Dlk1 | delta like non-canonical Notch ligand 1

GeneMGI:94900Synonyms: pref-1, DlkI, +5 more

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Mortality/aging

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:5Significant phenotypes
8Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased circulating glucose level1 supporting datasetDlk1em1(IMPC)WtsihomozygoteEarly adult8.85x10-6 
increased mean corpuscular hemoglobin1 supporting datasetDlk1em1(IMPC)WtsihomozygoteEarly adult9.51x10-5 
decreased lean body mass1 supporting datasetDlk1em1(IMPC)WtsihomozygoteEarly adult1.46x10-5 
preweaning lethality, incomplete penetrance1 supporting datasetDlk1em1(IMPC)WtsihomozygoteEarly adultN/A * 
increased total body fat amount1 supporting datasetDlk1em1(IMPC)WtsihomozygoteEarly adult6.59x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Dlk1em1(IMPC)WtsiDeletionmouse
Dlk1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Dlk1tm214456(L1L2_Bact_P)Reporter-tagged deletion allele (with selection cassette)targeting vector

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