Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Kcna4 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Microcephaly, Cataracts, Impaired Intellectual Development, And Dystonia With Abnormal Striatum | OMIM:618284 |
The table below shows human diseases predicted to be associated to Kcna4 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
15q13.3 microdeletion syndrome | Seizure | DECIPHER:74 | |
Intellectual Developmental Disorder, X-Linked 88 | Seizure | OMIM:300852 | |
Intellectual Developmental Disorder, X-Linked 96 | Seizure | OMIM:300802 | |
Intellectual Developmental Disorder, Autosomal Recessive 10 | Seizure | OMIM:611096 | |
Intellectual Developmental Disorder, Autosomal Dominant 3 | Seizure | OMIM:612580 | |
Intellectual Developmental Disorder, Autosomal Dominant 10 | Seizure | OMIM:614256 | |
Kifafa Seizure Disorder | Seizure | OMIM:245180 | |
Epilepsy, Nocturnal Frontal Lobe, 3 | Seizure | OMIM:605375 | |
Glycosylphosphatidylinositol Biosynthesis Defect 16 | Seizure | OMIM:617816 | |
Epilepsy, Nocturnal Frontal Lobe, 1 | Focal-onset seizure, Seizure | OMIM:600513 | |
Epilepsy, Familial Adult Myoclonic, 7 | Seizure, Myoclonic tremor | OMIM:618075 | |
Seizures, Benign Familial Infantile, 2 | Bilateral tonic-clonic seizure, Focal impaired awareness seizure | OMIM:605751 | |
Seizures, Benign Familial Neonatal, 3 | Bilateral tonic-clonic seizure | OMIM:608217 | |
Epilepsy, Idiopathic Generalized, Susceptibility To, 12 | Bilateral tonic-clonic seizure | OMIM:614847 | |
Epilepsy, Idiopathic Generalized, Susceptibility To, 14 | Bilateral tonic-clonic seizure, Generalized non-motor (absence) seizure, Seizure, Generalized myo... | OMIM:616685 | |
Epilepsy, Familial Temporal Lobe, 6 | Bilateral tonic-clonic seizure with focal onset, Focal impaired awareness seizure, Status epilept... | OMIM:615697 | |
Generalized Epilepsy With Febrile Seizures Plus, Type 2 | Bilateral tonic-clonic seizure, Focal hemiclonic seizure, Focal-onset seizure, Generalized non-mo... | OMIM:604403 | |
Generalized Epilepsy With Febrile Seizures Plus, Type 7 | Bilateral tonic-clonic seizure, Focal-onset seizure, Generalized non-motor (absence) seizure, Feb... | OMIM:613863 | |
Epilepsy, Idiopathic Generalized, Susceptibility To, 10 | Bilateral tonic-clonic seizure, Focal-onset seizure, Generalized non-motor (absence) seizure, Gen... | OMIM:613060 | |
Microcephaly, Cataracts, Impaired Intellectual Development, And Dystonia With Abnormal Striatum | OMIM:618284 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Kcna4tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Kcna4tm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
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