Registered for phenotyping at IMPC

Phenotyping is planned for a knockout strain of this gene but data is not currently available.

Gene Summary

Name:
TLE family member 5, transcriptional modulator
Synonyms:
Grg,  AES,  Grg5,  Aes

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Tle5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tle5 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Growth Hormone Deficiency, Isolated Partial
Postnatal growth retardation, Decreased response to growth hormone stimulation test, Small pituit... OMIM:615925
Pituitary Adenoma 5, Multiple Types
Pituitary adenoma OMIM:617540
Pituitary Carcinoma
Enlarged pituitary gland, Pituitary gonadotropic cell adenoma, Diabetes insipidus, Increased circ... ORPHA:300385
Isolated Growth Hormone Deficiency, Type Iv
Decreased response to growth hormone stimulation test, Impaired growth-hormone response to insuli... OMIM:618157
Isolated Growth Hormone Deficiency, Type Ii
Decreased response to growth hormone stimulation test, Pituitary dwarfism, Anterior pituitary hyp... OMIM:173100
Pituitary Hormone Deficiency, Combined, 3
Decreased response to growth hormone stimulation test, Pituitary dwarfism, Anterior hypopituitari... OMIM:221750
X-Linked Acrogigantism
Delayed puberty, Enlarged pituitary gland, Decreased thyroid-stimulating hormone level, Increased... ORPHA:300373
Pituitary Dermoid And Epidermoid Cysts
Enlarged pituitary gland, Anterior hypopituitarism, Panhypopituitarism, Hyperpituitarism, Hypogon... ORPHA:91351
Pituitary Hormone Deficiency, Combined Or Isolated, 7
Postnatal growth retardation, Anterior pituitary hypoplasia, Decreased response to growth hormone... OMIM:618160
Non-Acquired Combined Pituitary Hormone Deficiency-Sensorineural Hearing Loss-Spine Abnormalities Syndrome
Decreased response to growth hormone stimulation test, Anterior pituitary hypoplasia, Pituitary h... ORPHA:231720
Pituitary Deficiency Due To Rathke Cleft Cysts
Enlarged pituitary gland, Anterior hypopituitarism, Diabetes insipidus, Pituitary hypothyroidism,... ORPHA:91350
Craniopharyngioma
Delayed puberty, Central diabetes insipidus, Enlarged pituitary gland, Postnatal growth retardati... ORPHA:54595
Panhypopituitarism, X-Linked
Pituitary dwarfism, Panhypopituitarism OMIM:312000
Intellectual Developmental Disorder, X-Linked, With Panhypopituitarism
Hypothyroidism, Decreased response to growth hormone stimulation test, Panhypopituitarism, Short ... OMIM:300123
Pituicytoma
Central diabetes insipidus, Decreased response to growth hormone stimulation test, Pituitary hypo... ORPHA:251623
Alopecia, Neurologic Defects, And Endocrinopathy Syndrome
Delayed puberty, Small pituitary gland, Short stature, Central adrenal insufficiency, Hypogonadot... OMIM:612079
Hypogonadotropic Hypogonadism 6 With Or Without Anosmia
Delayed puberty, Cryptorchidism, Hypogonadotropic hypogonadism, Small pituitary gland OMIM:612702
Septooptic Dysplasia
Short stature, Anterior pituitary hypoplasia, Decreased response to growth hormone stimulation te... OMIM:182230
Hypogonadotropic Hypogonadism 15 With Or Without Anosmia
Decreased testicular size, Cryptorchidism, Small pituitary gland OMIM:614880
Panhypophysitis
Abnormal thalamic MRI signal intensity, Central diabetes insipidus, Reduced circulating prolactin... ORPHA:95513
Adenohypophysitis
Abnormal thalamic MRI signal intensity, Reduced circulating prolactin concentration, Pituitary hy... ORPHA:95512
Tsh-Secreting Pituitary Adenoma
Delayed puberty, Elevated circulating thyroid-stimulating hormone concentration, Enlarged pituita... ORPHA:91347
Developmental And Epileptic Encephalopathy 108
Small pituitary gland OMIM:620115
X-Linked Intellectual Disability With Isolated Growth Hormone Deficiency
Decreased response to growth hormone stimulation test, Anterior pituitary hypoplasia, Short statu... ORPHA:67045
Meningioma
Enlarged pituitary gland, Reduced circulating prolactin concentration, Decreased circulating ACTH... ORPHA:2495
Congenital Disorder Of Glycosylation, Type Iiq
Small pituitary gland OMIM:617395
Ziegler-Huang Syndrome
Anterior pituitary hypoplasia, Growth delay, Elevated circulating follicle stimulating hormone le... OMIM:620501
Pituitary Hormone Deficiency, Combined Or Isolated, 8
Decreased thyroid-stimulating hormone level, Anterior pituitary agenesis, Decreased circulating A... OMIM:620303
Cog2-Cdg
Small pituitary gland ORPHA:435934
Polyendocrine-Polyneuropathy Syndrome
Postnatal growth retardation, Anterior pituitary hypoplasia, Central hypothyroidism, Decreased te... OMIM:616113
Culler-Jones Syndrome
Diabetes insipidus, Anterior pituitary hypoplasia, Short stature, Hypogonadism, Hypopituitarism, ... OMIM:615849
Pituitary Hormone Deficiency, Combined Or Isolated, 1
Decreased thyroid-stimulating hormone level, Reduced circulating prolactin concentration, Reduced... OMIM:613038
Polyendocrine-Polyneuropathy Syndrome
Postnatal growth retardation, Decreased circulating follicle stimulating hormone concentration, D... ORPHA:453533
Ane Syndrome
Delayed puberty, Decreased response to growth hormone stimulation test, Reduced circulating prola... ORPHA:157954
Joubert Syndrome 38
Decreased response to growth hormone stimulation test, Small pituitary gland, Short stature, Decr... OMIM:619476
Non-Acquired Panhypopituitarism
Delayed puberty, Absence of secondary sex characteristics, Decreased response to growth hormone s... ORPHA:90695
Pituitary Adenoma 2, Growth Hormone-Secreting
Pituitary adenoma, Elevated circulating growth hormone concentration OMIM:300943
Sheehan Syndrome
Breast hypoplasia, Central diabetes insipidus, Reduced circulating prolactin concentration, Pitui... ORPHA:91355
X-Linked Intellectual Disability, Van Esch Type
Absence of secondary sex characteristics, Retractile testis, Hypergonadotropic hypogonadism, Decr... ORPHA:163976
Webb-Dattani Syndrome
Decreased response to growth hormone stimulation test, Diabetes insipidus, Anterior pituitary hyp... OMIM:615926
Craniofacial Anomalies And Anterior Segment Dysgenesis Syndrome
Small pituitary gland OMIM:614195
Primary Hypergonadotropic Hypogonadism-Partial Alopecia Syndrome
Delayed puberty, Absence of secondary sex characteristics, Breast hypoplasia, Increased circulati... ORPHA:2232
Sim1-Related Prader-Willi-Like Syndrome
Premature pubarche, Small pituitary gland, Central hypothyroidism, Absence of pubertal developmen... ORPHA:398079
Non-Functioning Pituitary Adenoma
Female hypogonadism, Hypogonadism, Central adrenal insufficiency, Adrenal insufficiency, Decrease... ORPHA:91349
Developmental And Epileptic Encephalopathy 105 With Hypopituitarism
Anterior pituitary hypoplasia, Pituitary hypothyroidism OMIM:619983
Fg Syndrome Type 1
Short stature, Abnormal social behavior, Cryptorchidism, Small pituitary gland ORPHA:93932
Pituitary Hormone Deficiency, Combined, 6
Decreased thyroid-stimulating hormone level, Decreased circulating ACTH concentration, Decreased ... OMIM:613986
Hydranencephaly
Postnatal growth retardation, Dysgenesis of the thalamus, Intrauterine growth retardation, Atroph... ORPHA:2177
Combined Pituitary Hormone Deficiencies, Genetic Forms
Delayed puberty, Absence of secondary sex characteristics, Decreased response to growth hormone s... ORPHA:95494
Immunodeficiency 54
Postnatal growth retardation, Adrenocorticotropic hormone excess, Short stature, Intrauterine gro... OMIM:609981
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
Decreased response to growth hormone stimulation test, Decreased circulating ACTH concentration, ... ORPHA:293978
Gangliocytoma
Adrenocorticotropic hormone excess, Abnormal pituitary gland morphology, Abnormal prolactin level... ORPHA:251937
Septo-Optic Dysplasia Spectrum
Maternal diabetes, Diabetes insipidus, Anterior pituitary hypoplasia, Abnormality of the hypothal... ORPHA:3157
Prader-Willi Syndrome
Decreased circulating inhibin B concentration, Decreased response to growth hormone stimulation t... ORPHA:739
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Decreased response to growth hormone stimulation test, Decreased thyroid-stimulating hormone leve... ORPHA:226307
Insulin-Like Growth Factor I Deficiency
Postnatal growth retardation, Short stature, Elevated circulating growth hormone concentration, D... OMIM:608747
Brain Malformation-Congenital Heart Disease-Postaxial Polydactyly Syndrome
Intrauterine growth retardation, Posterior pituitary hypoplasia, Abnormality of the anterior pitu... ORPHA:75389
Magel2-Related Prader-Willi-Like Syndrome
Premature pubarche, Small pituitary gland, Central hypothyroidism, Absence of pubertal developmen... ORPHA:398069
Giant Axonal Neuropathy
Abnormal pituitary gland morphology ORPHA:643
Isolated Exencephaly
Anterior pituitary hypoplasia, Maternal diabetes, Posterior pituitary agenesis ORPHA:563612
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Delayed puberty, Decreased circulating inhibin B concentration, Decreased response to growth horm... ORPHA:98754
Igg4-Related Thyroid Disease
Euthyroid goiter, Sialadenitis, Thyroiditis, Thyrotoxicosis with diffuse goiter, Abnormal pituita... ORPHA:64744
Prader-Willi Syndrome Due To Paternal 15Q11Q13 Deletion
Delayed puberty, Decreased circulating inhibin B concentration, Decreased response to growth horm... ORPHA:98793
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 2
Delayed puberty, Decreased circulating inhibin B concentration, Decreased response to growth horm... ORPHA:177904
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 1
Delayed puberty, Decreased circulating inhibin B concentration, Decreased response to growth horm... ORPHA:177901
Multiple Endocrine Neoplasia, Type Iv
Pancreatic endocrine tumor, Primary hyperparathyroidism, Hypothyroidism, Hashimoto thyroiditis, C... OMIM:610755
Acromelic Frontonasal Dysplasia
Hypopituitarism, Anterior pituitary hypoplasia, Cryptorchidism ORPHA:1827
Prolactinoma
Delayed puberty, Anterior hypopituitarism, Decreased circulating ACTH concentration, Pituitary hy... ORPHA:2965
Short-Rib Thoracic Dysplasia 21 Without Polydactyly
Disproportionate short-limb short stature, Small pituitary gland OMIM:619479
Chromosome 14Q11-Q22 Deletion Syndrome
Elevated circulating thyroid-stimulating hormone concentration, Anterior pituitary hypoplasia, Bi... OMIM:613457
Microphthalmia, Syndromic 3
Postnatal growth retardation, Anterior pituitary hypoplasia, Hypothalamic hamartoma, Short statur... OMIM:206900
Prader-Willi Syndrome Due To Translocation
Decreased response to growth hormone stimulation test, Abnormal social behavior, Anterior pituita... ORPHA:177907
Pseudohypoparathyroidism Type 1B
Decreased response to growth hormone stimulation test, Elevated circulating parathyroid hormone l... ORPHA:94089
Deeah Syndrome
Decreased response to growth hormone stimulation test, Anterior pituitary hypoplasia, Panhypopitu... OMIM:619004
14Q22Q23 Microdeletion Syndrome
Diabetes insipidus, Anterior pituitary hypoplasia, Adrenal hypoplasia, Abnormality of the hypotha... ORPHA:264200
Duplication Of The Pituitary Gland
Short stature, Abnormal hypothalamus morphology, Abnormal pituitary gland morphology ORPHA:314621
Dyrk1A-Related Intellectual Disability Syndrome
Breast hypoplasia, Anterior pituitary hypoplasia, Short stature, Intrauterine growth retardation,... ORPHA:464306
Lenz-Majewski Hyperostotic Dwarfism
Intrauterine growth retardation, Anterior pituitary hypoplasia, Cryptorchidism, Short stature OMIM:151050
Craniometadiaphyseal Osteosclerosis With Hip Dysplasia
Ectopic anterior pituitary gland OMIM:620558
Holoprosencephaly 9
Decreased response to growth hormone stimulation test, Anterior pituitary agenesis, Anterior pitu... OMIM:610829
Macrocephaly-Intellectual Disability-Left Ventricular Non Compaction Syndrome
Delayed puberty, Anterior pituitary hypoplasia, Bilateral cryptorchidism, Excessive shyness, Cryp... ORPHA:466791
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Decreased response to growth hormone stimulation test, Cryptorchidism, Thyroid hypoplasia, Small ... OMIM:619503
Ulnar-Mammary Syndrome
Delayed puberty, Breast hypoplasia, Anterior pituitary hypoplasia, Hypoplastic nipples, Ectopic p... OMIM:181450
Pseudohypoparathyroidism Type 1C
Decreased response to growth hormone stimulation test, Elevated circulating parathyroid hormone l... ORPHA:79444
Chilton-Okur-Chung Neurodevelopmental Syndrome
Intrauterine growth retardation, Anterior pituitary hypoplasia, Cryptorchidism, Short stature OMIM:619841
Autoimmune Polyendocrinopathy Type 3
Central diabetes insipidus, Hypergonadotropic hypogonadism, Anterior pituitary dysgenesis, Hashim... ORPHA:227982
Autoimmune Polyendocrinopathy Type 4
Central diabetes insipidus, Hypergonadotropic hypogonadism, Anterior pituitary dysgenesis, Thymom... ORPHA:227990
Pseudohypoparathyroidism Type 1A
Decreased response to growth hormone stimulation test, Elevated circulating parathyroid hormone l... ORPHA:79443
Igg4-Related Ophthalmic Disease
Enlarged lacrimal glands, Sialadenitis, Thyroiditis, Orchitis, Abnormality of the anterior pituitary ORPHA:449563
Biliary, Renal, Neurologic, And Skeletal Syndrome
Short stature, Anterior pituitary hypoplasia, Bile duct proliferation, Diabetes insipidus OMIM:619534
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Abnormality of the endocrine system, Hypothyroidism, Precocious puberty, Short stature, Abnormali... ORPHA:438213
Igg4-Related Kidney Disease
Sialadenitis, Thyroiditis, Abnormality of the anterior pituitary ORPHA:449395

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tle5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tle5.

No publications found that use IMPC mice or data for Tle5.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Tle5em1(IMPC)Wtsi Exon Deletion Mice
Tle5tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Tle5tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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