Gene Summary

Name:
distal-less homeobox 3
Synonyms:
Dlx-3

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal heart morphology Dlx3em1(IMPC)Mbp HET Early adult 0.00
increased circulating alkaline phosphatase level Dlx3em1(IMPC)Mbp HET Early adult 1.72×10-08
hemorrhage Dlx3em1(IMPC)Mbp HET E15.5 0.00
embryonic growth retardation Dlx3em1(IMPC)Mbp HET E15.5 0.00
small heart Dlx3em1(IMPC)Mbp HET Early adult 0.00
preweaning lethality, complete penetrance Dlx3em1(IMPC)Mbp HOM   Early adult 0.00
edema Dlx3em1(IMPC)Mbp HET E15.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

30 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

MicroCT E9.5

Embryo reconstruction

8 Images

Human diseases caused by Dlx3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dlx3 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Trichodentoosseous Syndrome
OMIM:190320
Tricho-Dento-Osseous Syndrome
ORPHA:3352
Amelogenesis Imperfecta, Type Iv
OMIM:104510

The table below shows human diseases predicted to be associated to Dlx3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Corneal Dystrophy, Fuchs Endothelial, 3
Edema OMIM:613267
Lipedema
Edema OMIM:614103
Pentosuria
Abnormal circulating carbohydrate concentration, Abnormality of circulating enzyme level ORPHA:2843
Angioedema, Hereditary, 6
Angioedema, Facial edema, Edema of the dorsum of hands OMIM:619363
Cardiomyopathy, Dilated, 1I
Elevated circulating creatine kinase concentration, Dilated cardiomyopathy, Cardiomegaly OMIM:604765
Pulmonary Edema Of Mountaineers, Susceptibility To
Pulmonary edema, Elevated pulmonary artery pressure, Edema OMIM:178400
Preeclampsia/Eclampsia 1
Hypertension, Intrauterine growth retardation, Edema OMIM:189800
Chilblain Lupus 2
Edema, Vasculitis OMIM:614415
Cardiomyopathy, Dilated, 3B
Dilated cardiomyopathy, Increased circulating creatine kinase MB isoform OMIM:302045
Lymphatic Malformation 11
Lymphedema, Pedal edema OMIM:619401
Lymphedema And Cerebral Arteriovenous Anomaly
Pulmonary arterial hypertension, Lymphedema OMIM:152900
Lymphatic Malformation 8
Nonimmune hydrops fetalis, Polyhydramnios, Pleural effusion, Generalized edema, Pericardial effusion OMIM:618773
Lymphatic Malformation 2
Lymphedema OMIM:611944
Lymphatic Malformation 7
Pulmonary edema, Facial edema, Nonimmune hydrops fetalis, Lymphedema, Edema, Pericardial effusion OMIM:617300
White Sponge Nevus 2
Edema OMIM:615785
Lymphangiectasia, Pulmonary, Congenital
Facial edema, Chylothorax, Mild postnatal growth retardation, Chylous ascites, Palpebral edema, N... OMIM:265300
Hennekam Lymphangiectasia-Lymphedema Syndrome 3
Polyhydramnios, Lymphedema, Facial edema, Edema OMIM:618154
Lymphatic Malformation 6
Facial edema, Chylothorax, Genital edema, Short stature, Nonimmune hydrops fetalis, Polyhydramnio... OMIM:616843
Deafness, Unilateral, With Delayed Endolymphatic Hydrops
Edema OMIM:612097
Aneurysm Of Sinus Of Valsalva
Edema, Aortic regurgitation, Congestive heart failure, Heart murmur ORPHA:1054
Trichodentoosseous Syndrome
OMIM:190320
Tricho-Dento-Osseous Syndrome
ORPHA:3352
Amelogenesis Imperfecta, Type Iv
OMIM:104510

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dlx3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dlx3.

No publications found that use IMPC mice or data for Dlx3.

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MGI Allele Allele Type Produced
Dlx3em1(IMPC)Mbp Exon Deletion Mice, Tissue
Dlx3tm69(L1L2_gt1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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