Cyb5r3 | cytochrome b5 reductase 3

GeneMGI:94893Synonyms: 2500002N19Rik, 0610016L08Rik, +2 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye Mortality/aging

16 No significant impact

5 Not tested

Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues

Phenotypes

cataract1 supporting datasetCyb5r3tm1b(KOMP)WtsiheterozygoteEarly adult4.64x10-6 
decreased fasting circulating glucose level1 supporting datasetCyb5r3tm1b(KOMP)WtsiheterozygoteEarly adult7.32x10-6 
preweaning lethality, complete penetrance1 supporting datasetCyb5r3tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoteSection images
100% (2/2)0.7% (4/570)
aortaheterozygoteSection images
100% (2/2)0.19% (1/533)
brainheterozygoteSection images
100% (2/2)0.86% (5/579)
brainstemheterozygoteSection images
100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoteSection images
100% (2/2)0.22% (1/454)
cerebellumheterozygoteSection images
100% (2/2)0.56% (3/532)
cerebral cortexheterozygoteSection images
100% (2/2)0.41% (2/491)
epididymisheterozygoteSection images
100% (1/1)87.5% (21/24)
esophagusheterozygoteSection images
100% (2/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Cyb5r3tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Cyb5r3tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse

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