Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
cAMP responsive element binding protein 1
Synonyms:
2310001E10Rik,  Creb,  3526402H21Rik,  Creb-1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Creb1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Creb1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Histiocytoma, Angiomatoid Fibrous
OMIM:612160

The table below shows human diseases predicted to be associated to Creb1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Photoparoxysmal Response 1
EEG with photoparoxysmal response OMIM:132100
Electroencephalographic Peculiarity: 14 And 6 Per Sec. Positive Spike Phenomenon
EEG abnormality OMIM:130200
Electroencephalographic Peculiarity: Fronto-Precentral Beta Wave Groups
EEG abnormality OMIM:130300
Pulmonary Hypoplasia, Primary
Neonatal death, Pulmonary hypoplasia OMIM:265430
Renal Hypodysplasia/Aplasia 2
Pulmonary hypoplasia OMIM:615721
Disseminated Sclerosis With Narcolepsy
Narcolepsy OMIM:223300
Lethal Congenital Contracture Syndrome 11
Pulmonary hypoplasia OMIM:617194
Thymic Aplasia With Fetal Death
Stillbirth, Pulmonary hypoplasia OMIM:274210
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 4
Pulmonary hypoplasia OMIM:615228
Combined Oxidative Phosphorylation Deficiency 8
Pulmonary hypoplasia OMIM:614096
Hydrops Fetalis, Nonimmune, With Gracile Bones And Dysmorphism
Pulmonary hypoplasia OMIM:613124
Larsen-Like Syndrome, Lethal Type
Neonatal death, Pulmonary hypoplasia OMIM:245650
Mitochondrial Complex I Deficiency, Nuclear Type 35
Neonatal death, Intrauterine growth retardation, Pulmonary hypoplasia OMIM:619003
Hydrocephalus With Associated Malformations
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:236640
Mesomelic Dwarfism-Cleft Palate-Camptodactyly Syndrome
Abnormal lung lobation, Pulmonary hypoplasia ORPHA:2631
Spondylospinal Thoracic Dysostosis
Pulmonary hypoplasia OMIM:601809
Nphp3-Related Meckel-Like Syndrome
Pulmonary hypoplasia ORPHA:3032
Neurodevelopmental Disorder With Spasticity, Hypomyelinating Leukodystrophy, And Brain Abnormalities
Pulmonary hypoplasia OMIM:616531
Renal Tubular Dysgenesis
Pulmonary hypoplasia ORPHA:3033
Dyssegmental Dysplasia, Silverman-Handmaker Type
Neonatal death, Pulmonary hypoplasia OMIM:224410
Lethal Congenital Contracture Syndrome 1
Neonatal death, Pulmonary hypoplasia OMIM:253310
Microphthalmia, Syndromic 12
Pulmonary hypoplasia OMIM:615524
Progressive Supranuclear Palsy
Cognitive impairment, Memory impairment, Dementia, Bradykinesia, Abnormal synaptic transmission, ... ORPHA:683
Aphalangy With Hemivertebrae
Pulmonary hypoplasia OMIM:207620
Diaphragmatic Defect-Limb Deficiency-Skull Defect Syndrome
Pulmonary hypoplasia ORPHA:2141
Congenital Diaphragmatic Hernia
Pulmonary hypoplasia ORPHA:2140
Coenzyme Q10 Deficiency, Primary, 8
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:616733
Lissencephaly Type Iii And Bone Dysplasia
Pulmonary hypoplasia OMIM:601160
Diaphragmatic Defects, Limb Deficiencies, And Ossification Defects Of Skull
Pulmonary hypoplasia OMIM:601163
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly
Neonatal death, Stillbirth, Pulmonary hypoplasia OMIM:236500
Atelosteogenesis, Type Ii
Stillbirth, Pulmonary hypoplasia OMIM:256050
Narcolepsy 3
Narcolepsy OMIM:609039
Narcolepsy 1
Narcolepsy OMIM:161400
Arthrogryposis Multiplex Congenita 1, Neurogenic, With Myelin Defect
Pulmonary hypoplasia OMIM:617468
Renal-Hepatic-Pancreatic Dysplasia 2
Stillbirth, Pulmonary hypoplasia OMIM:615415
Pallister-Hall-Like Syndrome
Pulmonary hypoplasia OMIM:241800
Spinal Muscular Atrophy With Congenital Bone Fractures 2
Pulmonary hypoplasia OMIM:616867
Achondrogenesis Type 2
Pulmonary hypoplasia ORPHA:93296
Narcolepsy 7
Narcolepsy OMIM:614250
Minicore Myopathy With External Ophthalmoplegia
Recurrent respiratory infections, Pulmonary hypoplasia OMIM:255320
Renal Tubular Dysgenesis
Pulmonary hypoplasia OMIM:267430
Matthew-Wood Syndrome
Abnormal lung morphology, Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:2470
Primary Pulmonary Hypoplasia
Intrauterine growth retardation, Recurrent respiratory infections, Pneumothorax, Abnormal pulmona... ORPHA:2257
Lethal Congenital Contracture Syndrome Type 1
Pulmonary hypoplasia ORPHA:1486
Thanatophoric Dysplasia
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:2655
Growth Delay-Hydrocephaly-Lung Hypoplasia Syndrome
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:3035
46,Xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs
Pulmonary hypoplasia, Intrauterine growth retardation, Bilateral lung agenesis, Pulmonary artery ... OMIM:611812
Serkal Syndrome
Pulmonary hypoplasia ORPHA:139466
Intellectual Developmental Disorder With Cardiac Defects And Dysmorphic Facies
Pulmonary artery atresia, Pulmonary hypoplasia OMIM:618316
Tonne-Kalscheuer Syndrome
Pulmonary hypoplasia OMIM:300978
Multiple Pterygium Syndrome, X-Linked
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:312150
Gillessen-Kaesbach-Nishimura Syndrome
Abnormal lung lobation, Pulmonary hypoplasia OMIM:263210
Fetal Akinesia Deformation Sequence
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:994
Multiple Pterygium Syndrome, Lethal Type
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:253290
Renal Hypodysplasia/Aplasia 1
Pulmonary hypoplasia OMIM:191830
Lissencephaly Type 3-Metacarpal Bone Dysplasia Syndrome
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:86822
Alg3-Cdg
Pulmonary hypoplasia ORPHA:79321
Pericardial And Diaphragmatic Defect
Pulmonary hypoplasia, Pulmonary sequestration ORPHA:2847
Nephronophthisis 2
Pulmonary hypoplasia OMIM:602088
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease
Neonatal death, Pulmonary hypoplasia OMIM:263200
Short-Rib Thoracic Dysplasia 19 With Or Without Polydactyly
Pulmonary hypoplasia OMIM:617895
Lethal Congenital Contracture Syndrome 10
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:617022
Odontochondrodysplasia 1
Recurrent respiratory infections, Pulmonary hypoplasia OMIM:184260
Osteochondrodysplasia, Complex Lethal, Symoens-Barnes-Gistelinck Type
Intrauterine growth retardation, Pleural effusion, Pulmonary hypoplasia OMIM:616897
Platyspondylic Dysplasia, Torrance Type
Pulmonary hypoplasia ORPHA:85166
1Q41Q42 Microdeletion Syndrome
Pulmonary hypoplasia ORPHA:250999
Microcephaly-Micromelia Syndrome
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:251230
Multiple Acyl-Coa Dehydrogenase Deficiency
Neonatal death, Pulmonary hypoplasia OMIM:231680
Maternal Uniparental Disomy Of Chromosome 2
Intrauterine growth retardation, Pulmonary hypoplasia, Respiratory infections in early life ORPHA:96179
Severe Congenital Nemaline Myopathy
Pulmonary hypoplasia ORPHA:171430
Scimitar Syndrome
Bronchogenic cyst, Pulmonary artery hypoplasia, Partial anomalous pulmonary venous return, Recurr... ORPHA:185
Marden-Walker Syndrome
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:248700
Meacham Syndrome
Stillbirth, Scimitar anomaly, Partial anomalous pulmonary venous return, Neonatal death, Congenit... OMIM:608978
Agnathia-Otocephaly Complex
Pulmonary hypoplasia OMIM:202650
Microphthalmia, Syndromic 9
Agenesis of pulmonary vessels, Intrauterine growth retardation, Bilateral lung agenesis, Pulmonar... OMIM:601186
Diaphanospondylodysostosis
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:608022
Meckel Syndrome, Type 6
Bilobed right lung, Pulmonary hypoplasia OMIM:612284
Acro-Renal-Mandibular Syndrome
Abnormal lung lobation, Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:958
Renal Dysplasia-Limb Defects Syndrome
Neonatal death, Intrauterine growth retardation, Pneumothorax, Pulmonary hypoplasia OMIM:266910
Gaucher Disease, Perinatal Lethal
Neonatal death, Intrauterine growth retardation, Pulmonary hypoplasia OMIM:608013
Congenital Hemidysplasia With Ichthyosiform Erythroderma And Limb Defects
Mild intrauterine growth retardation, Stillbirth, Pulmonary hypoplasia OMIM:308050
Kagami-Ogata Syndrome
Pulmonary hypoplasia OMIM:608149
Caudal Regression Syndrome
Pulmonary hypoplasia ORPHA:3027
Tetrasomy 5P
Recurrent respiratory infections, Pulmonary hypoplasia ORPHA:3309
Short-Rib Thoracic Dysplasia 7 With Or Without Polydactyly
Pulmonary hypoplasia OMIM:614091
Czeizel-Losonci Syndrome
Pulmonary hypoplasia ORPHA:2437
Spinal Muscular Atrophy With Congenital Bone Fractures 1
Pulmonary hypoplasia OMIM:616866
Gastrointestinal Defects And Immunodeficiency Syndrome 2
Pulmonary hypoplasia, Interstitial emphysema, Bronchiectasis OMIM:619708
Lethal Congenital Contracture Syndrome 9
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:616503
Renal Agenesis, Bilateral
Pulmonary hypoplasia ORPHA:1848
Cutis Laxa, Autosomal Recessive, Type Ic
Emphysema, Pulmonary artery stenosis, Pulmonary hypoplasia OMIM:613177
Acrocephalopolydactylous Dysplasia
Extrapulmonary sequestrum, Pulmonary hypoplasia OMIM:200995
Abnormal Origin Of Right Or Left Pulmonary Artery From The Aorta
Anomalous origin of right pulmonary artery from ascending aorta, Aortopulmonary window, Recurrent... ORPHA:99050
Distal Tetrasomy 15Q
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:314588
Short-Rib Thoracic Dysplasia 8 With Or Without Polydactyly
Pulmonary hypoplasia OMIM:615503
Teebi Hypertelorism Syndrome 1
Pulmonary hypoplasia OMIM:145420
Atelosteogenesis Type I
Pulmonary hypoplasia ORPHA:1190
Oligomeganephronia
Pulmonary hypoplasia, Pulmonary venous occlusion ORPHA:2260
Congenital Tracheomalacia
Emphysema, Recurrent upper respiratory tract infections, Pneumonia, Partial anomalous pulmonary v... ORPHA:95430
Stuve-Wiedemann Syndrome 1
Pulmonary arterial medial hypertrophy, Pulmonary hypoplasia OMIM:601559
Myopathy, Congenital, With Diaphragmatic Defects, Respiratory Insufficiency, And Dysmorphic Facies
Respiratory tract infection, Pulmonary hypoplasia OMIM:618975
Renal Agenesis
Pulmonary hypoplasia ORPHA:411709
Thoracoabdominal Syndrome
Pulmonary hypoplasia OMIM:313850
Genitopatellar Syndrome
Pulmonary hypoplasia ORPHA:85201
Raine Syndrome
Neonatal death, Pulmonary hypoplasia OMIM:259775
Chromosome 13Q33-Q34 Deletion Syndrome
Pulmonary hypoplasia OMIM:619148
Mosaic Trisomy 1
Pulmonary artery atresia, Pulmonary hypoplasia ORPHA:1692
Pentalogy Of Cantrell
Pulmonary hypoplasia ORPHA:1335
Joubert Syndrome 21
Pulmonary hypoplasia OMIM:615636
Truncus Arteriosus
Intrauterine growth retardation, Pulmonary artery hypoplasia, Pulmonary artery atresia, Pulmonary... ORPHA:3384
Mosaic Trisomy 16
Abnormal lung morphology, Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:1708
Autosomal Recessive Multiple Pterygium Syndrome
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:2990
Short-Rib Thoracic Dysplasia 12
Neonatal death, Intrauterine growth retardation, Pulmonary hypoplasia OMIM:269860
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Pulmonary hypoplasia OMIM:616546
Neu-Laxova Syndrome
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:2671
Meier-Gorlin Syndrome 7
Pulmonary hypoplasia OMIM:617063
Dyssegmental Dysplasia, Silverman-Handmaker Type
Pulmonary hypoplasia ORPHA:1865
Vacterl With Hydrocephalus
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:3412
Renal-Hepatic-Pancreatic Dysplasia 1
Pulmonary hypoplasia OMIM:208540
Pagod Syndrome
Pulmonary hypoplasia, Abnormality of the pulmonary artery, Pulmonary artery hypoplasia ORPHA:991
Short-Rib Thoracic Dysplasia 13 With Or Without Polydactyly
Pulmonary hypoplasia OMIM:616300
Fryns Syndrome
Pulmonary hypoplasia ORPHA:2059
Peroxisome Biogenesis Disorder 1A (Zellweger)
Pulmonary hypoplasia OMIM:214100
Short-Rib Thoracic Dysplasia 20 With Polydactyly
Neonatal death, Pulmonary hypoplasia OMIM:617925
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 1
Pulmonary hypoplasia OMIM:614080
Atelosteogenesis Type Ii
Pulmonary hypoplasia ORPHA:56304
Greenberg Dysplasia
Abnormal lung lobation, Neonatal death, Stillbirth, Pulmonary hypoplasia OMIM:215140
Spondylocostal Dysostosis With Anal Atresia And Urogenital Anomalies
Pulmonary hypoplasia OMIM:271520
Absence Of The Pulmonary Artery
Recurrent pneumonia, Bronchiectasis, Recurrent respiratory infections, Pulmonary hypoplasia, Pulm... ORPHA:980
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 2
Pulmonary hypoplasia OMIM:619351
Tarp Syndrome
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:2886
Multiple Pterygium Syndrome, Escobar Variant
Pulmonary hypoplasia OMIM:265000
Short-Rib Thoracic Dysplasia 1 With Or Without Polydactyly
Recurrent respiratory infections, Pulmonary hypoplasia OMIM:208500
Fetal Akinesia Deformation Sequence 1
Intrauterine growth retardation, Pulmonary hypoplasia, Stillbirth OMIM:208150
Aphalangy-Hemivertebrae-Urogenital-Intestinal Dysgenesis Syndrome
Pulmonary hypoplasia ORPHA:1112
Otopalatodigital Syndrome Type 2
Pulmonary hypoplasia ORPHA:90652
Acrorenal-Mandibular Syndrome
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:200980
Tetraamelia Syndrome 1
Peripheral pulmonary vessel aplasia, Pulmonary hypoplasia OMIM:273395
Mckusick-Kaufman Syndrome
Pulmonary hypoplasia OMIM:236700
Esophageal Atresia
Pulmonary hypoplasia, Recurrent respiratory infections, Bronchitis ORPHA:1199
Cardiac-Urogenital Syndrome
Scimitar anomaly, Pulmonary hypoplasia OMIM:618280
Alg9-Cdg
Abnormal lung lobation, Pulmonary hypoplasia ORPHA:79328
Restrictive Dermopathy 1
Intrauterine growth retardation, Pulmonary hypoplasia, Stillbirth OMIM:275210
Blomstrand Lethal Chondrodysplasia
Pulmonary hypoplasia ORPHA:50945
Short-Rib Thoracic Dysplasia 6 With Or Without Polydactyly
Pulmonary hypoplasia OMIM:263520
B3Galt6-Related Spondylodysplastic Ehlers-Danlos Syndrome
Repeated pneumothoraces, Pulmonary hypoplasia ORPHA:536467
Orofaciodigital Syndrome Type 4
Recurrent respiratory infections, Intrauterine growth retardation, Bilateral lung agenesis, Pulmo... ORPHA:2753
Opitz gbbb syndrome, type II
Pulmonary hypoplasia OMIM:145410
Meckel Syndrome, Type 1
Intrauterine growth retardation, Pulmonary hypoplasia OMIM:249000
Neu-Laxova Syndrome 1
Intrauterine growth retardation, Pulmonary hypoplasia, Stillbirth OMIM:256520
Fontaine Progeroid Syndrome
Intrauterine growth retardation, Pneumothorax, Neonatal death, Recurrent aspiration pneumonia, Pu... OMIM:612289
Fryns Syndrome
Chylothorax, Stillbirth, Pulmonary hypoplasia OMIM:229850
Smith-Lemli-Opitz Syndrome
Abnormal lung lobation, Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:818
Smith-Lemli-Opitz Syndrome
Abnormal lung lobation, Intrauterine growth retardation, Pulmonary hypoplasia OMIM:270400
Spondylodysplastic Ehlers-Danlos Syndrome
Pulmonary hypoplasia ORPHA:536471
Distal Monosomy 15Q
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:1596
Autosomal Recessive Polycystic Kidney Disease
Spontaneous pneumothorax, Recurrent pneumonia, Pulmonary hypoplasia ORPHA:731
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:83617
Penile Agenesis
Bilateral lung agenesis, Pulmonary hypoplasia ORPHA:49
Dpagt1-Cdg
Pulmonary hypoplasia ORPHA:86309
Schinzel-Giedion Syndrome
Recurrent pneumonia, Pulmonary hypoplasia ORPHA:798
Ulbright-Hodes Syndrome
Severe intrauterine growth retardation, Pneumothorax, Pulmonary hypoplasia ORPHA:3404
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Intrauterine growth retardation, Pulmonary artery stenosis, Pulmonary hypoplasia ORPHA:96334
Osteogenesis Imperfecta
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:666
Restrictive Dermopathy
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:1662
Congenital Total Pulmonary Venous Return Anomaly
Supracardiac total anomalous pulmonary venous connection, Mixed total anomalous pulmonary venous ... ORPHA:99125
Fraser Syndrome
Abnormal lung lobation, Pulmonary hypoplasia ORPHA:2052
Fraser Syndrome 1
Pulmonary hypoplasia OMIM:219000
Tetrasomy 9P
Intrauterine growth retardation, Pulmonary hypoplasia ORPHA:3310
Genitopatellar Syndrome
Pulmonary hypoplasia OMIM:606170
Short Rib-Polydactyly Syndrome, Verma-Naumoff Type
Pulmonary hypoplasia ORPHA:93271
Pallister-Killian Syndrome
Stillbirth, Pulmonary hypoplasia OMIM:601803
Craniofacial Microsomia
Pulmonary hypoplasia OMIM:164210
Microphthalmia, Syndromic 1
Pulmonary hypoplasia OMIM:309800
Histiocytoma, Angiomatoid Fibrous
OMIM:612160

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Creb1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Creb1.

No publications found that use IMPC mice or data for Creb1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Creb1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Creb1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter