Registered for phenotyping at IMPC

Phenotyping is planned for a knockout strain of this gene but data is not currently available.

Gene Summary

Name:
TLE family member 5, transcriptional modulator
Synonyms:
Grg,  AES,  Grg5,  Aes

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Tle5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tle5 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Growth Hormone Deficiency, Isolated Partial
Postnatal growth retardation, Decreased response to growth hormone stimulation test, Small pituit... OMIM:615925
Pituitary Adenoma 5, Multiple Types
Pituitary adenoma OMIM:617540
Pituitary Carcinoma
Pituitary growth hormone cell adenoma, Enlarged pituitary gland, Elevated circulating growth horm... ORPHA:300385
Thyroid Hormone Metabolism, Abnormal, 1
Hypothyroidism, Decreased circulating free T3, Elevated circulating thyroid-stimulating hormone c... OMIM:609698
Isolated Growth Hormone Deficiency, Type Iv
Severe short stature, Decreased response to growth hormone stimulation test, Impaired growth-horm... OMIM:618157
X-Linked Acrogigantism
Increased circulating insulin-like growth factor 1 concentration, Decreased thyroid-stimulating h... ORPHA:300373
Pituitary Hormone Deficiency, Combined, 3
Decreased response to growth hormone stimulation test, Short stature, Pituitary dwarfism, Anterio... OMIM:221750
Pituitary Dermoid And Epidermoid Cysts
Enlarged pituitary gland, Panhypopituitarism, Anterior hypopituitarism, Increased circulating pro... ORPHA:91351
Non-Acquired Isolated Growth Hormone Deficiency
Anterior hypopituitarism, Short stature ORPHA:631
Non-Acquired Combined Pituitary Hormone Deficiency-Sensorineural Hearing Loss-Spine Abnormalities Syndrome
Adrenocorticotropic hormone deficiency, Decreased response to growth hormone stimulation test, Sh... ORPHA:231720
Pituitary Hormone Deficiency, Combined Or Isolated, 7
Postnatal growth retardation, Decreased response to growth hormone stimulation test, Short stature OMIM:618160
Pituitary Deficiency Due To Rathke Cleft Cysts
Enlarged pituitary gland, Hypogonadotropic hypogonadism, Panhypopituitarism, Anterior hypopituita... ORPHA:91350
Craniopharyngioma
Growth delay, Enlarged pituitary gland, Type II diabetes mellitus, Postnatal growth retardation, ... ORPHA:54595
Hypogonadotropic Hypogonadism 15 With Or Without Anosmia
Cryptorchidism, Decreased testicular size, Small pituitary gland OMIM:614880
Panhypopituitarism, X-Linked
Pituitary dwarfism, Panhypopituitarism OMIM:312000
Short Stature-Delayed Bone Age Due To Thyroid Hormone Metabolism Deficiency
Abnormal circulating insulin concentration, Short stature, Decreased circulating free T3, Increas... ORPHA:171706
Congenital Disorder Of Glycosylation, Type Iiq
Small pituitary gland OMIM:617395
Intellectual Developmental Disorder, X-Linked, With Panhypopituitarism
Hypothyroidism, Panhypopituitarism, Decreased response to growth hormone stimulation test, Short ... OMIM:300123
Pituicytoma
Abnormality of the pituitary gland, Decreased serum testosterone concentration, Decreased respons... ORPHA:251623
Hypogonadotropic Hypogonadism 6 With Or Without Anosmia
Hypogonadotropic hypogonadism, Cryptorchidism, Small pituitary gland OMIM:612702
Hypothyroidism, Congenital, Nongoitrous, 9
Short stature, Inappropriately normal thyroid-stimulating hormone level, Thyroid hypoplasia, Cent... OMIM:301035
Septooptic Dysplasia
Short stature, Decreased response to growth hormone stimulation test, Anterior pituitary hypoplas... OMIM:182230
Hypothyroidism, Central, With Testicular Enlargement
Hypothyroidism, Reduced TSH response to thyrotrophin-releasing hormone stimulation test, Inapprop... OMIM:300888
Tsh-Secreting Pituitary Adenoma
Abnormality of the pituitary gland, Adrenocorticotropic hormone deficiency, Enlarged pituitary gl... ORPHA:91347
Panhypophysitis
Adrenocorticotropic hormone deficiency, Decreased serum testosterone concentration, Reduced circu... ORPHA:95513
Hypothyroidism, Congenital, Nongoitrous, 8
Inappropriately normal thyroid-stimulating hormone level, Central hypothyroidism OMIM:301033
Adenohypophysitis
Adrenocorticotropic hormone deficiency, Decreased serum testosterone concentration, Reduced circu... ORPHA:95512
Thyroid Hormone Resistance, Selective Pituitary
Elevated circulating thyroid-stimulating hormone concentration, Hyperthyroidism, Impaired sensiti... OMIM:145650
X-Linked Intellectual Disability With Isolated Growth Hormone Deficiency
Decreased response to growth hormone stimulation test, Short stature, Ectopic posterior pituitary... ORPHA:67045
Meningioma
Enlarged pituitary gland, Decreased serum testosterone concentration, Reduced circulating prolact... ORPHA:2495
Pituitary Hormone Deficiency, Combined Or Isolated, 1
Decreased thyroid-stimulating hormone level, Reduced TSH response to thyrotrophin-releasing hormo... OMIM:613038
Cog2-Cdg
Small pituitary gland ORPHA:435934
Hyperthyroidism, Familial Gestational
Decreased thyroid-stimulating hormone level, Hyperthyroidism OMIM:603373
Culler-Jones Syndrome
Short stature, Hypopituitarism, Ectopic posterior pituitary, Hypogonadism, Cryptorchidism, Anteri... OMIM:615849
Polyendocrine-Polyneuropathy Syndrome
Postnatal growth retardation, Short stature, Hypogonadism, Central hypothyroidism OMIM:616113
Wolfram-Like Syndrome
Primary gonadal insufficiency, Severe postnatal growth retardation, Hypothyroidism, Male hypogona... ORPHA:411590
Polyendocrine-Polyneuropathy Syndrome
Type II diabetes mellitus, Decreased serum testosterone concentration, Hypoinsulinemia, Hypogonad... ORPHA:453533
Hypothyroidism, Congenital, Nongoitrous, 1
Hypothyroidism, Elevated circulating thyroid-stimulating hormone concentration, Congenital hypoth... OMIM:275200
Diabetes Insipidus, Neurohypophyseal
Decreased circulating osteocalcin level, Central diabetes insipidus OMIM:125700
Ane Syndrome
Decreased serum testosterone concentration, Decreased response to growth hormone stimulation test... ORPHA:157954
Joubert Syndrome 38
Decreased response to growth hormone stimulation test, Small pituitary gland, Short stature, Ecto... OMIM:619476
Non-Acquired Panhypopituitarism
Ectopic anterior pituitary gland, Growth delay, Abnormal prolactin level, Decreased response to g... ORPHA:90695
Pituitary Adenoma 1, Multiple Types
Pituitary growth hormone cell adenoma, Pituitary adenoma, Elevated circulating growth hormone con... OMIM:102200
Sheehan Syndrome
Adrenocorticotropic hormone deficiency, Central adrenal insufficiency, Reduced circulating prolac... ORPHA:91355
Pituitary Adenoma 2, Growth Hormone-Secreting
Pituitary adenoma, Elevated circulating growth hormone concentration OMIM:300943
Post-Traumatic Pituitary Deficiency
Growth delay, Abnormal prolactin level, Decreased response to growth hormone stimulation test, Hy... ORPHA:95619
Pituitary Hormone Deficiency, Combined, 6
Ectopic posterior pituitary, Short stature OMIM:613986
Pituitary Deficiency Due To Empty Sella Turcica Syndrome
Adrenocorticotropic hormone deficiency, Precocious puberty, Decreased response to growth hormone ... ORPHA:91354
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
Decreased circulating androgen concentration, Decreased response to growth hormone stimulation te... ORPHA:293978
Myxedema
Hypothyroidism, Elevated circulating thyroid-stimulating hormone concentration, Goiter OMIM:255900
Non-Functioning Pituitary Adenoma
Central adrenal insufficiency, Hypogonadism, Central diabetes insipidus, Abnormality of the pitui... ORPHA:91349
Primary Hypergonadotropic Hypogonadism-Partial Alopecia Syndrome
Decreased serum testosterone concentration, Cryptorchidism, Small pituitary gland, Streak ovary, ... ORPHA:2232
Sim1-Related Prader-Willi-Like Syndrome
Precocious puberty, Type II diabetes mellitus, Small pituitary gland, Hypogonadotropic hypogonadi... ORPHA:398079
Hydranencephaly
Atrophic pituitary gland, Dysgenesis of the thalamus, Postnatal growth retardation, Thalamic edem... ORPHA:2177
Thyroid Hormone Resistance, Generalized, Autosomal Recessive
Type II diabetes mellitus, Impaired sensitivity to thyroid hormone, Compensated hypothyroidism, E... OMIM:274300
Thyrotoxic Periodic Paralysis, Susceptibility To, 2
Decreased thyroid-stimulating hormone level, Goiter, Hyperthyroidism OMIM:613239
Fg Syndrome Type 1
Cryptorchidism, Short stature, Small pituitary gland, Abnormal social behavior ORPHA:93932
Functioning Gonadotropic Adenoma
Increased serum testosterone level, Adrenocorticotropic hormone deficiency, Abnormal prolactin le... ORPHA:91348
Graves Disease, Susceptibility To, 1
Decreased thyroid-stimulating hormone level, Increased circulating free T3, Graves disease, Goiter OMIM:275000
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Decreased thyroid-stimulating hormone level, Growth delay, Decreased circulating T4 concentration... ORPHA:226307
Developmental And Epileptic Encephalopathy 105 With Hypopituitarism
Pituitary hypothyroidism, Anterior pituitary hypoplasia OMIM:619983
Immunodeficiency 54
Adrenal insufficiency, Adrenocorticotropic hormone excess, Short stature, Postnatal growth retard... OMIM:609981
Prader-Willi Syndrome
Precocious puberty, Central adrenal insufficiency, Small pituitary gland, Decreased response to g... ORPHA:739
Bdv Syndrome
Decreased thyroid-stimulating hormone level, Reduced TSH response to thyrotrophin-releasing hormo... OMIM:619326
Combined Pituitary Hormone Deficiencies, Genetic Forms
Ectopic anterior pituitary gland, Growth delay, Abnormal prolactin level, Decreased response to g... ORPHA:95494
Magel2-Related Prader-Willi-Like Syndrome
Precocious puberty, Type II diabetes mellitus, Small pituitary gland, Short stature, Absence of p... ORPHA:398069
Gangliocytoma
Abnormality of the pituitary gland, Pituitary null cell adenoma, Elevated circulating growth horm... ORPHA:251937
Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies
Decreased response to growth hormone stimulation test, Adrenal hypoplasia, Postnatal growth retar... OMIM:614732
Septo-Optic Dysplasia Spectrum
Short stature, Abnormality of the hypothalamus-pituitary axis, Maternal diabetes, Cryptorchidism,... ORPHA:3157
Congenital Hypothyroidism Due To Transplacental Passage Of Tsh-Binding Inhibitory Antibodies
Abnormality of thyroid physiology, Decreased thyroid-stimulating hormone level, Decreased circula... ORPHA:95715
Brain Malformation-Congenital Heart Disease-Postaxial Polydactyly Syndrome
Abnormality of the anterior pituitary, Short stature, Intrauterine growth retardation, Posterior ... ORPHA:75389
Giant Axonal Neuropathy
Abnormality of the pituitary gland ORPHA:643
Growth Hormone Insensitivity Syndrome With Immune Dysregulation 2, Autosomal Dominant
Short stature, Delayed puberty, Postnatal growth retardation, Decreased serum insulin-like growth... OMIM:618985
Isolated Exencephaly
Posterior pituitary agenesis, Maternal diabetes, Anterior pituitary hypoplasia ORPHA:563612
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Decreased circulating T4 concentration, Precocious puberty, Central adrenal insufficiency, Decrea... ORPHA:98754
Diabetes Insipidus, Neurohypophyseal, X-Linked
Central diabetes insipidus OMIM:304900
Prader-Willi Syndrome Due To Paternal 15Q11Q13 Deletion
Decreased circulating T4 concentration, Precocious puberty, Central adrenal insufficiency, Decrea... ORPHA:98793
Septopreoptic Holoprosencephaly
Central diabetes insipidus, Precocious puberty, Anterior hypopituitarism ORPHA:280195
Idiopathic Congenital Hypothyroidism
Elevated circulating thyroid-stimulating hormone concentration, Decreased circulating T4 concentr... ORPHA:95717
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 2
Decreased circulating T4 concentration, Precocious puberty, Central adrenal insufficiency, Decrea... ORPHA:177904
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 1
Decreased circulating T4 concentration, Precocious puberty, Central adrenal insufficiency, Decrea... ORPHA:177901
Allan-Herndon-Dudley Syndrome
Hypothyroidism, Elevated circulating thyroid-stimulating hormone concentration OMIM:300523
Familial Thyroid Dyshormonogenesis
Thyroid defect in oxidation and organification of iodide, Decreased circulating T4 concentration,... ORPHA:95716
Prader-Willi-Like Syndrome
Abnormality of the endocrine system, Precocious puberty, Decreased circulating T4 concentration, ... ORPHA:398073
Igg4-Related Thyroid Disease
Abnormality of the pituitary gland, Graves disease, Sialadenitis, Euthyroid goiter, Pancreatic fi... ORPHA:64744
Blue Diaper Syndrome
Elevated circulating thyroid-stimulating hormone concentration, Decreased circulating T4 concentr... ORPHA:94086
Prolactinoma
Abnormality of the pituitary gland, Adrenocorticotropic hormone deficiency, Elevated circulating ... ORPHA:2965
Multiple Endocrine Neoplasia, Type Iv
Pituitary adenoma, Elevated circulating growth hormone concentration, Parathyroid adenoma, Carcin... OMIM:610755
Short-Rib Thoracic Dysplasia 21 Without Polydactyly
Disproportionate short-limb short stature, Small pituitary gland OMIM:619479
Acromelic Frontonasal Dysplasia
Cryptorchidism, Hypopituitarism, Anterior pituitary hypoplasia ORPHA:1827
Multiple Endocrine Neoplasia, Type I
Pituitary adenoma, Elevated circulating growth hormone concentration, Glucagonoma, Parathyroid ad... OMIM:131100
Microphthalmia, Syndromic 3
Short stature, Hypothalamic hamartoma, Hypogonadotropic hypogonadism, Postnatal growth retardatio... OMIM:206900
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Elevated circulating thyroid-stimulating hormone concentration, Decreased circulating T4 concentr... ORPHA:226313
Pituitary Apoplexy
Adrenocorticotropic hormone deficiency, Pituitary adenoma, Elevated circulating growth hormone co... ORPHA:95613
Prader-Willi Syndrome Due To Translocation
Decreased response to growth hormone stimulation test, Abnormal social behavior, Short stature, H... ORPHA:177907
Genetic Transient Congenital Hypothyroidism
Thyroid defect in oxidation and organification of iodide, Decreased circulating T4 concentration,... ORPHA:226316
14Q22Q23 Microdeletion Syndrome
Short stature, Abnormality of the hypothalamus-pituitary axis, Adrenal hypoplasia, Cryptorchidism... ORPHA:264200
Pseudohypoparathyroidism Type 1B
Decreased response to growth hormone stimulation test, Short stature, Elevated circulating parath... ORPHA:94089
Holoprosencephaly 9
Decreased response to growth hormone stimulation test, Cryptorchidism, Short stature, Panhypopitu... OMIM:610829
Hypothyroidism Due To Tsh Receptor Mutations
Decreased circulating T4 concentration, Increased radioactive iodine uptake, Impaired sensitivity... ORPHA:90673
Deeah Syndrome
Decreased response to growth hormone stimulation test, Short stature, Decreased circulating free ... OMIM:619004
Isolated Thyroid-Stimulating Hormone Deficiency
Decreased thyroid-stimulating hormone level, Growth delay, Decreased circulating T4 concentration... ORPHA:90674
Premature Aging Syndrome, Penttinen Type
Elevated circulating thyroid-stimulating hormone concentration OMIM:601812
Acrodysostosis 1 With Or Without Hormone Resistance
Intrauterine growth retardation, Disproportionate short-limb short stature, Decreased growth horm... OMIM:101800
Duplication Of The Pituitary Gland
Abnormality of the pituitary gland, Abnormal hypothalamus morphology, Short stature ORPHA:314621
Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction
Decreased response to growth hormone stimulation test, Compensated hypothyroidism, Congenital hyp... OMIM:610978
Dyrk1A-Related Intellectual Disability Syndrome
Short stature, Breast hypoplasia, Cryptorchidism, Intrauterine growth retardation, Anterior pitui... ORPHA:464306
Hypothyroidism, Congenital, Nongoitrous, 2
Growth delay, Congenital hypothyroidism, Ectopic thyroid, Hypothyroidism, Elevated circulating th... OMIM:218700
Slc35A2-Cdg
Elevated circulating thyroid-stimulating hormone concentration, Precocious puberty, Intrauterine ... ORPHA:356961
Schimke Immunoosseous Dysplasia
Disproportionate short-trunk short stature, Elevated circulating thyroid-stimulating hormone conc... OMIM:242900
Brain-Lung-Thyroid Syndrome
Hypoparathyroidism, Abnormality of the thyroid gland, Short stature, Thyroid dysgenesis, Compensa... ORPHA:209905
Macrocephaly-Intellectual Disability-Left Ventricular Non Compaction Syndrome
Supernumerary nipple, Cryptorchidism, Shyness, Delayed puberty, Bilateral cryptorchidism, Anterio... ORPHA:466791
Ulnar-Mammary Syndrome
Axillary apocrine gland hypoplasia, Hypoplastic nipples, Ectopic posterior pituitary, Breast hypo... OMIM:181450
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Decreased response to growth hormone stimulation test, Cryptorchidism, Thyroid hypoplasia, Small ... OMIM:619503
Autoimmune Polyendocrinopathy Type 3
Thymoma, Graves disease, Hypergonadotropic hypogonadism, Autoimmune hypoparathyroidism, Type I di... ORPHA:227982
Chilton-Okur-Chung Neurodevelopmental Syndrome
Cryptorchidism, Intrauterine growth retardation, Anterior pituitary hypoplasia, Short stature OMIM:619841
Pseudohypoparathyroidism Type 1C
Decreased response to growth hormone stimulation test, Reduced circulating prolactin concentratio... ORPHA:79444
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Adrenocorticotropic hormone deficiency, Decreased response to growth hormone stimulation test, Sh... ORPHA:293987
Autoimmune Polyendocrinopathy Type 4
Thymoma, Hypergonadotropic hypogonadism, Type I diabetes mellitus, Central diabetes insipidus, An... ORPHA:227990
Woodhouse-Sakati Syndrome
Decreased serum testosterone concentration, Hypergonadotropic hypogonadism, Hypogonadotropic hypo... OMIM:241080
Pseudohypoparathyroidism Type 1A
Decreased response to growth hormone stimulation test, Reduced circulating prolactin concentratio... ORPHA:79443
Biliary, Renal, Neurologic, And Skeletal Syndrome
Bile duct proliferation, Short stature, Anterior pituitary hypoplasia, Diabetes insipidus OMIM:619534
Igg4-Related Ophthalmic Disease
Sialadenitis, Orchitis, Enlarged lacrimal glands, Abnormality of the anterior pituitary, Thyroiditis ORPHA:449563
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Abnormality of the endocrine system, Precocious puberty, Short stature, Increased circulating pro... ORPHA:438213
Igg4-Related Kidney Disease
Abnormality of the anterior pituitary, Sialadenitis, Thyroiditis ORPHA:449395
Proteasome-Associated Autoinflammatory Syndrome 1
Growth delay, Elevated circulating thyroid-stimulating hormone concentration, Parotitis, Short st... OMIM:256040
Alström Syndrome
Precocious puberty in females, Decreased circulating T4 concentration, Type II diabetes mellitus,... ORPHA:64
Pmm2-Cdg
Hyperinsulinemia, Elevated circulating growth hormone concentration, Hypogonadotropic hypogonadis... ORPHA:79318

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tle5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tle5.

No publications found that use IMPC mice or data for Tle5.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Tle5em1(IMPC)Wtsi Exon Deletion Mice
Tle5tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Tle5tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter