Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
glutamate receptor, ionotropic, AMPA3 (alpha 3)
Synonyms:
Glur-3,  Gluralpha3,  Glur3,  2900064I19Rik,  GluR3

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gria3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Gria3 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Intellectual Developmental Disorder, X-Linked, Syndromic, Wu Type
Limb tremor, Myoclonus, Focal tonic seizure, Seizure OMIM:300699
X-Linked Intellectual Disability Due To Gria3 Mutations
Slender build ORPHA:364028

The table below shows human diseases predicted to be associated to Gria3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Disseminated Sclerosis With Narcolepsy
Narcolepsy OMIM:223300
Developmental And Epileptic Encephalopathy 8
Exaggerated startle response, Seizure OMIM:300607
Progressive Supranuclear Palsy-Pure Akinesia With Gait Freezing Syndrome
Gait imbalance, Akinesia, Freezing of gait, Loss of ambulation, Falls, Unsteady gait, Short stepp... ORPHA:240094
Narcolepsy 3
Narcolepsy OMIM:609039
Spinocerebellar Ataxia Type 27
Akinesia, Limb ataxia, Truncal ataxia, Gait disturbance, Difficulty walking, Gait ataxia ORPHA:98764
Hyperekplexia-Epilepsy Syndrome
Focal impaired awareness seizure, Exaggerated startle response, Generalized tonic seizure ORPHA:163985
Narcolepsy 7
Narcolepsy OMIM:614250
Narcolepsy 1
Narcolepsy OMIM:161400
Hyperekplexia 3
Exaggerated startle response OMIM:614618
Spinocerebellar Ataxia Type 21
Akinesia, Gait ataxia, Progressive cerebellar ataxia ORPHA:98773
Atypical Juvenile Parkinsonism
Akinesia, Inability to walk, Shuffling gait, Gait ataxia, Short stepped shuffling gait ORPHA:391411
Developmental And Epileptic Encephalopathy 68
Status epilepticus, Myoclonus, Exaggerated startle response OMIM:618201
Parkinson Disease 17
Akinesia OMIM:614203
Hyperekplexia 1
Myoclonus, Nocturnal seizures, Exaggerated startle response, Seizure OMIM:149400
Corticobasal Syndrome
Gait disturbance, Somatic sensory dysfunction, Akinesia ORPHA:454887
Spinocerebellar Ataxia 21
Akinesia, Ataxia, Progressive cerebellar ataxia, Limb ataxia, Gait ataxia OMIM:607454
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination
Exaggerated startle response, Seizure OMIM:618367
Kufor-Rakeb Syndrome
Akinesia, Ataxia, Distal sensory impairment, Gait disturbance, Dysphagia OMIM:606693
Sporadic Adult-Onset Ataxia Of Unknown Etiology
Akinesia, Ataxia, Dysdiadochokinesis, Shuffling gait, Gait ataxia, Dysphagia ORPHA:247234
Renal Glucosuria
Polyphagia, Polydipsia OMIM:233100
Myopathy, Congenital, With Respiratory Insufficiency And Bone Fractures
Akinesia OMIM:618822
Hyperekplexia 2
Myoclonus, Exaggerated startle response OMIM:614619
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Narcolepsy OMIM:604121
Intellectual Developmental Disorder With Language Impairment And Early-Onset Dopa-Responsive Dystonia-Parkinsonism
Akinesia, Freezing of gait OMIM:619911
Lissencephaly Type Iii And Bone Dysplasia
Akinesia OMIM:601160
Type 1 Diabetes Mellitus
Polyphagia, Polydipsia OMIM:222100
Autosomal Dominant Cerebellar Ataxia
Akinesia, Progressive cerebellar ataxia, Pseudobulbar paralysis, Impaired vibratory sensation, Ch... ORPHA:99
Classic Progressive Supranuclear Palsy Syndrome
Gait imbalance, Neuromuscular dysphagia, Akinesia, Falls ORPHA:240071
Tay-Sachs Disease
Exaggerated startle response, Seizure OMIM:272800
Arthrogryposis Multiplex Congenita 6
Akinesia OMIM:619334
Gm2 Gangliosidosis, Ab Variant
Dystonia, Exaggerated startle response, Seizure ORPHA:309246
Postencephalitic Parkinsonism
Dysphagia, Akinesia, Paresthesia ORPHA:97349
Lethal Congenital Contracture Syndrome 2
Akinesia OMIM:607598
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Akinesia OMIM:225790
Gm2-Gangliosidosis, Ab Variant
Dystonia, Exaggerated startle response, Seizure OMIM:272750
Aceruloplasminemia
Akinesia, Ataxia, Limb ataxia, Chorea, Gait ataxia ORPHA:48818
Aromatic L-Amino Acid Decarboxylase Deficiency
Torticollis, Blepharospasm, Exaggerated startle response, Oculogyric crisis, Myoclonus, Athetosis... OMIM:608643
Myopathy, Congenital, Compton-North
Akinesia OMIM:612540
Manganese Poisoning
Gait disturbance, Akinesia ORPHA:306682
Perry Syndrome
Akinesia, Short stepped shuffling gait OMIM:168605
Acquired Central Diabetes Insipidus
Polydipsia ORPHA:95626
East Syndrome
Ataxia, Inability to walk, Polydipsia, Salt craving, Difficulty walking ORPHA:199343
Multiple Pterygium Syndrome, Lethal Type
Akinesia OMIM:253290
Fetal Akinesia Deformation Sequence
Akinesia ORPHA:994
Stiff-Person Syndrome
Myoclonic spasms, Exaggerated startle response, Opisthotonus OMIM:184850
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Narcolepsy ORPHA:314404
Asparagine Synthetase Deficiency
Exaggerated startle response, Seizure OMIM:615574
Parkinson Disease 23, Autosomal Recessive Early-Onset
Akinesia OMIM:616840
Hereditary Late-Onset Parkinson Disease
Dysphagia, Shuffling gait, Akinesia ORPHA:411602
Diabetes Insipidus, Neurohypophyseal, X-Linked
Polydipsia OMIM:304900
Stiff Person Spectrum Disorder
Exaggerated startle response ORPHA:3198
Spastic Tetraplegia And Axial Hypotonia, Progressive
Exaggerated startle response OMIM:618598
Gaucher Disease, Perinatal Lethal
Dysphagia, Akinesia OMIM:608013
Leukoencephalopathy, Progressive, Infantile-Onset, With Or Without Deafness
Akinesia OMIM:619147
Spastic Paraplegia, Optic Atrophy, And Neuropathy
Exaggerated startle response OMIM:609541
Supranuclear Palsy, Progressive, 2
Gait imbalance, Akinesia, Dysphagia, Falls OMIM:609454
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Exaggerated startle response ORPHA:320406
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Dystonia, Exaggerated startle response, Seizure ORPHA:438216
Neurodegeneration With Brain Iron Accumulation 1
Akinesia, Ataxia, Gait disturbance, Choreoathetosis, Dysphagia OMIM:234200
Tay-Sachs Disease
Typical absence seizure, Laryngeal dystonia, Exaggerated startle response, Focal impaired awarene... ORPHA:845
Sandhoff Disease
Bilateral tonic-clonic seizure, Myoclonic seizure, Exaggerated startle response OMIM:268800
Supranuclear Palsy, Progressive, 1
Gait imbalance, Akinesia, Dysphagia, Falls OMIM:601104
Teratoma, Pineal
Polydipsia OMIM:273120
Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance
Dysdiadochokinesis, Salt craving, Ataxia, Polydipsia OMIM:612780
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Narcolepsy ORPHA:293987
Niemann-Pick Disease Type C
Narcolepsy ORPHA:646
Arthrogryposis Multiplex Congenita 5
Akinesia OMIM:618947
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies
Generalized-onset seizure, Exaggerated startle response, Seizure OMIM:617527
Plaa-Associated Neurodevelopmental Disorder
Dystonia, Exaggerated startle response, Seizure ORPHA:521426
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Exaggerated startle response, Seizure OMIM:253800
Gm1 Gangliosidosis Type 1
Exaggerated startle response, Seizure ORPHA:79255
Glycine Encephalopathy With Normal Serum Glycine
Exaggerated startle response OMIM:617301
Dpagt1-Cdg
Akinesia, Ataxia, Inability to walk ORPHA:86309
African Trypanosomiasis
Narcolepsy ORPHA:3385
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Exaggerated startle response, Generalized tonic seizure, Myoclonus, Epileptic spasm, Bilateral to... ORPHA:438213
Intellectual Developmental Disorder, X-Linked, Syndromic, Wu Type
Limb tremor, Myoclonus, Focal tonic seizure, Seizure OMIM:300699
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities
Exaggerated startle response, Seizure OMIM:619522
X-Linked Intellectual Disability Due To Gria3 Mutations
Slender build ORPHA:364028

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gria3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gria3.

No publications found that use IMPC mice or data for Gria3.

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MGI Allele Allele Type Produced
Gria3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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