Cyp27a1 | cytochrome P450, family 27, subfamily a, polypeptide 1
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Liver/biliary system Hematopoietic system Cardiovascular system
16 No significant impact
3 Not tested
Data collections
Gene metrics:12Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
decreased circulating triglyceride level | 1 supporting dataset | Cyp27a1tm1.1(KOMP)Vlcg | homozygote | Early adult | 7.23x10-6 | ||
increased circulating alkaline phosphatase level | 1 supporting dataset | Cyp27a1tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.78x10-18 | ||
improved glucose tolerance | 1 supporting dataset | Cyp27a1tm1.1(KOMP)Vlcg | homozygote | Early adult | 7.41x10-5 | ||
decreased mean platelet volume | 1 supporting dataset | Cyp27a1tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.9x10-5 | ||
decreased circulating serum albumin level | 1 supporting dataset | Cyp27a1tm1.1(KOMP)Vlcg | homozygote | Early adult | 9.85x10-5 | ||
decreased circulating HDL cholesterol level | 1 supporting dataset | Cyp27a1tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.31x10-5 | ||
increased liver weight | 1 supporting dataset | Cyp27a1tm1.1(KOMP)Vlcg | homozygote | Early adult | 0 | ||
shortened QRS complex duration | 1 supporting dataset | Cyp27a1tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.71x10-5 | ||
increased lean body mass | 1 supporting dataset | Cyp27a1tm1.1(KOMP)Vlcg | homozygote | Early adult | 8.15x10-5 | ||
prolonged RR interval | 1 supporting dataset | Cyp27a1tm1.1(KOMP)Vlcg | homozygote | Early adult | 4.17x10-5 |
| | | | | | | | | |
adrenal gland | heterozygote | n/a | 0% (0/1) | 0.7% (4/570) |
aorta | heterozygote | n/a | 0% (0/1) | 0.19% (1/533) |
blood | heterozygote | n/a | 0% (0/1) | 0% (0/17) |
bone marrow | heterozygote | n/a | 0% (0/1) | 0% (0/22) |
brain | heterozygote | n/a | 0% (0/1) | 0.86% (5/579) |
brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
brown adipose tissue | heterozygote | n/a | 0% (0/1) | 0% (0/588) |
cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
cerebellum | heterozygote | n/a | 0% (0/1) | 0.56% (3/532) |
External links
No external links available for Cyp27a1.
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Cyp27a1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
Cyp27a1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
Cyp27a1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
Cyp27a1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |