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Gene: H2-Eb2 MGI:95902

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Gene Summary

Name:
histocompatibility 2, class II antigen E beta2
Synonyms:
Ia-5,  Ia5,  H-2Eb2,  A130038H09Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased leukocyte cell number H2-Eb2em1(IMPC)J HOM   Early adult 5.08×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Dorso Ventral Orientation

11 Images

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Electroretinography 3

Fundus file

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

11 Images

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X-ray

XRay Images Skull Lateral Orientation

11 Images

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X-ray

XRay Images Forepaw

11 Images

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X-ray

XRay Images Whole Body Dorso Ventral

11 Images

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PDF thumbnail PDF
Electrocardiogram (ECG)

Waveform Image

15 Images

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PDF thumbnail PDF
Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

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Human diseases caused by H2-Eb2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to H2-Eb2 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Systemic Lupus Erythematosus
Leukopenia, Hemolytic anemia, Thrombocytopenia ORPHA:536
Sarcoidosis
Hemolytic anemia, Eosinophilia, Increased T cell count, Anemia, Leukopenia, Thrombocytopenia ORPHA:797
Sarcoidosis, Susceptibility To, 1
Splenomegaly, Pancytopenia OMIM:181000
Follicular Lymphoma
Splenomegaly ORPHA:545
Systemic-Onset Juvenile Idiopathic Arthritis
Splenomegaly ORPHA:85414
Giant Cell Arteritis
ORPHA:397
Narcolepsy Type 1
ORPHA:2073
Narcolepsy Type 2
ORPHA:83465
Diffuse Cutaneous Systemic Sclerosis
ORPHA:220393
Autoimmune Pulmonary Alveolar Proteinosis
ORPHA:747
Bullous Pemphigoid
ORPHA:703
Multiple Sclerosis, Susceptibility To
OMIM:126200
Limited Cutaneous Systemic Sclerosis
ORPHA:220402

The table below shows human diseases predicted to be associated to H2-Eb2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Myelolymphatic Insufficiency
Leukopenia, Hyposegmentation of neutrophil nuclei OMIM:310350
Myeloproliferative Syndrome, Transient
Leukocytosis, Transient myeloproliferative syndrome OMIM:159595
Reticular Dysgenesis
Leukopenia, Congenital agranulocytosis, Lymphopenia, Hypoplasia of the thymus OMIM:267500
Acute Erythroid Leukemia
Anemia, Erythroid hypoplasia, Pancytopenia, Leukopenia ORPHA:318
Systemic Lupus Erythematosus
Leukopenia, Hemolytic anemia, Thrombocytopenia ORPHA:536
Sarcoidosis
Hemolytic anemia, Eosinophilia, Increased T cell count, Anemia, Leukopenia, Thrombocytopenia ORPHA:797
Sarcoidosis, Susceptibility To, 1
Splenomegaly, Pancytopenia OMIM:181000
Follicular Lymphoma
Splenomegaly ORPHA:545
Systemic-Onset Juvenile Idiopathic Arthritis
Splenomegaly ORPHA:85414
Giant Cell Arteritis
ORPHA:397
Narcolepsy Type 1
ORPHA:2073
Narcolepsy Type 2
ORPHA:83465
Diffuse Cutaneous Systemic Sclerosis
ORPHA:220393
Autoimmune Pulmonary Alveolar Proteinosis
ORPHA:747
Bullous Pemphigoid
ORPHA:703
Multiple Sclerosis, Susceptibility To
OMIM:126200
Limited Cutaneous Systemic Sclerosis
ORPHA:220402

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for H2-Eb2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to H2-Eb2.

No publications found that use IMPC mice or data for H2-Eb2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
H2-Eb2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
H2-Eb2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
H2-Eb2em1(IMPC)J Intra-exon deletion Mice
H2-Eb2em1(IMPC)Wtsi Deletion Mice

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