Gene: Cox4i1

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
hyperactivity Cox4i1tm1.1(KOMP)Vlcg HET postnatal 1.71×10-05
embryonic lethality prior to organogenesis Cox4i1tm1.1(KOMP)Vlcg HOM embryonic day 9.5 0.00
abnormal midbrain development Cox4i1tm1.1(KOMP)Vlcg HET embryonic day 9.5 0.00
abnormal hindbrain development Cox4i1tm1.1(KOMP)Vlcg HET embryonic day 9.5 0.00
embryonic lethality prior to tooth bud stage Cox4i1tm1.1(KOMP)Vlcg HOM embryonic day 12.5 0.00
pallor Cox4i1tm1.1(KOMP)Vlcg HET embryonic day 9.5 0.00
abnormal embryo size Cox4i1tm1.1(KOMP)Vlcg HET embryonic day 9.5 0.00
decreased grip strength Cox4i1tm1.1(KOMP)Vlcg HET postnatal 7.65×10-05
increased or absent threshold for auditory brainstem response Cox4i1tm1.1(KOMP)Vlcg HET postnatal 7.81×10-05
preweaning lethality, complete penetrance Cox4i1tm1.1(KOMP)Vlcg HOM n/a 0.00
abnormal neural tube closure Cox4i1tm1.1(KOMP)Vlcg HET embryonic day 9.5 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Section images
Aorta 2 No  (1/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No  (1/2) N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No  (2/2) N/A
Esophagus 2 No  (7/415)  (2/2) N/A
Eye 2 No  (1/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No  (1/2) N/A
Lower urinary tract 2 No  (1/2) N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No N/A
Mammary gland 2 No  (1/2) N/A
Olfactory lobe 2 No  (2/2) N/A
Ovary 2 No  (1/584)  (1/2)  Section images
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2)  Section images
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle 2 No  (1/2) N/A
Skin 2 No  (1/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (1/2)  Section images
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No  (1/2) N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No  (1/2) N/A
Vascular system 2 No N/A
White adipose tissue 2 No  (1/2) N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/51)  (2/2) N/A
Brain 4  (6/485)  (2/4) N/A
Central nervous system ganglion 2  (1/51) N/A
Ear 4  (1/485)  (2/4) N/A
Embryo 4  (1/485)  (2/4) N/A
Eye 4  (1/485) N/A
Foot 4  (1/485) N/A
Forebrain 4  (1/485)  (2/4) N/A
Forelimb 4  (1/485) N/A
Gut 2  (1/50)  (2/2) N/A
Hand 4  (1/485) N/A
Head 4  (5/485)  (2/4) N/A
Heart 4  (1/485)  (2/4) N/A
Hindbrain 4  (6/485)  (2/4) N/A
Hindlimb 4  (1/485) N/A
Liver 4  (1/485)  (2/4) N/A
Lung 4  (1/485)  (2/4) N/A
Mandibular process 4  (1/485)  (2/4) N/A
Maxillary process 4  (1/485)  (2/4) N/A
Midbrain 4  (1/485)  (2/4) N/A
Nose 2  (1/51) N/A
Oral cavity 4  (1/485)  (2/4) N/A
Skeleton 2  (1/51) N/A
Skin 4  (1/485) N/A
Spinal cord 2  (1/50)  (2/2) N/A
Tail 4  (1/485) N/A
Tail somite 4  (1/485) N/A
Trachea 2  (1/50)  (2/2) N/A
Urinary system 2  (1/50)  (2/2) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
16 Images
X-ray: XRay Images Hind Leg and Hip
16 Images
Eye Morphology: Images Ophthalmoscopy
4 Images
X-ray: XRay Images Lateral Orientation
32 Images
X-ray: XRay Images Dorso Ventral
16 Images
Adult LacZ: LacZ Images Section
12 Images
Combined SHIRPA and Dysmorphology
2 Images
Eye Morphology: Images Slit Lamp
9 Images
Gross Pathology and Tissue Collection
6 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Pancreas - hypoplasia Cox4i1tm1.1(KOMP)Vlcg HET postnatal

 Order Mouse and ES Cells

MGI Allele Allele Type Produced
Cox4i1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Cox4i1tm455699(L1L2_GT1_LF2A_LacZ_BetactP_neo) Targeting vectors
Cox4i1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells

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