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Gene: Col1a2

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Name
collagen, type I, alpha 2
MGI ID
MGI:88468
Synonyms
Col1a-2 Cola-2 Cola2
Viability
Data available
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (22) Measurements chart (235) All data table (820)
Expression & images (70) Disease models (0) Histopathology (1) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
short tibia Col1a2tm1b(EUCOMM)Wtsi HOM   Early adult 3.27×10-08
abnormal ulna morphology Col1a2tm1b(EUCOMM)Wtsi HOM   Early adult 9.67×10-05
enlarged spleen Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 0.00
abnormal tibia morphology Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 3.45×10-05
decreased lymphocyte cell number Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 7.15×10-05
increased spleen weight Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 3.09×10-06
abnormal radius morphology Col1a2tm1b(EUCOMM)Wtsi HOM   Early adult 9.67×10-05
enlarged heart Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 0.00
increased leukocyte cell number Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 2.21×10-05
abnormal femur morphology Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 5.91×10-07
decreased blood urea nitrogen level Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 1.52×10-05
increased bone mineral content Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 1.77×10-07
increased neutrophil cell number Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 1.96×10-06
increased bone mineral density Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 8.89×10-10
decreased total body fat amount Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 9.34×10-10
decreased prepulse inhibition Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 1.96×10-05
increased heart weight Col1a2tm1b(EUCOMM)Wtsi HOM   Early adult 2.25×10-07
dilated heart left ventricle Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 1.05×10-06
decreased grip strength Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 7.06×10-11
decreased mean platelet volume Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 6.33×10-05
increased circulating alkaline phosphatase level Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 1.29×10-07
increased large unstained cell number Col1a2tm1b(EUCOMM)Wtsi HOM Early adult 3.77×10-08

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (3/590) N/A
Aorta 4 No  (1/590)  (4/4)  Wholemount images
Bone 4 No  (4/4)  Wholemount images
Brain 4 No  (3/590)  (4/4)  Wholemount images
Brainstem 4 No  (2/590)  (4/4)  Wholemount images
Brown adipose tissue 4 No N/A
Cartilage tissue 4 No  (4/4)  Wholemount images
Cecum 2 No  (12/377) N/A
Cerebellum 4 No  (3/590)  (4/4)  Wholemount images
Cerebral cortex 4 No  (2/590) N/A
Esophagus 4 No  (7/415)  (3/4)  Wholemount images
Eye 4 No N/A
Gall bladder 4 No  (4/4)  Wholemount images
Heart 4 No  (1/590) N/A
Hippocampus 4 No  (3/590)  (2/4)  Wholemount images
Hypothalamus 4 No  (2/590)  (4/4)  Wholemount images
Kidney 4 No  (20/590)  (2/4)  Wholemount images
Large intestine 4 No  (10/590)  (1/4)  Wholemount images
Liver 4 No N/A
Lower urinary tract 4 No  (1/590)  (4/4)  Wholemount images
Lung 4 No  (1/590)  (2/4)  Wholemount images
Lymph node 4 No N/A
Mammary gland 4 No N/A
Olfactory lobe 4 No  (2/590)  (2/4)  Wholemount images
Oral epithelium 4 No  (2/4)  Wholemount images
Ovary 4 No  (1/590)  (2/4)  Wholemount images
Oviduct 4 No  (2/4)  Wholemount images
Pancreas 4 No  (5/590) N/A
Parathyroid gland 4 No N/A
Peripheral nervous system 4 No  (1/590)  Wholemount images
Peyer's patch 4 No N/A
Pituitary gland 4 No  (1/590)  (1/4)  Wholemount images
Prostate gland 4 No  (12/590)  (1/4)  Wholemount images
Skeletal muscle 4 No  (1/4) N/A
Skin 4 No  (3/4)  Wholemount images
Small intestine 4 No  (9/590)  (2/4)  Wholemount images
Spinal cord 4 No  (2/590)  (2/4)  Wholemount images
Spleen 4 No  (2/590) N/A
Stomach 4 No  (13/590)  (2/4)  Wholemount images
Striatum 4 No  (3/590) N/A
Testis 4 No  (5/590)  (2/4)  Wholemount images
Thymus 4 No N/A
Thyroid gland 4 No  (16/590)  (1/4)  Wholemount images
Trachea 4 No  (2/590)  (2/4)  Wholemount images
Trigeminal V nerve 2 No N/A
Uterus 4 No  (2/4)  Wholemount images
Vas deferens 2 No  (15/388)  Wholemount images
Vascular system 4 No  (2/4)  Wholemount images
White adipose tissue 4 No N/A
LacZ Wholemount Images
cardiovascular system (3)
Aorta expression
MA:0000062
digestive system (8)
Gall Bladder expression
MA:0000356
endocrine system (1)
Trachea expression
Thyroid gland expression
MA:0000441
MA:0000129
exocrine system (1)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
integumental system (2)
Skin expression
MA:0000151
musculoskeletal system (3)
Cartilage tissue expression
Bone expression
MA:0000104
MA:0001459
nervous system (8)
Brain expression
Brainstem expression
Cerebellum expression
Hippocampus expression
Hypothalamus expression
Olfactory Lobe expression
MA:0000191
MA:0000169
MA:0000198
MA:0000168
MA:0002413
MA:0000173
postnatal mouse (33)
Aorta expression
MA:0000062
reproductive system (5)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
respiratory system (3)
Lung expression
MA:0000415
set of connective tissues (3)
Cartilage tissue expression
Bone expression
MA:0000104
MA:0001459
trunk (18)
Aorta expression
MA:0000062
urinary system (4)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/506) Image Only N/A
Ear 1  (1/506) Image Only N/A
Embryo 1  (1/507) Image Only N/A
Eye 1  (1/506) Image Only N/A
Foot 1  (1/506) Image Only N/A
Forebrain 1  (1/506) Image Only N/A
Forelimb 1  (1/506) Image Only N/A
Hand 1  (1/506) Image Only N/A
Head 1  (5/506) Image Only N/A
Heart 1  (1/506) Image Only N/A
Hindbrain 1  (6/506) Image Only N/A
Hindlimb 1  (1/506) Image Only N/A
Liver 1  (1/504) Image Only N/A
Lung 1  (1/504) Image Only N/A
Mandibular process 1  (1/506) Image Only N/A
Maxillary process 1  (1/506) Image Only N/A
Midbrain 1  (1/506) Image Only N/A
Oral cavity 1  (1/504) Image Only N/A
Skin 1  (1/506) Image Only N/A
Tail 1  (1/506) Image Only N/A
Tail somite 1  (1/506) Image Only N/A

 Associated Images

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Adult LacZ: LacZ Images Wholemount
33 Images
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X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
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X-ray: XRay Images Whole Body Lateral Orientation
11 Images
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Histopathology
6 Images
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X-ray: XRay Images Whole Body Dorso Ventral
11 Images
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X-ray: XRay Images Skull Lateral Orientation
11 Images
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X-ray: XRay Images Forepaw
11 Images
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Embryo LacZ: LacZ images wholemount
8 Images
Immunophenotyping: Panel A FCS file(s)
6 Images
Immunophenotyping: Panel B FCS file(s)
6 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Femur - developmental and structural abnormality Col1a2tm1b(EUCOMM)Wtsi HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Col1a2tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Col1a2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells