Gene: Dlx3 MGI:94903
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The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal heart morphology | Dlx3em1(IMPC)Mbp | HET | Early adult | 0.00 | ||
increased circulating alkaline phosphatase level | Dlx3em1(IMPC)Mbp | HET | Early adult | 1.72×10-08 | ||
hemorrhage | Dlx3em1(IMPC)Mbp | HET | E15.5 | 0.00 | ||
embryonic growth retardation | Dlx3em1(IMPC)Mbp | HET | E15.5 | 0.00 | ||
small heart | Dlx3em1(IMPC)Mbp | HET | Early adult | 0.00 | ||
preweaning lethality, complete penetrance | Dlx3em1(IMPC)Mbp | HOM | Early adult | 0.00 | ||
edema | Dlx3em1(IMPC)Mbp | HET | E15.5 | 0.00 |
Human diseases caused by Dlx3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Dlx3 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Trichodentoosseous Syndrome | OMIM:190320 | ||
Tricho-Dento-Osseous Syndrome | ORPHA:3352 | ||
Amelogenesis Imperfecta, Type Iv | OMIM:104510 |
The table below shows human diseases predicted to be associated to Dlx3 by phenotypic similarity.
Histopathology
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Dlx3
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MGI Allele | Allele Type | Produced |
---|---|---|
Dlx3em1(IMPC)Mbp | Exon Deletion | Mice, Tissue |
Dlx3tm69(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
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