Idh2 - isocitrate dehydrogenase 2 (NADP+), mitochondrial | International Mouse Phenotyping Consortium

Phenotype	System	Allele	Zyg	Sex	Life Stage	P Value
long tibia		Idh2^{tm1b(EUCOMM)Hmgu}	HOM		postnatal	1.17×10^-05

Table Images

Expression No Expression Ambiguous No Tissue Available

Anatomy	#HET Specimens	HOM Images?	WT Expr	Mutant Expr	Images
Adrenal gland	2	No	(2/584)		N/A
Aorta	2	No			N/A
Bone	2	No			N/A
Brain	2	No		(2/2)	Wholemount images
Brainstem	2	No		(2/2)	Wholemount images
Brown adipose tissue	2	No			N/A
Cartilage tissue	2	No			N/A
Cerebellum	2	No		(2/2)	Wholemount images
Cerebral cortex	2	No			N/A
Esophagus	2	No	(7/415)		N/A
Eye	2	No		(2/2)	Wholemount images
Gall bladder	2	No			N/A
Heart	2	No		(2/2)	Wholemount images
Hippocampus	2	No		(2/2)	Wholemount images
Hypothalamus	2	No		(2/2)	Wholemount images
Kidney	2	No	(18/584)	(2/2)	Wholemount images
Large intestine	2	No	(10/584)	(2/2)	Wholemount images
Liver	2	No			N/A
Lower urinary tract	2	No			N/A
Lung	2	No		(1/2)	Wholemount images
Lymph node	2	No			N/A
Mammary gland	2	No			N/A
Olfactory lobe	2	No		(2/2)	Wholemount images
Oral epithelium	2	No			N/A
Ovary	2	No	(1/584)		Wholemount images
Oviduct	2	No		(1/2)	Wholemount images
Pancreas	2	No	(5/584)	(2/2)	Wholemount images
Parathyroid gland	2	No			N/A
Peripheral nervous system	2	No			N/A
Peyer's patch	2	No			N/A
Pituitary gland	2	No			N/A
Prostate gland	2	No	(12/584)	(1/2)	Wholemount images
Skeletal muscle	2	No			N/A
Skin	2	No			N/A
Small intestine	2	No	(9/584)		N/A
Spinal cord	2	No		(2/2)	Wholemount images
Spleen	2	No	(2/584)		N/A
Stomach	2	No	(12/584)	(2/2)	Wholemount images
Striatum	2	No		(2/2)	Wholemount images
Testis	2	No	(2/584)	(1/2)	Wholemount images
Thymus	2	No			N/A
Thyroid gland	2	No	(15/584)	(2/2)	Wholemount images
Trachea	2	No			N/A
Uterus	2	No			N/A
Vascular system	2	No		(2/2)	Wholemount images
White adipose tissue	2	No			N/A

cardiovascular system (2)
Heart expression
MA:0000072

digestive system (2)
Large Intestine expression
MA:0000333

endocrine system (1)
Thyroid gland expression
MA:0000129

exocrine system (1)
Prostate gland expression
MA:0000404

nervous system (4)
Hippocampus expression
Striatum expression
Brain expression
MA:0000191
MA:0000891
MA:0000168

postnatal mouse (16)
Eye expression
MA:0000261

reproductive system (3)
Ovary ambiguous
Oviduct expression
MA:0000384
MA:0000385

respiratory system (1)
Lung expression
MA:0000415

sensory organ (1)
Eye expression
MA:0000261

trunk (10)
Heart expression
MA:0000072

urinary system (1)
Kidney expression
MA:0000368

Table Images

Expression No Expression Ambiguous No Tissue Available

Anatomy	#HET Specimens	WT Expr	Mutant Expr	Images
Brain	4	(6/485)	(1/6)	N/A
Ear	4	(1/485)		N/A
Embryo	4	(1/485)	(6/6)	N/A
Eye	4	(1/485)	(2/6)	N/A
Foot	4	(1/485)		N/A
Forebrain	4	(1/485)	(1/6)	N/A
Forelimb	4	(1/485)	(1/6)	N/A
Hand	4	(1/485)		N/A
Head	4	(5/485)	(4/6)	N/A
Heart	4	(1/485)	(2/6)	N/A
Hindbrain	4	(6/485)	(1/6)	N/A
Hindlimb	4	(1/485)	(1/6)	N/A
Liver	4	(1/485)		N/A
Lung	4	(1/485)		N/A
Mandibular process	4	(1/485)		N/A
Maxillary process	4	(1/485)		N/A
Midbrain	4	(1/485)	(1/6)	N/A
Oral cavity	4	(1/485)		N/A
Skin	4	(1/485)		N/A
Tail	4	(1/485)	(1/6)	N/A
Tail somite	4	(1/485)		N/A

embryo or Unassigned (8)

MGI Allele	Allele Type	Availability
Idh2^{tm1a(EUCOMM)Hmgu}	KO first allele (reporter-tagged insertion with conditional potential)	Mice, Targeting vectors, ES Cells
Idh2^{tm1b(EUCOMM)Hmgu}	Reporter-tagged deletion allele (post-Cre)	Mice

Gene: Idh2