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Gene: Mt3 MGI:97173

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
metallothionein 3
Synonyms:
MT-3

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Mt3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Mt3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Gaze Palsy, Familial Horizontal, With Progressive Scoliosis 2, With Impaired Intellectual Development
Fusion of the left and right thalami, Seizure, Agenesis of corpus callosum OMIM:617542
Microcephaly, Postnatal Progressive, With Seizures And Brain Atrophy
Seizure, Decreased thalamic volume OMIM:613668
Neurodevelopmental Disorder With Seizures And Brain Atrophy
Focal-onset seizure, Decreased thalamic volume, Myoclonic seizure OMIM:619072
Diencephalic-Mesencephalic Junction Dysplasia Syndrome 2
Decreased thalamic volume OMIM:618646
Basal Ganglia Calcification, Idiopathic, 8, Autosomal Recessive
Seizure, Thalamic calcification OMIM:618824
New-Onset Refractory Status Epilepticus
Seizure precipitated by febrile infection, Bilateral tonic-clonic seizure with focal onset, Focal... ORPHA:363558
Oculoskeletodental Syndrome
Dysplastic corpus callosum, Hypercalcemia, Abnormal thalamus morphology, Hypocalcemia ORPHA:557003
Tubulinopathy-Associated Dysgyria
Startle-induced seizure, Abnormal thalamus morphology, Generalized non-motor (absence) seizure, I... ORPHA:467166
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 2
T2 hypointense thalamus, Seizure, Myoclonus OMIM:618193
Alexander Disease Type I
Seizure, Palatal tremor, Abnormal thalamic MRI signal intensity ORPHA:363717
Combined Oxidative Phosphorylation Deficiency 51
Focal T2 hyperintense thalamic lesion, Myoclonus OMIM:619057
Coasy Protein-Associated Neurodegeneration
Abnormal thalamus morphology ORPHA:397725
Familial Acute Necrotizing Encephalopathy
Abnormal thalamus morphology, Seizure, Gliosis ORPHA:88619
Spinocerebellar Ataxia With Epilepsy
Bilateral tonic-clonic seizure with focal onset, Focal T2 hyperintense thalamic lesion, Myoclonus ORPHA:254881
Basal Ganglia Calcification, Idiopathic, 5
Thalamic calcification OMIM:615483
Progressive Epilepsy-Intellectual Disability Syndrome, Finnish Type
Generalized myoclonic seizure, Seizure, Focal impaired awareness seizure, T2 hypointense thalamus ORPHA:1947
Basal Ganglia Calcification, Idiopathic, 7, Autosomal Recessive
Thalamic calcification OMIM:618317
Leukoencephalopathy With Dystonia And Motor Neuropathy
Focal T2 hyperintense thalamic lesion OMIM:613724
Leptin Receptor Deficiency
Abnormal hypothalamus morphology, Pituitary hypothyroidism, Decreased response to growth hormone ... OMIM:614963
Sandhoff Disease, Infantile Form
Bilateral tonic-clonic seizure, Abnormal thalamic MRI signal intensity, Myoclonic seizure, Seizur... ORPHA:309155
Cach Syndrome
Seizure, Lateral ventricle dilatation, T2 hypointense thalamus ORPHA:135
Panhypophysitis
Hyponatremia, Reduced circulating prolactin concentration, Adrenocorticotropic hormone deficiency... ORPHA:95513
Adenohypophysitis
Hyponatremia, Reduced circulating prolactin concentration, Adrenocorticotropic hormone deficiency... ORPHA:95512
Intellectual Disability-Facial Dysmorphism Syndrome Due To Setd5 Haploinsufficiency
Seizure, Febrile seizure (within the age range of 3 months to 6 years), Abnormal thalamus morphology ORPHA:404440
Cortical Dysgenesis With Pontocerebellar Hypoplasia Due To Tubb3 Mutation
Focal-onset seizure, Partial agenesis of the corpus callosum, Seizure, Lateral ventricle dilatati... ORPHA:300570
Juvenile Neuronal Ceroid Lipofuscinosis
Seizure, Focal T2 hyperintense thalamic lesion, Bilateral tonic-clonic seizure, Myoclonic spasms ORPHA:79264
3P25.3 Microdeletion Syndrome
Generalized myoclonic seizure, Abnormal thalamus morphology, Bilateral tonic-clonic seizure, Gene... ORPHA:435638
Congenital Muscular Dystrophy With Cerebellar Involvement
Seizure, Agenesis of corpus callosum, Decreased thalamic volume ORPHA:370959
Mitochondrial Complex Iv Deficiency, Nuclear Type 3
Focal T2 hyperintense thalamic lesion, Status epilepticus OMIM:619046
Chronic Bilirubin Encephalopathy
Seizure, Hypernatremia, Abnormal thalamic MRI signal intensity ORPHA:529808
Acute Bilirubin Encephalopathy
Seizure, Hypernatremia, Abnormal thalamic MRI signal intensity ORPHA:529799
Combined Oxidative Phosphorylation Defect Type 23
Seizure, Abnormal thalamic MRI signal intensity ORPHA:444013
Japanese Encephalitis
Hyponatremia, Bilateral tonic-clonic seizure, Focal motor seizure, Focal T2 hyperintense thalamic... ORPHA:79139
Mff-Related Encephalopathy Due To Mitochondrial And Peroxisomal Fission Defect
Seizure, Epileptic spasm, Abnormal thalamic MRI signal intensity ORPHA:485421
Leigh Syndrome
Infantile spasms, Abnormal thalamic MRI signal intensity, Seizure, Gliosis, Status epilepticus, A... ORPHA:506
Sensory Ataxic Neuropathy-Dysarthria-Ophthalmoparesis Syndrome
Seizure, Abnormal thalamic MRI signal intensity, Myoclonus ORPHA:70595
Neuroferritinopathy
T2 hypointense thalamus, Palatal tremor, Abnormal thalamic MRI signal intensity ORPHA:157846
Tay-Sachs Disease
Typical absence seizure, Abnormal thalamic MRI signal intensity, Seizure, Gliosis, Focal impaired... ORPHA:845
Progeria-Short Stature-Pigmented Nevi Syndrome
Abnormal thalamus morphology ORPHA:2959
Aceruloplasminemia
Decreased circulating copper concentration, Abnormal thalamic MRI signal intensity, Decreased ser... ORPHA:48818
Acute Disseminated Encephalomyelitis
Seizure, Abnormal thalamic MRI signal intensity, Atypical absence status epilepticus ORPHA:83597
Combined Oxidative Phosphorylation Defect Type 7
Abnormal thalamic MRI signal intensity ORPHA:254930
Hydranencephaly
Seizure, Thalamic edema, Dysgenesis of the thalamus, Atrophic pituitary gland ORPHA:2177
Rhombencephalosynapsis
Fusion of the left and right thalami ORPHA:59315
Neurodevelopmental Disorder With Dysmorphic Facies And Cerebellar Hypoplasia
Fusion of the left and right thalami, Seizure OMIM:619306
Meningioma
Enlarged pituitary gland, Hemifacial spasm, Reduced circulating prolactin concentration, Neoplasm... ORPHA:2495
Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome
Interhypothalamic adhesion, Agenesis of corpus callosum, Infantile spasms, Focal impaired awarene... OMIM:618929
Holoprosencephaly 7
Partial agenesis of the corpus callosum, Panhypopituitarism, Seizure, Fusion of the left and righ... OMIM:610828
Craniopharyngioma
Enlarged pituitary gland, Neoplasm of the anterior pituitary, Pituitary hypothyroidism, Abnormal ... ORPHA:54595
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Abnormality of the diencephalon ORPHA:2570
Multifocal Lymphangioendotheliomatosis-Thrombocytopenia Syndrome
Thalamic hemorrhage, Seizure ORPHA:464321
Hereditary Cryohydrocytosis With Reduced Stomatin
Seizure, Decreased thalamic volume ORPHA:168577
Duplication Of The Pituitary Gland
Abnormal hypothalamus morphology, Abnormal pituitary gland morphology, Agenesis of corpus callosum ORPHA:314621
Oculocerebral Hypopigmentation Syndrome, Preus Type
Seizure, Abnormality of the diencephalon ORPHA:2720
Holoprosencephaly-Caudal Dysgenesis Syndrome
Abnormality of the diencephalon ORPHA:2165
Autosomal Recessive Spastic Paraplegia Type 11
Hypothalamic atrophy, Seizure, Lateral ventricle dilatation ORPHA:2822
Bickerstaff Brainstem Encephalitis
Abnormal thalamic MRI signal intensity ORPHA:79138
Amoebiasis Due To Free-Living Amoebae
Abnormal hypothalamus morphology, Seizure ORPHA:68
Williams Syndrome
Abnormality of the diencephalon, Hypercalcemia ORPHA:904
Norrie Disease
Seizure, Abnormality of the diencephalon ORPHA:649

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mt3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mt3.

No publications found that use IMPC mice or data for Mt3.

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MGI Allele Allele Type Produced
Mt3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Mt3tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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