Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
chymotrypsinogen B1
Synonyms:
Prt-2,  2200008D09Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ctrb1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ctrb1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Chylomicronemia, Familial, Due To Circulating Inhibitor Of Lipoprotein Lipase
Splenomegaly, Recurrent pancreatitis OMIM:118830
Chylous Ascites
Lymphedema, Ascites, Pancreatitis ORPHA:1160
Retinitis Pigmentosa 71
Edema, Pancreatitis OMIM:616394
Congenital Pancreatic Cyst
Jaundice, Pancreatitis ORPHA:313906
Lipase Deficiency, Combined
Pancreatitis OMIM:246650
Corneal Dystrophy, Fuchs Endothelial, 3
Edema OMIM:613267
Mahvash Disease
Pancreatic alpha-cell hyperplasia, Recurrent pancreatitis OMIM:619290
Pancreatitis, Hereditary
Exocrine pancreatic insufficiency, Pancreatic pseudocyst, Pleural effusion, Pancreatic calcificat... OMIM:167800
Citrullinemia, Type Ii, Adult-Onset
Hepatic steatosis, Hepatocellular carcinoma, Cerebral edema, Pancreatitis OMIM:603471
Familial Partial Lipodystrophy, Köbberling Type
Hepatomegaly, Hepatic steatosis, Pancreatitis, Polycystic ovaries ORPHA:79084
Cholestasis, Benign Recurrent Intrahepatic, 1
Hepatomegaly, Intermittent jaundice, Intrahepatic cholestasis with episodic jaundice, Pancreatitis OMIM:243300
Mitochondrial Complex I Deficiency, Nuclear Type 8
Pancreatitis OMIM:618230
Permanent Neonatal Diabetes Mellitus-Pancreatic And Cerebellar Agenesis Syndrome
Aplasia/Hypoplasia of the pancreas ORPHA:65288
Gallbladder Disease 1
Cholesterol gallstones, Cholelithiasis, Hepatic fibrosis, Jaundice, Cholangitis, Pancreatitis, Ch... OMIM:600803
Pancreatitis, Sclerosing Cholangitis, And Sicca Complex
Sclerosing cholangitis, Angular cheilitis, Hepatomegaly, Jaundice, Xerostomia, Keratoconjunctivit... OMIM:260480
Tropical Calcific Pancreatitis
Neoplasm of the pancreas, Pancreatic calcification, Chronic pancreatitis OMIM:608189
Pancreatic Agenesis 1
Pancreatic hypoplasia, Exocrine pancreatic insufficiency OMIM:260370
Benign Recurrent Intrahepatic Cholestasis
Cirrhosis, Hepatocellular carcinoma, Cholelithiasis, Jaundice, Cholestatic liver disease, Pancrea... ORPHA:65682
Pancreatic Agenesis 2
Pancreatic hypoplasia OMIM:615935
Maturity-Onset Diabetes Of The Young, Type 8, With Exocrine Dysfunction
Abnormality of exocrine pancreas physiology OMIM:609812
Hyperparathyroidism 2 With Jaw Tumors
Parathyroid carcinoma, Recurrent pancreatitis, Parathyroid adenoma, Hyperparathyroidism, Pancreat... OMIM:145001
Hereditary Chronic Pancreatitis
Jaundice, Pancreatic calcification, Recurrent pancreatitis ORPHA:676
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut-
Hepatomegaly, Dehydration, Pancreatitis, Splenomegaly ORPHA:79312
Duodenal Atresia
Polyhydramnios, Abnormality of the pancreas, Annular pancreas ORPHA:1203
Triokinase And Fmn Cyclase Deficiency Syndrome
Hepatomegaly, Hepatic steatosis, Pancreatitis OMIM:618805
Combined Oxidative Phosphorylation Deficiency 52
Hepatic steatosis, Adrenal insufficiency, Pancreatitis OMIM:619386
Systemic Capillary Leak Syndrome
Pericarditis, Pleural effusion, Pedal edema, Pulmonary edema, Pancreatitis, Myocarditis ORPHA:188
Vitamin B12-Unresponsive Methylmalonic Acidemia
Hepatomegaly, Dehydration, Pancreatitis ORPHA:27
Lipodystrophy, Familial Partial, Type 1
Hepatomegaly, Acute pancreatitis OMIM:608600
Methylmalonic Aciduria Due To Methylmalonyl-Coa Mutase Deficiency
Hepatomegaly, Dehydration, Tubulointerstitial nephritis, Pancreatitis OMIM:251000
Maple Syrup Urine Disease
Cerebral edema, Pancreatitis OMIM:248600
Adult Acute Respiratory Distress Syndrome
Pulmonary edema, Pneumonia, Pancreatitis ORPHA:70578
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut0
Hepatomegaly, Pancreatitis ORPHA:289916
Hypocalciuric Hypercalcemia, Familial, Type I
Parathyroid adenoma, Hyperparathyroidism, Pancreatitis OMIM:145980
Cluster Headache, Familial
Edema, Hyperhidrosis OMIM:119915
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Recurrent pneumonia, Lymphadenitis, Pleural effusion, Ulcerative colitis, Acute pancreatitis, Per... OMIM:618935
Lipodystrophy, Familial Partial, Type 7
Pancreatitis OMIM:606721
Campomelia, Cumming Type
Lymphedema, Pancreatic cysts, Polysplenia, Polycystic liver disease OMIM:211890
Apolipoprotein C-Ii Deficiency
Hepatomegaly, Pancreatitis, Splenomegaly OMIM:207750
Amyloidosis, Familial Visceral
Skin rash, Cholestasis, Hepatomegaly, Edema, Splenomegaly OMIM:105200
Cidec-Related Familial Partial Lipodystrophy
Hepatomegaly, Hepatic steatosis, Pancreatitis, Polycystic ovaries ORPHA:435651
Acute Lung Injury
Edema, Pneumonia, Acute pancreatitis ORPHA:178320
Marburg Hemorrhagic Fever
Jaundice, Skin rash, Pancreatitis ORPHA:99826
Cach Syndrome
Oligohydramnios, Optic neuritis, Pancreatitis, Hepatosplenomegaly, Premature ovarian insufficiency ORPHA:135
Beckwith-Wiedemann Syndrome
Cryptorchidism, Enlarged kidney, Hepatomegaly, Pancreatic hyperplasia, Cardiomegaly, Hepatoblastoma OMIM:130650
Rat-Bite Fever
Skin rash, Pustule, Endocarditis, Pericarditis, Lymphadenitis, Maculopapular exanthema, Septic ar... ORPHA:31205
Hypocalciuric Hypercalcemia, Familial, Type Ii
Primary hyperparathyroidism, Pancreatitis OMIM:145981
Propionic Acidemia
Hepatomegaly, Eczema, Dehydration, Pancreatitis OMIM:606054
Martinez-Frias Syndrome
Hypoplasia of the gallbladder, Pancreatic hypoplasia, Annular pancreas, Extrahepatic biliary duct... OMIM:601346
Familial Partial Lipodystrophy, Dunnigan Type
Hepatic steatosis, Polycystic ovaries, Hepatomegaly, Pancreatitis, Splenomegaly ORPHA:2348
Cryptosporidiosis
Cholangitis, Dehydration, Biliary tract abnormality, Pancreatitis ORPHA:1549
Microsporidiosis
Peritonitis, Thyroiditis, Pneumonia, Biliary tract abnormality, Abnormality of the parathyroid gl... ORPHA:2552
Microscopic Polyangiitis
Peritonitis, Skin rash, Pericarditis, Increased inflammatory response, Uveitis, Episcleritis, Pan... ORPHA:727
Matthew-Wood Syndrome
Cryptorchidism, Abnormal spleen morphology, Annular pancreas, Aplasia/Hypoplasia of the pancreas ORPHA:2470
Primary Lipodystrophy
Cirrhosis, Hepatic steatosis, Polycystic ovaries, Pancreatitis, Splenomegaly ORPHA:90970
Legionnaires Disease
Endocarditis, Pericarditis, Jaundice, Hepatitis, Encephalitis, Pancreatitis, Splenomegaly, Myocar... ORPHA:549
Annular Pancreas
Annular pancreas ORPHA:675
Pancreas, Annular
Annular pancreas OMIM:167750
Progressive Encephalopathy With Leukodystrophy Due To Decr Deficiency
Aspiration pneumonia, Pancreatitis ORPHA:431361
Pparg-Related Familial Partial Lipodystrophy
Cirrhosis, Hepatic steatosis, Polycystic ovaries, Hepatomegaly, Pancreatitis, Splenomegaly ORPHA:79083
Autosomal Erythropoietic Protoporphyria
Eczema, Cirrhosis, Edema, Cholelithiasis ORPHA:79278
Hyperlipoproteinemia, Type I
Jaundice, Hepatosplenomegaly, Pancreatitis, Splenomegaly OMIM:238600
Mitchell-Riley Syndrome
Annular pancreas, Biliary atresia, Cholestasis, Pancreatic hypoplasia, Absent gallbladder, Acholi... OMIM:615710
Protoporphyria, Erythropoietic, 1
Eczema, Edema, Cholelithiasis OMIM:177000
Primary Sclerosing Cholangitis
Cirrhosis, Thyroiditis, Hepatocellular carcinoma, Pleural effusion, Uveitis, Ulcerative colitis, ... ORPHA:171
Citrullinemia Type Ii
Hepatic steatosis, Hepatocellular carcinoma, Hepatic fibrosis, Hepatomegaly, Pancreatitis, Cerebr... ORPHA:247585
Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency
Hypothyroidism, Iridocyclitis, Pancreatitis ORPHA:412057
Mirizzi Syndrome
Gallbladder perforation, Cholesterol gallstones, Cholelithiasis, Jaundice, Abnormality of the duc... ORPHA:521219
Cystic Fibrosis
Recurrent pneumonia, Cirrhosis, Exocrine pancreatic insufficiency, Bronchiectasis, Biliary cirrho... OMIM:219700
Familial Mediterranean Fever
Peritonitis, Skin rash, Pericarditis, Pedal edema, Orchitis, Erysipelas, Ascites, Pancreatitis, S... ORPHA:342
Nephronophthisis-Like Nephropathy 1
Pancreatic cysts, Chronic pancreatitis OMIM:613159
Peripheral Primitive Neuroectodermal Tumor
Ovarian neoplasm, Jaundice, Ascites, Pancreatitis, Neoplasm of the pancreas ORPHA:370348
Hennekam Lymphangiectasia-Lymphedema Syndrome 3
Polyhydramnios, Hydrocele testis, Lymphedema, Facial edema, Edema OMIM:618154
Mccune-Albright Syndrome
Ovarian cyst, Hyperplasia of the Leydig cells, Elevated circulating growth hormone concentration,... ORPHA:562
Homocystinuria Due To Cystathionine Beta-Synthase Deficiency
Hepatic steatosis, Pancreatitis OMIM:236200
Familial Chylomicronemia Syndrome
Hepatic steatosis, Recurrent pancreatitis, Acute pancreatitis, Jaundice, Perianal abscess, Hepato... ORPHA:444490
Glycogen Storage Disease Iv
Polyhydramnios, Cirrhosis, Hydrops fetalis, Edema, Ascites, Portal hypertension, Hepatosplenomegaly OMIM:232500
Caroli Syndrome
Cirrhosis, Intrahepatic cholestasis, Hepatomegaly, Jaundice, Cholangitis, Congenital hepatic fibr... ORPHA:480520
Pancreatic insufficiency, combined exocrine
Anasarca, Exocrine pancreatic insufficiency OMIM:260450
Igg4-Related Kidney Disease
Chronic sinusitis, Abnormality of mesentery morphology, Prostatitis, Sialadenitis, Pericarditis, ... ORPHA:449395
African Iron Overload
Peritonitis, Micronodular cirrhosis, Increased circulating cortisol level, Viral hepatitis, Hepat... ORPHA:139507
Infantile Multisystem Neurologic-Endocrine-Pancreatic Disease
Exocrine pancreatic insufficiency, Hyperechogenic pancreas, Hypothyroidism, Hepatomegaly, Abnorma... ORPHA:456312
Lymphatic Malformation 7
Lymphedema, Pericardial effusion, Facial edema, Edema, Nonimmune hydrops fetalis, Pulmonary edema OMIM:617300
Acquired Generalized Lipodystrophy
Cirrhosis, Hepatic steatosis, Panniculitis, Acute pancreatitis, Hepatomegaly, Polycystic ovaries ORPHA:79086
Dysbetalipoproteinemia
Hepatic steatosis, Hypothyroidism, Acute pancreatitis, Hepatomegaly, Gout ORPHA:412
Pulmonary Edema Of Mountaineers, Susceptibility To
Edema, Pulmonary edema OMIM:178400
Lymphatic Malformation 8
Polyhydramnios, Pleural effusion, Pericardial effusion, Nonimmune hydrops fetalis, Generalized edema OMIM:618773
Hypocalciuric Hypercalcemia, Familial, Type Iii
Primary hyperparathyroidism, Pancreatitis OMIM:600740
Glycogen Storage Disease Ia
Enlarged kidney, Hepatocellular carcinoma, Hepatomegaly, Gout, Pancreatitis OMIM:232200
17Q12 Microdeletion Syndrome
Cryptorchidism, Pancreatic aplasia, Oligohydramnios ORPHA:261265
Lymphatic Malformation 6
Polyhydramnios, Hydrocele testis, Lymphedema, Hypothyroidism, Pleural effusion, Facial edema, Chy... OMIM:616843
Glycogen Storage Disease Ib
Enlarged kidney, Hepatocellular carcinoma, Hepatomegaly, Gout, Pancreatitis OMIM:232220
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Hepatic steatosis, Hypothyroidism, Jaundice, Arthritis, Abnormality of exocrine pancreas physiolo... ORPHA:93111
Coccidioidomycosis
Peritonitis, Skin rash, Osteomyelitis, Folliculitis, Pericarditis, Panniculitis, Exudative pleura... ORPHA:228123
Igg4-Related Ophthalmic Disease
Prostatitis, Enlarged lacrimal glands, Sialadenitis, Abnormality of the anterior pituitary, Palpe... ORPHA:449563
Visceral Myopathy 1
Polyhydramnios, Pancreatitis OMIM:155310
Schimke Immuno-Osseous Dysplasia
Abnormality of thyroid physiology, Minimal change glomerulonephritis, Pancreatitis ORPHA:1830
Cholestasis, Progressive Familial Intrahepatic, 5
Jaundice, Cirrhosis, Edema OMIM:617049
Diabetes Mellitus, Neonatal, With Congenital Hypothyroidism
Pancreatic cysts, Cholestasis, Hepatic fibrosis, Hepatomegaly, Hepatitis, Pancreatic hypoplasia, ... OMIM:610199
3-Hydroxy-3-Methylglutaric Aciduria
Acute pancreatitis, Hepatomegaly, Jaundice, Dehydration, Edema, Lipid accumulation in hepatocytes ORPHA:20
Behçet Disease
Endocarditis, Pericarditis, Increased inflammatory response, Retrobulbar optic neuritis, Pleural ... ORPHA:117
Idiopathic Hypereosinophilic Syndrome
Inflammatory abnormality of the skin, Joint swelling, Erythroderma, Pleural effusion, Colitis, An... ORPHA:3260
Zygomycosis
Peritonitis, Pustule, Nephritis, Endocarditis, Pericarditis, Enterocolitis, Splenic abscess, Pleu... ORPHA:73263
Autosomal Semi-Dominant Severe Lipodystrophic Laminopathy
Hepatic steatosis, Polycystic ovaries, Hepatomegaly, Pancreatitis, Splenomegaly ORPHA:280365
Igg4-Related Pachymeningitis
Lymphadenitis, Pancreatitis, Sinusitis, Nephritis, Parotitis ORPHA:449427
Primary Parathyroid Hyperplasia
Parathyroid hyperplasia, Primary hyperparathyroidism, Pancreatitis ORPHA:99878
Proteasome-Associated Autoinflammatory Syndrome 4
Panniculitis, Hepatomegaly, Edema, Splenomegaly, Myositis OMIM:619183
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib
Inflammation of the large intestine, Enlarged kidney, Hepatocellular adenoma, Hepatocellular carc... ORPHA:79259
Shiga Toxin-Associated Hemolytic Uremic Syndrome
Peritonitis, Dehydration, Acute colitis, Pancreatitis ORPHA:90038
Multiple Acyl-Coa Dehydrogenase Deficiency
Hepatomegaly, Acute pancreatitis, Hepatic periportal necrosis ORPHA:26791
Infection-Related Hemolytic Uremic Syndrome
Acute colitis, Pneumonia, Septic arthritis, Pleural empyema, Edema, Pancreatitis, Myocarditis, Ge... ORPHA:544482
Pauci-Immune Glomerulonephritis
Scleritis, Arteritis, Glomerulonephritis, Tubulointerstitial nephritis, Pancreatitis, Crescentic ... ORPHA:93126
Granulomatosis With Polyangiitis
Prostatitis, Skin rash, Pericarditis, Increased inflammatory response, Chronic otitis media, Infl... ORPHA:900
Lymphangiectasia, Pulmonary, Congenital
Polyhydramnios, Palpebral edema, Pleural effusion, Pedal edema, Facial edema, Edema, Ascites, Non... OMIM:265300
Triglyceride Deposit Cardiomyovasculopathy
Hepatomegaly, Inflammatory abnormality of the skin, Pancreatitis, Splenomegaly ORPHA:565612
Multiple Endocrine Neoplasia Type 4
Parathyroid hyperplasia, Parathyroid carcinoma, Abnormality of pancreas physiology, Pituitary gro... ORPHA:276152
Hyperparathyroidism-Jaw Tumor Syndrome
Abnormality of the parathyroid morphology, Primary hyperparathyroidism, Pancreatitis, Testicular ... ORPHA:99880
Familial Adenomatous Polyposis
Goiter, Thyroiditis, Hypothyroidism, Biliary tract obstruction, Pancreatitis, Neoplasm of the gal... ORPHA:733
Parathyroid Carcinoma
Parathyroid carcinoma, Abnormality of the parathyroid morphology, Primary hyperparathyroidism, Pa... ORPHA:143
Lipodystrophy, Familial Partial, Type 2
Hepatomegaly, Acute pancreatitis, Hepatic steatosis, Polycystic ovaries OMIM:151660
Seckel Syndrome 10
Hepatic steatosis, Elevated circulating follicle stimulating hormone level, Elevated circulating ... OMIM:617253
Lysinuric Protein Intolerance
Hepatomegaly, Pancreatitis, Splenomegaly OMIM:222700
Glycogen Storage Disease Ic
Chronic pancreatitis, Hepatocellular carcinoma, Hepatomegaly, Gout, Hepatoblastoma OMIM:232240
Stevens-Johnson Syndrome
Conjunctivitis, Pancreatitis ORPHA:36426
Dextrocardia
Abnormality of the spleen, Pancreatic hypoplasia, Abnormality of abdominal situs ORPHA:1666
Mody
Hepatocellular adenoma, Pancreatic hypoplasia, Exocrine pancreatic insufficiency ORPHA:552
Lipodystrophy, Congenital Generalized, Type 1
Cirrhosis, Hepatic steatosis, Acute pancreatitis, Hepatomegaly, Polycystic ovaries, Splenomegaly OMIM:608594
Toxic Epidermal Necrolysis
Conjunctivitis, Pancreatitis ORPHA:537
Pancreatic And Cerebellar Agenesis
Pancreatic hypoplasia OMIM:609069
Isolated Permanent Neonatal Diabetes Mellitus
Dehydration, Pancreatic hypoplasia, Reduced pancreatic beta cells ORPHA:99885
Melas
Hypothyroidism, Hypoparathyroidism, Recurrent pancreatitis ORPHA:550
Lipodystrophy, Congenital Generalized, Type 2
Cirrhosis, Hepatic steatosis, Acute pancreatitis, Hepatomegaly, Polycystic ovaries, Splenomegaly OMIM:269700
Familial Hypocalciuric Hypercalcemia
Pancreatitis ORPHA:405
Scorpion Envenomation
Acute pancreatitis, Hyperhidrosis, Pulmonary edema, Edema, Myocarditis ORPHA:466677
Igg4-Related Submandibular Gland Disease
Prostatitis, Enlarged lacrimal glands, Sialadenitis, Abnormal salivary gland morphology, Facial e... ORPHA:449432
Pancreatic Hypoplasia-Diabetes-Congenital Heart Disease Syndrome
Exocrine pancreatic insufficiency, Oligohydramnios, Aplasia/Hypoplasia of the gallbladder, Biliar... ORPHA:2255
Lysinuric Protein Intolerance
Cirrhosis, Membranous nephropathy, Hepatomegaly, Glomerulonephritis, Tubulointerstitial nephritis... ORPHA:470
Pancreatic Agenesis-Holoprosencephaly Syndrome
Absent gallbladder, Pancreatic aplasia ORPHA:556955
Neutral Lipid Storage Myopathy
Chronic pancreatitis, Hepatic steatosis, Hepatomegaly, Cholecystitis, Pineal cyst ORPHA:98908
Histiocytosis-Lymphadenopathy Plus Syndrome
Hepatomegaly, Pancreatic hypoplasia, Episcleritis, Cardiomegaly, Splenomegaly, Retroperitoneal fi... OMIM:602782
Shwachman-Diamond Syndrome
Skin rash, Exocrine pancreatic insufficiency, Pneumonia, Hypopituitarism, Hepatomegaly, Pancreati... ORPHA:811
Renal Cysts And Diabetes Syndrome
Gout, Pancreatic hypoplasia, Exocrine pancreatic insufficiency, Biliary tract abnormality OMIM:137920
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Cryptorchidism, Seborrheic dermatitis, Superficial dermal perivascular inflammatory infiltrate, B... ORPHA:83617
Alström Syndrome
Decreased circulating T4 level, Elevated circulating thyroid-stimulating hormone concentration, A... ORPHA:64
Heart Defects, Congenital, And Other Congenital Anomalies
Absent gallbladder, Pancreatic hypoplasia, Biliary atresia OMIM:600001

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ctrb1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ctrb1.

No publications found that use IMPC mice or data for Ctrb1.

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MGI Allele Allele Type Produced
Ctrb1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ctrb1tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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