Cyb5r3 | cytochrome b5 reductase 3
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Mortality/aging
16 No significant impact
5 Not tested
Data collections
Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
cataract | 1 supporting dataset | Cyb5r3tm1b(KOMP)Wtsi | heterozygote | Early adult | 4.64x10-6 | ||
decreased fasting circulating glucose level | 1 supporting dataset | Cyb5r3tm1b(KOMP)Wtsi | heterozygote | Early adult | 7.32x10-6 | ||
preweaning lethality, complete penetrance | 1 supporting dataset | Cyb5r3tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | |
adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
External links
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Cyb5r3tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Cyb5r3tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |