Gene: Egr1

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Name
early growth response 1
MGI ID
MGI:95295
Synonyms
NGFIA TIS8 Zif268 Zenk Krox24 ETR103 Krox-24 Krox-1 Egr-1 Zfp-6 NGF1-A A530045N19Rik NGFI-A
Viability
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal neural tube closure Egr1tm1b(NCOM)Mfgc HOM E9.5 0.00
abnormal body length Egr1tm1b(NCOM)Mfgc HET Early adult 6.31×10-06
abnormal embryo size Egr1tm1b(NCOM)Mfgc HOM E9.5 0.00
abnormal neural tube closure Egr1tm1b(NCOM)Mfgc HET E9.5 0.00
female infertility Egr1tm1b(NCOM)Mfgc HOM Early adult 0.00
male infertility Egr1tm1b(NCOM)Mfgc HOM Early adult 0.00
abnormal optic disk morphology Egr1tm1b(NCOM)Mfgc HOM Early adult 3.33×10-06
preweaning lethality, incomplete penetrance Egr1tm1b(NCOM)Mfgc HOM Early adult 1.00×10-07
abnormal hindbrain development Egr1tm1b(NCOM)Mfgc HET E9.5 0.00
abnormal tibia morphology Egr1tm1b(NCOM)Mfgc HET Early adult 1.24×10-09
short tibia Egr1tm1b(NCOM)Mfgc HET Early adult 8.95×10-06
abnormal midbrain development Egr1tm1b(NCOM)Mfgc HOM E9.5 0.00
abnormal monocyte cell number Egr1tm1b(NCOM)Mfgc HET Early adult 1.70×10-05
small uterus Egr1tm1b(NCOM)Mfgc HOM Early adult 0.00
abnormal hindbrain development Egr1tm1b(NCOM)Mfgc HOM E9.5 0.00
abnormal forebrain development Egr1tm1b(NCOM)Mfgc HET E9.5 0.00
abnormal grip strength Egr1tm1b(NCOM)Mfgc HET Early adult 7.75×10-05
abnormal embryo size Egr1tm1b(NCOM)Mfgc HET E9.5 0.00
abnormal forebrain development Egr1tm1b(NCOM)Mfgc HOM E9.5 0.00
absent seminal vesicle Egr1tm1b(NCOM)Mfgc HOM Early adult 0.00
abnormal midbrain development Egr1tm1b(NCOM)Mfgc HET E9.5 0.00

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

No Adult expression data was found for this gene.
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/65)  (3/3) N/A
Brain 4  (6/506)  (3/5) N/A
Central nervous system ganglion 2  (1/74)  (3/3) N/A
Ear 4  (1/506)  (3/5) N/A
Embryo 4  (1/507)  (5/5) N/A
Eye 4  (1/506)  (3/5) N/A
Foot 4  (1/506) N/A
Forebrain 4  (1/506)  (3/5) N/A
Forelimb 4  (1/506)  (3/5) N/A
Gut 2  (1/60)  (3/3) N/A
Hand 4  (1/505) N/A
Head 4  (5/506)  (3/5) N/A
Heart 4  (1/506)  (3/5) N/A
Hindbrain 4  (6/506)  (3/5) N/A
Hindlimb 4  (1/505)  (3/5) N/A
Liver 4  (1/506)  (3/5) N/A
Lung 4  (1/502)  (3/5) N/A
Mandibular process 4  (1/506) N/A
Maxillary process 4  (1/506) N/A
Midbrain 4  (1/506)  (3/5) N/A
Nose 2  (1/74)  (3/3) N/A
Oral cavity 4  (1/506)  (3/5) N/A
2  (7/40)  (3/3) N/A
Skeleton 2  (1/74)  (3/3) N/A
Skin 4  (1/506)  (3/5) N/A
Spinal cord 2  (1/73)  (3/3) N/A
Tail 4  (1/506)  (3/5) N/A
Tail somite 4  (1/506)  (3/5) N/A
Trachea 2  (1/60)  (3/3) N/A
Urinary system 2  (1/60)  (3/3) N/A

 Associated Images

Immunophenotyping: Panel A FCS file(s)
6 Images
Immunophenotyping: Panel B FCS file(s)
6 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
14 Images
Eye Morphology: Images Ophthalmoscopy
6 Images
Embryo LacZ: LacZ images wholemount
20 Images
Gross Pathology and Tissue Collection
18 Images
X-ray: XRay Images Whole Body Dorso Ventral
14 Images
X-ray: XRay Images Whole Body Lateral Orientation
14 Images
Gross Morphology Embryo E9.5
4 Images
X-ray: XRay Images Skull Lateral Orientation
14 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Testes - process of degenerative change Egr1tm1b(NCOM)Mfgc HOM Early adult
Ovary - developmental and structural abnormality Egr1tm1b(NCOM)Mfgc HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Egr1tm1b(NCOM)Mfgc Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Egr1tm1a(NCOM)Mfgc KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Egr1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Egr1tm214497(L1L2_Bact_P) Targeting vectors

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