Genes Phenotypes

Gene: Col1a2

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Name
collagen, type I, alpha 2
MGI ID
MGI:88468
Synonyms
Cola2 Col1a-2 Cola-2
Viability
Homozygous - Viable
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (12) Measurements chart (243) All data table (590)
Expression & images (49) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating alkaline phosphatase level Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 1.04×10-05
enlarged heart Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 0.00
increased bone mineral content Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 2.60×10-07
dilated heart left ventricle Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 7.61×10-06
abnormal optic disk morphology Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 3.90×10-05
enlarged spleen Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 0.00
increased heart weight Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 3.81×10-06
increased bone mineral density Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 1.55×10-05
abnormal tibia morphology Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 4.81×10-05
abnormal femur morphology Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 9.74×10-07
decreased total body fat amount Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 8.08×10-06
decreased grip strength Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 2.69×10-11

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cecum 2 No  (12/379) N/A
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415)  (1/2)  Wholemount images
Eye 2 No N/A
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/2)  Wholemount images
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  Wholemount images
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Trigeminal V nerve 2 No N/A
Uterus 2 No  (1/2)  Wholemount images
Vas deferens 2 No  (15/388)  Wholemount images
Vascular system 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (1)
Aorta expression
MA:0000062
digestive system (3)
Gall Bladder expression
MA:0000356
integumental system (1)
Skin expression
MA:0000151
musculoskeletal system (1)
Cartilage tissue expression
Bone expression
MA:0000104
MA:0001459
nervous system (3)
Peripheral Nervous System no expression
Hypothalamus expression
Brain expression
Cerebellum expression
Brainstem expression
MA:0000218
MA:0000173
MA:0000168
MA:0000198
MA:0000169
postnatal mouse (13)
Aorta expression
MA:0000062
reproductive system (2)
Oviduct expression
Uterus expression
MA:0000385
MA:0000389
set of connective tissues (1)
Cartilage tissue expression
Bone expression
MA:0000104
MA:0001459
trunk (6)
Aorta expression
MA:0000062
urinary system (2)
Lower Urinary Tract expression
MA:0002636
LacZ Section Images
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
11 Images
X-ray: XRay Images Forepaw
11 Images
X-ray: XRay Images Whole Body Dorso Ventral
11 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
X-ray: XRay Images Skull Lateral Orientation
11 Images
Adult LacZ: LacZ Images Wholemount
13 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Col1a2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Col1a2tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue