
Carious teeth, Enamel hypoplasia, Xerostomia, Widely spaced teeth OMIM:620193
Sjogren Syndrome
Xerostomia OMIM:270150
Infant Botulism
Constipation, Xerostomia, Bowel incontinence, Dysphagia ORPHA:178478
Diffuse Cutaneous Systemic Sclerosis
Malabsorption, Carious teeth, Xerostomia, Gastroesophageal reflux, Dysphagia ORPHA:220393
Ramos-Arroyo Syndrome
Aganglionic megacolon, Carious teeth, Xerostomia, Chronic constipation, Smooth tongue, Narrow mou... ORPHA:1051
Granulomatosis With Polyangiitis
Prostatitis, Pancreatitis ORPHA:900
Rat-Bite Fever
Parotitis ORPHA:31205
Primary Sjögren Syndrome
Vaginal dryness, Xerostomia, Thyroiditis, Parotitis ORPHA:289390
Chronic Graft Versus Host Disease
Phimosis, Esophageal stricture, Diarrhea, Xerostomia, Ascites, Pleural effusion, Gastroesophageal... ORPHA:99921
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Abnormal penis morphology, Oral mucosal blisters, Intestinal perforation, Oral-pharyngeal dysphag... ORPHA:95455
Lambert-Eaton Myasthenic Syndrome
Constipation, Xerostomia, Hypohidrosis ORPHA:43393

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Nkx3-1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nkx3-1.

No publications found that use IMPC mice or data for Nkx3-1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Nkx3-1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Nkx3-1tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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