Gene: Itpr1

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Name
inositol 1,4,5-trisphosphate receptor 1
MGI ID
MGI:96623
Synonyms
P400 IP3R1 Itpr-1 Pcp-1 Ip3r opt InsP3R type I Pcp1 wblo
Viability
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Itpr1tm1.1(NCOM)Mfgc HOM Early adult 0.00
decreased basophil cell number Itpr1tm1.1(NCOM)Mfgc HET Early adult 3.71×10-05
abnormal neural tube closure Itpr1tm1.1(NCOM)Mfgc HET E9.5 0.00
abnormal embryo size Itpr1tm1.1(NCOM)Mfgc HET E9.5 0.00
small epididymis Itpr1tm1.1(NCOM)Mfgc HET Early adult 0.00
abnormal forebrain development Itpr1tm1.1(NCOM)Mfgc HET E9.5 0.00
abnormal embryo size Itpr1tm1.1(NCOM)Mfgc HOM E9.5 0.00
abnormal forebrain development Itpr1tm1.1(NCOM)Mfgc HOM E9.5 0.00
abnormal neural tube closure Itpr1tm1.1(NCOM)Mfgc HOM E9.5 0.00
abnormal hindbrain development Itpr1tm1.1(NCOM)Mfgc HET E9.5 0.00
abnormal hindbrain development Itpr1tm1.1(NCOM)Mfgc HOM E9.5 0.00
decreased circulating bilirubin level Itpr1tm1.1(NCOM)Mfgc HET Early adult 4.48×10-05
preweaning lethality, complete penetrance Itpr1tm1.1(NCOM)Mfgc HOM Early adult 0.00

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

No Adult expression data was found for this gene.
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/65) N/A
Brain 4  (6/506)  (2/5) N/A
Central nervous system ganglion 2  (1/74)  (2/2) N/A
Ear 4  (1/506) N/A
Embryo 4  (1/507)  (5/5) N/A
Eye 4  (1/506)  (2/5) N/A
Foot 4  (1/506) N/A
Forebrain 4  (1/506) N/A
Forelimb 4  (1/506) N/A
Gut 2  (1/60) N/A
Hand 4  (1/506) N/A
Head 4  (5/506) N/A
Heart 4  (1/506)  (2/5) N/A
Hindbrain 4  (6/506) N/A
Hindlimb 4  (1/506) N/A
Liver 4  (1/504) N/A
Lung 4  (1/504) N/A
Mandibular process 4  (1/506) N/A
Maxillary process 4  (1/506) N/A
Midbrain 4  (1/506) N/A
Nose 2  (1/76) N/A
Oral cavity 4  (1/504) N/A
Chorioallantoic placenta 2  (7/39)  (2/2) N/A
Skeleton 2  (1/76) N/A
Skin 4  (1/506)  (2/5) N/A
Spinal cord 2  (1/73) N/A
Tail 4  (1/506) N/A
Tail somite 4  (1/506)  (2/5) N/A
Trachea 2  (1/60) N/A
Urinary system 2  (1/60)  (2/2) N/A

 Associated Images

Immunophenotyping: Panel B FCS file(s)
6 Images
Embryo LacZ: LacZ images wholemount
20 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Immunophenotyping: Panel A FCS file(s)
6 Images
Gross Morphology Embryo E9.5
2 Images
Gross Pathology and Tissue Collection
8 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Itpr1tm1.1(NCOM)Mfgc Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Itpr1tm357032(L1L2_Bact_P) Targeting vectors
Itpr1tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells

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