Cybb | cytochrome b-245, beta polypeptide
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Immune system Growth/size/body region Hematopoietic system
17 No significant impact
4 Not tested
Data collections
Gene metrics:2Significant phenotypes
4Associated diseases
Expression examined in:91Adult tissues
63Embryo tissues
| decreased mean corpuscular volume | 1 supporting dataset | Cybbtm2b(KOMP)Wtsi | homozygote | Early adult | 4.03x10-6 | ||
| increased spleen weight | 1 supporting dataset | Cybbtm2b(KOMP)Wtsi | homozygote | Early adult | 1.87x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/1) | 0.7% (4/570) |
| adrenal gland | hemizygote | n/a | 0% (0/1) | 0.7% (4/570) |
| aorta | hemizygote | n/a | 0% (0/1) | 0.19% (1/533) |
| aorta | heterozygote | n/a | 0% (0/1) | 0.19% (1/533) |
| bone | hemizygote | n/a | 0% (0/1) | 0% (0/394) |
| bone | heterozygote | n/a | 0% (0/1) | 0% (0/394) |
| brain | hemizygote | n/a | 0% (0/1) | 0.86% (5/579) |
| brain | heterozygote | n/a | 100% (1/1) | 0.86% (5/579) |
| brainstem | hemizygote | n/a | 0% (0/1) | 0.41% (2/490) |
| brainstem | heterozygote | n/a | 100% (1/1) | 0.41% (2/490) |
Human diseases caused by Cybb mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cybb.
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| Cybbtm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cybbtm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Cybbtm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cybbtm2b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |