Ppfibp2 | PTPRF interacting protein, binding protein 2 (liprin beta 2)
Physiological systems
20 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Digestive/alimentary Vision/eye Behavior/neurological Renal/urinary system
11 No significant impact
4 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged urinary bladder | 1 supporting dataset | Ppfibp2em1(IMPC)Tcp | homozygote | Late adult | N/A * | ||
| abnormal seminal vesicle morphology | 1 supporting dataset | Ppfibp2em1(IMPC)Tcp | homozygote | Late adult | N/A * | ||
| abnormal stomach morphology | 1 supporting dataset | Ppfibp2em1(IMPC)Tcp | homozygote | Late adult | N/A * | ||
| abnormal vocalization | 1 supporting dataset | Ppfibp2em1(IMPC)Tcp | homozygote | Late adult | 2.44x10-7 | ||
| thick skin | 1 supporting dataset | Ppfibp2em1(IMPC)Tcp | homozygote | Late adult | N/A * | ||
| enlarged lymph nodes | 1 supporting dataset | Ppfibp2em1(IMPC)Tcp | homozygote | Late adult | N/A * | ||
| enlarged lymph nodes | 1 supporting dataset | Ppfibp2em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| decreased grip strength | 2 supporting datasets | Ppfibp2em1(IMPC)Tcp | homozygote | Middle aged adult | 3.74x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Ppfibp2em1(IMPC)Tcp | homozygote | Late adult | 9.96x10-6 | ||
| decreased grip strength | 2 supporting datasets | Ppfibp2em1(IMPC)Tcp | homozygote | Late adult | 4.83x10-6 |
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Human diseases caused by Ppfibp2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Ppfibp2.
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| Ppfibp2em1(IMPC)Tcp | Exon Deletion | | mouse |
| Ppfibp2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Ppfibp2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ppfibp2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |