Gene: Lifr

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Name
LIF receptor alpha
MGI ID
MGI:96788
Synonyms
soluble differentiation-stimulating factor receptor A230075M04Rik
Viability
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal brain morphology Lifrtm1b(EUCOMM)Hmgu HET Early adult 0.00
preweaning lethality, complete penetrance Lifrtm1b(EUCOMM)Hmgu HOM   Early adult 0.00
hypoactivity Lifrtm1b(EUCOMM)Hmgu HET Early adult 3.83×10-05
decreased red blood cell distribution width Lifrtm1b(EUCOMM)Hmgu HET Early adult 6.65×10-05

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Select physiological systems to view:
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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/583) N/A
Aorta 2 No  (1/583)  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (4/583)  (2/2)  Wholemount images
Brainstem 2 No  (2/583) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/583)  (2/2)  Wholemount images
Cerebellum 2 No  (3/583)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/583) N/A
Esophagus 2 No  (7/407) N/A
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/583)  (2/2)  Wholemount images
Hippocampus 2 No  (3/583) N/A
Hypothalamus 2 No  (2/583) N/A
Kidney 2 No  (21/583)  (2/2)  Wholemount images
Large intestine 2 No  (10/583)  (1/2)  Wholemount images
Liver 2 No  (2/2)  Wholemount images
Lower urinary tract 2 No  (1/583)  (2/2)  Wholemount images
Lung 2 No  (2/583)  (2/2)  Wholemount images
Lymph node 2 No  (1/583)  (2/2)  Wholemount images
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/583)  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/583) N/A
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/583)  (2/2)  Wholemount images
Parathyroid gland 2 No  (1/563)  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/583)  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/583)  (2/2)  Wholemount images
Prostate gland 2 No  (12/583)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (1/583)  (2/2)  Wholemount images
Small intestine 2 No  (9/583) N/A
Spinal cord 2 No  (3/583)  (2/2)  Wholemount images
Spleen 2 No  (3/583) N/A
Stomach 2 No  (13/583)  (2/2)  Wholemount images
Striatum 2 No  (3/583) N/A
Testis 2 No  (6/583)  (1/2)  Wholemount images
Thymus 2 No  (1/583)  (2/2)  Wholemount images
Thyroid gland 2 No  (17/583)  (2/2)  Wholemount images
Trachea 2 No  (3/583)  (2/2)  Wholemount images
Uterus 2 No N/A
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
2  (6/505)  (2/4) N/A
2  (1/505) N/A
2  (1/506)  (4/4) N/A
2  (1/505)  (2/4) N/A
2  (1/505)  (1/4) N/A
2  (1/505)  (1/4) N/A
2  (1/505)  (3/4) N/A
2  (1/505) N/A
2  (5/505)  (4/4) N/A
2  (1/505)  (2/4) N/A
2  (6/505)  (1/4) N/A
2  (1/505)  (3/4) N/A
2  (1/503)  (2/4) N/A
2  (1/503) N/A
2  (1/505) N/A
2  (1/505)  (1/4) N/A
2  (1/505)  (1/4) N/A
2  (1/503) N/A
2  (1/505)  (2/4) N/A
2  (1/505)  (1/4) N/A
2  (1/505)  (1/4) N/A

 Associated Images

X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Echo: M-Mode Images
28 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Adult LacZ: LacZ Images Wholemount
21 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Lifrtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Lifrtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Lifrtm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Lifrtm1c(EUCOMM)Hmgu Wild type floxed exon (post-Flp) Mice

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