Gene: Ngfr

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Name
nerve growth factor receptor (TNFR superfamily, member 16)
MGI ID
MGI:97323
Synonyms
p75 p75NGFR p75NTR p75 neurotrophin receptor LNGFR Tnfrsf16
Viability
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased exploration in new environment Ngfrtm1b(EUCOMM)Wtsi HOM   Early adult 2.62×10-05
preweaning lethality, incomplete penetrance Ngfrtm1b(EUCOMM)Wtsi HOM   Early adult 0.00
abnormal eye morphology Ngfrtm1a(EUCOMM)Wtsi HET   Early adult 8.00×10-07
decreased total body fat amount Ngfrtm1b(EUCOMM)Wtsi HOM   Early adult 3.78×10-05
abnormal retina morphology Ngfrtm1a(EUCOMM)Wtsi HET   Early adult 1.68×10-07
limb grasping Ngfrtm1b(EUCOMM)Wtsi HET   Early adult 8.39×10-06
abnormal gait Ngfrtm1b(EUCOMM)Wtsi HOM Early adult 7.36×10-15
tremors Ngfrtm1b(EUCOMM)Wtsi HOM Early adult 1.61×10-06
abnormal digit morphology Ngfrtm1b(EUCOMM)Wtsi HOM   Early adult 1.25×10-08
limb grasping Ngfrtm1b(EUCOMM)Wtsi HOM Early adult 8.81×10-14

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Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/584) N/A
Aorta 2 No  (1/584) N/A
Bone 2 No N/A
Brain 2 No  (4/584)  (2/2)  Wholemount images
Brainstem 2 No  (2/584)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/584) N/A
Cerebellum 2 No  (3/584)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/584) N/A
Esophagus 2 No  (7/408) N/A
Eye 2 No  (1/2)  Wholemount images
Gall bladder 2 No N/A
Heart 2 No  (2/584) N/A
Hippocampus 2 No  (3/584) N/A
Hypothalamus 2 No  (2/584) N/A
Kidney 2 No  (21/584) N/A
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/584) N/A
Lung 2 No  (2/584)  Wholemount images
Lymph node 2 No  (1/584) N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/584) N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No  (1/562)  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/584)  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/584) N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/584) N/A
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (3/584) N/A
Spleen 2 No  (3/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (3/584)  (2/2)  Wholemount images
Testis 2 No  (6/584) N/A
Thymus 2 No  (1/584)  (1/2)  Wholemount images
Thyroid gland 2 No  (16/584) N/A
Trachea 2 No  (3/584) N/A
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/507)  (4/4) N/A
Ear 2  (1/507) N/A
Embryo 2  (1/508)  (4/4) N/A
Eye 2  (1/507)  (2/4) N/A
Footplate 2  (1/507) N/A
Forebrain 2  (1/507)  (4/4) N/A
Forelimb 2  (1/507)  (4/4) N/A
Handplate 2  (1/507) N/A
Head 2  (5/507)  (4/4) N/A
Heart 2  (1/507) Image Only N/A
Hindbrain 2  (6/507)  (4/4) N/A
Hindlimb 2  (1/507)  (4/4) N/A
Liver 2  (1/502)  (2/4) N/A
Lung 2  (1/502)  (2/4) N/A
Mandibular process 2  (1/507)  (2/4) N/A
Maxillary process 2  (1/507)  (2/4) N/A
Midbrain 2  (1/507)  (4/4) N/A
Oral cavity 2  (1/502)  (2/4) N/A
Skin 2  (1/507) N/A
Tail 2  (1/507)  (4/4) N/A
Tail somite group 2  (1/507) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
12 Images
Echo: M-Mode Images
48 Images
X-ray: XRay Images Whole Body Dorso Ventral
14 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
14 Images
X-ray: XRay Images Whole Body Lateral Orientation
14 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Hind Leg and Hip
1 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Ngfrtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Ngfrtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ngfrtm1c(EUCOMM)Wtsi Wild type floxed exon (post-Flp) Mice
Ngfrtm73(L1L2_gt0) Targeting vectors
Ngfrtm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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