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Gene: Fpgs MGI:95576

Gene Summary

Name:

folylpolyglutamyl synthetase

Synonyms:

N/A

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype	System	Allele	Zyg	Sex	Life Stage	P Value
increased startle reflex		Fpgs^{tm1a(EUCOMM)Hmgu}	HET		Early adult	2.97×10^-07
increased IgM level		Fpgs^{tm1a(EUCOMM)Hmgu}	HET		Early adult	1.24×10^-05

Download data as: TSV XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Fpgs mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Fpgs (0 diseases)
Human diseases predicted to be associated with Fpgs (246 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Fpgs by phenotypic similarity.

Disease	Matching phenotypes	Source
Immunodeficiency 86	Decreased circulating IgG level, Impaired oxidative burst, Increased circulating IgM level	OMIM:619549
Pa Polymorphism Of Alpha-2-Globulin	Abnormal immunoglobulin level	OMIM:260100
Immunodeficiency With Hyper-Igm, Type 3	Decreased circulating IgG level, Decreased circulating IgE, Increased circulating IgM level, Decr...	OMIM:606843
Lymphoma, Hodgkin, Classic	Polyclonal elevation of IgM	OMIM:236000
Macroglobulinemia, Waldenstrom, Susceptibility To, 1	Monoclonal immunoglobulin M proteinemia, Polyclonal elevation of IgM	OMIM:153600
Immunodeficiency With Hyper-Igm, Type 5	Decreased circulating IgG level, Decreased circulating IgA level, Impaired Ig class switch recomb...	OMIM:608106
Retinal Telangiectasia And Hypogammaglobulinemia	Decreased circulating IgG level, Reduced delayed hypersensitivity	OMIM:267900
Lymphoid System Deterioration, Progressive	Decreased circulating total IgM, Decreased circulating IgG level	OMIM:247630
Immunoglobulin M, Level Of	Decreased circulating total IgM	OMIM:308250
Immunodeficiency, Common Variable, 4	Decreased circulating total IgM, Complete or near-complete absence of specific antibody response ...	OMIM:613494
Polyneuropathy Associated With Igm Monoclonal Gammapathy With Anti-Mag	Monoclonal immunoglobulin M proteinemia	ORPHA:639
Hyperimmunoglobulin G1(A1) Syndrome	Increased circulating IgA level, Increased circulating IgG level	OMIM:144120
B-Cell Expansion With Nfkb And T-Cell Anergy	Decreased circulating total IgM, Decreased specific antibody response to polysaccharide vaccine, ...	OMIM:616452
Immunodeficiency 25	Increased circulating IgG level, Complete or near-complete absence of specific antibody response ...	OMIM:610163
Immunodeficiency 14A, Autosomal Dominant	Decreased circulating IgG2 level, Decreased specific pneumococcal antibody level, Increased circu...	OMIM:615513
Axonal Polyneuropathy Associated With Igg/Igm/Iga Monoclonal Gammopathy	Monoclonal immunoglobulin M proteinemia, Cryoglobulinemia	ORPHA:209004
Histiocytosis, Familial Lipochrome	Increased circulating antibody level	OMIM:235900
Asthma, Short Stature, And Elevated Iga	Increased circulating IgA level	OMIM:208600
Agammaglobulinemia 10, Autosomal Dominant	Decreased circulating total IgM, Decreased circulating IgA level, Decreased circulating IgG level...	OMIM:619707
Immunodeficiency, Common Variable, 14	Decreased circulating total IgM, Decreased circulating IgG level, Defective B cell differentiatio...	OMIM:617765
Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome	Reduced antigen-specific T cell proliferation, Reduced delayed hypersensitivity, Increased circul...	OMIM:617241
Immunodeficiency, Common Variable, 3	Decreased circulating total IgM, Chronic decreased circulating total IgG, Reduced isohemagglutini...	OMIM:613493
Immune Deficiency, Familial Variable	Decreased circulating IgG level, Decreased circulating IgA level	OMIM:146830
Immunodeficiency 78 With Autoimmunity And Developmental Delay	Increased circulating IgG level, Increased circulating IgM level	OMIM:619220
Immunodeficiency 64	Decreased circulating IgG level, Increased circulating IgG level, Increased circulating IgM level...	OMIM:618534
Deafness, Neural, With Atypical Atopic Dermatitis	Increased circulating IgE level	OMIM:221700
Agammaglobulinemia 4, Autosomal Recessive	Decreased circulating total IgM, Decreased circulating IgA level, Decreased circulating IgG level...	OMIM:613502
Caspase 8 Deficiency	Decreased T cell activation, Decreased circulating total IgM, Decreased circulating IgG level, De...	OMIM:607271
Myeloma, Multiple	Paraproteinemia	OMIM:254500
Ectodermal Dysplasia And Immunodeficiency 1	Reduced natural killer cell activity, Increased circulating IgM level, Dysgammaglobulinemia, Incr...	OMIM:300291
Lymphoproliferative Syndrome, X-Linked, 1	Decreased circulating IgG level, Reduced natural killer cell activity, Increased circulating IgM ...	OMIM:308240
Autoimmune Lymphoproliferative Syndrome	Increased circulating IgG level, Increased circulating IgM level, Increased circulating IgA level...	OMIM:601859
Hemosiderosis, Pulmonary, With Deficiency Of Gamma-A Globulin	Decreased circulating IgA level	OMIM:235500
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia	Decreased circulating total IgM, Decreased circulating IgG level	OMIM:618987
Neutropenia, Chronic Familial	Increased circulating antibody level	OMIM:162700
Immunodeficiency 33	Decreased circulating total IgM, Increased circulating IgA level	OMIM:300636
Persistent Polyclonal B-Cell Lymphocytosis	Decreased circulating total IgM	OMIM:606445
Agammaglobulinemia 2, Autosomal Recessive	Decreased circulating total IgM, Decreased circulating IgA level, Agammaglobulinemia	OMIM:613500
Transcobalamin Deficiency	Decreased circulating total IgM, Decreased circulating IgA level, Decreased circulating antibody ...	ORPHA:859
Hyper-Ige Recurrent Infection Syndrome 5, Autosomal Recessive	Decreased circulating total IgM, Increased circulating IgE level, Decreased circulating IgG level	OMIM:618944
Immunodeficiency With Hyper-Igm, Type 1	Decreased T cell activation, Decreased circulating IgG level, Decreased circulating IgE, Increase...	OMIM:308230
Cirrhosis, Familial	Increased circulating antibody level	OMIM:118900
Agammaglobulinemia 6, Autosomal Recessive	Decreased circulating total IgM, Decreased circulating IgA level, Decreased circulating IgG level...	OMIM:612692
Ige Responsiveness, Atopic	Increased circulating IgE level	OMIM:147050
Immunodeficiency Due To Defect In Mapbp-Interacting Protein	Decreased circulating total IgM	OMIM:610798
Severe Combined Immunodeficiency, X-Linked	Decreased circulating IgG level, Decreased circulating total IgM, Decreased circulating IgE, Redu...	OMIM:300400
Palmoplantar Keratoderma, Epidermolytic	Increased circulating IgE level	OMIM:144200
Immunodeficiency 35	Increased circulating IgE level	OMIM:611521
Hyperekplexia 3	Exaggerated startle response	OMIM:614618
Immunodeficiency 27A	Increased circulating IgG level, Increased circulating IgM level	OMIM:209950
Schnitzler Syndrome	Increased circulating IgM level	ORPHA:37748
Lymphopenic Hypergammaglobulinemia, Antibody Deficiency, Autoimmune Hemolytic Anemia, And Glomerulonephritis	Increased circulating antibody level	OMIM:247800
Immunodeficiency 70	Decreased circulating total IgM, Decreased circulating total IgG, Decreased circulating total IgA...	OMIM:618969
Intellectual Developmental Disorder, X-Linked, Syndromic, Chudley-Schwartz Type	Decreased circulating IgG level, Decreased circulating IgA level, Decreased circulating total IgM	OMIM:300861
Developmental And Epileptic Encephalopathy 8	Exaggerated startle response	OMIM:300607
Autoimmune Lymphoproliferative Syndrome, Type Iia	Increased circulating IgG level, Increased circulating IgM level, Increased circulating IgA level...	OMIM:603909
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity	Increased circulating antibody level	OMIM:618495
Thrombocytopenia With Elevated Serum Iga And Renal Disease	Increased circulating IgA level	OMIM:314000
Adult Idiopathic Neutropenia	Increased circulating IgM level	ORPHA:2688
Immunodeficiency 14B, Autosomal Recessive	Decreased circulating total IgM, Decreased circulating IgA level, Reduced natural killer cell act...	OMIM:619281
Boutonneuse Fever	Increased circulating IgG level, Increased circulating IgM level	ORPHA:83313
Immunodeficiency, Common Variable, 1	Decreased circulating IgG level, Decreased circulating IgA level, Decreased circulating total IgM...	OMIM:607594
Angiostrongyliasis	Increased circulating IgA level, Increased circulating specific IgE antibody, Increased circulati...	ORPHA:74
Kimura Disease	Increased circulating IgE level	ORPHA:482
Immunodeficiency, Common Variable, 11	Decreased circulating IgG level, Increased circulating IgE level	OMIM:615767
Immunodeficiency, Ovarian Dysgenesis, And Pulmonary Fibrosis	Decreased circulating total IgM, Decreased circulating IgA level, Decreased circulating IgG level	OMIM:611926
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1	Decreased circulating IgA level, Increased circulating IgM level	OMIM:242860
Simple Cryoglobulinemia	Monoclonal elevation of IgG, Monoclonal immunoglobulin M proteinemia, Paraproteinemia, Increased ...	ORPHA:91139
O'Sullivan-Mcleod Syndrome	Increased circulating antibody level, Tremor	ORPHA:99965
Immunodeficiency 72 With Autoinflammation	Increased circulating IgG level, Increased circulating IgE level	OMIM:618982
Immune Deficiency Disease	Decreased circulating total IgM	OMIM:242850
Insulin Autoimmune Syndrome	Increased circulating antibody level	ORPHA:411593
Microcephalic Primordial Dwarfism, Toriello Type	Decreased circulating total IgM, Decreased circulating IgG level	ORPHA:2643
Immunodeficiency 60 And Autoimmunity	Decreased circulating total IgM, Decreased circulating IgA level, Decreased circulating IgE, Decr...	OMIM:618394
Autoinflammation, Panniculitis, And Dermatosis Syndrome	Increased circulating IgA level, Increased circulating IgM level	OMIM:617099
Immunodeficiency 103, Susceptibility To Fungal Infections	Increased circulating IgE level	OMIM:212050
Erythema Elevatum Diutinum	Increased circulating antibody level	ORPHA:90000
Neutropenia, Severe Congenital, 5, Autosomal Recessive	Increased circulating antibody level	OMIM:615285
Aicardi-Goutieres Syndrome 7	Increased circulating antibody level, Dystonia	OMIM:615846
Immunodeficiency 23	Increased circulating IgG level, Increased circulating IgE level, Increased circulating IgM level	OMIM:615816
Microcephalic Primordial Dwarfism, Toriello Type	Decreased circulating IgG level, Decreased circulating total IgM	OMIM:251190
Sneddon Syndrome	Decreased circulating total IgM, Tremor	OMIM:182410
Japanese Encephalitis	Opisthotonus, Dystonia, Increased circulating IgM level, Pill-rolling tremor, Increased circulati...	ORPHA:79139
Immunodeficiency 93 And Hypertrophic Cardiomyopathy	Decreased circulating IgG level, Decreased circulating total IgM, Agammaglobulinemia	OMIM:619705
Calcific Aortic Disease With Immunologic Abnormalities, Familial	Increased circulating antibody level	OMIM:114065
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency	Abnormality of humoral immunity, Increased circulating IgE level, Lack of T cell function	ORPHA:277
Pulmonary Nodular Lymphoid Hyperplasia, Familial	Increased circulating antibody level	OMIM:178610
Mucopolysaccharidosis-Plus Syndrome	Bone marrow hypocellularity, Increased circulating IgM level	OMIM:617303
Hyper-Ige Recurrent Infection Syndrome 4A, Autosomal Dominant	Decreased circulating IgG level, Decreased circulating IgA level, Decreased circulating total IgM...	OMIM:619752
Immunodeficiency 85 And Autoimmunity	Decreased circulating IgG level, Decreased circulating IgA level, Decreased circulating IgE, Decr...	OMIM:619510
Neutropenia, Severe Congenital, 1, Autosomal Dominant	Increased circulating antibody level	OMIM:202700
Autoinflammation, Antibody Deficiency, And Immune Dysregulation	Decreased circulating total IgM, Decreased circulating IgA level	OMIM:614878
Lassa Fever	Increased circulating IgM level	ORPHA:99824
Mu-Heavy Chain Disease	Increased circulating antibody level	ORPHA:100024
Proteasome-Associated Autoinflammatory Syndrome 2	Increased circulating antibody level	OMIM:618048
X-Linked Lymphoproliferative Disease	Decreased circulating IgG level, Decreased circulating total IgM, Bone marrow hypocellularity, In...	ORPHA:2442
Immunodeficiency 89 And Autoimmunity	Increased circulating IgA level, Increased circulating IgG level, Increased circulating IgE level	OMIM:619632
Interstitial Lung Disease 2	Increased circulating antibody level	OMIM:178500
Hyperekplexia 2	Exaggerated startle response	OMIM:614619
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation	Decreased circulating IgG level, Decreased circulating total IgM, Decreased circulating IgA level...	OMIM:616100
Hyperekplexia-Epilepsy Syndrome	Exaggerated startle response	ORPHA:163985
Skeletal Dysplasia-Epilepsy-Short Stature Syndrome	Increased circulating IgE level	ORPHA:1858
Immunodeficiency 67	Increased circulating IgE level	OMIM:607676
Tick-Borne Encephalitis	Abnormality of serum cytokine level, Increased circulating IgG level, Tremor, Increased circulati...	ORPHA:297
Autoimmune Lymphoproliferative Syndrome, Type Iii	Decreased serum complement C4, Reduced natural killer cell activity, Increased circulating antibo...	OMIM:615559
Peeling Skin Syndrome 1	Increased circulating IgE level	OMIM:270300
Dystrophic Epidermolysis Bullosa Pruriginosa	Increased circulating IgE level	ORPHA:89843
Ras-Associated Autoimmune Leukoproliferative Disorder	Increased circulating antibody level, Decreased lymphocyte apoptosis	OMIM:614470
Zika Virus Disease	Increased circulating IgM level	ORPHA:448237
Chilblain Lupus	Increased circulating antibody level	ORPHA:90280
Primary Biliary Cholangitis	Increased circulating IgA level, Increased circulating IgM level	ORPHA:186
T-B+ Severe Combined Immunodeficiency Due To Cd3Delta/Cd3Epsilon/Cd3Zeta	Increased circulating antibody level, Decreased circulating IgG level, Decreased circulating tota...	ORPHA:169160
Hyper-Ige Recurrent Infection Syndrome 2, Autosomal Recessive	Decreased circulating total IgM, Increased circulating IgG level, Increased circulating IgE level	OMIM:243700
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency	Increased circulating IgG level, Increased circulating IgA level, Increased circulating antibody ...	ORPHA:169154
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency	Decreased circulating IgG level, Reduced antigen-specific T cell proliferation, Decreased circula...	ORPHA:331206
Growth Hormone Insensitivity Syndrome With Immune Dysregulation 2, Autosomal Dominant	Increased circulating IgE level	OMIM:618985
Igg4-Related Aortitis	Increased circulating antibody level, Increased circulating IgG4 level, Complement deficiency, In...	ORPHA:449400
Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders	Decreased circulating IgG level, Bone marrow hypocellularity, Increased circulating IgM level	ORPHA:505248
Immunodeficiency, Common Variable, 10	Decreased circulating IgG level, Decreased circulating IgA level, Decreased circulating total IgM	OMIM:615577
Myotonic Dystrophy 2	Decreased circulating total IgM, Decreased circulating IgG level	OMIM:602668
Caffey Disease	Increased circulating antibody level	ORPHA:1310
Subacute Inflammatory Demyelinating Polyneuropathy	Increased circulating IgG level, Tremor	ORPHA:206594
Primary Biliary Cholangitis/Primary Sclerosing Cholangitis And Autoimmune Hepatitis Overlap Syndrome	Increased circulating IgG level, Increased circulating IgM level	ORPHA:562639
Inflammatory Pseudotumor Of The Liver	Increased hepatitis B virus antibody level	ORPHA:90003
C3 Glomerulopathy	Decreased serum complement C4, Decreased serum complement C3, Paraproteinemia	ORPHA:329918
Adult-Onset Nemaline Myopathy	Paraproteinemia	ORPHA:171442
Transcobalamin Ii Deficiency	Decreased circulating total IgM, Decreased circulating IgA level, Decreased circulating IgG level	OMIM:275350
Rift Valley Fever	Increased circulating IgG level, Increased circulating IgM level	ORPHA:319251
Developmental And Epileptic Encephalopathy 68	Exaggerated startle response	OMIM:618201
Hyper-Ige Recurrent Infection Syndrome 4B, Autosomal Recessive	Increased circulating IgE level	OMIM:618523
Hyper-Ige Recurrent Infection Syndrome 1, Autosomal Dominant	Increased circulating IgE level	OMIM:147060
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination	Exaggerated startle response	OMIM:618367
Aromatic L-Amino Acid Decarboxylase Deficiency	Oculogyric crisis, Blepharospasm, Athetosis, Limb dystonia, Limb tremor, Exaggerated startle resp...	OMIM:608643
Hypotrichosis Simplex Of The Scalp	Increased circulating IgE level	ORPHA:90368
Combined Immunodeficiency With Faciooculoskeletal Anomalies	Decreased circulating total IgM, Intention tremor, Decreased circulating total IgG, Decreased cir...	ORPHA:221139
Combined Immunodeficiency Due To Dock8 Deficiency	Increased circulating IgE level	ORPHA:217390
Igg4-Related Dacryoadenitis And Sialadenitis	Increased circulating IgA level, Increased circulating IgG4 level, Increased circulating IgM level	ORPHA:79078
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency	Decreased circulating IgG level, Increased circulating IgG level, Abnormal immunoglobulin level, ...	ORPHA:276
Coccidioidomycosis	Increased circulating IgG level, Increased circulating IgM level	ORPHA:228123
Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome	Increased circulating antibody level	ORPHA:69126
Subcorneal Pustular Dermatosis	Increased circulating antibody level	ORPHA:48377
Spastic Tetraplegia And Axial Hypotonia, Progressive	Exaggerated startle response	OMIM:618598
Gm2 Gangliosidosis, Ab Variant	Dystonia, Exaggerated startle response	ORPHA:309246
Primary Intestinal Lymphangiectasia	Decreased circulating IgG level, Decreased circulating total IgM, Decreased circulating IgA level...	ORPHA:90362
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency	Decreased circulating total IgM, Decreased circulating IgA level, Absent specific antibody respon...	OMIM:102700
Mogs-Cdg	Decreased circulating IgG level, Decreased circulating total IgM, Dystonia, Decreased circulating...	ORPHA:79330
Inflammatory Skin And Bowel Disease, Neonatal, 1	Increased circulating IgE level	OMIM:614328
Netherton Syndrome	Decreased circulating IgG level, Increased circulating IgE level	OMIM:256500
Bloom Syndrome	Decreased circulating IgG level, Decreased circulating IgA level, Decreased circulating total IgM	OMIM:210900
Agammaglobulinemia, X-Linked	Decreased circulating IgG level, Decreased circulating total IgM, Decreased circulating IgE, Agam...	OMIM:300755
Hyperekplexia 1	Exaggerated startle response	OMIM:149400
T-B+ Severe Combined Immunodeficiency Due To Jak3 Deficiency	Decreased circulating IgG level, Decreased circulating total IgM, Partial IgA deficiency, Lack of...	ORPHA:35078
Stiff Person Spectrum Disorder	Exaggerated startle response	ORPHA:3198
Urban-Rogers-Meyer Syndrome	Increased circulating IgE level	ORPHA:3409
Gm2-Gangliosidosis, Ab Variant	Dystonia, Exaggerated startle response	OMIM:272750
Tularemia	Increased circulating antibody level	ORPHA:3392
Leishmaniasis	Increased circulating antibody level	ORPHA:507
Waldenström Macroglobulinemia	Monoclonal immunoglobulin M proteinemia, Cryoglobulinemia	ORPHA:33226
Immunodeficiency, Common Variable, 8, With Autoimmunity	Decreased circulating IgG level, Decreased circulating IgA level, Decreased circulating total IgM...	OMIM:614700
Wiskott-Aldrich Syndrome, Autosomal Dominant	Decreased circulating total IgM, Increased circulating IgA level, Decreased specific anti-polysac...	OMIM:600903
Brucellosis	Increased circulating IgG level, Increased circulating IgM level	ORPHA:1304
Tay-Sachs Disease	Exaggerated startle response	OMIM:272800
Thrombocytopenia 1	Increased circulating IgA level, Increased circulating IgE level	OMIM:313900
Pyoderma Gangrenosum	Increased circulating antibody level	ORPHA:48104
Spastic Paraplegia, Optic Atrophy, And Neuropathy	Exaggerated startle response	OMIM:609541
Autoinflammation With Arthritis And Dyskeratosis	Increased circulating IgA level, Increased circulating IgG level	OMIM:617388
Primary Sclerosing Cholangitis	Polyclonal elevation of IgM	ORPHA:171
Tempi Syndrome	Increased circulating IgG level	ORPHA:284227
Alg12-Cdg	Abnormal circulating IgA level, Partial absence of specific antibody response to Haemophilus infl...	ORPHA:79324
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome	Exaggerated startle response	ORPHA:320406
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity	Decreased specific anti-polysaccharide antibody level, Decreased circulating IgA level, Decreased...	OMIM:606367
Crimean-Congo Hemorrhagic Fever	Increased circulating IgG level, Increased circulating IgM level	ORPHA:99827
Stiff-Person Syndrome	Opisthotonus, Exaggerated startle response	OMIM:184850
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 2	Increased circulating antibody level, Head tremor, Dystonia, Tremor	OMIM:606002
Iga Pemphigus	Increased circulating IgA level, Monoclonal elevation of circulating IgA	ORPHA:555905
Skeletal Dysplasia-T-Cell Immunodeficiency-Developmental Delay Syndrome	Decreased circulating IgG level, Decreased circulating total IgM, Opisthotonus, Decreased circula...	ORPHA:508533
Netherton Syndrome	Increased circulating IgE level, Decreased circulating antibody level	ORPHA:634
Encephalitis Lethargica	Increased circulating antibody level, Tremor	ORPHA:83600
Immunodeficiency 47	Decreased circulating total IgM, Chronic decreased circulating total IgG, Decreased circulating t...	OMIM:300972
Autoimmune Lymphoproliferative Syndrome	Decreased circulating IgG level, Decreased circulating total IgM, Abnormal circulating interleuki...	ORPHA:3261
Autoimmune Hepatitis	Increased circulating antibody level, Increased circulating IgG level	ORPHA:2137
Igg4-Related Submandibular Gland Disease	Increased circulating IgG level, Increased circulating IgG4 level, Increased circulating antibody...	ORPHA:449432
Prolidase Deficiency	Increased circulating antibody level	OMIM:170100
Sting-Associated Vasculopathy, Infantile-Onset	Increased circulating IgA level, Increased circulating IgG level	OMIM:615934
Osteopetrosis, Autosomal Recessive 7	Decreased circulating IgG level, Decreased circulating IgA level, Decreased circulating total IgM	OMIM:612301
Asparagine Synthetase Deficiency	Exaggerated startle response	OMIM:615574
Idiopathic Chronic Eosinophilic Pneumonia	Increased circulating IgE level	ORPHA:2902
Yellow Fever	Increased circulating interleukin 6 concentration, Increased circulating IgM level	ORPHA:99829
Trichothiodystrophy 3, Photosensitive	Increased circulating IgA level	OMIM:616395
Recurrent Infections Associated With Rare Immunoglobulin Isotypes Deficiency	Decreased circulating IgG level, Decreased circulating IgA level, Decreased circulating total IgM...	ORPHA:183675
Aspergillosis	Increased circulating IgE level	ORPHA:1163
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation	Dystonia, Exaggerated startle response	ORPHA:438216
Pneumocystosis	Increased circulating antibody level	ORPHA:723
Hyperimmunoglobulinemia D With Periodic Fever	Increased circulating IgA level	ORPHA:343
Pgm3-Cdg	Reduced antigen-specific T cell proliferation, Increased circulating IgG level, Bone marrow hypoc...	ORPHA:443811
Secondary Intestinal Lymphangiectasia	Decreased circulating IgG1 level, Decreased circulating total IgM, Decreased circulating IgA leve...	ORPHA:90363
Selective Igm Deficiency	Decreased circulating total IgM, Decreased specific antibody response to vaccination, Paraprotein...	ORPHA:331235
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked	Increased circulating IgE level	OMIM:304790
Tay-Sachs Disease	Laryngeal dystonia, Dystonia, Tremor, Exaggerated startle response	ORPHA:845
Wiskott-Aldrich Syndrome	Decreased circulating total IgM, Increased circulating IgA level, Decreased specific anti-polysac...	OMIM:301000
Glycine Encephalopathy With Normal Serum Glycine	Exaggerated startle response	OMIM:617301
Bloom Syndrome	Decreased circulating IgG level, Decreased circulating total IgM, Decreased circulating IgA level...	ORPHA:125
Riddle Syndrome	Decreased circulating IgG level, Decreased circulating IgA level, Decreased circulating total IgM	ORPHA:420741
Multiple Myeloma	Increased circulating IgA level, Increased circulating IgG level, Decreased circulating antibody ...	ORPHA:29073
Autosomal Dominant Hyper-Ige Syndrome	Increased circulating IgE level	ORPHA:2314
Sandhoff Disease	Exaggerated startle response	OMIM:268800
Intellectual Disability-Seizures-Hypophosphatasia-Ophthalmic-Skeletal Anomalies Syndrome	Decreased circulating total IgM, Decreased circulating IgA level	ORPHA:369837
Scleromyxedema	Paraproteinemia	ORPHA:167635
Ebola Hemorrhagic Fever	Increased circulating antibody level	ORPHA:319218
Plaa-Associated Neurodevelopmental Disorder	Dystonia, Exaggerated startle response	ORPHA:521426
Inflammatory Bowel Disease, Immunodeficiency, And Encephalopathy	Decreased T cell activation, Defective T cell proliferation, Increased circulating IgE level, Inc...	OMIM:618213
Cystic Echinococcosis	Increased circulating antibody level	ORPHA:400
Congenital Analbuminemia	Increased circulating antibody level	ORPHA:86816
Gaucher Disease Type 1	Increased circulating antibody level	ORPHA:77259
Poems Syndrome	Increased circulating antibody level	ORPHA:2905
Proteasome-Associated Autoinflammatory Syndrome 3	Increased circulating antibody level	OMIM:617591
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4	Exaggerated startle response	OMIM:253800
Gm1 Gangliosidosis Type 1	Exaggerated startle response	ORPHA:79255
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies	Exaggerated startle response	OMIM:617527
Aapoaiv Amyloidosis	Paraproteinemia	ORPHA:439232
Hyper-Igd Syndrome	Increased circulating IgA level, Increased circulating IgD level	OMIM:260920
Al Amyloidosis	Increased circulating antibody level	ORPHA:85443
Igg4-Related Kidney Disease	Decreased serum complement C4, Increased circulating IgG1 level, Increased circulating IgG level,...	ORPHA:449395
Q Fever	Increased circulating antibody level, Cryoglobulinemia	ORPHA:781
Insulin-Resistance Syndrome Type B	Increased circulating IgA level, Decreased serum complement factor B, Increased circulating IgG l...	ORPHA:2298
Lead Poisoning	Abnormality of humoral immunity, Increased circulating IgE level	ORPHA:330015
Postinfectious Vasculitis	Increased circulating antibody level, Increased circulating IgA level, Abnormality of humoral imm...	ORPHA:48435
Alveolar Echinococcosis	Increased circulating antibody level	ORPHA:284
Primary Sjögren Syndrome	Decreased serum complement C4, Decreased circulating antibody level, Increased circulating antibo...	ORPHA:289390
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome	Increased circulating IgE level	ORPHA:37042
Proteasome-Associated Autoinflammatory Syndrome 1	Increased circulating antibody level, Increased circulating IgA level, Increased circulating IgG ...	OMIM:256040
Gaucher Disease Type 3	Increased circulating antibody level	ORPHA:77261
Trichinellosis	Increased circulating IgE level	ORPHA:863
Gaucher Disease	Increased circulating antibody level, Tremor	ORPHA:355
Cysticercosis	Increased circulating antibody level	ORPHA:1560
Lysinuric Protein Intolerance	Increased circulating antibody level, Abnormality of humoral immunity, Complement deficiency, Dec...	ORPHA:470
Immunodeficiency 82 With Systemic Inflammation	Decreased lymphocyte proliferation in response to mitogen, Decreased circulating total IgG, Decre...	OMIM:619381
Sarcoidosis, Susceptibility To, 1	Increased circulating antibody level, Abnormality of T cell physiology	OMIM:181000
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome	Decreased circulating total IgM	ORPHA:83617
Igg4-Related Ophthalmic Disease	Increased circulating IgG4 level, Increased circulating IgE level	ORPHA:449563
Simpson-Golabi-Behmel Syndrome	Increased circulating IgE level	ORPHA:373
Marburg Hemorrhagic Fever	Increased circulating antibody level	ORPHA:99826
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome	Dystonia, Exaggerated startle response	ORPHA:438213
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities	Exaggerated startle response	OMIM:619522
Tubulointerstitial Nephritis And Uveitis Syndrome	Increased circulating antibody level, Increased circulating IgG level	ORPHA:91500
Viss Syndrome	Decreased circulating IgA level, Increased circulating IgE level, Increased circulating IgG level	OMIM:619472

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Fpgs

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fpgs.

No publications found that use IMPC mice or data for Fpgs.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

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MGI Allele	Allele Type	Produced
Fpgs^{tm1e(EUCOMM)Hmgu}	Targeted, non-conditional allele	ES Cells
Fpgs^{tm1(KOMP)Vlcg}	Reporter-tagged deletion allele (with selection cassette)	Mice, ES Cells
Fpgs^{tm26672(L1L2_gt0)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors
Fpgs^{tm1a(EUCOMM)Hmgu}	KO first allele (reporter-tagged insertion with conditional potential)	Mice, Targeting vectors, ES Cells

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