Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Synonyms:
Glif

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Mif mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Mif by orthology or direct annotation.

The table below shows human diseases predicted to be associated to Mif by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Auditory Neuropathy, Autosomal Dominant 1
Absence of acoustic reflex, Sensorineural hearing impairment, Abnormal auditory evoked potentials... OMIM:609129
Reticulum Cell Sarcoma
Sarcoma, Neoplasm OMIM:267730
Li-Fraumeni Syndrome 2
Sarcoma, Breast carcinoma, Meningioma, Stomach cancer, Glioma OMIM:609265
Deafness, Autosomal Recessive 9
Absence of acoustic reflex, Sensorineural hearing impairment, Absent brainstem auditory responses OMIM:601071
Ewing Sarcoma
Ewing sarcoma OMIM:612219
Myofibromatosis, Infantile, 1
Fibroma, Myofibromatosis OMIM:228550
Cerebral Sarcoma
Fibrosarcoma, Neoplasm OMIM:117600
Melanoma-Pancreatic Cancer Syndrome
Squamous cell carcinoma, Sarcoma, Melanoma, Oropharyngeal squamous cell carcinoma, Pancreatic ade... OMIM:606719
Multiple Fibroadenomas Of The Breast
Fibroadenoma of the breast OMIM:615554
Alveolar Soft Part Sarcoma
Alveolar soft part sarcoma OMIM:606243
Sarcoma, Synovial
Synovial sarcoma OMIM:300813
Chondrosarcoma, Extraskeletal Myxoid
Chondrosarcoma OMIM:612237
Chondrosarcoma
Chondrosarcoma OMIM:215300
Enchondromatosis, Multiple, Ollier Type
Hemangioma, Chondrosarcoma, Multiple enchondromatosis OMIM:166000
Rhabdoid Tumor Predisposition Syndrome 2
Carcinoma, Neoplasm of the central nervous system OMIM:613325
Nut Midline Carcinoma
Ewing sarcoma, Squamous cell carcinoma, Leukemia, Neuroblastoma, Neoplasm, Oropharyngeal squamous... ORPHA:443167
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12Rb1 Deficiency
Vasculitis in the skin, Abnormal circulating interleukin concentration, Lymphadenitis, Pneumonia,... ORPHA:319552
Multiple Enchondromatosis, Maffucci Type
Hemangioma, Chondrosarcoma, Multiple enchondromatosis OMIM:614569
Abcd Syndrome
Abnormal auditory evoked potentials, Aganglionic megacolon, Hearing impairment OMIM:600501
Li-Fraumeni Syndrome
Prostate neoplasm, Adrenocortical carcinoma, Colon cancer, Breast carcinoma, Osteosarcoma, Lung a... OMIM:151623
Charcot-Marie-Tooth Disease, Type 4B1
Abnormal auditory evoked potentials, Facial palsy, Decreased motor nerve conduction velocity OMIM:601382
Colorectal Cancer, Susceptibility To, 12
Colorectal polyposis, Carcinoma OMIM:615083
Immunodeficiency 35
Recurrent viral infections, Recurrent mycobacterial infections, Recurrent fungal infections, Recu... OMIM:611521
Optic Atrophy 8
Abnormal auditory evoked potentials, Sensorineural hearing impairment, Prolonged somatosensory ev... OMIM:616648
Immunodeficiency, Common Variable, 4
Decreased circulating total IgM, Recurrent pneumonia, Decreased circulating IgG level, Recurrent ... OMIM:613494
Undifferentiated Pleomorphic Sarcoma
Soft tissue sarcoma ORPHA:2023
Acquired Ichthyosis
Lymphoma, Sarcoma, Multiple myeloma, Neoplasm ORPHA:454
Maffucci Syndrome
Multiple enchondromatosis, Sarcoma, Neoplasm of the adrenal cortex, Chondrosarcoma, Hemangiomatos... ORPHA:163634
Ollier Disease
Visceral angiomatosis, Multiple enchondromatosis, Sarcoma, Lymphangioma, Chondrosarcoma, Neoplasm... ORPHA:296
Lichen Sclerosus Et Atrophicus
Squamous cell carcinoma, Carcinoma OMIM:151590
Dermatofibrosarcoma Protuberans
Fibrosarcoma, Neoplasm of the skin ORPHA:31112
Ravine Syndrome
Abnormal auditory evoked potentials ORPHA:99852
Autosomal Recessive Spastic Paraplegia Type 44
Abnormality of somatosensory evoked potentials, Sensorineural hearing impairment, Abnormal audito... ORPHA:320401
Agammaglobulinemia 2, Autosomal Recessive
Decreased circulating total IgM, Recurrent otitis media, Recurrent pneumonia, Agammaglobulinemia,... OMIM:613500
Immunodeficiency, Common Variable, 3
Decreased circulating total IgM, Recurrent otitis media, Chronic decreased circulating total IgG,... OMIM:613493
Neurodevelopmental Disorder With Hypotonia, Neuropathy, And Deafness
Absent brainstem auditory responses, Facial palsy, EEG abnormality, Sensorineural hearing impairment OMIM:617519
Paraneoplastic Pemphigus
Sarcoma, B-cell lymphoma, Thymoma ORPHA:63455
Charcot-Marie-Tooth Disease, Type 4D
Abnormal auditory evoked potentials, Hearing impairment, Decreased nerve conduction velocity OMIM:601455
Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, And Neuropathy
Abnormal auditory evoked potentials, Progressive sensorineural hearing impairment, Optic atrophy OMIM:125250
Charcot-Marie-Tooth Disease, Type 4C
Abnormal cranial nerve morphology, Decreased motor nerve conduction velocity, Prolonged brainstem... OMIM:601596
Agammaglobulinemia 4, Autosomal Recessive
Decreased circulating total IgM, Recurrent otitis media, Decreased circulating IgG level, Recurre... OMIM:613502
Mohr-Tranebjaerg Syndrome
Abnormality of somatosensory evoked potentials, Vestibular dysfunction, Agammaglobulinemia, Preli... ORPHA:52368
Progressive Osseous Heteroplasia
Sarcoma ORPHA:2762
Apc-Related Attenuated Familial Adenomatous Polyposis
Adrenocortical carcinoma, Colon cancer, Osteoma, Lipoma, Pilomatrixoma, Adenomatous colonic polyp... ORPHA:247806
Immune Deficiency Disease
Decreased circulating total IgM, Recurrent viral infections, Cholangitis, Recurrent bacterial inf... OMIM:242850
Large Congenital Melanocytic Nevus
Sarcoma, Rhabdomyosarcoma, Cutaneous melanoma, Neoplasm, Neoplasm of the skin ORPHA:626
Infantile Myofibromatosis
Sarcoma, Fibroma, Gingival fibromatosis, Benign neoplasm of the central nervous system, Neoplasm ... ORPHA:2591
Mast Cell Sarcoma
Sarcoma ORPHA:66661
Neutropenia, Severe Congenital, 1, Autosomal Dominant
Eosinophilia, Monocytosis, Thrombocytosis, Congenital agranulocytosis, Neutropenia, Anemia, Incre... OMIM:202700
Gardner Syndrome
Hepatoblastoma, Adrenocortical carcinoma, Colon cancer, Osteoma, Lipoma, Pilomatrixoma, Adenomato... ORPHA:79665
Liposarcoma
Sarcoma ORPHA:69078
Rhabdoid Tumor
Sarcoma, Renal neoplasm, Neoplasm of the liver, Neoplasm of the central nervous system ORPHA:69077
Muir-Torre Syndrome
Benign genitourinary tract neoplasm, Adenoma sebaceum, Carcinoma, Colon cancer, Breast carcinoma,... OMIM:158320
Autosomal Dominant Optic Atrophy Plus Syndrome
Absent brainstem auditory responses, Sensorineural hearing impairment, Temporal optic disc pallor... ORPHA:1215
Attenuated Familial Adenomatous Polyposis
Colorectal polyposis, Thyroid adenoma, Fibroma, Papilloma, Adenocarcinoma of the colon, Uterine l... ORPHA:220460
Familial Adenomatous Polyposis 1
Multiple lipomas, Hepatoblastoma, Papillary thyroid carcinoma, Adrenocortical carcinoma, Colon ca... OMIM:175100
Desmoplastic Small Round Cell Tumor
Sarcoma, Testicular neoplasm, Ovarian neoplasm, Neoplasm of the central nervous system, Neoplasm ... ORPHA:83469
Acrocraniofacial Dysostosis
Abnormality of the outer ear, Conductive hearing impairment, Abnormal auditory evoked potentials,... OMIM:201050
Familial Hemophagocytic Lymphohistiocytosis
Increased circulating interleukin 6 concentration, Abnormality of serum cytokine level, Abnormali... ORPHA:540
Central Nervous System Calcification-Deafness-Tubular Acidosis-Anemia Syndrome
Vestibular areflexia, Atopic dermatitis, Absent brainstem auditory responses, Thrombocytopenia, H... ORPHA:3240
Colorectal Cancer, Susceptibility To, 10
Colorectal polyposis, Endometrial carcinoma, Carcinoma OMIM:612591
Macrophage Activation Syndrome
Increased circulating interleukin 6 concentration, Abnormal circulating interleukin concentration... ORPHA:158061
Car T Cell Therapy-Associated Cytokine Release Syndrome
Increased circulating interleukin 6 concentration, Abnormality of serum cytokine level, Reduced e... ORPHA:542323
Immunodeficiency 60 And Autoimmunity
Pancytopenia, Decreased basophil count, Decreased circulating total IgM, Decreased proportion of ... OMIM:618394
Axenfeld-Rieger Anomaly With Partially Absent Eye Muscles, Distinctive Face, Hydrocephaly, And Skeletal Abnormalities
Abnormal auditory evoked potentials, Sensorineural hearing impairment OMIM:109120
Yellow Nail Syndrome
Renal neoplasm, Sarcoma, Biliary tract neoplasm, Neoplasm, Neoplasm of the lung ORPHA:662
Gastrointestinal Stromal Tumor
Gastrointestinal stroma tumor, Esophageal neoplasm, Neoplasm of the gastrointestinal tract, Sarco... ORPHA:44890
Neurofibromatosis, Type I
Plexiform neurofibroma, Rhabdomyosarcoma, Neurofibrosarcoma, Neurofibromas, Spinal neurofibromas,... OMIM:162200
Familial Adenomatous Polyposis
Hepatoblastoma, Neoplasm of the gastrointestinal tract, Colon cancer, Osteoma, Neoplasm of the ga... ORPHA:733
Desmoid Tumor
Fibroma, Intestinal polyposis, Desmoid tumors, Neoplasm of the skin ORPHA:873
Acromesomelic Dysplasia, Grebe Type
Sarcoma ORPHA:2098
Chronic Bilirubin Encephalopathy
Abnormal auditory evoked potentials, Sensorineural hearing impairment, Hemolytic anemia ORPHA:529808
Acute Bilirubin Encephalopathy
Abnormal auditory evoked potentials, Sensorineural hearing impairment, Hemolytic anemia ORPHA:529799
Retinoblastoma
Ewing sarcoma, Leukemia, Lymphoma, Pinealoma, Osteosarcoma, Retinoblastoma OMIM:180200
Sweet Syndrome
Increased circulating interleukin 6 concentration, Sterile abscess, Abnormal circulating interleu... ORPHA:3243
Tuberous Sclerosis 2
Renal angiomyolipoma, Cortical tubers, Adenoma sebaceum, Cardiac rhabdomyoma, Pulmonary lymphangi... OMIM:613254
Werner Syndrome
Gastrointestinal carcinoma, Renal neoplasm, Squamous cell carcinoma, Sarcoma, Melanoma, Breast ca... ORPHA:902
Spondyloepiphyseal Dysplasia, Sensorineural Hearing Loss, Impaired Intellectual Development, And Leber Congenital Amaurosis
Abnormal auditory evoked potentials, Sensorineural hearing impairment, Optic disc pallor OMIM:619260
Chromosome 17Q11.2 Deletion Syndrome, 1.4-Mb
Plexiform neurofibroma, Subcutaneous neurofibromas, Neurofibrosarcoma, Neurofibromas, Spinal neur... OMIM:613675
Ovarian Fibrothecoma
Ovarian fibroma, Fibrosarcoma, Diffuse leiomyomatosis ORPHA:314478
Late-Infantile/Juvenile Krabbe Disease
EEG with persistent abnormal rhythmic activity, Prolonged brainstem auditory evoked potentials, D... ORPHA:206443
Mogs-Cdg
Decreased circulating IgG level, Decreased circulating total IgM, Hepatosplenomegaly, Sensorineur... ORPHA:79330
Retinoblastoma
Ewing sarcoma, Leukemia, Rhabdomyosarcoma, Melanoma, Lymphoma, Osteosarcoma, Leiomyosarcoma, Pine... ORPHA:790
Terminal Osseous Dysplasia
Fibroma OMIM:300244
Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy
Sarcoma, Neoplasm of the breast, Testicular neoplasm, Neoplasm of the thyroid gland ORPHA:457059
Arthrogryposis, Distal, Type 2A
Abnormal auditory evoked potentials, Hearing impairment OMIM:193700
Adult-Onset Autosomal Dominant Leukodystrophy
Abnormality of somatosensory evoked potentials, EEG with generalized slow activity, Orthostatic h... ORPHA:99027
Chronic Myeloid Leukemia
Leukocytosis, Thrombocytosis, Myeloproliferative disorder, Splenomegaly, Thrombocytopenia, Abnorm... ORPHA:521
Cockayne Syndrome Type 1
Uveitis, Hearing impairment, Conjunctivitis, Anemia, Macrotia, Absent brainstem auditory response... ORPHA:90321
Adult Krabbe Disease
EEG abnormality, Prolonged brainstem auditory evoked potentials ORPHA:206448
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease
Hepatosplenomegaly, Sensorineural hearing impairment, Aganglionic megacolon, Abnormal autonomic n... OMIM:609136
Mastocytosis
Chronic leukemia, Sarcoma, Acute leukemia ORPHA:98292
Charcot-Marie-Tooth Disease Type 1F
Sensorineural hearing impairment, Optic nerve hypoplasia, Absent brainstem auditory responses, De... ORPHA:101085
Adult Acute Respiratory Distress Syndrome
Increased circulating interleukin 6 concentration, Abnormal circulating interleukin concentration... ORPHA:70578
Acute Lung Injury
Increased circulating interleukin 6 concentration, Abnormality of serum cytokine level, Acute pan... ORPHA:178320
Aregenerative Anemia
Pancytopenia, Abnormality of interleukin secretion, Decreased proportion of CD4-positive helper T... ORPHA:101096
Infantile Krabbe Disease
Decreased nerve conduction velocity, Prolonged brainstem auditory evoked potentials, Optic atroph... ORPHA:206436
Milroy Disease
Angiosarcoma, Neoplasm of the skin ORPHA:79452
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma
Histiocytoma, Osteosarcoma, Fibrosarcoma OMIM:112250
17Q11 Microdeletion Syndrome
Gastrointestinal stroma tumor, Cerebellar glioma, Plexiform neurofibroma, Schwannoma, Leukemia, R... ORPHA:97685
Neurofibromatosis Type 1
Multiple lipomas, Plexiform neurofibroma, Neoplasm of the gastrointestinal tract, Leukemia, Sarco... ORPHA:636
Trisomy 10P
Abnormality of the ear, Low-set ears, EEG with burst suppression, Abnormal auditory evoked potent... ORPHA:171929
Cowden Syndrome
Colorectal polyposis, Melanoma, Adenoma sebaceum, Fibroma, Papilloma, Breast carcinoma, Cavernous... ORPHA:201
Monosomy 22
Gonadal neoplasm, Schwannoma, Sarcoma, Meningioma ORPHA:96123
Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion
Schwannoma, Subcutaneous neurofibromas, Neurofibrosarcoma, Spinal neurofibromas, Lisch nodules, H... ORPHA:363700
Multiple Endocrine Neoplasia Type 4
Renal angiomyolipoma, Pituitary corticotropic cell adenoma, Parathyroid carcinoma, Subcutaneous l... ORPHA:276152
Cerebrotendinous Xanthomatosis
Abnormality of somatosensory evoked potentials, Optic neuropathy, Decreased nerve conduction velo... ORPHA:909
Cockayne Syndrome B
Sensorineural hearing impairment, Splenomegaly, Decreased nerve conduction velocity, Abnormal aud... OMIM:133540
Cockayne Syndrome A
Sensorineural hearing impairment, Splenomegaly, Decreased nerve conduction velocity, Abnormal aud... OMIM:216400
Meige Disease
Angiosarcoma ORPHA:90186
Lymphedema-Distichiasis Syndrome
Fibrosarcoma ORPHA:33001
Psoriasis-Related Juvenile Idiopathic Arthritis
Uveitis, Iritis, Abnormality of tumor necrosis factor secretion, Sacroiliac arthritis, Iridocycli... ORPHA:85436
X-Linked Alport Syndrome-Diffuse Leiomyomatosis
Esophageal neoplasm, Fibroma, Vulvar neoplasm, Uterine neoplasm, Diffuse leiomyomatosis, Tracheob... ORPHA:1018
Hyperparathyroidism-Jaw Tumor Syndrome
Renal hamartoma, Fibroma, Testicular neoplasm, Parathyroid adenoma, Uterine leiomyoma, Lipoma, Pa... ORPHA:99880
Parathyroid Carcinoma
Parathyroid carcinoma, Renal hamartoma, Fibroma, Testicular neoplasm, Uterine leiomyoma, Lipoma, ... ORPHA:143
Mend Syndrome
Abnormal auditory evoked potentials, Low-set ears ORPHA:401973
Tuberous Sclerosis Complex
Renal angiomyolipoma, Cortical tubers, Cardiac rhabdomyoma, Retinal astrocytic hamartoma, Pulmona... ORPHA:805
Fanconi Anemia, Complementation Group E
Prolonged G2 phase of cell cycle, Leukemia OMIM:600901
Fanconi Anemia, Complementation Group A
Prolonged G2 phase of cell cycle, Leukemia OMIM:227650
Noonan Syndrome 1
Juvenile myelomonocytic leukemia, Neurofibrosarcoma OMIM:163950
Multiple Endocrine Neoplasia Type 1
Intestinal carcinoid, Pituitary corticotropic cell adenoma, Pulmonary carcinoid tumor, Adrenocort... ORPHA:652
Aicardi Syndrome
Teratoma, Hepatoblastoma, Carcinoma, Metastatic angiosarcoma, Hemangioma, Lipoma OMIM:304050
Fanconi Anemia, Complementation Group C
Prolonged G2 phase of cell cycle, Leukemia OMIM:227645
Fanconi Anemia, Complementation Group D2
Prolonged G2 phase of cell cycle, Leukemia OMIM:227646
Parenteral Nutrition-Associated Cholestasis
Splenomegaly, Abnormality of cytokine secretion ORPHA:567983
Cystic Fibrosis
Recurrent respiratory infections, Decreased circulating antibody level ORPHA:586
Systemic-Onset Juvenile Idiopathic Arthritis
Elevated circulating C-reactive protein concentration, Pericarditis, Anterior uveitis, Skin rash,... ORPHA:85414

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mif

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mif.

No publications found that use IMPC mice or data for Mif.

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MGI Allele Allele Type Produced
Miftm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Miftm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Miftm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Miftm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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