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Gene: Nfkb1

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Name
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
MGI ID
MGI:97312
Synonyms
NF kappaB1 p50 subunit of NF kappaB p50/p105 p50 nuclear factor kappaB p50 NF-kappaB NF-kappaB p50
Viability
Data available
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (11) Measurements chart (266) All data table (609)
Expression & images (45) Disease models (0) Histopathology (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal skin condition Nfkb1tm1a(KOMP)Wtsi HOM Early adult 2.02×10-05
decreased circulating sodium level Nfkb1tm1a(KOMP)Wtsi HOM Early adult 5.87×10-07
increased circulating alkaline phosphatase level Nfkb1tm1a(KOMP)Wtsi HOM   Early adult 1.27×10-05
decreased circulating amylase level Nfkb1tm1a(KOMP)Wtsi HOM Early adult 5.76×10-06
increased circulating free fatty acids level Nfkb1tm1a(KOMP)Wtsi HOM   Early adult 5.85×10-05
increased leukocyte cell number Nfkb1tm1a(KOMP)Wtsi HOM   Early adult 2.24×10-07
increased circulating alanine transaminase level Nfkb1tm1a(KOMP)Wtsi HOM Early adult 1.40×10-05
abnormal coat/hair pigmentation Nfkb1tm1a(KOMP)Wtsi HOM   Early adult 4.28×10-06
decreased lean body mass Nfkb1tm1a(KOMP)Wtsi HOM Early adult 5.40×10-05
abnormal cornea morphology Nfkb1tm1a(KOMP)Wtsi HOM Early adult 2.05×10-08
increased circulating aspartate transaminase level Nfkb1tm1a(KOMP)Wtsi HOM Early adult 3.00×10-05

Download data as:  TSV  XLS

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
2 No  (4/583)  (2/2) N/A
2 No  (1/583) N/A
2 No N/A
2 No  (1/2) N/A
2 No  (4/583)  (2/2) N/A
2 No  (2/583) N/A
2 No N/A
2 No  (1/583)  (2/2) N/A
2 No  (3/583) N/A
2 No  (2/583) N/A
2 No  (1/2) N/A
2 No  (1/2) N/A
2 No  (2/583)  (2/2) N/A
2 No  (3/583) N/A
2 No  (2/583) N/A
2 No  (21/583)  (1/2) N/A
2 No  (10/583)  (2/2) N/A
2 No N/A
2 No  (1/583)  (1/2) N/A
2 No  (2/583)  (2/2) N/A
2 No  (1/583)  (2/2) N/A
2 No N/A
2 No  (2/2) N/A
2 No  (2/583) N/A
2 No  (1/583)  (1/2) N/A
2 No  (1/2) N/A
2 No  (5/583) N/A
2 No  (1/563)  (1/2) N/A
2 No  (2/583)  (2/2) N/A
2 No  (1/176)  (2/2) N/A
2 No  (1/583)  (1/2) N/A
2 No  (12/583) N/A
2 No  (2/2) N/A
2 No  (1/583)  (2/2) N/A
2 No  (9/583)  (2/2) N/A
2 No  (3/583)  (2/2) N/A
2 No  (3/583)  (2/2) N/A
2 No  (13/583)  (2/2) N/A
2 No  (3/583) N/A
2 No  (6/583)  (1/2) N/A
2 No  (1/583)  (2/2) N/A
2 No  (17/583)  (1/2) N/A
2 No  (3/583)  (2/2) N/A
2 No N/A
2 No N/A
LacZ Wholemount Images
LacZ Section Images
LacZ Section Images
Nfkb1tm1a(KOMP)Wtsi
spinal cord, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
lymph node, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
tail, skin, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
testis, HET, Male, WTSI
Nfkb1tm1a(KOMP)Wtsi
eye, HET, Male, WTSI

View all 21 images

Nfkb1tm1a(KOMP)Wtsi
spinal cord, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
testis, HET, Male, WTSI
Nfkb1tm1a(KOMP)Wtsi
lung, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
peyer's patch, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
oviduct, HET, Female, WTSI

View all 12 images

Nfkb1tm1a(KOMP)Wtsi
peyer's patch, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
large intestine, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
oesophagus, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
gall bladder, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
lymph node, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
peyer's patch, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
spleen, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
thymus, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
spinal cord, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
pituitary gland, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
testis, HET, Male, WTSI
Nfkb1tm1a(KOMP)Wtsi
oviduct, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
cartilage tissue, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
cartilage tissue, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
heart, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
parathyroid gland, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
tail, skin, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
lung, HET, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
eye, HET, Male, WTSI
Nfkb1tm1a(KOMP)Wtsi
kidney, HET, Female, WTSI
No Embryo expression data was found for this gene.

 Associated Images

Legacy Phenotype Associated Images
Nfkb1tm1a(KOMP)Wtsi
head, HOM, Male, WTSI
Nfkb1tm1a(KOMP)Wtsi
body, HOM, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
forearm, HOM, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
head, HOM, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
forearm, HOM, Female, WTSI

View all 166 images

Nfkb1tm1a(KOMP)Wtsi
back skin, HOM, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
back skin, HOM, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
back skin, HOM, Female, WTSI
Nfkb1tm1a(KOMP)Wtsi
eye, corneal opacity, HOM, Female, WTSI

 Disease Models

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 Histopathology

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Nfkb1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Nfkb1tm272628(L1L2_Bact_P) Targeting vectors