Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
dishevelled segment polarity protein 1
Synonyms:
N/A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dvl1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dvl1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Autosomal Dominant Robinow Syndrome
ORPHA:3107
Robinow Syndrome, Autosomal Dominant 2
OMIM:616331

The table below shows human diseases predicted to be associated to Dvl1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Autism, Susceptibility To, 20
Impaired social interactions OMIM:618830
Hereditary Geniospasm
Abnormal social behavior ORPHA:53372
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Abnormal social behavior ORPHA:436151
Asperger Syndrome, X-Linked, Susceptibility To, 2
Impaired ability to form peer relationships, Impaired use of nonverbal behaviors OMIM:300497
Asperger Syndrome, X-Linked, Susceptibility To, 1
Impaired ability to form peer relationships, Impaired use of nonverbal behaviors OMIM:300494
Asperger Syndrome, Susceptibility To, 1
Impaired ability to form peer relationships, Impaired use of nonverbal behaviors OMIM:608638
Asperger Syndrome, Susceptibility To, 2
Impaired ability to form peer relationships, Impaired use of nonverbal behaviors OMIM:608631
Intellectual Developmental Disorder, Autosomal Recessive 66
Shyness OMIM:618221
Intellectual Developmental Disorder With Autism And Speech Delay
Impaired social interactions OMIM:606053
Glycosylphosphatidylinositol Biosynthesis Defect 17
Overfriendliness OMIM:618010
Chromosome Xp11.23-P11.22 Duplication Syndrome
Shyness OMIM:300801
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
No social interaction, Impaired social interactions ORPHA:329249
Hsd10 Disease
Tremor, Abnormal social behavior ORPHA:391417
11Q22.2Q22.3 Microdeletion Syndrome
Abnormal social behavior, Poor eye contact ORPHA:444002
Dopa-Responsive Dystonia
Tremor, Abnormal social behavior, Fatigable weakness ORPHA:255
Female Restricted Epilepsy With Intellectual Disability
Abnormal social behavior ORPHA:101039
Severe Intellectual Disability And Progressive Spastic Paraplegia
Shyness ORPHA:280763
Lamb-Shaffer Syndrome
Abnormal social behavior ORPHA:530983
Tonne-Kalscheuer Syndrome
Tremor, Shyness OMIM:300978
X-Linked Intellectual Disability, Cilliers Type
Shyness ORPHA:163971
Developmental And Epileptic Encephalopathy 8
Exaggerated startle response OMIM:300607
Hyperekplexia 3
Exaggerated startle response OMIM:614618
Metachromatic Leukodystrophy, Juvenile Form
Abnormal social behavior, Intention tremor ORPHA:309263
Early-Onset Autosomal Dominant Alzheimer Disease
Abnormal social behavior ORPHA:1020
Childhood Absence Epilepsy
Abnormal social behavior ORPHA:64280
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Impaired social interactions, Poor eye contact, Shyness ORPHA:449291
Hyperekplexia-Epilepsy Syndrome
Exaggerated startle response ORPHA:163985
Blepharophimosis-Impaired Intellectual Development Syndrome
Overfriendliness OMIM:619293
Metachromatic Leukodystrophy, Adult Form
Abnormal social behavior, Intention tremor ORPHA:309271
Metachromatic Leukodystrophy, Late Infantile Form
Abnormal social behavior ORPHA:309256
Hyperekplexia 2
Exaggerated startle response OMIM:614619
Developmental Delay-Facial Dysmorphism Syndrome Due To Med13L Deficiency
Overfriendliness ORPHA:369891
48,Xxxy Syndrome
Tremor, Abnormal social behavior ORPHA:96263
Luscan-Lumish Syndrome
Shyness OMIM:616831
Cri-Du-Chat Syndrome
Overfriendliness OMIM:123450
Developmental And Epileptic Encephalopathy 68
Exaggerated startle response OMIM:618201
Fg Syndrome Type 1
Abnormal social behavior ORPHA:93932
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination
Exaggerated startle response OMIM:618367
Early-Onset Schizophrenia
Lack of peer relationships, No social interaction, Shyness ORPHA:96369
Spastic Paraplegia, Optic Atrophy, And Neuropathy
Exaggerated startle response OMIM:609541
Spastic Tetraplegia And Axial Hypotonia, Progressive
Exaggerated startle response OMIM:618598
49,Xxxxy Syndrome
Tremor, Shyness, Overfriendliness ORPHA:96264
Stiff Person Spectrum Disorder
Exaggerated startle response ORPHA:3198
Hyperekplexia 1
Exaggerated startle response OMIM:149400
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Exaggerated startle response ORPHA:320406
Tay-Sachs Disease
Exaggerated startle response OMIM:272800
Stiff-Person Syndrome
Opisthotonus, Exaggerated startle response OMIM:184850
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Abnormal social behavior, Intention tremor ORPHA:314647
Van Esch-O'Driscoll Syndrome
Shyness OMIM:301030
Gm2 Gangliosidosis, Ab Variant
Exaggerated startle response ORPHA:309246
Koolen-De Vries Syndrome
Overfriendliness ORPHA:96169
Prader-Willi Syndrome Due To Translocation
Abnormal social behavior, Impaired social interactions ORPHA:177907
Dihydropyrimidine Dehydrogenase Deficiency
Abnormal social behavior ORPHA:1675
Asparagine Synthetase Deficiency
Exaggerated startle response OMIM:615574
Gm2-Gangliosidosis, Ab Variant
Exaggerated startle response OMIM:272750
Aromatic L-Amino Acid Decarboxylase Deficiency
Limb tremor, Exaggerated startle response OMIM:608643
Trichothiodystrophy
Impaired social reciprocity, Intention tremor ORPHA:33364
Trichotillomania
Hair-pulling OMIM:613229
1P21.3 Microdeletion Syndrome
Shyness ORPHA:293948
Mend Syndrome
Abnormal social behavior ORPHA:401973
Glycine Encephalopathy With Normal Serum Glycine
Exaggerated startle response OMIM:617301
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Exaggerated startle response ORPHA:438216
Niemann-Pick Disease Type C
Tremor, Abnormal social behavior, Intention tremor ORPHA:646
Sandhoff Disease
Exaggerated startle response OMIM:268800
Koolen-De Vries Syndrome Due To A Point Mutation
Overfriendliness, Abnormal social behavior ORPHA:363965
17Q21.31 Microdeletion Syndrome
Overfriendliness, Abnormal social behavior ORPHA:363958
Tay-Sachs Disease
Tremor, Exaggerated startle response ORPHA:845
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Exaggerated startle response OMIM:253800
Gm1 Gangliosidosis Type 1
Exaggerated startle response ORPHA:79255
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies
Exaggerated startle response OMIM:617527
Plaa-Associated Neurodevelopmental Disorder
Exaggerated startle response ORPHA:521426
Tuberous Sclerosis Complex
Abnormal social behavior ORPHA:805
Williams Syndrome
Tremor, Overfriendliness, Abnormal social behavior ORPHA:904
Macrocephaly-Intellectual Disability-Left Ventricular Non Compaction Syndrome
Shyness, Intention tremor ORPHA:466791
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities
Exaggerated startle response OMIM:619522
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Exaggerated startle response ORPHA:438213
Autosomal Dominant Robinow Syndrome
ORPHA:3107
Robinow Syndrome, Autosomal Dominant 2
OMIM:616331

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dvl1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dvl1.

No publications found that use IMPC mice or data for Dvl1.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Dvl1tm3e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Dvl1tm2e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Dvl1tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Dvl1tm3a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Dvl1tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Dvl1tm43022(L1L2_gt2) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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