Myb | myeloblastosis oncogene
Physiological systems
23 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Embryo Nervous system Mortality/aging Cardiovascular system
17 No significant impact
1 Not tested
Gene metrics:6Significant phenotypes
3Associated diseases
Expression examined in:73Adult tissues
73Embryo tissues
spina bifida | 1 supporting dataset | Mybtm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
abnormal skin appearance | 1 supporting dataset | Mybtm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
pallor | 1 supporting dataset | Mybtm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
edema | 1 supporting dataset | Mybtm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
preweaning lethality, incomplete penetrance | 3 supporting datasets | Mybtm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
hemorrhage | 1 supporting dataset | Mybtm1b(KOMP)Wtsi | heterozygote | E15.5 | N/A * | ||
hemorrhage | 1 supporting dataset | Mybtm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
spina bifida | 1 supporting dataset | Mybtm1b(KOMP)Wtsi | heterozygote | E15.5 | N/A * |
| | | | | | | | | |
adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
cecum | heterozygote | Section images | 100% (2/2) | 7.75% (22/284) |
cerebellum | heterozygote | Section images | 50% (1/2) | 0.56% (3/532) |
External links
No external links available for Myb.
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Mybtm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Mybtm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Mybtm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |