Gene: Ghrhr

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Name
growth hormone releasing hormone receptor
MGI ID
MGI:95710
Synonyms
Ghrfr
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased grip strength Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 4.20×10-05
decreased bone mineral content Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 1.20×10-34
decreased vertical activity Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 7.14×10-14
hyperactivity Ghrhrtm1.1(KOMP)Vlcg HET Early adult 4.83×10-06
shortened PQ interval Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 9.25×10-05
abnormal sleep behavior Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 4.73×10-05
increased total body fat amount Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 5.27×10-20
decreased lean body mass Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 9.77×10-35
increased grip strength Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 1.87×10-05
abnormal auditory brainstem response Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 0.0326
decreased heart weight Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 1.38×10-18
decreased circulating HDL cholesterol level Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 2.00×10-09
shortened PR interval Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 3.15×10-05
decreased body length Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 0.00
decreased bone mineral density Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 3.71×10-29
decreased circulating glucose level Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 4.86×10-14
abnormal bone structure Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 0.00
decreased circulating cholesterol level Ghrhrtm1.1(KOMP)Vlcg HOM Early adult 9.06×10-07

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590) N/A
Aorta 2 No  (1/590) N/A
Brain 2 No  (3/590)  (1/2)  Section images
Brainstem 2 No  (2/590)  (1/2)  Section images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (3/590)  (1/2)  Section images
Cerebral cortex 2 No  (2/590)  (1/2)  Section images
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No  (1/590) N/A
Hippocampus 2 No  (3/590) N/A
Hypothalamus 2 No  (2/590)  (1/2)  Section images
Kidney 2 No  (20/590)  (2/2)  Section images
Large intestine 2 No  (10/590)  (1/2)  Section images
Liver 2 No N/A
Lower urinary tract 2 No  (1/590) N/A
Lung 2 No  (1/590) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No  (1/2)  Section images
Olfactory lobe 2 No  (2/590)  (1/2)  Section images
Ovary 2 No  (1/590) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/590) N/A
Peripheral nervous system 2 No  (1/590) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/590)  (1/2)  Section images
Prostate gland 2 No  (12/590) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/590)  (1/2)  Section images
Spinal cord 2 No  (2/590)  (1/2)  Section images
Spleen 2 No  (2/590) N/A
Stomach 2 No  (13/590) N/A
Striatum 2 No  (3/590) N/A
Submandibular gland 2 No  (2/132)  (2/2)  Section images
Testis 2 No  (5/590) N/A
Thalamus 2 No  (1/2)  Section images
Thymus 2 No N/A
Thyroid gland 2 No  (16/590) N/A
Trachea 2 No  (2/590) N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/506) N/A
Dorsal root ganglion 2  (1/61) N/A
Ear 2  (1/506) N/A
Embryo 2  (1/507) N/A
Eye 2  (1/506) N/A
Foot 2  (1/506) N/A
Forebrain 2  (1/506) N/A
Forelimb 2  (1/506) N/A
Fronto-nasal process 2  (1/62) N/A
Hand 2  (1/506) N/A
Head 2  (5/506) N/A
Heart 2  (1/506) N/A
Hindbrain 2  (6/506) N/A
Hindlimb 2  (1/506) N/A
Liver 2  (1/504) N/A
Lung 2  (1/504) N/A
Mandibular process 2  (1/506) N/A
Maxillary process 2  (1/506) N/A
Midbrain 2  (1/506) N/A
Nose 2  (1/76) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/506) N/A
Spinal cord 2  (1/73) N/A
Tail 2  (1/506) N/A
Tail somite 2  (1/506) N/A

 Associated Images

Original Image
Adult LacZ: LacZ Images Section
14 Images
Electroretinography: Rod waveform (pdf format)
7 Images
Sleep Wake: Wake state (bmp file)
22 Images
Combined SHIRPA and Dysmorphology
13 Images
Electroretinography: Cone waveform (pdf format)
7 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Ghrhrtm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Ghrhrtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ghrhrtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells

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