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Genes Phenotypes

Gene: Csk

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Name
c-src tyrosine kinase
MGI ID
MGI:88537
Synonyms
N/A
Viability
Homozygous - Lethal
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (9) Measurements chart (211) All data table (577)
Expression & images (112) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Csktm2b(EUCOMM)Hmgu HOM Early adult 0.00
abnormal embryo size Csktm2b(EUCOMM)Hmgu HOM E9.5 0.00
abnormal retinal inner nuclear layer morphology Csktm2b(EUCOMM)Hmgu HET Early adult 4.80×10-13
abnormal embryo size Csktm2b(EUCOMM)Hmgu HET E9.5 0.00
abnormal retinal vasculature morphology Csktm2b(EUCOMM)Hmgu HET Early adult 5.85×10-06
abnormal neural tube closure Csktm2b(EUCOMM)Hmgu HOM E9.5 0.00
embryonic lethality prior to tooth bud stage Csktm2b(EUCOMM)Hmgu HOM E12.5 0.00
decreased total retina thickness Csktm2b(EUCOMM)Hmgu HET Early adult 1.87×10-08
abnormal embryo turning Csktm2b(EUCOMM)Hmgu HOM E9.5 0.00

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Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590)  (2/2)  Wholemount images
Aorta 2 No  (1/590)  (2/2) N/A
Bone 2 No  (2/2) N/A
Brain 2 No  (3/590)  (2/2)  Wholemount images
Brainstem 2 No  (2/590)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2) N/A
Cerebellum 2 No  (3/590)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/590)  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No N/A
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (1/590)  (2/2) N/A
Hippocampus 2 No  (3/590)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/590)  (2/2)  Wholemount images
Kidney 2 No  (20/590)  (2/2)  Wholemount images
Large intestine 2 No  (10/590)  (2/2)  Wholemount images
Liver 2 No  (2/2)  Wholemount images
Lower urinary tract 2 No  (1/590)  (2/2)  Wholemount images
Lung 2 No  (1/590)  (2/2) N/A
Lymph node 2 No  (2/2) N/A
Mammary gland 2 No N/A
Mesenteric lymph node 2 No  (2/2) N/A
Olfactory lobe 2 No  (2/590)  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/590)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/590)  (2/2) N/A
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (1/590)  (2/2) N/A
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (1/590)  (1/2) N/A
Prostate gland 2 No  (12/590)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/590)  (2/2)  Wholemount images
Spinal cord 2 No  (2/590)  (2/2)  Wholemount images
Spleen 2 No  (2/590)  (2/2) N/A
Stomach 2 No  (13/590)  (2/2)  Wholemount images
Striatum 2 No  (3/590)  (2/2)  Wholemount images
Testis 2 No  (5/590)  (1/2) N/A
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (16/590)  (2/2)  Wholemount images
Trachea 2 No  (2/590)  (2/2)  Wholemount images
Trigeminal V nerve 2 No  (2/2) N/A
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
Vas deferens 2 No  (15/388)  (1/2)  Wholemount images
Vascular system 2 No  (2/2) N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
Unassigned Top Level MA (14)
digestive system (4)
Large Intestine expression
Large Intestine expression
MA:0000333
endocrine system (2)
Adrenal gland expression
Adrenal gland expression
MA:0000116
exocrine system (1)
Lower Urinary Tract expression
Lower Urinary Tract expression
Prostate gland expression
Prostate gland expression
Vas Deferens expression
Vas Deferens expression
MA:0002636
MA:0000413
MA:0000404
immune system (2)
Small Intestine expression
Small Intestine expression
Peyers Patch expression
Peyers Patch expression
MA:0000137
MA:0000337
nervous system (3)
Brain expression
Brain expression
Brain expression
Brain expression
Brain expression
Brain expression
Brain expression
Brainstem expression
Brainstem expression
Cerebral Cortex expression
Cerebral Cortex expression
Cerebellum expression
Cerebellum expression
Hippocampus expression
Hippocampus expression
Hypothalamus expression
Hypothalamus expression
Olfactory Lobe expression
Olfactory Lobe expression
Striatum expression
Striatum expression
MA:0000191
MA:0000169
MA:0000198
MA:0000891
MA:0000168
MA:0002413
MA:0000185
MA:0000173
postnatal mouse (12)
Adrenal gland expression
Adrenal gland expression
MA:0000116
reproductive system (1)
Lower Urinary Tract expression
Lower Urinary Tract expression
Prostate gland expression
Prostate gland expression
Vas Deferens expression
Vas Deferens expression
MA:0002636
MA:0000413
MA:0000404
respiratory system (1)
Trachea expression
Trachea expression
Thyroid gland expression
Thyroid gland expression
Parathyroid gland expression
Parathyroid gland expression
MA:0000128
MA:0000441
MA:0000129
trunk (10)
Adrenal gland expression
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/61)  (2/2) N/A
Axial skeleton 2  (1/65)  (2/2) N/A
Brain 2  (6/506)  (2/2) N/A
Central nervous system ganglion 2  (1/74)  (2/2) N/A
Cranium 2  (1/65)  (2/2) N/A
Dorsal root ganglion 2  (1/61)  (2/2) N/A
Ear 2  (1/506)  (2/2) N/A
Embryo 2  (1/507)  (2/2) N/A
Outer ear 2  (1/72)  (2/2) N/A
Eye 2  (1/506)  (2/2) N/A
Femur pre-cartilage condensation 2  (1/56)  (2/2) N/A
Foot 2  (1/506)  (2/2) N/A
Forearm 2  (1/303)  (2/2) N/A
Forebrain 2  (1/506)  (2/2) N/A
Forelimb 2  (1/506)  (2/2) N/A
Fronto-nasal process 2  (1/62)  (2/2) N/A
Gut 2  (1/60)  (2/2) N/A
Hand 2  (1/506)  (2/2) N/A
Head 2  (5/506)  (2/2) N/A
Head mesenchyme 2  (1/61)  (2/2) N/A
Heart 2  (1/506)  (2/2) N/A
Heart ventricle 2  (1/61)  (2/2) N/A
Hindbrain 2  (6/506)  (2/2) N/A
Hindlimb 2  (1/506)  (2/2) N/A
Humerus pre-cartilage condensation 2  (1/65)  (2/2) N/A
Inner ear 2  (1/65)  (2/2) N/A
Intestine 2  (1/59)  (2/2) N/A
Liver 2  (1/504)  (2/2) N/A
Lower leg 2  (1/303)  (2/2) N/A
Lung 2  (1/504)  (2/2) N/A
Mandibular process 2  (1/506)  (2/2) N/A
Maxillary process 2  (1/506)  (2/2) N/A
Mesonephros of female 2  (1/56)  (1/2) N/A
Mesonephros of male 2  (1/56)  (1/2) N/A
Metanephros 2  (1/56)  (2/2) N/A
Midbrain 2  (1/506)  (2/2) N/A
Nasal septum 2  (1/61)  (2/2) N/A
Nose 2  (1/76)  (2/2) N/A
Notochord 2  (1/61)  (2/2) N/A
Oral cavity 2  (1/504)  (2/2) N/A
Outflow tract 2  (1/61)  (2/2) N/A
Pancreas 2  (1/56)  (2/2) N/A
Pericardium 2  (1/56)  (2/2) N/A
Pharynx 2  (1/57)  (2/2) N/A
Radius-ulna pre-cartilage condensation 2  (1/65)  (2/2) N/A
Rib pre-cartilage condensation 2  (1/58)  (2/2) N/A
Skeleton 2  (1/76)  (2/2) N/A
Skin 2  (1/506)  (2/2) N/A
Spinal cord 2  (1/73)  (2/2) N/A
Stomach 2  (1/56)  (2/2) N/A
Tail 2  (1/506)  (2/2) N/A
Tail somite 2  (1/506)  (2/2) N/A
Thoracic vertebral cartilage condensation 2  (1/56)  (2/2) N/A
Tongue 2  (1/56)  (2/2) N/A
Trachea 2  (1/60)  (2/2) N/A
Trunk mesenchyme 2  (1/61)  (2/2) N/A
Umbilical artery embryonic part 2  (1/61)  (2/2) N/A
Umbilical vein embryonic part 2  (1/61)  (2/2) N/A
Upper arm 2  (1/303)  (2/2) N/A
Upper leg 2  (1/303)  (2/2) N/A
Urinary system 2  (1/60)  (2/2) N/A
Vibrissa 2  (1/72)  (2/2) N/A

 Associated Images

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Eye Morphology: VIP of right fundus
15 Images
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X-ray: XRay Images Forepaw
12 Images
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Eye Morphology: VIP of left eye
15 Images
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Eye Morphology: VIP of right eye
15 Images
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Eye Morphology: VIP of left fundus
15 Images
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Adult LacZ: LacZ Images Wholemount
26 Images
thumbnail
Embryo LacZ: LacZ images wholemount
4 Images
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X-ray: XRay Images Whole Body Dorso Ventral
12 Images
thumbnail
X-ray: XRay Images Skull Lateral Orientation
12 Images
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X-ray: XRay Images Whole Body Lateral Orientation
12 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Csktm2b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Csktm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Csktm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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