Gene: Egr1

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Name
early growth response 1
MGI ID
MGI:95295
Synonyms
A530045N19Rik Zif268 Krox24 Krox-1 Egr-1 NGFIA TIS8 Zfp-6 NGF1-A Zenk NGFI-A Krox-24 ETR103
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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
short tibia Egr1tm1b(NCOM)Mfgc HET postnatal 1.21×10-09
female infertility Egr1tm1b(NCOM)Mfgc HOM postpartum stage 0.00
abnormal hindbrain development Egr1tm1b(NCOM)Mfgc HOM embryonic day 9.5 0.00
preweaning lethality, incomplete penetrance Egr1tm1b(NCOM)Mfgc HOM n/a 0.00
abnormal neural tube closure Egr1tm1b(NCOM)Mfgc HOM embryonic day 9.5 0.00
abnormal forebrain development Egr1tm1b(NCOM)Mfgc HOM embryonic day 9.5 0.00
embryonic growth retardation Egr1tm1b(NCOM)Mfgc HOM embryonic day 9.5 0.00
absent seminal vesicle Egr1tm1b(NCOM)Mfgc HOM postnatal 0.00
decreased body length Egr1tm1b(NCOM)Mfgc HET postnatal 3.90×10-07
abnormal embryo size Egr1tm1b(NCOM)Mfgc HOM embryonic day 9.5 0.00
abnormal midbrain development Egr1tm1b(NCOM)Mfgc HOM embryonic day 9.5 0.00
embryonic lethality prior to tooth bud stage Egr1tm1b(NCOM)Mfgc HOM embryonic day 12.5 0.00
male infertility Egr1tm1b(NCOM)Mfgc HOM postpartum stage 0.00
small uterus Egr1tm1b(NCOM)Mfgc HOM postnatal 0.00

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

No Adult expression data was found for this gene.
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/51)  (3/3) N/A
Brain 4  (6/485)  (3/5) N/A
Central nervous system ganglion 2  (1/51)  (3/3) N/A
Ear 4  (1/485)  (3/5) N/A
Embryo 4  (1/485)  (5/5) N/A
Eye 4  (1/485)  (3/5) N/A
Foot 4  (1/485) N/A
Forebrain 4  (1/485)  (3/5) N/A
Forelimb 4  (1/485)  (3/5) N/A
Gut 2  (1/50)  (3/3) N/A
Hand 4  (1/485) N/A
Head 4  (5/485)  (3/5) N/A
Heart 4  (1/485)  (3/5) N/A
Hindbrain 4  (6/485)  (3/5) N/A
Hindlimb 4  (1/485)  (3/5) N/A
Liver 4  (1/485)  (3/5) N/A
Lung 4  (1/485)  (3/5) N/A
Mandibular process 4  (1/485) N/A
Maxillary process 4  (1/485) N/A
Midbrain 4  (1/485)  (3/5) N/A
Nose 2  (1/51)  (3/3) N/A
Oral cavity 4  (1/485)  (3/5) N/A
2  (7/25)  (3/3) N/A
Skeleton 2  (1/51)  (3/3) N/A
Skin 4  (1/485)  (3/5) N/A
Spinal cord 2  (1/50)  (3/3) N/A
Tail 4  (1/485)  (3/5) N/A
Tail somite 4  (1/485)  (3/5) N/A
Trachea 2  (1/50)  (3/3) N/A
Urinary system 2  (1/50)  (3/3) N/A

 Associated Images

Gross Pathology and Tissue Collection
18 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
14 Images
X-ray: XRay Images Dorso Ventral
14 Images
Eye Morphology: Images Ophthalmoscopy
6 Images
X-ray: XRay Images Skull Lateral Orientation
14 Images
X-ray: XRay Images Lateral Orientation
14 Images
Gross Morphology Embryo E9.5
4 Images
Histopathology
10 Images
Embryo LacZ: LacZ images wholemount
8 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Testes - process of degenerative change Egr1tm1b(NCOM)Mfgc HOM postnatal
Ovary - developmental and structural abnormality Egr1tm1b(NCOM)Mfgc HOM postnatal

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Egr1tm1a(NCOM)Mfgc KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Egr1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Egr1tm214497(L1L2_Bact_P) Targeting vectors
Egr1tm1b(NCOM)Mfgc Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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