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Gene: Hao2 MGI:96012

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Gene Summary

Name:
hydroxyacid oxidase 2
Synonyms:
Hao3

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Dorso Ventral Orientation

14 Images

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X-ray

XRay Images Whole Body Dorso Ventral

14 Images

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X-ray

XRay Images Forepaw

14 Images

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X-ray

XRay Images Whole Body Lateral Orientation

14 Images

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X-ray

XRay Images Skull Lateral Orientation

14 Images

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Eye Morphology

Images Slit Lamp

5 Images

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Legacy Phenotype Associated Images
Hao2em1(IMPC)Wtsi
HOM, Male, WTSI
Hao2em1(IMPC)Wtsi
HOM, Male, WTSI
Hao2em1(IMPC)Wtsi
HOM, Male, WTSI
Hao2em1(IMPC)Wtsi
HOM, Female, WTSI
Hao2em1(IMPC)Wtsi
HOM, Female, WTSI

View all 90 images

Hao2em1(IMPC)Wtsi
abnormal tail morphology, kinked tail, WT, Female, WTSI
Hao2em1(IMPC)Wtsi
kinked tail, abnormal tail morphology, WT, Female, WTSI
Hao2em1(IMPC)Wtsi
head, asymmetric snout, abnormal snout morphology, HOM, Female, WTSI
Hao2em1(IMPC)Wtsi
abnormal snout morphology, head, asymmetric snout, HOM, Female, WTSI
Hao2em1(IMPC)Wtsi
abnormal snout morphology, upturned snout, head, HOM, Female, WTSI

View all 6 images

Hao2em1(IMPC)Wtsi
abnormal placement of pupils, HOM, Female, WTSI
Hao2em1(IMPC)Wtsi
cataract, HOM, Female, WTSI
Hao2em1(IMPC)Wtsi
abnormal cornea morphology, HOM, Female, WTSI
Hao2em1(IMPC)Wtsi
narrow eye opening, HOM, Female, WTSI
Hao2em1(IMPC)Wtsi
abnormal placement of pupils, HOM, Female, WTSI

Human diseases caused by Hao2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Hao2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Hao2.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Hao2em1(IMPC)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Hao2em1(IMPC)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Hao2em2Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Hao2em1Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Hao2em2Wtsi PMC5827107

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MGI Allele Allele Type Produced
Hao2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Hao2tm35784(L1L2_gt2) Targeting vectors
Hao2em1(IMPC)Wtsi Exdel Mice

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