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Gene: Mpg MGI:97073

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Gene Summary

Name:
N-methylpurine-DNA glycosylase
Synonyms:
Mid1,  3-methyladenine DNA glycosylase,  alkylpurine-DNA-N-glycosylase,  APNG,  Aag

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating alkaline phosphatase level Mpgtm1a(EUCOMM)Wtsi HOM   Early adult 4.16×10-05

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

15 Images

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X-ray

XRay Images Whole Body Dorso Ventral

15 Images

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DSS Histology

Images

8 Images

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X-ray

XRay Images Whole Body Lateral Orientation

14 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

13 Images

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X-ray

XRay Images Forepaw

14 Images

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Anti-nuclear antibody assay

Images

6 Images

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Eye Morphology

Images Slit Lamp

1 Images

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FCS thumbnail FCS
Ear epidermis immunophenotyping

Images

12 Images

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Legacy Phenotype Associated Images
Mpgtm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Mpgtm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Mpgtm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Mpgtm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Mpgtm1a(EUCOMM)Wtsi
HOM, Male, WTSI

View all 81 images

Mpgtm1a(EUCOMM)Wtsi
polydactylous syndactyly, HOM, Male, WTSI
Mpgtm1a(EUCOMM)Wtsi
eyelids fail to open, HOM, Female, WTSI

Human diseases caused by Mpg mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Mpg by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cramps, Familial Adolescent
Elevated circulating creatine kinase concentration OMIM:218050
Isolated Asymptomatic Elevation Of Creatine Phosphokinase
Elevated circulating creatine kinase concentration ORPHA:206599
Muscle Cramps, Familial
Elevated circulating creatine kinase concentration OMIM:158400
Hemochromatosis, Type 5
Increased circulating ferritin concentration OMIM:615517
Plasma Fibronectin Deficiency
Reduced circulating fibronectin level OMIM:614101
Pentosuria
Abnormal circulating carbohydrate concentration, Abnormality of circulating enzyme level ORPHA:2843
Autoimmune Disease
Autoimmunity, Autoimmune antibody positivity OMIM:109100
Diabetes Mellitus, Ketosis-Prone
Insulin resistance, Beta-cell dysfunction, Autoimmunity, Diabetes mellitus OMIM:612227
Pemphigus Vulgaris, Familial
Autoimmunity, Autoimmune antibody positivity OMIM:169610
Complement Component 4, Partial Deficiency Of
Systemic lupus erythematosus OMIM:120790
Hyperinsulinemic Hypoglycemia, Familial, 7
Hyperinsulinemia, Hyperinsulinemic hypoglycemia, Hypoglycemia, Pancreatic islet-cell hyperplasia,... OMIM:610021
Insulin Autoimmune Syndrome
Systemic lupus erythematosus, Hyperinsulinemic hypoglycemia, Insulin resistance, Autoimmune antib... ORPHA:411593
Hyperinsulinemic Hypoglycemia, Familial, 2
Hypoglycemia, Pancreatic islet-cell hyperplasia, Hyperinsulinemic hypoglycemia, Nesidioblastosis OMIM:601820
Lupus Erythematosus Tumidus
Anti-La/SS-B antibody positivity, Antinuclear antibody positivity, Autoimmune antibody positivity... ORPHA:90283
Tn Polyagglutination Syndrome
Autoimmunity OMIM:300622
Vacuolar Myopathy With Sarcoplasmic Reticulum Protein Aggregates
Elevated circulating creatine kinase concentration ORPHA:88635
Hyperinsulinemic Hypoglycemia, Familial, 1
Pancreatic islet-cell hyperplasia, Hyperinsulinemic hypoglycemia, Hypoglycemic seizures OMIM:256450
Complement Component 8 Deficiency, Type I
Systemic lupus erythematosus OMIM:613790
Lipodystrophy, Familial Partial, Type 1
Increased adipose tissue around the neck, Hepatomegaly, Loss of gluteal subcutaneous adipose tiss... OMIM:608600
Complement Component C1S Deficiency
Hepatitis, Systemic lupus erythematosus, Hashimoto thyroiditis OMIM:613783
Maturity-Onset Diabetes Of The Young, Type 3
Maturity-onset diabetes of the young, Type II diabetes mellitus, Hyperglycemia OMIM:600496
Maturity-Onset Diabetes Of The Young, Type 10
Diabetic ketoacidosis, Hyperglycemia, Maturity-onset diabetes of the young, Diabetes mellitus OMIM:613370
Hashimoto Thyroiditis
Hashimoto thyroiditis, Autoimmune antibody positivity OMIM:140300
Hyperinsulinemic Hypoglycemia, Familial, 6
Abnormality of the pancreatic islet cells, Hyperinsulinemic hypoglycemia, Hypoglycemic seizures OMIM:606762
C1Q Deficiency
Systemic lupus erythematosus, Autoimmunity OMIM:613652
Type 1 Diabetes Mellitus
Autoimmunity, Hyperglycemia, Diabetes mellitus OMIM:222100
Alopecia Areata 1
Autoimmunity OMIM:104000
Glycogen Storage Disease 0, Liver
Postprandial hyperglycemia, Neonatal hypoglycemia, Fasting hypoglycemia OMIM:240600
Systemic Lupus Erythematosus 16
Systemic lupus erythematosus OMIM:614420
Hyperproinsulinemia
Hyperinsulinemia, Hyperglycemia OMIM:616214
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Systemic lupus erythematosus, Splenomegaly, Autoimmune thrombocytopenia, Hepatitis, Autoimmunity,... ORPHA:444463
Erythrocyte Lactate Transporter Defect
Elevated circulating creatine kinase concentration OMIM:245340
Lipodystrophy, Familial Partial, Type 3
Reduced subcutaneous adipose tissue, Type II diabetes mellitus, Hyperinsulinemia, Cirrhosis, Loss... OMIM:604367
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Hyperinsulinemia, Hyperinsulinemic hypoglycemia, Hypoketotic hypoglycemia, Reactive hypoglycemia,... ORPHA:276608
Mahvash Disease
Type II diabetes mellitus, Recurrent pancreatitis, Pancreatic alpha-cell hyperplasia, Increased g... OMIM:619290
Transient Neonatal Diabetes Mellitus
Hypoinsulinemia, Maturity-onset diabetes of the young, Diabetic ketoacidosis, Maternal diabetes, ... ORPHA:99886
Mucous Membrane Pemphigoid
Autoimmunity ORPHA:46486
Lipase Deficiency, Combined
Hypertriglyceridemia, Lipodystrophy, Type II diabetes mellitus, Pancreatitis OMIM:246650
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Hyperinsulinemia, Hyperinsulinemic hypoglycemia, Hepatomegaly, Excessive insulin response to gluc... ORPHA:276580
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Hyperinsulinemia, Hyperinsulinemic hypoglycemia, Hepatomegaly, Excessive insulin response to gluc... ORPHA:276575
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency
Elevated circulating growth hormone concentration, Hyperinsulinemic hypoglycemia, Increased circu... ORPHA:79644
Complement Component C1R/C1S Deficiency
Autoimmunity OMIM:216950
Hemochromatosis Type 2
Abnormality of endocrine pancreas physiology, Congenital hepatic fibrosis, Hypogonadism, Diabetes... ORPHA:79230
Hypogonadism, Male, With Mental Retardation And Skeletal Anomalies
Hypergonadotropic hypogonadism, Glucose intolerance, Male hypogonadism, Hyperglycemia OMIM:307500
Diabetes Mellitus, Transient Neonatal, 1
Transient neonatal diabetes mellitus, Hyperglycemia OMIM:601410
Lipodystrophy, Familial Partial, Type 2
Reduced subcutaneous adipose tissue, Increased adipose tissue around the neck, Type II diabetes m... OMIM:151660
Hyperinsulinism Due To Ucp2 Deficiency
Hyperinsulinemic hypoglycemia, Hepatomegaly, Excessive insulin response to glucagon test, Hypoket... ORPHA:276556
Insulinoma
Abnormality of the pancreatic islet cells, Hyperinsulinemia, Hyperinsulinemic hypoglycemia, Neopl... ORPHA:97279
Inclusion Body Myositis
Autoimmunity ORPHA:611
Eosinophilopenia
Autoimmunity OMIM:131430
Complement Component 2 Deficiency
Systemic lupus erythematosus OMIM:217000
Autoimmune Hemolytic Anemia, Cold Type
Autoimmunity, Splenomegaly ORPHA:228312
Immunodeficiency 7
Autoimmunity OMIM:615387
Immunoglobulin A Deficiency 2
Autoimmunity OMIM:609529
Acquired Partial Lipodystrophy
Insulin resistance, Hepatic steatosis, Autoimmunity ORPHA:79087
Mody
Glucose intolerance, Exocrine pancreatic insufficiency, Hypoinsulinemia, Hyperinsulinemic hypogly... ORPHA:552
Diabetes Mellitus, Permanent Neonatal, 2
Type I diabetes mellitus, Flexion contracture, Hyperglycemia OMIM:618856
Immunoglobulin A Deficiency 1
Autoimmunity OMIM:137100
Donohue Syndrome
Postprandial hyperglycemia, Hyperinsulinemia, Precocious puberty, Cholestasis, Hepatic fibrosis, ... OMIM:246200
Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities
Postprandial hyperglycemia, Hyperinsulinemia, Diabetic ketoacidosis, Hypoglycemia, Insulin-resist... OMIM:262190
Diabetes Mellitus, Transient Neonatal, 3
Transient neonatal diabetes mellitus, Maternal diabetes, Hyperglycemia OMIM:610582
Immunodeficiency 31C
Autoimmune hemolytic anemia, Autoimmunity, Diabetes mellitus OMIM:614162
Hyperinsulinism Due To Hnf4A Deficiency
Hyperinsulinemia, Hyperinsulinemic hypoglycemia, Hepatomegaly, Increased hepatic glycogen content... ORPHA:263455
Insulin-Resistance Syndrome Type B
Hyperinsulinemia, Glycosuria, Polycystic ovaries, Enlarged polycystic ovaries, Hyperglycemia, Sys... ORPHA:2298
Secondary Non-Traumatic Avascular Necrosis
Rheumatoid arthritis, Systemic lupus erythematosus, Autoimmunity ORPHA:399180
Alpha-Fetoprotein, Hereditary Persistence Of
Elevated alpha-fetoprotein OMIM:615970
Febrile Infection-Related Epilepsy Syndrome
Autoimmunity ORPHA:163703
Cone-Rod Synaptic Disorder Syndrome, Congenital Nonprogressive
Hyperglycemia OMIM:618970
Diabetes Mellitus, Permanent Neonatal, 4
Diabetic ketoacidosis, Elevated hemoglobin A1c, Type I diabetes mellitus, Hyperglycemia OMIM:618858
Combined Immunodeficiency Due To Partial Rag1 Deficiency
Autoimmune hemolytic anemia, Neutropenia in presence of anti-neutropil antibodies, Autoimmunity, ... ORPHA:231154
Cleft Lip/Palate With Characteristic Facies, Intestinal Malrotation, And Lethal Congenital Heart Disease
Pancreatic islet-cell hyperplasia OMIM:601165
Autoimmune Disease, Multisystem, Infantile-Onset, 2
Autoimmunity OMIM:617006
Linear Iga Dermatosis
Autoimmunity ORPHA:46488
Mandibuloacral Dysplasia With Type B Lipodystrophy
Glucose intolerance, Hyperlipidemia, Hyperinsulinemia, Flexion contracture, Loss of truncal subcu... OMIM:608612
Bullous Pemphigoid
Autoimmunity, Diabetes mellitus ORPHA:703
Preeclampsia
Polycystic ovaries, Type I diabetes mellitus, Abnormality of the hepatic vasculature, Autoimmunity ORPHA:275555
Diabetes Mellitus, Permanent Neonatal, 1
Elevated hemoglobin A1c, Type I diabetes mellitus, Hyperglycemia, Diabetes mellitus OMIM:606176
Diabetes And Deafness, Maternally Inherited
Type II diabetes mellitus, Hyperglycemia OMIM:520000
Pemphigus Erythematosus
Antinuclear antibody positivity, Systemic lupus erythematosus, Autoimmunity, Anti-acetylcholine r... ORPHA:79480
Igg4-Related Thyroid Disease
Abnormality of the pituitary gland, Sialadenitis, Euthyroid goiter, Pancreatic fibrosis, Sclerosi... ORPHA:64744
Autoimmune Disease, Multisystem, Infantile-Onset, 1
Exocrine pancreatic insufficiency, Neutropenia in presence of anti-neutropil antibodies, Hepatosp... OMIM:615952
Pituitary Deficiency Due To Empty Sella Turcica Syndrome
Adrenocorticotropic hormone deficiency, Decreased response to growth hormone stimulation test, In... ORPHA:91354
Mitchell-Riley Syndrome
Annular pancreas, Biliary atresia, Cholestasis, Pancreatic hypoplasia, Absent gallbladder, Acholi... OMIM:615710
Pancreatic And Cerebellar Agenesis
Reduced subcutaneous adipose tissue, Hypoglycemia, Pancreatic hypoplasia, Diabetes mellitus, Anem... OMIM:609069
Syndromic Multisystem Autoimmune Disease Due To Itch Deficiency
Neutropenia in presence of anti-neutropil antibodies, Smooth muscle antibody positivity, Cirrhosi... ORPHA:228426
Mandibuloacral Dysplasia With Type A Lipodystrophy
Reduced subcutaneous adipose tissue, Increased adipose tissue around the neck, Hyperlipidemia, Hy... OMIM:248370
Acth-Independent Macronodular Adrenal Hyperplasia 2
Increased circulating cortisol level, Macronodular adrenal hyperplasia, Increased urinary cortiso... OMIM:615954
Ras-Associated Autoimmune Leukoproliferative Disorder
Autoimmunity, Autoimmune thrombocytopenia, Hepatomegaly, Splenomegaly OMIM:614470
Sjogren Syndrome
Rheumatoid arthritis, Autoimmunity OMIM:270150
Diabetes Mellitus, Permanent Neonatal, 3
Type I diabetes mellitus, Glycosuria, Hyperglycemia OMIM:618857
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Autoimmune hemolytic anemia, Autoimmunity, Hepatomegaly, Splenomegaly OMIM:618495
Subcorneal Pustular Dermatosis
Rheumatoid arthritis, Systemic lupus erythematosus, Autoimmunity ORPHA:48377
Autoimmune Hemolytic Anemia, Warm Type
Systemic lupus erythematosus, Splenomegaly, Autoimmunity, Autoimmune hemolytic anemia, Jaundice ORPHA:90033
Glycogen Storage Disease Due To Hepatic Glycogen Synthase Deficiency
Postprandial hyperglycemia, Hyperlipidemia, Glycosuria, Ketotic hypoglycemia ORPHA:2089
Isolated Sedoheptulokinase Deficiency
Postprandial hyperglycemia, Cholestatic liver disease, Flexion contracture, Steatorrhea, Inguinal... ORPHA:440713
Unclassified Myelodysplastic Syndrome
Autoimmunity ORPHA:98827
Mitochondrial Complex Iv Deficiency, Nuclear Type 5
Hypoglycemia, Microvesicular hepatic steatosis, Hyperglycemia, Increased hepatocellular lipid dro... OMIM:220111
Short Syndrome
Glucose intolerance, Lipoatrophy, Inguinal hernia, Lipodystrophy, Insulin-resistant diabetes mell... OMIM:269880
Greig Cephalopolysyndactyly Syndrome
Joint contracture of the hand, Inguinal hernia, Camptodactyly of toe, Umbilical hernia, Hyperglyc... OMIM:175700
Mixed-Type Autoimmune Hemolytic Anemia
Autoimmune hemolytic anemia, Systemic lupus erythematosus, Autoimmunity ORPHA:90036
Primary Biliary Cholangitis/Primary Sclerosing Cholangitis And Autoimmune Hepatitis Overlap Syndrome
Liver kidney microsome type 1 antibody positivity, Cholestatic liver disease, Smooth muscle antib... ORPHA:562639
Acquired Aneurysmal Subarachnoid Hemorrhage
Leukocytosis, Hypothyroidism, Hypercholesterolemia, Hypopituitarism, Hyperglycemia ORPHA:90065
Systemic-Onset Juvenile Idiopathic Arthritis
Juvenile rheumatoid arthritis, Autoimmunity, Hepatomegaly, Splenomegaly ORPHA:85414
Symptomatic Form Of Hemochromatosis Type 1
Cholangiocarcinoma, Testicular atrophy, Hepatomegaly, Decreased serum testosterone concentration,... ORPHA:465508
Immunodeficiency 22
Autoimmunity OMIM:615758
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Jaundice, Aplasia/Hypoplasia of the pancreas, Abnormality of endocrine pancreas physiology, Hypot... ORPHA:93111
Fanconi-Bickel Syndrome
Postprandial hyperglycemia, Hepatomegaly, Increased hepatic glycogen content, Hepatocellular carc... ORPHA:2088
Cold Agglutinin Disease
Autoimmunity, Hepatomegaly, Splenomegaly ORPHA:56425
Acquired Generalized Lipodystrophy
Hyperinsulinemia, Hepatomegaly, Polycystic ovaries, Cirrhosis, Acute pancreatitis, Autoimmunity, ... ORPHA:79086
Necrotizing Enterocolitis
Leukocytosis, Peritonitis, Abnormal glucose homeostasis, Neutropenia, Thrombocytopenia, Hyperglyc... ORPHA:391673
Diffuse Alveolar Hemorrhage
Antiphospholipid antibody positivity, Antineutrophil antibody positivity, Rheumatoid factor posit... ORPHA:90060
Combined Oxidative Phosphorylation Deficiency 54
Hypergonadotropic hypogonadism, Hyperglycemia OMIM:619737
Gamma-Heavy Chain Disease
Hepatomegaly, Splenomegaly, Rheumatoid arthritis, Autoimmune thrombocytopenia, Autoimmunity, Auto... ORPHA:100026
Autoimmune Polyendocrinopathy Type 3
Antiphospholipid antibody positivity, Rheumatoid arthritis, Autoimmune thrombocytopenia, Autoimmu... ORPHA:227982
Autoimmune Polyendocrinopathy Type 4
Antiphospholipid antibody positivity, Rheumatoid arthritis, Autoimmune thrombocytopenia, Autoimmu... ORPHA:227990
Isolated Permanent Neonatal Diabetes Mellitus
Lower-limb joint contracture, Glycosuria, Neonatal insulin-dependent diabetes mellitus, Pancreati... ORPHA:99885
Autoimmune Polyendocrinopathy Type 1
Hypoparathyroidism, Autoimmunity, Adrenal hyperplasia ORPHA:3453
Autoimmune Hemolytic Anemia
Autoimmunity, Splenomegaly ORPHA:98375
Overlap Myositis
Systemic lupus erythematosus, Rheumatoid arthritis, Autoimmunity, Diabetes mellitus, Antinuclear ... ORPHA:206572
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus
Hepatomegaly, Reduced pancreatic beta cells, Type I diabetes mellitus, Insulin-resistant diabetes... OMIM:226980
Pemphigus Vulgaris
Autoimmunity ORPHA:704
Oligoarticular Juvenile Idiopathic Arthritis
Rheumatoid arthritis, Antinuclear antibody positivity, Autoimmunity ORPHA:85410
T-Cell Lymphoma, Subcutaneous Panniculitis-Like
Autoimmunity, Splenomegaly OMIM:618398
Lymphoproliferative Syndrome 1
Hepatomegaly, Splenomegaly, Autoimmune thrombocytopenia, Autoimmunity, Autoimmune hemolytic anemia OMIM:613011
Bardet-Biedl Syndrome 9
Hyperglycemia OMIM:615986
Hypokalemic Periodic Paralysis
Postprandial hyperglycemia, Adrenocortical adenoma ORPHA:681
Severe Combined Immunodeficiency Due To Dclre1C Deficiency
Juvenile rheumatoid arthritis, Autoimmunity, Hashimoto thyroiditis ORPHA:275
Rabson-Mendenhall Syndrome
Postprandial hyperglycemia, Increased serum testosterone level, Reduced subcutaneous adipose tiss... ORPHA:769
Nodular Non-Suppurative Panniculitis
Autoimmunity, Hepatomegaly, Splenomegaly ORPHA:33577
Beta-Ketothiolase Deficiency
Hepatomegaly, Leukocytosis, Hypoglycemia, Thrombocytosis, Hyperglycemia ORPHA:134
Macrophage Activation Syndrome
Systemic lupus erythematosus, Hepatomegaly, Splenomegaly, Juvenile rheumatoid arthritis, Hepatiti... ORPHA:158061
Purine Nucleoside Phosphorylase Deficiency
Autoimmune hemolytic anemia, Systemic lupus erythematosus, Autoimmunity, Autoimmune thrombocytopenia ORPHA:760
Igg4-Related Aortitis
Antinuclear antibody positivity, Autoimmunity, Cytoplasmic antineutrophil antibody positivity ORPHA:449400
Spondyloenchondrodysplasia
Systemic lupus erythematosus, Decreased response to growth hormone stimulation test, Juvenile rhe... ORPHA:1855
Dermatitis Herpetiformis
Autoimmunity ORPHA:1656
Late-Onset Isolated Acth Deficiency
Hypoparathyroidism, Adrenocorticotropic hormone deficiency, Pituitary adenoma, Hypoglycemia, Hepa... ORPHA:199299
Primary Biliary Cholangitis
Cirrhosis, Hepatocellular carcinoma, Hepatitis, Autoimmunity, Hepatic fibrosis, Portal hypertensi... ORPHA:186
Stiff-Person Syndrome
Autoimmunity, Diabetes mellitus OMIM:184850
Combined Immunodeficiency-Enteropathy Spectrum
Hypoplasia of the thymus, Peritoneal abscess, Hepatitis, Type I diabetes mellitus, Autoimmunity, ... ORPHA:436252
Extracranial Carotid Artery Aneurysm
Autoimmunity, Diabetes mellitus ORPHA:494424
Tyrosinemia, Type I
Hepatomegaly, Splenomegaly, Cirrhosis, Hepatocellular carcinoma, Hypoglycemia, Pancreatic islet-c... OMIM:276700
Myasthenia Gravis
Autoimmunity OMIM:254200
Simpson-Golabi-Behmel Syndrome
Hepatomegaly, Hepatoblastoma, Congenital diaphragmatic hernia, Splenomegaly, Inguinal hernia, Cam... ORPHA:373
Heart Defects, Congenital, And Other Congenital Anomalies
Congenital diaphragmatic hernia, Inguinal hernia, Biliary atresia, Glycosuria, Aplasia of the lef... OMIM:600001
Primary Sclerosing Cholangitis
Cholelithiasis, Abnormal biliary tract morphology, Cholangiocarcinoma, Pancreatitis, Hepatomegaly... ORPHA:171
Igg4-Related Submandibular Gland Disease
Abnormal pancreas morphology, Sialadenitis, Abnormal salivary gland morphology, Abnormality of th... ORPHA:449432
Atypical Werner Syndrome
Hyperinsulinemia, Type II diabetes mellitus, Lipoatrophy, Chondrocalcinosis, Glycosuria, Generali... ORPHA:79474
Leprechaunism
Postprandial hyperglycemia, Reduced subcutaneous adipose tissue, Hyperinsulinemia, Hepatomegaly, ... ORPHA:508
Alpha-Fetoprotein Deficiency
Decreased levels of alpha-fetoprotein OMIM:615969
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Adrenocorticotropic hormone deficiency, Hyperlipidemia, Decreased response to growth hormone stim... ORPHA:293987
Dend Syndrome
Elevated hemoglobin A1c, Hyperglycemia ORPHA:79134
Thyrotoxic Periodic Paralysis
Postprandial hyperglycemia, Graves disease, Hyperthyroidism, Hyperhidrosis, Thyrotoxicosis with t... ORPHA:79102
Perlman Syndrome
Pancreatic islet-cell hyperplasia, Congenital diaphragmatic hernia OMIM:267000
Greenberg Dysplasia
Hepatic calcification, Pancreatic islet-cell hyperplasia, Hepatosplenomegaly, Hepatomegaly OMIM:215140
Igg4-Related Dacryoadenitis And Sialadenitis
Antinuclear antibody positivity, Abnormal salivary gland morphology, Abnormality of the submandib... ORPHA:79078
Pyruvate Carboxylase Deficiency
Hypoglycemia, Hepatomegaly, Hyperglycemia ORPHA:3008
Scorpion Envenomation
Acute pancreatitis, Glycosuria, Hyperhidrosis, Hyperglycemia ORPHA:466677
Cognitive Impairment-Coarse Facies-Heart Defects-Obesity-Pulmonary Involvement-Short Stature-Skeletal Dysplasia Syndrome
Hypothyroidism, Patent ductus arteriosus, Decreased response to growth hormone stimulation test, ... ORPHA:444077
Familial Hypocalciuric Hypercalcemia
Pancreatitis, Autoimmunity ORPHA:405
Simpson-Golabi-Behmel Syndrome, Type 1
Hepatomegaly, Hepatoblastoma, Congenital diaphragmatic hernia, Splenomegaly, Inguinal hernia, Pan... OMIM:312870

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mpg

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mpg.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Mpgtm1a(EUCOMM)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Mpgtm1a(EUCOMM)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Mpgtm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Mpgtm1a(EUCOMM)Wtsi