Gene: Gria3 MGI:95810

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
glutamate receptor, ionotropic, AMPA3 (alpha 3)
Synonyms:
Glur-3,  Glur3,  GluR3,  2900064I19Rik,  Gluralpha3

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gria3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Gria3 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Intellectual Developmental Disorder, X-Linked, Syndromic, Wu Type
Slender build OMIM:300699
X-Linked Intellectual Disability Due To Gria3 Mutations
Status epilepticus, Seizure, Myoclonus, Bilateral tonic-clonic seizure ORPHA:364028

The table below shows human diseases predicted to be associated to Gria3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Disseminated Sclerosis With Narcolepsy
Narcolepsy OMIM:223300
Developmental And Epileptic Encephalopathy 8
Seizure, Exaggerated startle response OMIM:300607
Narcolepsy 3
Narcolepsy OMIM:609039
Narcolepsy 1
Narcolepsy OMIM:161400
Hyperekplexia-Epilepsy Syndrome
Exaggerated startle response, Generalized tonic seizure, Focal impaired awareness seizure ORPHA:163985
Narcolepsy 7
Narcolepsy OMIM:614250
Hyperekplexia 3
Exaggerated startle response OMIM:614618
Hyperekplexia 2
Exaggerated startle response, Myoclonus OMIM:614619
Hereditary Central Diabetes Insipidus
Polydipsia, Lethargy ORPHA:30925
Developmental And Epileptic Encephalopathy 68
Status epilepticus, Exaggerated startle response, Myoclonus OMIM:618201
Hyperekplexia 1
Seizure, Exaggerated startle response, Myoclonus, Nocturnal seizures OMIM:149400
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination
Seizure, Exaggerated startle response OMIM:618367
Renal Glucosuria
Polydipsia, Polyphagia OMIM:233100
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Narcolepsy OMIM:604121
Type 1 Diabetes Mellitus
Polydipsia, Polyphagia OMIM:222100
Tay-Sachs Disease
Seizure, Exaggerated startle response OMIM:272800
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Central Diabetes Insipidus
Polydipsia, Lethargy ORPHA:178029
Gm2 Gangliosidosis, Ab Variant
Seizure, Exaggerated startle response ORPHA:309246
Acquired Central Diabetes Insipidus
Polydipsia ORPHA:95626
East Syndrome
Inability to walk, Difficulty walking, Ataxia, Salt craving, Polydipsia ORPHA:199343
Spastic Paraplegia, Optic Atrophy, And Neuropathy
Exaggerated startle response OMIM:609541
Gm2-Gangliosidosis, Ab Variant
Seizure, Exaggerated startle response OMIM:272750
Stiff-Person Syndrome
Opisthotonus, Exaggerated startle response, Myoclonic spasms OMIM:184850
Spastic Tetraplegia And Axial Hypotonia, Progressive
Exaggerated startle response OMIM:618598
Diabetes Insipidus, Neurohypophyseal Type
Polydipsia OMIM:304900
Asparagine Synthetase Deficiency
Seizure, Exaggerated startle response OMIM:615574
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Narcolepsy ORPHA:314404
Stiff Person Spectrum Disorder
Exaggerated startle response ORPHA:3198
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Exaggerated startle response ORPHA:320406
Sandhoff Disease
Exaggerated startle response, Myoclonic seizure, Bilateral tonic-clonic seizure OMIM:268800
Brain-Lung-Thyroid Syndrome
Abnormal drinking behavior, Dystonia, Chorea, Ataxia, Abnormal eating behavior, Falls, Hyperactiv... ORPHA:209905
Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance
Dysdiadochokinesis, Polydipsia, Salt craving, Ataxia OMIM:612780
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Seizure, Exaggerated startle response ORPHA:438216
Teratoma, Pineal
Polydipsia OMIM:273120
Aromatic L-Amino Acid Decarboxylase Deficiency
Limb tremor, Exaggerated startle response, Myoclonus OMIM:608643
Tay-Sachs Disease
Tremor, Seizure, Exaggerated startle response, Myoclonus, Focal impaired awareness seizure, Typic... ORPHA:845
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Narcolepsy ORPHA:293987
Niemann-Pick Disease Type C
Narcolepsy ORPHA:646
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies
Seizure, Exaggerated startle response, Generalized-onset seizure OMIM:617527
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Seizure, Exaggerated startle response OMIM:253800
Gm1 Gangliosidosis Type 1
Seizure, Exaggerated startle response ORPHA:79255
Glycine Encephalopathy With Normal Serum Glycine
Exaggerated startle response OMIM:617301
Plaa-Associated Neurodevelopmental Disorder
Seizure, Exaggerated startle response ORPHA:521426
African Trypanosomiasis
Narcolepsy ORPHA:3385
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Generalized tonic seizure, Seizure, Exaggerated startle response, Myoclonus, Bilateral tonic-clon... ORPHA:438213
Intellectual Developmental Disorder, X-Linked, Syndromic, Wu Type
Slender build OMIM:300699
X-Linked Intellectual Disability Due To Gria3 Mutations
Status epilepticus, Seizure, Myoclonus, Bilateral tonic-clonic seizure ORPHA:364028

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gria3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gria3.

No publications found that use IMPC mice or data for Gria3.

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MGI Allele Allele Type Produced
Gria3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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