Gene: Nfkb1

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Name
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
MGI ID
MGI:97312
Synonyms
nuclear factor kappaB p50 p50 subunit of NF kappaB NF-kappaB NF kappaB1 p50 NF-kappaB p50 p50/p105
Embryo Screen
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal cornea morphology Nfkb1tm1a(KOMP)Wtsi HOM postnatal 6.05×10-08
decreased effector memory CD4-positive, alpha-beta T cell number Nfkb1tm1a(KOMP)Wtsi HOM postnatal 3.96×10-05
increased circulating alkaline phosphatase level Nfkb1tm1a(KOMP)Wtsi HOM postnatal 4.22×10-05
decreased lean body mass Nfkb1tm1a(KOMP)Wtsi HOM postnatal 6.56×10-07
decreased circulating amylase level Nfkb1tm1a(KOMP)Wtsi HOM postnatal 1.72×10-05
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Nfkb1tm1a(KOMP)Wtsi HOM postnatal 1.15×10-07
increased CD4-positive, alpha beta T cell number Nfkb1tm1a(KOMP)Wtsi HOM postnatal 1.32×10-08
increased leukocyte cell number Nfkb1tm1a(KOMP)Wtsi HOM postnatal 1.04×10-06
abnormal skin condition Nfkb1tm1a(KOMP)Wtsi HOM postnatal 6.28×10-05
increased circulating free fatty acid level Nfkb1tm1a(KOMP)Wtsi HOM postnatal 5.03×10-05
increased T cell number Nfkb1tm1a(KOMP)Wtsi HOM postnatal 3.60×10-06
abnormal coat/hair pigmentation Nfkb1tm1a(KOMP)Wtsi HOM postnatal 4.28×10-06
decreased NK cell number Nfkb1tm1a(KOMP)Wtsi HOM postnatal 3.37×10-07

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No N/A
Blood vessel 2 No N/A
Bone 2 No  (1/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No  (1/2) N/A
Gall bladder 2 No  (1/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (1/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/2) N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No  (2/2) N/A
Mammary gland 2 No N/A
Esophagus 2 No  (2/2) N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No  (1/2) N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No  (2/2) N/A
Pituitary gland 2 No  (1/2) N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle tissue 2 No  (2/2) N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No  (2/2) N/A
Thyroid gland 2 No  (15/584)  (1/2) N/A
Trachea 2 No  (2/2) N/A
Uterus 2 No N/A
White adipose tissue 2 No N/A
LacZ Section Images

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No Embryo expression data was found for this gene.

 Associated Images

Phenotype associated images not available

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Produced
Nfkb1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Nfkb1tm272628(L1L2_Bact_P) Targeting vectors