Myb | myeloblastosis oncogene

GeneMGI:97249Synonyms: c-myb

Physiological systems

23 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Integument Embryo Nervous system Mortality/aging Cardiovascular system

17 No significant impact

1 Not tested

Gene metrics:6Significant phenotypes
3Associated diseases
Expression examined in:73Adult tissues
73Embryo tissues

Phenotypes

spina bifida1 supporting datasetMybtm1b(KOMP)WtsihomozygoteE15.5N/A * 
abnormal skin appearance1 supporting datasetMybtm1b(KOMP)WtsihomozygoteE15.5N/A * 
pallor1 supporting datasetMybtm1b(KOMP)WtsihomozygoteE15.5N/A * 
edema1 supporting datasetMybtm1b(KOMP)WtsihomozygoteE15.5N/A * 
preweaning lethality, incomplete penetrance3 supporting datasetsMybtm1b(KOMP)WtsihomozygoteEarly adultN/A * 
hemorrhage1 supporting datasetMybtm1b(KOMP)WtsiheterozygoteE15.5N/A * 
hemorrhage1 supporting datasetMybtm1b(KOMP)WtsihomozygoteE15.5N/A * 
spina bifida1 supporting datasetMybtm1b(KOMP)WtsiheterozygoteE15.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
bloodheterozygoten/a0% (0/2)0% (0/17)
bone marrowheterozygoteSection images
100% (2/2)0% (0/22)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/an/a0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/an/a0.22% (1/454)
cecumheterozygoteSection images
100% (2/2)7.75% (22/284)
cerebellumheterozygoteSection images
50% (1/2)0.56% (3/532)
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Histopathology

IMPC related publications

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Mybtm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Mybtm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
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