Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
DNA methyltransferase 1
Synonyms:
MommeD2,  MTase,  Cxxc9,  Dnmt1o

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dnmt1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dnmt1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Neuropathy, Hereditary Sensory, Type Ie
Dementia, Irritability, Delirium, Memory impairment OMIM:614116
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Depression, Dementia, Memory impairment OMIM:604121
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Depression, Mental deterioration, Memory impairment ORPHA:314404

The table below shows human diseases predicted to be associated to Dnmt1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Oocyte/Zygote/Embryo Maturation Arrest 4
Oocyte arrest at metaphase I, Female infertility OMIM:617743
Oocyte/Zygote/Embryo Maturation Arrest 2
Oocyte arrest at metaphase I, Female infertility OMIM:616780
Oocyte/Zygote/Embryo Maturation Arrest 14
Oocyte maturation arrest, Female infertility OMIM:620276
Oocyte/Zygote/Embryo Maturation Arrest 5
Female infertility, Lack of oocyte pronucleus formation OMIM:617996
Female Infertility Due To Oocyte Meiotic Arrest
Abnormal meiosis, Oocyte arrest at metaphase I, Female infertility ORPHA:488191
Oocyte/Zygote/Embryo Maturation Arrest 13
Female infertility OMIM:620154
Oocyte/Zygote/Embryo Maturation Arrest 21
Female infertility OMIM:620610
Oocyte/Zygote/Embryo Maturation Arrest 12
Female infertility OMIM:619697
Oocyte/Zygote/Embryo Maturation Arrest 6
Female infertility OMIM:618353
Oocyte/Zygote/Embryo Maturation Arrest 1
Female infertility OMIM:615774
Oocyte/Zygote/Embryo Maturation Arrest 3
Female infertility OMIM:617712
Oocyte/Zygote/Embryo Maturation Arrest 18
Female infertility OMIM:620332
Oocyte/Zygote/Embryo Maturation Arrest 19
Female infertility OMIM:620333
Oocyte/Zygote/Embryo Maturation Arrest 11
Female infertility OMIM:619643
Oocyte/Zygote/Embryo Maturation Arrest 7
Female infertility OMIM:618550
Oocyte/Zygote/Embryo Maturation Arrest 15
Female infertility OMIM:616814
Progesterone Resistance
Female infertility OMIM:264080
Oocyte/Zygote/Embryo Maturation Arrest 9
Oocyte arrest at metaphase I, Female infertility, Abnormality of the menstrual cycle OMIM:619011
Premature Ovarian Failure 19
Secondary amenorrhea, Premature ovarian insufficiency, Irregular menstruation, Female infertility OMIM:619245
Hydatidiform Mole, Recurrent, 3
Female infertility OMIM:618431
Hydatidiform Mole, Recurrent, 4
Female infertility OMIM:618432
Oocyte/Zygote/Embryo Maturation Arrest 17
Amenorrhea, Female infertility OMIM:620319
Oocyte/Zygote/Embryo Maturation Arrest 20
Amenorrhea, Female infertility OMIM:620383
Oocyte/Zygote/Embryo Maturation Arrest 10
Female infertility OMIM:619176
Oocyte/Zygote/Embryo Maturation Arrest 8
Female infertility, Abnormality of the menstrual cycle OMIM:619009
Premature Ovarian Failure 2B
Premature ovarian insufficiency, Female infertility, Primary amenorrhea OMIM:300604
Hyperprolactinemia
Oligomenorrhea, Menorrhagia, Female infertility OMIM:615555
Premature Ovarian Failure 22
Secondary amenorrhea, Premature ovarian insufficiency, Female infertility OMIM:620548
Asherman Syndrome
Secondary amenorrhea, Infertility, Oligomenorrhea, Dysmenorrhea, Abnormality of the menstrual cyc... ORPHA:137686
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Premature Ovarian Failure 13
Oligomenorrhea, Amenorrhea, Female infertility OMIM:617442
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Premature Ovarian Failure 20
Secondary amenorrhea, Female infertility OMIM:619938
Premature Ovarian Failure 6
Premature ovarian insufficiency, Secondary amenorrhea, Female infertility, Primary amenorrhea, St... OMIM:612310
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Frontal Encephalocele
Hydrocephalus, Encephalocele, Spina bifida ORPHA:1931
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Growth Hormone Deficiency, Isolated Partial
Postnatal growth retardation, Short stature OMIM:615925
Acalvaria
Hydrocephalus, Holoprosencephaly, Spina bifida ORPHA:945
Intrauterine Growth Retardation With Increased Mitomycin C Sensitivity
Postnatal growth retardation, Intrauterine growth retardation OMIM:600546
Ovarian Dysgenesis 3
Female infertility, Primary amenorrhea OMIM:614324
Hemihyperplasia, Isolated
Myelomeningocele OMIM:235000
Neural Tube Defects, Susceptibility To
Hydrocephalus, Myelomeningocele, Anencephaly, Spina bifida occulta OMIM:182940
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Anencephaly, Spina bifida ORPHA:2476
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Craniorachischisis
Sirenomelia, Anencephaly, Myelomeningocele, Spinal dysraphism, Cervical spina bifida ORPHA:63260
Ring Chromosome Y Syndrome
Male infertility, Male hypogonadism, Azoospermia, Abnormal spermatogenesis, Female infertility, S... ORPHA:261529
Subependymal Nodular Heterotopia
Occipital encephalocele, Nasofrontal encephalocele, Myelomeningocele, Meningocele ORPHA:101030
Ciliary Dyskinesia, Primary, 37
Female infertility OMIM:617577
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Schisis Association
Anencephaly, Encephalocele, Spina bifida ORPHA:63862
Muscular Dystrophy, Congenital Hearing Loss, And Ovarian Insufficiency Syndrome
Premature ovarian insufficiency, Female infertility OMIM:619518
Chiari Malformation Type Ii
Hydrocephalus, Cervical myelopathy, Myelomeningocele, Spina bifida OMIM:207950
Caudal Duplication
Myelomeningocele, Spina bifida ORPHA:1756
Wildervanck Syndrome
Meningocele ORPHA:3456
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Humero-Radial Synostosis
Meningocele ORPHA:3265
Thoraco-Abdominal Enteric Duplication
Meningocele ORPHA:1759
Muscle-Eye-Brain Disease
Hydrocephalus, Holoprosencephaly, Meningocele ORPHA:588
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Neuropathy, Hereditary Sensory, Type Ie
Dementia, Irritability, Delirium, Memory impairment OMIM:614116
Aminopterin/Methotrexate Embryofetopathy
Anencephaly, Encephalocele, Meningocele, Hydrocephalus, Holoprosencephaly, Spinal dysraphism ORPHA:1908
Meckel Syndrome, Type 4
Hydrocephalus, Anencephaly, Encephalocele, Meningocele OMIM:611134
Meckel Syndrome, Type 2
Anencephaly, Encephalocele, Meningocele OMIM:603194
Intellectual Developmental Disorder, Autosomal Dominant 72
Spina bifida OMIM:620439
Isolated Klippel-Feil Syndrome
Spina bifida ORPHA:2345
Sirenomelia
Sirenomelia, Spina bifida ORPHA:3169
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Blepharophimosis, Ptosis, And Epicanthus Inversus
Amenorrhea, Premature ovarian insufficiency, Female infertility, Irregular menstruation OMIM:110100
Camptodactyly Syndrome, Guadalajara Type 1
Spina bifida ORPHA:1327
Isolated Posterior Meningocele
Neural tube defect, Meningocele, Hydrocephalus, Lipomyelomeningocele, Occipital meningocele ORPHA:268810
Czeizel-Losonci Syndrome
Hydrocephalus, Spina bifida occulta, Myelomeningocele, Spina bifida ORPHA:2437
Primary Ciliary Dyskinesia
Male infertility, Abnormal sperm motility, Female infertility ORPHA:244
Waardenburg Syndrome Type 1
Spina bifida, Meningocele ORPHA:894
Triploidy
Hydrocephalus, Holoprosencephaly, Meningocele ORPHA:3376
Cleft Lip/Palate-Deafness-Sacral Lipoma Syndrome
Meningocele ORPHA:2003
Fountain Syndrome
Spina bifida occulta, Spina bifida ORPHA:3219
Neurocutaneous Melanocytosis
Meningocele ORPHA:2481
Joubert Syndrome 14
Hydrocephalus, Encephalocele, Meningocele OMIM:614424
Amish Lethal Microcephaly
Spina bifida ORPHA:99742
Autosomal Recessive Spondylocostal Dysostosis
Meningocele, Spina bifida occulta, Umbilical hernia ORPHA:2311
Sacral Defect With Anterior Meningocele
Myeloschisis, Meningocele, Hydrocephalus, Dermal sinus tract, Myelomeningocele OMIM:600145
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida ORPHA:1120
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Meningocele ORPHA:2031
Fliedner-Zweier Syndrome
Meningocele OMIM:620511
Iniencephaly
Anencephaly, Encephalocele, Hydrocephalus, Myelomeningocele, Spina bifida, Holoprosencephaly, Spi... ORPHA:63259
Aromatase Deficiency
Primary amenorrhea, Female infertility, Male infertility, Hypergonadotropic hypogonadism ORPHA:91
Pelvis-Shoulder Dysplasia
Hydrocephalus, Spina bifida, Hydranencephaly ORPHA:2839
Cerebrocostomandibular Syndrome
Hydranencephaly, Spina bifida, Myelomeningocele, Meningocele ORPHA:1393
Acromelic Frontonasal Dysplasia
Encephalocele, Meningocele ORPHA:1827
Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Plus
Premature ovarian insufficiency, Secondary amenorrhea, Hypergonadotropic hypogonadism, Oligomenor... ORPHA:572333
Lateral Meningocele Syndrome
Meningocele, Umbilical hernia ORPHA:2789
Lateral Meningocele Syndrome
Hydrocephalus, Meningocele, Umbilical hernia OMIM:130720
Lumbar Syndrome
Myelomeningocele, Spina bifida ORPHA:83628
Neu-Laxova Syndrome 2
Spina bifida OMIM:616038
Chromosome 17P13.1 Deletion Syndrome
Hydrocephalus, Spina bifida, Umbilical hernia OMIM:613776
Trisomy 20P
Spina bifida, Umbilical hernia ORPHA:261318
Phakomatosis Pigmentokeratotica
Spina bifida ORPHA:2874
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida OMIM:193500
Vacterl With Hydrocephalus
Hydrocephalus, Aqueductal stenosis, Spina bifida ORPHA:3412
Cloacal Exstrophy
Myelomeningocele, Spina bifida ORPHA:93929
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Occipital encephalocele, Meningocele ORPHA:397715
Curry-Jones Syndrome
Occipital meningocele, Lipomyelomeningocele OMIM:601707
Limb Body Wall Complex
Short umbilical cord, Anencephaly, Encephalocele, Spina bifida occulta, Hydrocephalus, Myelomenin... ORPHA:2369
Mosaic Trisomy 9
Spina bifida ORPHA:99776
Trisomy 18
Holoprosencephaly, Anencephaly, Spina bifida ORPHA:3380
Nail-Patella Syndrome
Spina bifida OMIM:161200
Lathosterolosis
Meningocele ORPHA:46059
Pagod Syndrome
Spina bifida, Encephalocele, Meningocele ORPHA:991
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Hydrocephalus, Occipital meningocele, Anencephaly OMIM:616546
Neu-Laxova Syndrome
Spina bifida ORPHA:2671
Fibular Hemimelia
Spina bifida ORPHA:93323
Focal Dermal Hypoplasia
Spina bifida, Umbilical hernia ORPHA:2092
Basal Cell Nevus Syndrome 1
Hydrocephalus, Spina bifida OMIM:109400
Hallermann-Streiff Syndrome
Spina bifida OMIM:234100
Turner Syndrome Due To Structural X Chromosome Anomalies
Secondary amenorrhea, Premature ovarian insufficiency, Female infertility, Primary amenorrhea ORPHA:99413
Turner Syndrome
Secondary amenorrhea, Premature ovarian insufficiency, Female infertility, Primary amenorrhea ORPHA:881
Mosaic Monosomy X
Secondary amenorrhea, Premature ovarian insufficiency, Female infertility, Primary amenorrhea ORPHA:99228
Monosomy X
Secondary amenorrhea, Premature ovarian insufficiency, Female infertility, Primary amenorrhea ORPHA:99226
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Meningocele ORPHA:1010
Phocomelia, Schinzel Type
Meningocele ORPHA:2879
Holoprosencephaly 7
Semilobar holoprosencephaly, Alobar holoprosencephaly, Hydrocephalus, Lobar holoprosencephaly, Oc... OMIM:610828
Neurofibromatosis, Type I
Hydrocephalus, Aqueductal stenosis, Spina bifida OMIM:162200
Orofaciodigital Syndrome Vi
Occipital meningocele OMIM:277170
Neu-Laxova Syndrome 1
Short umbilical cord, Stillbirth, Small placenta, Hydranencephaly, Spina bifida, Neonatal death OMIM:256520
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Spina bifida ORPHA:508498
Aicardi Syndrome
Spina bifida OMIM:304050
Campomelic Dysplasia
Hydrocephalus, Spinal dysraphism, Spina bifida OMIM:114290
Jacobsen Syndrome
Spina bifida ORPHA:2308
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Depression, Dementia, Memory impairment OMIM:604121
22Q11.2 Deletion Syndrome
Hydrocephalus, Umbilical hernia, Meningocele, Spina bifida ORPHA:567
Koolen-De Vries Syndrome Due To A Point Mutation
Hydrocephalus, Spina bifida ORPHA:363965
17Q21.31 Microdeletion Syndrome
Hydrocephalus, Spina bifida ORPHA:363958
Fanconi Anemia
Hydrocephalus, Umbilical hernia, Spina bifida ORPHA:84
Thrombocytopenia-Absent Radius Syndrome
Spina bifida OMIM:274000
Knobloch Syndrome 1
Occipital encephalocele, Occipital meningocele, Spina bifida occulta OMIM:267750
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Spina bifida OMIM:619480
Arima Syndrome
Occipital meningocele OMIM:243910
Cutis Laxa, Autosomal Recessive, Type Ib
Neonatal death, Spina bifida OMIM:614437
Vater/Vacterl Association
Occipital encephalocele, Patent urachus, Spina bifida OMIM:192350
Rubinstein-Taybi Syndrome 1
Spina bifida occulta, Spina bifida OMIM:180849
Holoprosencephaly 9
Hydrocephalus, Occipital meningocele, Holoprosencephaly, Alobar holoprosencephaly OMIM:610829
Marfan Syndrome
Meningocele ORPHA:558
Femoral-Facial Syndrome
Encephalocele, Spina bifida OMIM:134780
Otopalatodigital Syndrome, Type Ii
Hydrocephalus, Stillbirth, Spina bifida, Umbilical hernia OMIM:304120
Exstrophy-Epispadias Complex
Hydrocephalus, Spina bifida ORPHA:322
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Depression, Mental deterioration, Memory impairment ORPHA:314404
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Occipital meningocele OMIM:276820

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dnmt1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dnmt1.

No publications found that use IMPC mice or data for Dnmt1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Dnmt1tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Dnmt1tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Dnmt1tm2e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Dnmt1tm170606(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Dnmt1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Dnmt1em1(IMPC)Ccpcz Exon Deletion Mice

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