Genes Phenotypes

Gene: Nfkb1

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Name
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
MGI ID
MGI:97312
Synonyms
nuclear factor kappaB p50 p50 subunit of NF kappaB NF-kappaB NF kappaB1 p50 NF-kappaB p50 p50/p105
Viability
Homozygous - Viable
Embryo Screen
N/A
Other links
MGI   Ensembl  
Significant phenotypes (13) Measurements chart (281) All data table (640)
Expression & images (45) Disease models (0) Order (2)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal cornea morphology Nfkb1tm1a(KOMP)Wtsi HOM postnatal 6.05×10-08
decreased effector memory CD4-positive, alpha-beta T cell number Nfkb1tm1a(KOMP)Wtsi HOM postnatal 3.96×10-05
increased circulating alkaline phosphatase level Nfkb1tm1a(KOMP)Wtsi HOM postnatal 4.22×10-05
decreased lean body mass Nfkb1tm1a(KOMP)Wtsi HOM postnatal 6.56×10-07
decreased circulating amylase level Nfkb1tm1a(KOMP)Wtsi HOM postnatal 1.72×10-05
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Nfkb1tm1a(KOMP)Wtsi HOM postnatal 1.15×10-07
increased CD4-positive, alpha beta T cell number Nfkb1tm1a(KOMP)Wtsi HOM postnatal 1.32×10-08
increased leukocyte cell number Nfkb1tm1a(KOMP)Wtsi HOM postnatal 1.04×10-06
abnormal skin condition Nfkb1tm1a(KOMP)Wtsi HOM postnatal 6.28×10-05
increased circulating free fatty acid level Nfkb1tm1a(KOMP)Wtsi HOM postnatal 5.03×10-05
increased T cell number Nfkb1tm1a(KOMP)Wtsi HOM postnatal 3.60×10-06
abnormal coat/hair pigmentation Nfkb1tm1a(KOMP)Wtsi HOM postnatal 4.28×10-06
decreased NK cell number Nfkb1tm1a(KOMP)Wtsi HOM postnatal 3.37×10-07

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No N/A
Blood vessel 2 No N/A
Bone 2 No  (1/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No  (1/2) N/A
Gall bladder 2 No  (1/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (1/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/2) N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No  (2/2) N/A
Mammary gland 2 No N/A
Esophagus 2 No  (2/2) N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No  (1/2) N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No  (2/2) N/A
Pituitary gland 2 No  (1/2) N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle tissue 2 No  (2/2) N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No  (2/2) N/A
Thyroid gland 2 No  (15/584)  (1/2) N/A
Trachea 2 No  (2/2) N/A
Uterus 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
LacZ Section Images
LacZ Section Images
Nfkb1tm1a(KOMP)Wtsi
parathyroid gland, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
heart, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
lung, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
spleen, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
peyer's patch, HET, Female, WTSI

View all 19 images

Nfkb1tm1a(KOMP)Wtsi
heart, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
lung, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
spleen, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
peyer's patch, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
kidney, HET, Female, WTSI

View all 11 images

Nfkb1tm1a(KOMP)Wtsi
peyer's patch, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
large intestine, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
oesophagus, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
gall bladder, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
spleen, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
peyer's patch, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
lymph node, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
thymus, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
spinal cord, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
pituitary gland, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
cartilage tissue, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
cartilage tissue, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
heart, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
parathyroid gland, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
tail, skin, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
oviduct, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
lung, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
kidney, HET, Female, WTSI
No Embryo expression data was found for this gene.

 Associated Images

Phenotype associated images not available

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Produced
Nfkb1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Nfkb1tm272628(L1L2_Bact_P) Targeting vectors