Gene Summary

neural cell adhesion molecule 2
RNCAM,  R4B12 antigen,  Ocam,  Ncam-2

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased eosinophil cell number Ncam2tm1b(EUCOMM)Hmgu HOM Early adult 5.17×10-06
decreased cardiac muscle contractility Ncam2tm1b(EUCOMM)Hmgu HOM   Early adult 4.17×10-05
dilated heart left ventricle Ncam2tm1b(EUCOMM)Hmgu HOM Early adult 8.28×10-05
decreased prepulse inhibition Ncam2tm1b(EUCOMM)Hmgu HOM   Early adult 6.73×10-06
increased circulating alkaline phosphatase level Ncam2tm1b(EUCOMM)Hmgu HOM   Early adult 2.90×10-05
decreased exploration in new environment Ncam2tm1b(EUCOMM)Hmgu HOM Early adult 3.64×10-06

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Whole Body Dorso Ventral

10 Images


XRay Images Whole Body Lateral Orientation

10 Images


Panel B FCS file(s)

6 Images


Panel A FCS file(s)

6 Images

Human diseases caused by Ncam2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ncam2 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Eosinophilia, Familial
Leukocytosis, Eosinophilia, Myocardial eosinophilic infiltration, Anemia, Thrombocytopenia OMIM:131400
Hypereosinophilic Syndrome, Idiopathic
Splenomegaly, Restrictive cardiomyopathy, Myeloproliferative disorder, Eosinophilia, Endocardial ... OMIM:607685
Loeffler Endocarditis
Right bundle branch block, Pericarditis, Myocardial fibrosis, Abnormal morphology of the chordae ... ORPHA:75566
Immunodeficiency 88
Eosinophilia OMIM:619630
Myeloproliferative Disorder, Chronic, With Eosinophilia
Myeloproliferative disorder, Eosinophilia OMIM:131440
Neutropenia, Lethal Congenital, With Eosinophilia
Eosinophilia, Neutropenia OMIM:257100
Neutropenia, Severe Congenital, 1, Autosomal Dominant
Acute monocytic leukemia, Eosinophilia, Monocytosis, Congenital agranulocytosis, Thrombocytosis, ... OMIM:202700
Nevoid Hypermelanosis, Linear And Whorled
Eosinophilia OMIM:614323
Immunodeficiency 103, Susceptibility To Fungal Infections
Abnormal proportion of CD8-positive T cells, Abnormal B cell count, Decreased serum iron, Hypereo... OMIM:212050
Ichthyosis-Prematurity Syndrome
Eosinophilia ORPHA:88621
Acute Myelomonocytic Leukemia
Anemia, Eosinophilia, Thrombocytopenia, Leukocytosis ORPHA:517
Juvenile Temporal Arteritis
Eosinophilia, Leukocytosis ORPHA:26137
Immunodeficiency 11B With Atopic Dermatitis
Eosinophilia OMIM:617638
Cardiomyopathy, Dilated, 1I
Reduced systolic function, Elevated circulating creatine kinase concentration, Dilated cardiomyop... OMIM:604765
Immunodeficiency 7
Hypereosinophilia OMIM:615387
Generalized Eruptive Histiocytosis
Histiocytosis, Leukemia, Hypereosinophilia ORPHA:157991
Myalgia-Eosinophilia Syndrome Associated With Tryptophan
Eosinophilia, Lymphopenia ORPHA:2582
Macrosomia Adiposa Congenita
Eosinophilia OMIM:248100
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 1
Eosinophilia, Elevated circulating creatine kinase concentration OMIM:253600
Halothane Hepatitis
Eosinophilia OMIM:234350
Autoimmune Lymphoproliferative Syndrome
Neutropenia in presence of anti-neutropil antibodies, Coombs-positive hemolytic anemia, Splenomeg... OMIM:601859
Kimura Disease
Eosinophilia ORPHA:482
Omenn Syndrome
Hypoproteinemia, Splenomegaly, Eosinophilia, Hypoplasia of the thymus, Severe B lymphocytopenia, ... OMIM:603554
Intellectual Developmental Disorder With Speech Delay, Dysmorphic Facies, And T-Cell Abnormalities
Eosinophilia, Anxiety OMIM:618092
Immunodeficiency 97 With Autoinflammation
Increased circulating ferritin concentration, Neutropenia in presence of anti-neutropil antibodie... OMIM:619802
Decreased eosinophil count OMIM:131430
Cinca Syndrome
Elevated circulating C-reactive protein concentration, Leukocytosis, Eosinophilia, Hepatosplenome... OMIM:607115
Eosinophilic Gastroenteritis
Elevated circulating C-reactive protein concentration, Leukocytosis, Eosinophilia, Hematochezia, ... ORPHA:2070
Eosinophil Peroxidase Deficiency
Eosinophil nuclear hypersegmentation OMIM:261500
Roifman Syndrome
Ventricular septal defect, Eosinophilia, Noncompaction cardiomyopathy, Splenomegaly OMIM:616651
Autoimmune Lymphoproliferative Syndrome, Type Iia
Neutropenia in presence of anti-neutropil antibodies, Coombs-positive hemolytic anemia, Splenomeg... OMIM:603909
Hyper-Ige Recurrent Infection Syndrome 3, Autosomal Recessive
Eosinophilia OMIM:618282
Wells Syndrome
Eosinophilia ORPHA:901
Roifman Syndrome
Eosinophilia, Noncompaction cardiomyopathy, Hepatosplenomegaly ORPHA:353298
Tropical Endomyocardial Fibrosis
Pulmonary venous hypertension, Systolic heart murmur, Decreased QRS voltage, Reduced left ventric... ORPHA:75565
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Lymphopenia, Lymphocytosis, Eosinophilia, Hepatosplenomegaly, Autoimmune thrombocytopenia, T lymp... ORPHA:169154
Esophagitis, Eosinophilic, 1
Eosinophilia OMIM:610247
Esophagitis, Eosinophilic, 2
Eosinophilia OMIM:613412
Eosinophilic Fasciitis
Eosinophilia, Abnormal eosinophil morphology ORPHA:3165
Hyper-Ige Recurrent Infection Syndrome 1, Autosomal Dominant
Eosinophilia, Cutaneous abscess OMIM:147060
Systemic Mastocytosis With Associated Hematologic Neoplasm
Abnormal mast cell morphology, Neutrophilia, Leukocytosis, Splenomegaly, Myeloproliferative disor... ORPHA:98849
Autosomal Dominant Severe Congenital Neutropenia
Lymphopenia, Eosinophilia, Monocytosis, Aplastic anemia, Acute lymphoblastic leukemia, Neutropeni... ORPHA:486
Hyper-Ige Recurrent Infection Syndrome 4B, Autosomal Recessive
Eosinophilia OMIM:618523
Familial Dilated Cardiomyopathy
Left bundle branch block, Mitral regurgitation, Palpitations, Left ventricular hypertrophy, Eleva... ORPHA:217607
Hyper-Ige Recurrent Infection Syndrome 2, Autosomal Recessive
Cerebral vasculitis, Eosinophilia, Subarachnoid hemorrhage, Decreased proportion of CD4-positive ... OMIM:243700
Transient ischemic attack, Intestinal bleeding, Raynaud phenomenon, Cognitive impairment, Right v... ORPHA:801
Autoinflammation With Arthritis And Dyskeratosis
Elevated circulating C-reactive protein concentration, Splenomegaly, Corneal neovascularization, ... OMIM:617388
Eosinophilic Granulomatosis With Polyangiitis
Abnormal pericardium morphology, Recurrent intrapulmonary hemorrhage, Eosinophilia, Endocarditis,... ORPHA:183
Immunodeficiency 25
Autoimmune hemolytic anemia, Eosinophilia, T lymphocytopenia OMIM:610163
Idiopathic Chronic Eosinophilic Pneumonia
Elevated circulating C-reactive protein concentration, Hypereosinophilia, Leukocytosis ORPHA:2902
Peeling Skin Syndrome 1
Eosinophilia OMIM:270300
Immunodeficiency 49
Eosinophilia, Lymphopenia OMIM:617237
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Abnormal T cell count, Lymphopenia, Eosinophilia, Hepatosplenomegaly, Abnormal B cell count, Abno... ORPHA:331206
T-B+ Severe Combined Immunodeficiency Due To Cd3Delta/Cd3Epsilon/Cd3Zeta
Eosinophilia, Lymphopenia, Decreased proportion of CD3-positive T cells, Hepatosplenomegaly ORPHA:169160
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Coombs-positive hemolytic anemia, Eosinophilia, Autoimmune thrombocytopenia, Neutropenia, Anemia,... OMIM:304790
Omenn Syndrome
Leukocytosis, Splenomegaly, Eosinophilia, Abnormal lymphocyte morphology, Anemia ORPHA:39041
O'Sullivan-Mcleod Syndrome
Eosinophilia ORPHA:99965
Abnormal proportion of CD8-positive T cells, Lymphopenia, Neutropenia in presence of anti-neutrop... ORPHA:443811
Idiopathic Hypereosinophilic Syndrome
Supraventricular arrhythmia, Dementia, Neutrophilia, Vasculitis in the skin, Raynaud phenomenon, ... ORPHA:3260
Igg4-Related Aortitis
Elevated circulating C-reactive protein concentration, Hypereosinophilia ORPHA:449400
Autoinflammation, Immune Dysregulation, And Eosinophilia
Eosinophilia, Hepatosplenomegaly OMIM:618999
Eosinophilia, Intracranial hemorrhage, Neutropenia ORPHA:1163
Idiopathic Acute Eosinophilic Pneumonia
Abnormal eosinophil morphology ORPHA:724
Cystic Echinococcosis
Hyperbilirubinemia, Eosinophilia, Abscess, Peritoneal abscess, Splenic cyst, Abnormal heart morph... ORPHA:400
Combined Immunodeficiency Due To Zap70 Deficiency
Lymphocytosis, Eosinophilia, Hepatosplenomegaly, Autoimmune thrombocytopenia, Decreased proportio... ORPHA:911
Drug Reaction With Eosinophilia And Systemic Symptoms
Eosinophilia, Cardiac arrest, Lymphocytosis, Myocarditis ORPHA:139402
Mucoepithelial Dysplasia, Hereditary
Corneal neovascularization, Melena, Eosinophilia, Cor pulmonale OMIM:158310
Hereditary Folate Malabsorption
Megaloblastic anemia, Eosinophilia, Thrombocytopenia, Pancytopenia ORPHA:90045
Late-Onset Isolated Acth Deficiency
Orthostatic hypotension, Eosinophilia, Normocytic anemia, Hypotension, Macrocytic anemia, Hyponat... ORPHA:199299
Immunodeficiency 23
Lymphopenia, Vasculitis in the skin, Eosinophilia, Abscess, Hemolytic anemia, Neutropenia OMIM:615816
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Lymphopenia, Aplasia of the thymus, Splenomegaly, Abnormally low T cell receptor excision circle ... OMIM:602450
Netherton Syndrome
Hypereosinophilia OMIM:256500
Allergic Bronchopulmonary Aspergillosis
Pulmonary arterial hypertension, Abnormal eosinophil morphology ORPHA:1164
Alveolar Echinococcosis
Cutaneous abscess, Budd-Chiari syndrome, Abnormal pericardium morphology, Abnormal spleen morphol... ORPHA:284
Autoimmune Lymphoproliferative Syndrome
Autoimmune hemolytic anemia, Abnormal proportion of CD8-positive T cells, Lymphopenia, Coombs-pos... ORPHA:3261
Hypereosinophilia, Irritability ORPHA:74
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency
Lymphopenia, Splenomegaly, Aplasia of the thymus, Severe B lymphocytopenia, Eosinophilia, Autoimm... OMIM:102700
Incontinentia Pigmenti
Telangiectasia of the skin, Cognitive impairment, Eosinophilia, Retinal hemorrhage, Cerebral isch... ORPHA:464
Igg4-Related Pachymeningitis
Mental deterioration, Eosinophilia, Elevated circulating C-reactive protein concentration ORPHA:449427
Immunodeficiency 89 And Autoimmunity
Elevated circulating C-reactive protein concentration, Decreased eosinophil count, Hypochromic mi... OMIM:619632
Immunoskeletal Dysplasia With Neurodevelopmental Abnormalities
Eosinophilia, Lymphopenia OMIM:617425
Autosomal Dominant Hyper-Ige Syndrome
Eosinophilia ORPHA:2314
Wiskott-Aldrich Syndrome
Melena, Lymphopenia, Hematemesis, Eosinophilia, Decreased mean platelet volume, Absent microvilli... OMIM:301000
Iga Pemphigus
Cutaneous abscess, Eosinophilia ORPHA:555905
Skeletal Dysplasia-T-Cell Immunodeficiency-Developmental Delay Syndrome
Lymphopenia, T lymphocytopenia, Decreased proportion of CD8-positive T cells, Mitral valve prolap... ORPHA:508533
Cognitive impairment, Eosinophilia, Abscess, Abnormality of the spleen, Vasculitis, Cerebral isch... ORPHA:228123
Cyclic Neutropenia
Lymphopenia, Cyclic neutropenia, Perianal abscess, Tooth abscess, Thrombocytopenia, Decreased eos... ORPHA:2686
Thrombocytopenia-Absent Radius Syndrome
Atrial septal defect, Leukocytosis, Atrioventricular canal defect, Eosinophilia, Hepatosplenomega... OMIM:274000
Incontinentia Pigmenti
Eosinophilia, Retinal hemorrhage, Leukocytosis OMIM:308300
Igg4-Related Kidney Disease
Elevated circulating C-reactive protein concentration, Eosinophilia, Decreased retinol-binding pr... ORPHA:449395
Cushing Disease
Lymphopenia, Leukocytosis, Decreased eosinophil count, Panic attack, Memory impairment, Myocardia... ORPHA:96253
Wiskott-Aldrich Syndrome
Neutropenia, Lymphopenia, Hematemesis, Abnormal eosinophil morphology, Recurrent intrapulmonary h... ORPHA:906
Eosinophilia, Leukopenia, Arrhythmia, Thrombocytopenia, Hemolytic anemia, Ventricular tachycardia... ORPHA:797
Igg4-Related Ophthalmic Disease
Eosinophilia, Elevated circulating C-reactive protein concentration ORPHA:449563
Lymphatic Filariasis
Hypereosinophilia ORPHA:2035
Igg4-Related Submandibular Gland Disease
Eosinophilia ORPHA:449432
Viss Syndrome
Double outlet right ventricle, Atrial septal defect, Right ventricular hypertrophy, Epidural hemo... OMIM:619472
Cushing Syndrome Due To Ectopic Acth Secretion
Lymphopenia, Leukocytosis, Decreased eosinophil count, Anxiety, Panic attack, Memory impairment, ... ORPHA:99889
Telangiectasia of the skin, Abnormal eosinophil morphology, Sinus tachycardia, Arrhythmia, Myocar... ORPHA:221


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ncam2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ncam2.

No publications found that use IMPC mice or data for Ncam2.

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MGI Allele Allele Type Produced
Ncam2tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ncam2tm1(NCOM)Cmhd Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Ncam2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Ncam2tm2e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Ncam2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ncam2tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice

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