Genes Phenotypes

Gene: Gna11

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Name
guanine nucleotide binding protein, alpha 11
MGI ID
MGI:95766
Synonyms
Dsk7
Viability
Homozygous - Viable
View
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (20) Measurements chart (504) All data table (1116)
Expression & images (67) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
decreased hemoglobin content Gna11tm1a(EUCOMM)Wtsi HOM postnatal 4.42×10-24
decreased hematocrit Gna11tm1b(EUCOMM)Wtsi HOM postnatal 1.62×10-11
short tibia Gna11tm1b(EUCOMM)Wtsi HOM postnatal 7.89×10-06
abnormal bone mineralization Gna11tm1a(EUCOMM)Wtsi HOM postnatal 7.11×10-05
decreased circulating phosphate level Gna11tm1a(EUCOMM)Wtsi HOM postnatal 1.20×10-06
decreased body weight Gna11tm1a(EUCOMM)Wtsi HOM postnatal 5.32×10-10
increased startle reflex Gna11tm1a(EUCOMM)Wtsi HOM postnatal 9.04×10-05
increased circulating calcium level Gna11tm1a(EUCOMM)Wtsi HOM postnatal 9.78×10-33
decreased bone mineral content Gna11tm1b(EUCOMM)Wtsi HOM postnatal 2.74×10-06
decreased hemoglobin content Gna11tm1b(EUCOMM)Wtsi HOM postnatal 2.07×10-24
decreased bone mineral density Gna11tm1a(EUCOMM)Wtsi HOM postnatal 4.03×10-07
increased fasted circulating glucose level Gna11tm1b(EUCOMM)Wtsi HOM postnatal 9.79×10-05
vertebral fusion Gna11tm1b(EUCOMM)Wtsi HOM postnatal 1.17×10-06
increased red blood cell distribution width Gna11tm1b(EUCOMM)Wtsi HOM postnatal 1.79×10-09
abnormal behavior Gna11tm1a(EUCOMM)Wtsi HOM postnatal 4.73×10-05
decreased circulating triglyceride level Gna11tm1a(EUCOMM)Wtsi HOM postnatal 1.06×10-06
decreased bone mineral density Gna11tm1b(EUCOMM)Wtsi HOM postnatal 2.20×10-05
decreased circulating amylase level Gna11tm1a(EUCOMM)Wtsi HOM postnatal 1.19×10-13
decreased erythrocyte cell number Gna11tm1b(EUCOMM)Wtsi HOM postnatal 2.03×10-09
decreased circulating total protein level Gna11tm1a(EUCOMM)Wtsi HOM postnatal 2.42×10-05

Download data as:  TSV  XLS

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (1)
Vascular System expression
MA:0002718
digestive system (3)
Large Intestine expression
MA:0000333
endocrine system (2)
Adrenal gland expression
MA:0000116
exocrine system (1)
Prostate gland expression
MA:0000404
nervous system (4)
Brain expression
MA:0000168
postnatal mouse (15)
Adrenal gland expression
MA:0000116
reproductive system (3)
Ovary expression
Oviduct expression
MA:0000384
MA:0000385
trunk (10)
Adrenal gland expression
MA:0000116
urinary system (1)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  (3/4) N/A
Eye 2  (1/485) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485) N/A
Hand 2  (1/485) N/A
Head 2  (5/485)  (1/4) N/A
Heart 2  (1/485) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Tail 2  (1/485)  (3/4) N/A
Tail somite 2  (1/485) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
Echo: M-Mode Images
32 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
X-ray: XRay Images Lateral Orientation
12 Images
X-ray: XRay Images Dorso Ventral
12 Images
Embryo LacZ: LacZ images wholemount
8 Images
Adult LacZ: LacZ Images Wholemount
15 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Gna11tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Gna11tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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