Cyp19a1 | cytochrome P450, family 19, subfamily a, polypeptide 1

GeneMGI:88587Synonyms: Ar, Int-5, +5 more

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological

13 No significant impact

5 Not tested

Gene metrics:19Significant phenotypes
4Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues

Phenotypes

abnormal gait1 supporting datasetCyp19a1tm1b(EUCOMM)HmguhomozygoteLate adult5.44x10-5 
increased circulating serum albumin level1 supporting datasetCyp19a1tm1b(EUCOMM)HmguhomozygoteEarly adult7.79x10-9 
decreased locomotor activity5 supporting datasetsCyp19a1tm1b(EUCOMM)HmguhomozygoteEarly adult4.33x10-5 
thrombocytosis1 supporting datasetCyp19a1tm1b(EUCOMM)HmguhomozygoteLate adult5.91x10-10 
increased neutrophil cell number2 supporting datasetsCyp19a1tm1b(EUCOMM)HmguhomozygoteLate adult1.28x10-6 
decreased locomotor activity8 supporting datasetsCyp19a1tm1b(EUCOMM)HmguhomozygoteLate adult9.1x10-15 
increased fasting circulating glucose level1 supporting datasetCyp19a1tm1b(EUCOMM)HmguhomozygoteLate adult3.67x10-6 
increased total body fat amount2 supporting datasetsCyp19a1tm1b(EUCOMM)HmguhomozygoteEarly adult5.61x10-6 
decreased mean corpuscular hemoglobin concentration1 supporting datasetCyp19a1tm1b(EUCOMM)HmguhomozygoteLate adult6.27x10-5 
tremors1 supporting datasetCyp19a1tm1b(EUCOMM)HmguhomozygoteLate adult7.32x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cyp19a1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Cyp19a1tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Cyp19a1tm1e(EUCOMM)HmguTargeted, non-conditional allelees cell

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