Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

NK3 homeobox 1
bagpipe,  NKX3.1,  Nkx-3.1,  Bax,  NKX3A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Nkx3-1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Nkx3-1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Testicular Torsion
Testicular torsion, Torsion of appendix of testis OMIM:187400
Testicular Microlithiasis
Testicular microlithiasis OMIM:610441
Drug Metabolism, Poor, Cyp2D6-Related
Neoplasm OMIM:608902
Cancer, Familial, With In Vitro Radioresistance
Neoplasm OMIM:114450
Nasopharyngeal Carcinoma, Susceptibility To, 2
Neoplasm OMIM:161550
Multiple Self-Healing Squamous Epithelioma, Susceptibility To
Neoplasm OMIM:132800
Adamantinoma Of Long Bones
Neoplasm OMIM:102660
Salivary Gland Adenoma, Pleomorphic
Salivary gland neoplasm OMIM:181030
Cheilitis Glandularis
Abnormal salivary gland morphology, Thick lower lip vermilion ORPHA:1221
Hearing Loss-Familial Salivary Gland Insensitivity To Aldosterone Syndrome
Abnormal salivary gland morphology ORPHA:3225
Kimura Disease
Abnormal salivary gland morphology ORPHA:482
Van Der Woude Syndrome
Abnormal salivary gland morphology, Hypodontia, Cleft palate, Cleft upper lip, Lower lip pit, Lip... ORPHA:888
Breast-Ovarian Cancer, Familial, Susceptibility To, 1
Breast carcinoma, Ovarian neoplasm OMIM:604370
Breast-Ovarian Cancer, Familial, Susceptibility To, 2
Breast carcinoma, Ovarian neoplasm OMIM:612555
Breast-Ovarian Cancer, Familial, Susceptibility To, 3
Breast carcinoma, Ovarian carcinoma OMIM:613399
Ovarian Cancer
Breast carcinoma, Ovarian papillary adenocarcinoma, Dysgerminoma OMIM:167000
Brooke-Spiegler Syndrome
Abnormality of the submandibular glands, Salivary gland neoplasm, Abnormality of the sublingual g... ORPHA:79493
Ovarian Fibromata
Ovarian fibroma OMIM:166970
Variant Abeta2M Amyloidosis
Abnormal salivary gland morphology, Intestinal perforation, Abnormality of the tongue ORPHA:314652
Oxoglutaric Aciduria
Abnormal salivary gland morphology ORPHA:31
Reticulum Cell Sarcoma
Sarcoma, Neoplasm OMIM:267730
Cerebral Sarcoma
Fibrosarcoma, Neoplasm OMIM:117600
Pancreatic Cancer, Susceptibility To, 5
Pancreatic adenocarcinoma, Melanoma OMIM:618680
Hereditary Breast And Ovarian Cancer Syndrome
Ovarian neoplasm, Neoplasm of the pancreas, Breast carcinoma, Abnormal fallopian tube morphology,... ORPHA:145
Pancreatic Cancer, Susceptibility To, 1
Pancreatic adenocarcinoma OMIM:606856
Pancreatic Cancer, Susceptibility To, 2
Neoplasm of the pancreas OMIM:613347
Leiomyoma, Uterine
Uterine leiomyoma OMIM:150699
Igg4-Related Submandibular Gland Disease
Abnormal salivary gland morphology, Prostatitis, Abnormal pancreas morphology, Xerostomia, Facial... ORPHA:449432
Muir-Torre Syndrome
Neoplasm of the stomach, Endometrial carcinoma, Adenoma sebaceum, Salivary gland neoplasm, Colon ... ORPHA:587
Igg4-Related Thyroid Disease
Dysphagia, Goiter, Nodular goiter, Abnormality of the pituitary gland, Euthyroid goiter, Thyrotox... ORPHA:64744
Abnormal parotid gland morphology, Prostatitis, Parotitis ORPHA:31202
Colorectal Cancer, Hereditary Nonpolyposis, Type 4
Hereditary nonpolyposis colorectal carcinoma, Ovarian neoplasm, Endometrial carcinoma OMIM:614337
Treacher Collins Syndrome 1
Cleft palate, Wide mouth, Abnormal parotid gland morphology, Cleft soft palate, Narrow mouth, Cry... OMIM:154500
Benign Schwannoma
Abnormal parotid gland morphology, Intestinal polyposis, Abnormal esophagus morphology ORPHA:252164
Melanoma-Pancreatic Cancer Syndrome
Pancreatic squamous cell carcinoma, Pancreatic adenocarcinoma, Oropharyngeal squamous cell carcin... OMIM:606719
Salivary Duct Calculi
Abnormality of the mouth, Parotitis OMIM:181010
Serrated Polyposis Syndrome
Colorectal polyposis, Ovarian neoplasm, Bladder carcinoma, Hodgkin lymphoma, Adenomatous colonic ... ORPHA:157798
Al Amyloidosis
Abnormal salivary gland morphology, Dysphagia, Macroglossia, Xerostomia, Gastroparesis, Gastroint... ORPHA:85443
Cowden-Like syndrome
Endometrial carcinoma, Breast carcinoma, Papillary thyroid carcinoma, Uterine leiomyoma OMIM:612359
46,Xy Sex Reversal 10
Sex reversal, Gonadoblastoma, Dysgerminoma, Micropenis, Ambiguous genitalia, Decreased testicular... OMIM:616425
Darier-White Disease
Enlargement of parotid gland OMIM:124200
Igg4-Related Dacryoadenitis And Sialadenitis
Abnormal salivary gland morphology, Xerostomia, Nodular goiter, Facial edema, Abnormality of the ... ORPHA:79078
Pancreatic Cancer
Neoplasm of the pancreas OMIM:260350
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3
Carious teeth, Absence of Stensen duct, Cleft palate, Hypoplastic nipples, Microdontia, Urethral ... OMIM:604292
Prune Belly Syndrome
Urethral valve, Congenital posterior urethral valve, Xerostomia, Anal atresia, Oligohydramnios, C... OMIM:100100
Premature Ovarian Failure 8
Ovarian neoplasm, Premature ovarian insufficiency, Increased circulating gonadotropin level OMIM:615723
Lacrimoauriculodentodigital Syndrome
Abnormal salivary gland morphology, Carious teeth, Lacrimal gland aplasia, Hypodontia, Dysphagia,... ORPHA:2363
Igg4-Related Ophthalmic Disease
Abnormality of the anterior pituitary, Prostatitis, Pancreatitis, Thyroiditis, Palpebral edema, C... ORPHA:449563
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Carious teeth, Absence of Stensen duct, Cleft palate, Hypoplastic nipples, Microdontia, Oligodont... OMIM:129900
Insulin-Resistance Syndrome Type B
Abnormal salivary gland morphology, Enlarged ovaries, Polycystic ovaries, Enlarged polycystic ova... ORPHA:2298
Nut Midline Carcinoma
Neuroblastoma, Pancreatic squamous cell carcinoma, Leukemia, Oropharyngeal squamous cell carcinom... ORPHA:443167
Li-Fraumeni Syndrome
Ovarian neoplasm, Acute lymphoblastic leukemia, Astrocytoma, Thyroid carcinoma, Choriocarcinoma, ... ORPHA:524
Sarcoidosis, Susceptibility To, 1
Abnormal salivary gland morphology, Inflammation of the large intestine, Pericardial effusion, Pl... OMIM:181000
Enlargement of parotid gland, Intestinal bleeding, Multiple intestinal neurofibromatosis ORPHA:252183
Teratoma, Ovarian
Ovarian teratoma OMIM:166950
Familial Multinodular Goiter
Colorectal polyposis, Ovarian neoplasm, Testicular seminoma, Thyroid carcinoma, Sertoli cell neop... ORPHA:276399
Blau Syndrome
Abnormal salivary gland morphology, Xerostomia, Joint swelling ORPHA:90340
Endometrial Cancer
Endometrial carcinoma OMIM:608089
Igg4-Related Kidney Disease
Abnormality of the anterior pituitary, Prostatitis, Urethritis, Pancreatitis, Thyroiditis, Sialad... ORPHA:449395
Agammaglobulinemia, X-Linked
Epididymitis, Neoplasm, Prostatitis OMIM:300755
Lacrimoauriculodentodigital Syndrome
Carious teeth, Conical incisor, Lacrimal gland aplasia, Aplasia of the parotid gland, Absence of ... OMIM:149730
Sim1-Related Prader-Willi-Like Syndrome
Hypoplastic labia minora, Central hypothyroidism, Xerostomia, Hypogonadotropic hypogonadism, Exte... ORPHA:398079
Ectodermal Dysplasia 11B, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive
Hypodontia, Hypoplastic nipples, Abnormal number of teeth, Xerostomia, Conical tooth, Everted low... OMIM:614941
Prader-Willi Syndrome
Hypoplastic labia minora, Gastroparesis, Periodontitis, Vomiting, Precocious puberty, Hypoplastic... ORPHA:739
Burning Mouth Syndrome
Strawberry tongue, Parageusia, Tongue pain, Xerostomia, Abnormality of the gingiva, Burning mouth... ORPHA:353253
Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia
Decreased response to growth hormone stimulation test, Epididymitis, Prostatitis OMIM:307200
Magel2-Related Prader-Willi-Like Syndrome
Hypoplastic labia minora, Chronic constipation, Central hypothyroidism, Xerostomia, Small scrotum... ORPHA:398069
Hypohidrotic Ectodermal Dysplasia
Xerostomia, Abnormality of dental morphology, Thick vermilion border, Hypohidrosis, Breast aplasi... ORPHA:238468
Aplasia Of Lacrimal And Salivary Glands
Carious teeth, Lacrimal gland aplasia, Xerostomia, Lacrimal gland hypoplasia OMIM:180920
Kikuchi-Fujimoto Disease
Oral ulcer, Enlargement of parotid gland, Pleural effusion, Palpebral edema ORPHA:50918
Hereditary Acrokeratotic Poikiloderma
Gingival bleeding, Open bite, Xerostomia, Abnormal preputium morphology, Abnormality of the ureth... ORPHA:2907
Lymphoid leukemia, Neoplasm, Prostatitis ORPHA:1546
Abnormal reproductive system morphology, Chylothorax, Parotitis, Hyperthyroidism, Enlargement of ... ORPHA:797
Eec Syndrome
Hypospadias, Carious teeth, Cleft palate, Microdontia, Urethral atresia, Xerostomia, Hypoplasia o... ORPHA:1896
Prostatitis ORPHA:56
Helix Syndrome
Xerostomia, Anhidrosis, Hyperparathyroidism, Hypohidrosis OMIM:617671
Abnormality of the endometrium, Prostatitis, Urethritis, Pancreatitis, Abnormal fallopian tube mo... ORPHA:2552
Whim Syndrome
Severe periodontitis, Abnormality of the small intestine, Cervix cancer, Parotitis ORPHA:51636
Autoimmune Polyendocrinopathy Type 3
Autoimmune hypoparathyroidism, Celiac disease, Atrophic gastritis, Xerostomia, Graves disease, Hy... ORPHA:227982
Rat-Bite Fever
Parotitis ORPHA:31205
Granulomatosis With Polyangiitis
Pancreatitis, Prostatitis ORPHA:900


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Nkx3-1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nkx3-1.

No publications found that use IMPC mice or data for Nkx3-1.

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MGI Allele Allele Type Produced
Nkx3-1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Nkx3-1tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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