Gene: Cyp27a1

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cytochrome P450, family 27, subfamily a, polypeptide 1
cholesterol 27 hydroxylase Cyp27 1300013A03Rik
Embryo viewer
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Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased total body fat amount Cyp27a1tm1.1(KOMP)Vlcg HOM Early adult 1.67×10-06
improved glucose tolerance Cyp27a1tm1.1(KOMP)Vlcg HOM Early adult 2.01×10-05
enlarged heart Cyp27a1tm1.1(KOMP)Vlcg HOM Early adult 0.00
increased liver weight Cyp27a1tm1.1(KOMP)Vlcg HOM   Early adult 1.24×10-07
abnormal heart morphology Cyp27a1tm1.1(KOMP)Vlcg HOM Early adult 0.00
decreased circulating insulin level Cyp27a1tm1.1(KOMP)Vlcg HOM Early adult 1.24×10-19
decreased mean platelet volume Cyp27a1tm1.1(KOMP)Vlcg HOM Early adult 1.15×10-07
increased lean body mass Cyp27a1tm1.1(KOMP)Vlcg HOM Early adult 5.54×10-07
increased spleen weight Cyp27a1tm1.1(KOMP)Vlcg HOM   Early adult 2.46×10-05

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Select physiological systems to view:
Viewing: all phenotypes


IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 1 No  (4/583) N/A
Aorta 1 No  (1/583) N/A
Blood 1 No N/A
Bone marrow 1 No N/A
Brain 1 No  (4/583) N/A
Brainstem 1 No  (2/583) N/A
Brown adipose tissue 1 No N/A
Cartilage tissue 1 No  (1/583) N/A
Cecum 1 No  (12/371) N/A
Cerebellum 1 No  (3/583) N/A
Cerebral cortex 1 No  (2/583) N/A
Chest bone 1 No N/A
Colon 1 No  (12/127) N/A
Diaphragm 1 No N/A
Duodenum 1 No  (2/127) N/A
Epididymis 1 No  (18/132)  (1/1)  Section images
Esophagus 1 No  (7/407) N/A
Eye 1 No N/A
Gall bladder 1 No N/A
Gonadal fat pad 1 No N/A
Harderian gland 1 No N/A
Heart 1 No  (2/583) N/A
Hindlimb 1 No N/A
Hippocampus 1 No  (3/583) N/A
Hypothalamus 1 No  (2/583) N/A
Ileum 1 No  (14/127) N/A
Jejunum 1 No  (6/127) N/A
Kidney 1 No  (21/583)  (1/1)  Section images
Large intestine 1 No  (10/583) N/A
Liver 1 No N/A
Lower urinary tract 1 No  (1/583) N/A
Lung 1 No  (2/583) N/A
Lymph node 1 No  (1/583) N/A
Mammary gland 1 No N/A
Mesenteric adipose tissue 1 No N/A
Mesenteric lymph node 1 No N/A
Midbrain 1 No N/A
Olfactory lobe 1 No  (2/583) N/A
Ovary 1 No  (1/583) N/A
Oviduct 1 No N/A
Pancreas 1 No  (5/583) N/A
Parathyroid gland 1 No  (1/563) N/A
Parotid gland 1 No N/A
Penis 1 No N/A
Peripheral nervous system 1 No  (2/583) N/A
Peyer's patch 1 No N/A
Pituitary gland 1 No  (1/583) N/A
Prostate gland 1 No  (12/583)  (1/1)  Section images
Quadriceps 1 No N/A
Sciatic nerve 1 No N/A
Skeletal muscle 1 No N/A
Skin 1 No  (1/583) N/A
Small intestine 1 No  (9/583) N/A
Spinal cord 1 No  (3/583) N/A
Spleen 1 No  (3/583) N/A
Stomach 1 No  (13/583) N/A
Stomach pyloric region 1 No N/A
Striatum 1 No  (3/583) N/A
Sublingual gland 1 No N/A
Submandibular gland 1 No  (2/130) N/A
Testis 1 No  (6/583)  (1/1)  Section images
Thymus 1 No  (1/583) N/A
Thyroid gland 1 No  (17/583) N/A
Tongue 1 No  (5/127) N/A
Trachea 1 No  (3/583) N/A
Trigeminal V nerve 1 No N/A
Urinary bladder 1 No N/A
Uterus 1 No N/A
Vagina 1 No N/A
Vas deferens 1 No  (15/382) N/A
Vascular system 1 No N/A
Vesicular gland 1 No N/A
White adipose tissue 1 No N/A
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Adult LacZ: LacZ Images Section
7 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Cyp27a1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Cyp27a1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cyp27a1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells

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