Genes Phenotypes

Gene: Nfkb1

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Name
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
MGI ID
MGI:97312
Synonyms
NF kappaB1 p50 NF-kappaB nuclear factor kappaB p50 p50 subunit of NF kappaB p50/p105 NF-kappaB p50
Viability
Homozygous - Viable
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (12) Measurements chart (260) All data table (458)
Expression & images (45) Disease models (0) Order (2)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal coat/hair pigmentation Nfkb1tm1a(KOMP)Wtsi HOM Early adult 4.28×10-06
increased leukocyte cell number Nfkb1tm1a(KOMP)Wtsi HOM Early adult 5.65×10-14
decreased lean body mass Nfkb1tm1a(KOMP)Wtsi HOM Early adult 6.56×10-07
decreased circulating amylase level Nfkb1tm1a(KOMP)Wtsi HOM Early adult 1.81×10-05
decreased mean corpuscular hemoglobin concentration Nfkb1tm1a(KOMP)Wtsi HOM Early adult 5.31×10-05
decreased thermal nociceptive threshold Nfkb1tm1a(KOMP)Wtsi HOM Early adult 6.17×10-05
increased thermal nociceptive threshold Nfkb1tm1a(KOMP)Wtsi HOM Early adult 6.17×10-05
abnormal cornea morphology Nfkb1tm1a(KOMP)Wtsi HOM Early adult 2.05×10-08
abnormal skin condition Nfkb1tm1a(KOMP)Wtsi HOM Early adult 2.02×10-05
decreased circulating sodium level Nfkb1tm1a(KOMP)Wtsi HOM Early adult 1.66×10-06
increased circulating alkaline phosphatase level Nfkb1tm1a(KOMP)Wtsi HOM Early adult 1.74×10-05
increased circulating free fatty acid level Nfkb1tm1a(KOMP)Wtsi HOM Early adult 5.03×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No N/A
Blood vessel 2 No N/A
Bone 2 No  (1/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No  (1/2) N/A
Gall bladder 2 No  (1/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (1/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/2) N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No  (2/2) N/A
Mammary gland 2 No N/A
Esophagus 2 No  (2/2) N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No  (1/2) N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No  (2/2) N/A
Pituitary gland 2 No  (1/2) N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle tissue 2 No  (2/2) N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No  (2/2) N/A
Thyroid gland 2 No  (15/584)  (1/2) N/A
Trachea 2 No  (2/2) N/A
Uterus 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
LacZ Section Images
LacZ Section Images
Nfkb1tm1a(KOMP)Wtsi
cartilage tissue, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
oesophagus, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
spleen, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
spinal cord, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
gall bladder, HET, Female, WTSI

View all 21 images

Nfkb1tm1a(KOMP)Wtsi
oesophagus, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
spleen, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
spinal cord, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
gall bladder, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
lung, HET, Female, WTSI

View all 12 images

Nfkb1tm1a(KOMP)Wtsi
oesophagus, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
gall bladder, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
peyer's patch, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
large intestine, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
spleen, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
peyer's patch, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
thymus, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
lymph node, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
spinal cord, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
pituitary gland, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
testis, HET, Male, WTSI
Nfkb1tm1a(KOMP)Wtsi
oviduct, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
cartilage tissue, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
cartilage tissue, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
heart, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
parathyroid gland, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
tail, skin, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
lung, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
eye, HET, Male, WTSI
Nfkb1tm1a(KOMP)Wtsi
kidney, HET, Female, WTSI
No Embryo expression data was found for this gene.

 Associated Images

Legacy Phenotype Associated Images
Nfkb1tm1a(KOMP)Wtsi
head, HOM, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
forearm, HOM, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
body, HOM, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
body, HOM, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
body, HOM, Female, WTSI

View all 166 images

Nfkb1tm1a(KOMP)Wtsi
back skin, HOM, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
back skin, HOM, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
back skin, HOM, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
eye, corneal opacity, HOM, Female, WTSI

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Nfkb1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Nfkb1tm272628(L1L2_Bact_P) Targeting vectors