Gene: Ghr

Name
growth hormone receptor
MGI ID
MGI:95708
Synonyms
GHR/BP GHBP
View
N/A
Other links
View data by physiological system
Significant
Not Significant
Not tested

Filtered by: all phenotypes

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Allele Center Procedure / Parameter Zygosity Mutants Statistical
Method
P Value Status
Ghrtm1b(KOMP)Wtsi JAX Auditory Brain Stem Response / 12kHz-evoked ABR Threshold HET 0f:2m 1.00 Success
Ghrtm1b(KOMP)Wtsi JAX Auditory Brain Stem Response / 12kHz-evoked ABR Threshold HET 0f:2m 1.00 Success
Ghrtm1b(KOMP)Wtsi JAX Electrocardiogram (ECG) / PQ HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.222 Success
Ghrtm1b(KOMP)Wtsi JAX Electrocardiogram (ECG) / RR HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.714 Success
Ghrtm1b(KOMP)Wtsi JAX Electrocardiogram (ECG) / QTc HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.228 Success
Ghrtm1b(KOMP)Wtsi JAX Light-Dark Test / Percent time in light HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.00224 Success
Ghrtm1b(KOMP)Wtsi JAX Light-Dark Test / Time mobile dark side HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.116 Success
Ghrtm1b(KOMP)Wtsi JAX Light-Dark Test / Fecal boli HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.564 Success
Ghrtm1b(KOMP)Wtsi JAX Fertility of Homozygous Knock-out Mice / Gross Findings Female HOM f:m Supplied as data Success
Ghrtm1b(KOMP)Wtsi JAX Electrocardiogram (ECG) / rMSSD HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.130 Success
Ghrtm1b(KOMP)Wtsi JAX Light-Dark Test / Side changes HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.298 Success
Ghrtm1b(KOMP)Wtsi JAX Electrocardiogram (ECG) / PR HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.302 Success
Ghrtm1b(KOMP)Wtsi JAX Auditory Brain Stem Response / 24kHz-evoked ABR Threshold HET 0f:2m 1.00 Success
Ghrtm1b(KOMP)Wtsi JAX Auditory Brain Stem Response / 24kHz-evoked ABR Threshold HET 0f:2m 1.00 Success
Ghrtm1b(KOMP)Wtsi JAX Light-Dark Test / Light side time spent HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.756 Success
Ghrtm1b(KOMP)Wtsi JAX Electrocardiogram (ECG) / HRV HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.00727 Success
Ghrtm1b(KOMP)Wtsi JAX Electrocardiogram (ECG) / QRS HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.854 Success
Ghrtm1b(KOMP)Wtsi JAX Electrocardiogram (ECG) / HR HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.667 Success
Ghrtm1b(KOMP)Wtsi JAX Auditory Brain Stem Response / 30kHz-evoked ABR Threshold HET 0f:2m 1.00 Success
Ghrtm1b(KOMP)Wtsi JAX Auditory Brain Stem Response / 30kHz-evoked ABR Threshold HET 0f:2m 1.00 Success
Ghrtm1b(KOMP)Wtsi JAX Auditory Brain Stem Response / 6kHz-evoked ABR Threshold HET 0f:2m 1.00 Success
Ghrtm1b(KOMP)Wtsi JAX Auditory Brain Stem Response / 6kHz-evoked ABR Threshold HET 0f:2m 1.00 Success
Ghrtm1b(KOMP)Wtsi JAX Light-Dark Test / Time mobile light side HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.671 Success
Ghrtm1b(KOMP)Wtsi JAX Light-Dark Test / Latency to first transition into dark HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.383 Success
Ghrtm1b(KOMP)Wtsi JAX Viability Primary Screen / Outcome HOM 44f:42m Supplied as data Success
Ghrtm1b(KOMP)Wtsi JAX Electrocardiogram (ECG) / QTc Dispersion HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.687 Success
Ghrtm1b(KOMP)Wtsi JAX Fertility of Homozygous Knock-out Mice / Gross Findings Male HOM f:m Supplied as data Success
Ghrtm1b(KOMP)Wtsi JAX Electrocardiogram (ECG) / CV HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.00680 Success
Ghrtm1b(KOMP)Wtsi JAX Electrocardiogram (ECG) / ST HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.407 Success
Ghrtm1b(KOMP)Wtsi JAX Auditory Brain Stem Response / 18kHz-evoked ABR Threshold HET 0f:2m 1.00 Success
Ghrtm1b(KOMP)Wtsi JAX Auditory Brain Stem Response / 18kHz-evoked ABR Threshold HET 0f:2m 1.00 Success
Ghrtm1b(KOMP)Wtsi JAX Light-Dark Test / Percent time in dark HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.00224 Success
Ghrtm1b(KOMP)Wtsi JAX Light-Dark Test / Dark side time spent HET 6f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.756 Success

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 1 No  (2/584)  (1/1) N/A
Aorta 1 No  (1/1) N/A
Bone marrow 1 No N/A
Brain 1 No  (1/1) N/A
Brainstem 1 No  (1/1) N/A
Brown adipose tissue 1 No  (1/1) N/A
Cartilage tissue 1 No  (1/1) N/A
Cerebellum 1 No  (1/1) N/A
Cerebral cortex 1 No  (1/1) N/A
Epididymis 1 No  (18/134) N/A
Esophagus 1 No  (7/415) N/A
Eye 1 No  (1/1) N/A
Heart 1 No  (1/1) N/A
Hippocampus 1 No  (1/1) N/A
Hypothalamus 1 No  (1/1) N/A
Kidney 1 No  (18/584)  (1/1) N/A
Large intestine 1 No  (10/584)  (1/1) N/A
Liver 1 No  (1/1) N/A
Lower urinary tract 1 No N/A
Lung 1 No  (1/1) N/A
Lymph node 1 No N/A
Mammary gland 1 No N/A
Midbrain 1 No  (1/1) N/A
Olfactory lobe 1 No  (1/1) N/A
Ovary 1 No  (1/584) N/A
Oviduct 1 No N/A
Pancreas 1 No  (5/584)  (1/1) N/A
Peripheral nervous system 1 No  (1/1) N/A
Peyer's patch 1 No N/A
Pituitary gland 1 No N/A
Prostate gland 1 No  (12/584) N/A
Skeletal muscle 1 No  (1/1) N/A
Skin 1 No  (1/1) N/A
Small intestine 1 No  (9/584)  (1/1) N/A
Spinal cord 1 No  (1/1) N/A
Spleen 1 No  (2/584)  (1/1) N/A
Stomach 1 No  (12/584)  (1/1) N/A
Striatum 1 No N/A
Submandibular gland 1 No  (2/132)  (1/1) N/A
Testis 1 No  (2/584)  (1/1) N/A
Thalamus 1 No  (1/1) N/A
Thymus 1 No  (1/1) N/A
Thyroid gland 1 No  (15/584) N/A
Trachea 1 No  (1/1) N/A
Urinary bladder 1 No  (1/1) N/A
Uterus 1 No N/A
Vascular system 1 No  (1/1) N/A
Vesicular gland 1 No N/A
White adipose tissue 1 No  (1/1) N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (1/3) N/A
Dorsal root ganglion 1  (1/47) Image Only N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  (2/3)  Wholemount images
Eye 2  (1/485) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485)  (2/3) N/A
Fronto-nasal process 1  (1/48) Image Only N/A
Hand 2  (1/485) N/A
Head 2  (5/485)  (2/3) N/A
Heart 2  (1/485)  (2/3) N/A
Hindbrain 2  (6/485)  (1/3) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485)  (1/3) N/A
Lung 2  (1/485)  (1/3) N/A
Mandibular process 2  (1/485)  (2/3) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485) N/A
Nose 1  (1/51) N/A
Oral cavity 2  (1/485) Image Only N/A
Skin 2  (1/485) N/A
Spinal cord 2  (1/50)  (1/2) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A
Umbilical artery embryonic part 1  (1/47)  (1/1) N/A
Umbilical vein embryonic part 1  (1/47)  (1/1) N/A

 Associated Images

X-ray: XRay Images Lateral Orientation
13 Images
Embryo LacZ: LacZ images wholemount
16 Images
X-ray: XRay Images Skull Lateral Orientation
13 Images
X-ray: XRay Images Forepaw
13 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
13 Images
X-ray: XRay Images Dorso Ventral
13 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Ghrtm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Ghrtm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice