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Gene: Lyn

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Name
LYN proto-oncogene, Src family tyrosine kinase
MGI ID
MGI:96892
Synonyms
Hck-2 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
Viability
Data available
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (16) Measurements chart (194) All data table (431)
Expression & images (67) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
enlarged spleen Lyntm1b(EUCOMM)Hmgu HOM Late adult 0.00
increased circulating total protein level Lyntm1b(EUCOMM)Hmgu HOM Early adult 8.85×10-05
decreased large unstained cell number Lyntm1b(EUCOMM)Hmgu HOM Early adult 1.47×10-06
increased neutrophil cell number Lyntm1b(EUCOMM)Hmgu HOM Early adult 5.52×10-08
increased red blood cell distribution width Lyntm1b(EUCOMM)Hmgu HOM Early adult 4.53×10-05
increased blood urea nitrogen level Lyntm1b(EUCOMM)Hmgu HOM Early adult 1.08×10-05
decreased leukocyte cell number Lyntm1b(EUCOMM)Hmgu HOM Early adult 1.88×10-21
increased monocyte cell number Lyntm1b(EUCOMM)Hmgu HOM Early adult 1.41×10-14
thrombocytopenia Lyntm1b(EUCOMM)Hmgu HOM Early adult 3.95×10-13
abnormal gait Lyntm1b(EUCOMM)Hmgu HOM Early adult 1.14×10-13
increased spleen weight Lyntm1b(EUCOMM)Hmgu HOM Early adult 9.75×10-07
decreased circulating bilirubin level Lyntm1b(EUCOMM)Hmgu HOM Early adult 1.11×10-05
abnormal maxilla morphology Lyntm1b(EUCOMM)Hmgu HOM Early adult 3.45×10-05
decreased hemoglobin content Lyntm1b(EUCOMM)Hmgu HOM Early adult 2.88×10-11
small thymus Lyntm1b(EUCOMM)Hmgu HOM Late adult 0.00
decreased lymphocyte cell number Lyntm1b(EUCOMM)Hmgu HOM Early adult 3.48×10-29

Download data as:  TSV  XLS

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/583) N/A
Aorta 2 No  (1/583) N/A
Bone 2 No N/A
Brain 2 No  (4/583) N/A
Brainstem 2 No  (2/583) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/583) N/A
Cerebellum 2 No  (3/583) N/A
Cerebral cortex 2 No  (2/583) N/A
Esophagus 2 No  (7/407) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (2/583) N/A
Hippocampus 2 No  (3/583) N/A
Hypothalamus 2 No  (2/583) N/A
Kidney 2 No  (21/583)  (2/2)  Wholemount images
Large intestine 2 No  (10/583) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/583) N/A
Lung 2 No  (2/583) N/A
Lymph node 2 No  (1/583) N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/583) N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/583) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/583) N/A
Parathyroid gland 2 No  (1/563) N/A
Peripheral nervous system 2 No  (2/583) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/583) N/A
Prostate gland 2 No  (12/583) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/583) N/A
Small intestine 2 No  (9/583) N/A
Spinal cord 2 No  (3/583) N/A
Spleen 2 No  (3/583) N/A
Stomach 2 No  (13/583)  (1/2)  Wholemount images
Striatum 2 No  (3/583) N/A
Testis 2 No  (6/583)  (1/2)  Wholemount images
Thymus 2 No  (1/583) N/A
Thyroid gland 2 No  (17/583)  (1/2)  Wholemount images
Trachea 2 No  (3/583) N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
digestive system (1)
Stomach expression
MA:0000353
endocrine system (1)
Thyroid gland expression
MA:0000129
postnatal mouse (4)
Kidney expression
MA:0000368
reproductive system (1)
Testis expression
MA:0000411
trunk (3)
Kidney expression
MA:0000368
urinary system (1)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
1  (6/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/506) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A
1  (5/505) Image Only N/A
1  (1/505) Image Only N/A
1  (6/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/503) Image Only N/A
1  (1/503) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/503) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A

 Associated Images

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X-ray: XRay Images Whole Body Dorso Ventral
10 Images
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X-ray: XRay Images Whole Body Lateral Orientation
10 Images
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X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
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Adult LacZ: LacZ Images Wholemount
4 Images
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Embryo LacZ: LacZ images wholemount
8 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Lyntm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Lyntm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Lyntm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice