Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

NK3 homeobox 1
bagpipe,  NKX3.1,  Nkx-3.1,  Bax,  NKX3A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Nkx3-1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Nkx3-1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Testicular Torsion
Testicular torsion, Torsion of appendix of testis OMIM:187400
Testicular Microlithiasis
Testicular microlithiasis OMIM:610441
Drug Metabolism, Poor, Cyp2D6-Related
Neoplasm OMIM:608902
Cancer, Familial, With In Vitro Radioresistance
Neoplasm OMIM:114450
Nasopharyngeal Carcinoma, Susceptibility To, 2
Neoplasm OMIM:161550
Multiple Self-Healing Squamous Epithelioma, Susceptibility To
Neoplasm OMIM:132800
Adamantinoma Of Long Bones
Neoplasm OMIM:102660
Salivary Gland Adenoma, Pleomorphic
Salivary gland neoplasm OMIM:181030
Cheilitis Glandularis
Thick lower lip vermilion, Abnormal salivary gland morphology ORPHA:1221
Hearing Loss-Familial Salivary Gland Insensitivity To Aldosterone Syndrome
Abnormal salivary gland morphology ORPHA:3225
Kimura Disease
Abnormal salivary gland morphology ORPHA:482
Van Der Woude Syndrome
Cleft upper lip, Lip pit, Lower lip pit, Hypodontia, Abnormal salivary gland morphology, Cleft pa... ORPHA:888
Breast-Ovarian Cancer, Familial, Susceptibility To, 1
Breast carcinoma, Ovarian neoplasm OMIM:604370
Breast-Ovarian Cancer, Familial, Susceptibility To, 2
Breast carcinoma, Ovarian neoplasm OMIM:612555
Breast-Ovarian Cancer, Familial, Susceptibility To, 3
Breast carcinoma, Ovarian carcinoma OMIM:613399
Ovarian Cancer
Breast carcinoma, Ovarian papillary adenocarcinoma, Dysgerminoma OMIM:167000
Brooke-Spiegler Syndrome
Abnormality of the submandibular glands, Abnormality of the sublingual glands, Salivary gland neo... ORPHA:79493
Ovarian Fibromata
Ovarian fibroma OMIM:166970
Variant Abeta2M Amyloidosis
Intestinal perforation, Abnormality of the tongue, Abnormal salivary gland morphology ORPHA:314652
Oxoglutaric Aciduria
Abnormal salivary gland morphology ORPHA:31
Reticulum Cell Sarcoma
Sarcoma, Neoplasm OMIM:267730
Pancreatic Cancer, Susceptibility To, 5
Pancreatic adenocarcinoma, Melanoma OMIM:618680
Hereditary Breast And Ovarian Cancer Syndrome
Breast carcinoma, Abnormal fallopian tube morphology, Prostate cancer, Neoplasm of the pancreas, ... ORPHA:145
Pancreatic Cancer, Susceptibility To, 1
Pancreatic adenocarcinoma OMIM:606856
Pancreatic Cancer, Susceptibility To, 2
Neoplasm of the pancreas OMIM:613347
Leiomyoma, Uterine
Uterine leiomyoma OMIM:150699
Igg4-Related Submandibular Gland Disease
Sialadenitis, Prostatitis, Periorbital edema, Abnormality of the submandibular glands, Abnormal s... ORPHA:449432
Thyroid Cancer, Nonmedullary, 4
Prostate cancer, Basal cell carcinoma, Papillary thyroid carcinoma, Goiter, Ovarian neoplasm OMIM:616534
Muir-Torre Syndrome
Neoplasm of the stomach, Adenoma sebaceum, Colon cancer, Salivary gland neoplasm, Endometrial car... ORPHA:587
Lynch Syndrome 5
Neoplasm of the pancreas, Ovarian neoplasm, Endometrial carcinoma, Hereditary nonpolyposis colore... OMIM:614350
Igg4-Related Thyroid Disease
Hypothyroidism, Nodular goiter, Thyroiditis, Thyrotoxicosis with diffuse goiter, Graves disease, ... ORPHA:64744
Lynch Syndrome 4
Ovarian neoplasm, Endometrial carcinoma, Hereditary nonpolyposis colorectal carcinoma OMIM:614337
Parotitis, Prostatitis, Abnormal parotid gland morphology ORPHA:31202
Treacher Collins Syndrome 1
Cleft soft palate, Wide mouth, Abnormal parotid gland morphology, Narrow mouth, Cryptorchidism, C... OMIM:154500
Melanoma-Pancreatic Cancer Syndrome
Pancreatic adenocarcinoma, Oropharyngeal squamous cell carcinoma, Sarcoma, Squamous cell carcinom... OMIM:606719
Al Amyloidosis
Macroglossia, Abnormal salivary gland morphology, Xerostomia, Peripheral edema, Dysphagia, Gastro... ORPHA:85443
Serrated Polyposis Syndrome
Pancreatic adenocarcinoma, Breast carcinoma, Colorectal polyposis, Bladder carcinoma, Prostate ca... ORPHA:157798
Cowden-Like syndrome
Breast carcinoma, Uterine leiomyoma, Papillary thyroid carcinoma, Endometrial carcinoma OMIM:612359
Parotid Salivary Glands, Polycystic Dysgenetic Disease Of
Enlargement of parotid gland OMIM:600343
Darier-White Disease
Enlargement of parotid gland OMIM:124200
Igg4-Related Dacryoadenitis And Sialadenitis
Nodular goiter, Thyroiditis, Abnormality of the submandibular glands, Abnormal salivary gland mor... ORPHA:79078
Pancreatic Cancer
Neoplasm of the pancreas OMIM:260350
Prune Belly Syndrome
Congenital posterior urethral valve, Anal atresia, Oligohydramnios, Xerostomia, Cryptorchidism OMIM:100100
Benign Schwannoma
Abnormal esophagus morphology, Intestinal polyposis, Abnormal parotid gland morphology ORPHA:252164
Lacrimoauriculodentodigital Syndrome
Enamel hypoplasia, Dysphagia, Bicornuate uterus, Microdontia, Hypodontia, Bifid uvula, Lacrimal g... ORPHA:2363
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3
Cleft upper lip, Decreased response to growth hormone stimulation test, Selective tooth agenesis,... OMIM:604292
Igg4-Related Ophthalmic Disease
Abnormality of the anterior pituitary, Sialadenitis, Prostatitis, Thyroiditis, Periorbital edema,... ORPHA:449563
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Cleft upper lip, Decreased response to growth hormone stimulation test, Selective tooth agenesis,... OMIM:129900
Insulin-Resistance Syndrome Type B
Enlarged ovaries, Polycystic ovaries, Abnormal salivary gland morphology, Enlarged polycystic ova... ORPHA:2298
Nut Midline Carcinoma
Oropharyngeal squamous cell carcinoma, Squamous cell carcinoma, Pancreatic squamous cell carcinom... ORPHA:443167
Li-Fraumeni Syndrome
Acute myeloid leukemia, Neoplasm of the gastrointestinal tract, Neoplasm of the central nervous s... ORPHA:524
Sarcoidosis, Susceptibility To, 1
Pericardial effusion, Pleural effusion, Inflammation of the large intestine, Abnormal salivary gl... OMIM:181000
Muir-Torre Syndrome
Breast carcinoma, Adenoma sebaceum, Duodenal adenocarcinoma, Malignant genitourinary tract tumor,... OMIM:158320
Teratoma, Ovarian
Ovarian teratoma OMIM:166950
Multiple intestinal neurofibromatosis, Enlargement of parotid gland, Intestinal bleeding ORPHA:252183
Endometrial Cancer
Endometrial carcinoma OMIM:608089
Blau Syndrome
Joint swelling, Abnormal salivary gland morphology, Xerostomia ORPHA:90340
Sim1-Related Prader-Willi-Like Syndrome
Central hypothyroidism, Precocious puberty, Hypogonadism, External genital hypoplasia, Decreased ... ORPHA:398079
Tumor Predisposition Syndrome 2
Acute myeloid leukemia, Ductal carcinoma in situ, Juvenile type ovarian granulosa cell tumor, Sch... OMIM:619975
Prader-Willi Syndrome
Central hypothyroidism, Precocious puberty, Hypoplastic labia majora, Small pituitary gland, Peri... ORPHA:739
Familial Multinodular Goiter
Pilomatrixoma, Pleuropulmonary blastoma, Cerebellar medulloblastoma, Colorectal polyposis, Alveol... ORPHA:276399
Lacrimoauriculodentodigital Syndrome 1
Enamel hypoplasia, Conical incisor, Delayed eruption of primary teeth, Microdontia, Absence of St... OMIM:149730
Igg4-Related Kidney Disease
Abnormality of the anterior pituitary, Pedal edema, Sialadenitis, Prostatitis, Thyroiditis, Ureth... ORPHA:449395
Ectodermal Dysplasia 11B, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive
Conical tooth, Hypodontia, Anhidrosis, Absent nipple, Everted lower lip vermilion, Xerostomia, Hy... OMIM:614941
Magel2-Related Prader-Willi-Like Syndrome
Central hypothyroidism, Gastroesophageal reflux, Precocious puberty, Hypogonadism, External genit... ORPHA:398069
Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia
Epididymitis, Prostatitis, Decreased response to growth hormone stimulation test OMIM:307200
Burning Mouth Syndrome
Abnormality of taste sensation, Strawberry tongue, Tongue pain, Parageusia, Xerostomia, Smooth to... ORPHA:353253
Hypohidrotic Ectodermal Dysplasia
Hypohidrosis, Abnormality of dental morphology, Breast aplasia, Tooth agenesis, Xerostomia, Abnor... ORPHA:238468
Aplasia Of Lacrimal And Salivary Glands
Carious teeth, Lacrimal gland hypoplasia, Xerostomia, Lacrimal gland aplasia OMIM:180920
Kikuchi-Fujimoto Disease
Pleural effusion, Oral ulcer, Enlargement of parotid gland, Palpebral edema ORPHA:50918
Hereditary Acrokeratotic Poikiloderma
Gingivitis, Abnormal pigmentation of the oral mucosa, Abnormal preputium morphology, Premature lo... ORPHA:2907
Agammaglobulinemia, X-Linked
Delayed speech and language development, Epididymitis, Hepatocellular carcinoma, Prostatitis OMIM:300755
Lymphoid leukemia, Neoplasm, Prostatitis ORPHA:1546
Hypothyroidism, Hyperthyroidism, Pleural effusion, Abnormal reproductive system morphology, Parot... ORPHA:797
Kilquist Syndrome
Midgut malrotation, Gastroesophageal reflux, Wide mouth, Chronic constipation, Absent speech, Int... OMIM:619080
Eec Syndrome
Urethral atresia, Hypohidrosis, Hypoplasia of the thymus, Decreased response to growth hormone st... ORPHA:1896
Whim Syndrome
Abnormal small intestine morphology, Parotitis, Severe periodontitis, Cervix cancer ORPHA:51636
Prostatitis ORPHA:56
Helix Syndrome
Hyperparathyroidism, Hypohidrosis, Xerostomia, Anhidrosis OMIM:617671
Abnormal fallopian tube morphology, Prostatitis, Thyroiditis, Urethritis, Abnormality of the para... ORPHA:2552
Autoimmune Polyendocrinopathy Type 3
Autoimmune hypoparathyroidism, Atrophic gastritis, Anterior pituitary dysgenesis, Primary adrenal... ORPHA:227982
Autoimmune Polyendocrinopathy Type 4
Atrophic gastritis, Anterior pituitary dysgenesis, Primary adrenal insufficiency, Central diabete... ORPHA:227990
Achalasia, Familial Esophageal
Achalasia, Xerostomia OMIM:200400
Granulomatosis With Polyangiitis
Pancreatitis, Prostatitis ORPHA:900
Rat-Bite Fever
Parotitis ORPHA:31205
Chronic Graft Versus Host Disease
Gastroesophageal reflux, Esophageal stricture, Diarrhea, Esophageal ulceration, Phimosis, Pleural... ORPHA:99921


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Nkx3-1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nkx3-1.

No publications found that use IMPC mice or data for Nkx3-1.

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MGI Allele Allele Type Produced
Nkx3-1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Nkx3-1tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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