Gene: Ncam2 MGI:97282

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Gene Summary

neural cell adhesion molecule 2
RNCAM,  R4B12 antigen,  Ncam-2,  Ocam

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased prepulse inhibition Ncam2tm1b(EUCOMM)Hmgu HOM   Early adult 6.73×10-06
decreased exploration in new environment Ncam2tm1b(EUCOMM)Hmgu HOM Early adult 3.64×10-06
dilated heart left ventricle Ncam2tm1b(EUCOMM)Hmgu HOM Early adult 8.28×10-05
increased circulating alkaline phosphatase level Ncam2tm1b(EUCOMM)Hmgu HOM   Early adult 2.90×10-05
increased eosinophil cell number Ncam2tm1b(EUCOMM)Hmgu HOM Early adult 5.17×10-06
decreased cardiac muscle contractility Ncam2tm1b(EUCOMM)Hmgu HOM   Early adult 4.17×10-05

Download data as:  TSV  XLS

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Whole Body Dorso Ventral

10 Images


XRay Images Whole Body Lateral Orientation

10 Images


Panel A FCS file(s)

6 Images


Panel B FCS file(s)

6 Images

Human diseases caused by Ncam2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ncam2 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Eosinophilia, Familial
Leukocytosis, Thrombocytopenia, Anemia, Eosinophilia, Myocardial eosinophilic infiltration OMIM:131400
Hypereosinophilic Syndrome, Idiopathic
Restrictive cardiomyopathy, Endocardial fibrosis, Splenomegaly, Myeloproliferative disorder, Eosi... OMIM:607685
Myeloproliferative Disorder, Chronic, With Eosinophilia
Myeloproliferative disorder, Eosinophilia OMIM:131440
Neutropenia, Lethal Congenital, With Eosinophilia
Neutropenia, Eosinophilia OMIM:257100
Neutropenia, Severe Congenital, 1, Autosomal Dominant
Congenital agranulocytosis, Monocytosis, Thrombocytosis, Acute monocytic leukemia, Neutropenia, A... OMIM:202700
Nevoid Hypermelanosis, Linear And Whorled
Eosinophilia OMIM:614323
Ichthyosis-Prematurity Syndrome
Eosinophilia ORPHA:88621
Acute Myelomonocytic Leukemia
Leukocytosis, Thrombocytopenia, Eosinophilia, Anemia ORPHA:517
Juvenile Temporal Arteritis
Leukocytosis, Eosinophilia ORPHA:26137
Immunodeficiency 11B With Atopic Dermatitis
Eosinophilia OMIM:617638
T-Cell Receptor-Alpha/Beta Deficiency
Hypereosinophilia OMIM:615387
Generalized Eruptive Histiocytosis
Histiocytosis, Leukemia, Hypereosinophilia ORPHA:157991
Candidiasis, Familial, 2
Decreased serum iron, Hypereosinophilia OMIM:212050
Myalgia-Eosinophilia Syndrome Associated With Tryptophan
Lymphopenia, Eosinophilia ORPHA:2582
Macrosomia Adiposa Congenita
Eosinophilia OMIM:248100
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 1
Elevated circulating creatine kinase concentration, Eosinophilia OMIM:253600
Hyper-Ige Recurrent Infection Syndrome 2, Autosomal Recessive
Subarachnoid hemorrhage, Cerebral vasculitis, Eosinophilia OMIM:243700
Halothane Hepatitis
Eosinophilia OMIM:234350
Autoimmune Lymphoproliferative Syndrome
Iron deficiency anemia, Coombs-positive hemolytic anemia, Elevated proportion of CD4-negative, CD... OMIM:601859
Kimura Disease
Eosinophilia ORPHA:482
Omenn Syndrome
Severe B lymphocytopenia, Hypoproteinemia, Thrombocytopenia, Hypoplasia of the thymus, B lymphocy... OMIM:603554
Intellectual Developmental Disorder With Speech Delay, Dysmorphic Facies, And T-Cell Abnormalities
Anxiety, Eosinophilia OMIM:618092
Cinca Syndrome
Leukocytosis, Elevated circulating C-reactive protein concentration, Anemia, Hepatosplenomegaly, ... OMIM:607115
Decreased eosinophil count OMIM:131430
Eosinophilic Gastroenteritis
Hematochezia, Leukocytosis, Hypoalbuminemia, Anemia, Elevated circulating C-reactive protein conc... ORPHA:2070
Eosinophil Peroxidase Deficiency
Abnormal eosinophil morphology OMIM:261500
Roifman Syndrome
Ventricular septal defect, Noncompaction cardiomyopathy, Eosinophilia, Splenomegaly OMIM:616651
Autoimmune Lymphoproliferative Syndrome, Type Iia
Iron deficiency anemia, Coombs-positive hemolytic anemia, Elevated proportion of CD4-negative, CD... OMIM:603909
Wells Syndrome
Eosinophilia ORPHA:901
Roifman Syndrome
Hepatosplenomegaly, Noncompaction cardiomyopathy, Eosinophilia ORPHA:353298
Tropical Endomyocardial Fibrosis
Atrial flutter, P pulmonale, Tricuspid regurgitation, Abnormal T-wave, Hypoalbuminemia, Cardiomeg... ORPHA:75565
Hyper-Ige Recurrent Infection Syndrome 3, Autosomal Recessive
Eosinophilia OMIM:618282
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Lymphocytosis, T lymphocytopenia, Decreased proportion of CD8-positive T cells, Autoimmune thromb... ORPHA:169154
Eosinophilic Fasciitis
Abnormal eosinophil morphology, Eosinophilia ORPHA:3165
Esophagitis, Eosinophilic, 1
Eosinophilia OMIM:610247
Esophagitis, Eosinophilic, 2
Eosinophilia OMIM:613412
Systemic Mastocytosis With Associated Hematologic Neoplasm
Myeloid leukemia, Hypotension, Leukocytosis, Chronic lymphatic leukemia, Normocytic anemia, Throm... ORPHA:98849
Hyper-Ige Recurrent Infection Syndrome 1, Autosomal Dominant
Eosinophilia OMIM:147060
Autosomal Dominant Severe Congenital Neutropenia
Monocytosis, Lymphopenia, Leukemia, Neutropenia, Acute myeloid leukemia, Aplastic anemia, Acute l... ORPHA:486
Familial Dilated Cardiomyopathy
Ventricular arrhythmia, Palpitations, Reduced ejection fraction, Arrhythmia, Abnormal circulating... ORPHA:217607
Autoinflammation With Arthritis And Dyskeratosis
Autoimmune hemolytic anemia, Hypereosinophilia, Elevated circulating C-reactive protein concentra... OMIM:617388
Cognitive impairment, Intestinal bleeding, Pericarditis, Right ventricular failure, Interstitial ... ORPHA:801
Eosinophilic Granulomatosis With Polyangiitis
Endocarditis, Abnormal pericardium morphology, Recurrent intrapulmonary hemorrhage, Hypertension,... ORPHA:183
Hyper-Ige Recurrent Infection Syndrome 4, Autosomal Recessive
Eosinophilia OMIM:618523
Immunodeficiency 25
Autoimmune hemolytic anemia, T lymphocytopenia, Eosinophilia OMIM:610163
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Autoimmune hemolytic anemia, Decreased proportion of CD3-positive T cells, Lymphopenia, Abnormal ... ORPHA:331206
Immunodeficiency 49
Lymphopenia, Eosinophilia OMIM:617237
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Coombs-positive hemolytic anemia, Autoimmune thrombocytopenia, Neutropenia, Thrombocytopenia, Ane... OMIM:304790
T-B+ Severe Combined Immunodeficiency Due To Cd3Delta/Cd3Epsilon/Cd3Zeta
Decreased proportion of CD3-positive T cells, Hepatosplenomegaly, Eosinophilia, Lymphopenia ORPHA:169160
O'Sullivan-Mcleod Syndrome
Eosinophilia ORPHA:99965
Omenn Syndrome
Leukocytosis, Abnormal lymphocyte morphology, Anemia, Splenomegaly, Eosinophilia ORPHA:39041
T lymphocytopenia, Abnormal CD4:CD8 ratio, Cutaneous abscess, Hemolytic anemia, Vasculitis in the... ORPHA:443811
Igg4-Related Aortitis
Hypereosinophilia, Elevated circulating C-reactive protein concentration ORPHA:449400
Autoinflammation, Immune Dysregulation, And Eosinophilia
Hepatosplenomegaly, Eosinophilia OMIM:618999
Idiopathic Hypereosinophilic Syndrome
Thrombocytosis, Supraventricular arrhythmia, Dementia, Intracranial hemorrhage, Leukocytosis, Vas... ORPHA:3260
Idiopathic Acute Eosinophilic Pneumonia
Abnormal eosinophil morphology ORPHA:724
Cystic Echinococcosis
Peritoneal abscess, Abnormal heart morphology, Hyperbilirubinemia, Splenic cyst, Abscess, Eosinop... ORPHA:400
Intracranial hemorrhage, Neutropenia, Eosinophilia ORPHA:1163
Combined Immunodeficiency Due To Zap70 Deficiency
Lymphocytosis, Decreased proportion of CD8-positive T cells, Autoimmune thrombocytopenia, Autoimm... ORPHA:911
Drug Rash With Eosinophilia And Systemic Symptoms
Lymphocytosis, Cardiac arrest, Eosinophilia, Myocarditis ORPHA:139402
Late-Onset Isolated Acth Deficiency
Orthostatic hypotension, Hypotension, Hyponatremia, Hyperuricemia, Normocytic anemia, Hypercalcem... ORPHA:199299
Hereditary Folate Malabsorption
Pancytopenia, Thrombocytopenia, Eosinophilia, Megaloblastic anemia ORPHA:90045
Immunodeficiency 23
Hemolytic anemia, Vasculitis in the skin, Lymphopenia, Neutropenia, Abscess, Eosinophilia OMIM:615816
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency
Severe B lymphocytopenia, Aplasia of the thymus, Autoimmune thrombocytopenia, Autoimmune hemolyti... OMIM:102700
Mucoepithelial Dysplasia, Hereditary
Cor pulmonale, Eosinophilia, Corneal neovascularization, Melena OMIM:158310
Allergic Bronchopulmonary Aspergillosis
Pulmonary arterial hypertension, Abnormal eosinophil morphology ORPHA:1164
Netherton Syndrome
Hypereosinophilia OMIM:256500
Wiskott-Aldrich Syndrome
Iron deficiency anemia, Decreased mean platelet volume, Small vessel vasculitis, Decreased propor... OMIM:301000
Autoimmune Lymphoproliferative Syndrome
Coombs-positive hemolytic anemia, Lymphocytosis, Elevated proportion of CD4-negative, CD8-negativ... ORPHA:3261
Alveolar Echinococcosis
Cutaneous abscess, Budd-Chiari syndrome, Abnormal spleen morphology, Abnormal pericardium morphol... ORPHA:284
Hypereosinophilia, Irritability ORPHA:74
Igg4-Related Pachymeningitis
Mental deterioration, Elevated circulating C-reactive protein concentration, Eosinophilia ORPHA:449427
Immunoskeletal Dysplasia With Neurodevelopmental Abnormalities
Lymphopenia, Eosinophilia OMIM:617425
Autosomal Dominant Hyper-Ige Syndrome
Eosinophilia ORPHA:2314
Incontinentia Pigmenti
Telangiectasia of the skin, Congestive heart failure, Cerebral ischemia, Pulmonary arterial hyper... ORPHA:464
Thrombocytopenia-Absent Radius Syndrome
Atrial septal defect, Ventricular septal defect, Leukocytosis, Thrombocytopenia, Anemia, Tetralog... OMIM:274000
Iga Pemphigus
Cutaneous abscess, Eosinophilia ORPHA:555905
Skeletal Dysplasia-T-Cell Immunodeficiency-Developmental Delay Syndrome
T lymphocytopenia, Decreased proportion of CD8-positive T cells, Lymphopenia, Decreased proportio... ORPHA:508533
Pericarditis, Granuloma, Vasospasm, Cerebral ischemia, Cognitive impairment, Vasculitis, Abnormal... ORPHA:228123
Cyclic Neutropenia
Decreased eosinophil count, Tooth abscess, Lymphopenia, Thrombocytopenia, Perianal abscess, Cycli... ORPHA:2686
Incontinentia Pigmenti
Leukocytosis, Retinal hemorrhage, Eosinophilia OMIM:308300
Igg4-Related Kidney Disease
Arteritis, Pericarditis, Elevated circulating creatinine concentration, Decreased retinol-binding... ORPHA:449395
Arrhythmia, Hemolytic anemia, Increased T cell count, Abnormal cardiac ventricular function, Vent... ORPHA:797
Wiskott-Aldrich Syndrome
Arrhythmia, Hemolytic anemia, Chronic leukemia, Internal hemorrhage, Hematemesis, Intracranial he... ORPHA:906
Igg4-Related Ophthalmic Disease
Elevated circulating C-reactive protein concentration, Eosinophilia ORPHA:449563
Lymphatic Filariasis
Hypereosinophilia ORPHA:2035
Igg4-Related Submandibular Gland Disease
Eosinophilia ORPHA:449432
Arrhythmia, Pericarditis, Sinus tachycardia, Telangiectasia of the skin, Myocardial infarction, A... ORPHA:221


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ncam2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ncam2.

No publications found that use IMPC mice or data for Ncam2.

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MGI Allele Allele Type Produced
Ncam2tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ncam2tm1(NCOM)Cmhd Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Ncam2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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