Gene: Ghrhr

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Name
growth hormone releasing hormone receptor
MGI ID
MGI:95710
Synonyms
Ghrfr
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased body length Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 0.00
decreased vertical activity Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 3.97×10-09
increased total body fat amount Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 2.99×10-06
increased grip strength Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 1.80×10-05
abnormal bone structure Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 0.00
abnormal behavioral response to light Ghrhrtm1.1(KOMP)Vlcg HET Early adult 1.63×10-05
decreased lean body mass Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 0.00
decreased bone mineral density Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 1.16×10-18
abnormal sleep behavior Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 2.77×10-07
decreased heart weight Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 8.49×10-10
decreased grip strength Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 2.15×10-16
decreased bone mineral content Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 1.64×10-18

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Brain 2 No  (1/2) N/A
Brainstem 2 No  (1/2) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (1/2) N/A
Cerebral cortex 2 No  (1/2) N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No  (1/2) N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (1/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No  (1/2) N/A
Olfactory lobe 2 No  (1/2) N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/2) N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584)  (1/2) N/A
Spinal cord 2 No  (1/2) N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Submandibular gland 2 No  (2/132)  (2/2) N/A
Testis 2 No  (2/584) N/A
Thalamus 2 No  (1/2) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504) N/A
Dorsal root ganglion 2  (1/57) N/A
Ear 2  (1/504) N/A
Embryo 2  (1/505) N/A
Eye 2  (1/504) N/A
Foot 2  (1/504) N/A
Forebrain 2  (1/504) N/A
Forelimb 2  (1/504) N/A
Fronto-nasal process 2  (1/58) N/A
Hand 2  (1/503) N/A
Head 2  (5/504) N/A
Heart 2  (1/504) N/A
Hindbrain 2  (6/504) N/A
Hindlimb 2  (1/503) N/A
Liver 2  (1/504) N/A
Lung 2  (1/500) N/A
Mandibular process 2  (1/504) N/A
Maxillary process 2  (1/504) N/A
Midbrain 2  (1/504) N/A
Nose 2  (1/70) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/504) N/A
Spinal cord 2  (1/69) N/A
Tail 2  (1/504) N/A
Tail somite 2  (1/504) N/A

 Associated Images

Electroretinography: Cone waveform (pdf format)
7 Images
Sleep Wake: Wake state (bmp file)
22 Images
Combined SHIRPA and Dysmorphology
13 Images
Electroretinography: Rod waveform (pdf format)
7 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Ghrhrtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Ghrhrtm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Ghrhrtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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