Il1a | interleukin 1 alpha

GeneMGI:96542Synonyms: Il-1a

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye Hematopoietic system Behavior/neurological

13 No significant impact

7 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues

Phenotypes

decreased hemoglobin content1 supporting datasetIl1atm1b(EUCOMM)WtsihomozygoteEarly adult6.58x10-6 
increased startle reflex1 supporting datasetIl1atm1b(EUCOMM)WtsihomozygoteEarly adult8.85x10-7 
decreased circulating serum albumin level1 supporting datasetIl1atm1b(EUCOMM)WtsihomozygoteEarly adult4.68x10-5 
decreased erythrocyte cell number1 supporting datasetIl1atm1b(EUCOMM)WtsihomozygoteEarly adult2.99x10-6 
cataract1 supporting datasetIl1atm1b(EUCOMM)WtsihomozygoteEarly adult9.84x10-5 
decreased hematocrit1 supporting datasetIl1atm1b(EUCOMM)WtsihomozygoteEarly adult1.07x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
brainheterozygoteSection images
100% (2/2)0.86% (5/579)
brainstemheterozygoteSection images
100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
cerebral cortexheterozygoten/a0% (0/2)0.41% (2/491)
epididymisheterozygoteSection images
100% (1/1)87.5% (21/24)
esophagusheterozygoteSection images
100% (2/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Il1atm1(NCOM)CmhdReporter-tagged deletion allele (with selection cassette)targeting vector
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Il1atm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
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Il1atm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse

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