Genes Phenotypes

Gene: Lrp1

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Name
low density lipoprotein receptor-related protein 1
MGI ID
MGI:96828
Synonyms
A2mr b2b1554Clo CD91
Viability
Homozygous - Lethal
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (9) Measurements chart (210) All data table (678)
Expression & images (73) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
cardiovascular system phenotype Lrp1tm1.1(KOMP)Wtsi HET Early adult 3.10×10-05
pallor Lrp1tm1.1(KOMP)Wtsi HOM E12.5 0.00
decreased exploration in new environment Lrp1tm1.1(KOMP)Wtsi HET Early adult 2.57×10-05
abnormal sleep behavior Lrp1tm1.1(KOMP)Wtsi HET Early adult 5.91×10-06
decreased heart rate variability Lrp1tm1.1(KOMP)Wtsi HET Early adult 4.94×10-05
abnormal limb bud morphology Lrp1tm1.1(KOMP)Wtsi HOM E12.5 0.00
abnormal pericardium morphology Lrp1tm1.1(KOMP)Wtsi HOM E12.5 0.00
abnormal embryo size Lrp1tm1.1(KOMP)Wtsi HOM E12.5 0.00
preweaning lethality, complete penetrance Lrp1tm1.1(KOMP)Wtsi HOM Early adult 0.00

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Viewing: all phenotypes
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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No  (2/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No  (2/2) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2) N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No  (2/2) N/A
Epididymis 2 No  (18/134)  (1/2) N/A
Esophagus 2 No  (7/415)  (2/2) N/A
Eye 2 No  (2/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No  (2/2) N/A
Hypothalamus 2 No  (2/2) N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No  (2/2) N/A
Lower urinary tract 2 No N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No  (2/2) N/A
Mammary gland 2 No  (1/2) N/A
Midbrain 2 No  (2/2) N/A
Olfactory lobe 2 No  (2/2) N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2) N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (2/2) N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No  (2/2) N/A
Submandibular gland 2 No  (2/132)  (2/2) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thalamus 2 No  (2/2) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No  (2/2) N/A
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
Vascular system 2 No  (2/2) N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504)  (1/3) N/A
Dorsal root ganglion 1  (1/57) N/A
Ear 2  (1/504) N/A
Embryo 2  (1/505)  (2/3)  Wholemount images
Eye 2  (1/504) N/A
Foot 2  (1/504) N/A
Forebrain 2  (1/504) N/A
Forelimb 2  (1/504) N/A
Fronto-nasal process 1  (1/58) Image Only N/A
Hand 2  (1/503) N/A
Head 2  (5/504)  (2/3) N/A
Heart 2  (1/504) N/A
Hindbrain 2  (6/504)  (1/3) N/A
Hindlimb 2  (1/503) N/A
Liver 2  (1/504) N/A
Lung 2  (1/500) N/A
Mandibular process 2  (1/504) N/A
Maxillary process 2  (1/504) N/A
Midbrain 2  (1/504) N/A
Nose 1  (1/70) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/504)  (1/3) N/A
Spinal cord 1  (1/69) N/A
Tail 2  (1/504) N/A
Tail somite 2  (1/504) N/A
embryo or Unassigned (12)
Embryo imageOnly
EMAPA:16039 embryo

 Associated Images

Gross Morphology Embryo E12.5
2 Images
Combined SHIRPA and Dysmorphology
8 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Forepaw
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Embryo LacZ: LacZ images wholemount
12 Images
Eye Morphology: Images Ophthalmoscopy
2 Images
Sleep Wake: Wake state (bmp file)
11 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Lrp1tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Lrp1tm1.1(KOMP)Wtsi Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice

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