Gene: Col18a1

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased vertical activity Col18a1tm1.1(KOMP)Vlcg HOM Early adult 8.53×10-07
abnormal retinal vasculature morphology Col18a1tm1.1(KOMP)Vlcg HOM Early adult 3.92×10-16
decreased circulating cholesterol level Col18a1tm1.1(KOMP)Vlcg HOM   Early adult 3.93×10-08
abnormal retina morphology Col18a1tm1.1(KOMP)Vlcg HOM Early adult 8.14×10-05
abnormal placement of pupils Col18a1tm1.1(KOMP)Vlcg HOM Early adult 4.77×10-05
increased circulating free fatty acid level Col18a1tm1.1(KOMP)Vlcg HOM Early adult 5.67×10-05
abnormal iris pigmentation Col18a1tm1.1(KOMP)Vlcg HOM Early adult 7.25×10-16
hyperactivity Col18a1tm1.1(KOMP)Vlcg HOM   Early adult 6.67×10-05
abnormal optic disk morphology Col18a1tm1.1(KOMP)Vlcg HOM Early adult 1.72×10-11
increased fasting circulating glucose level Col18a1tm1.1(KOMP)Vlcg HOM   Early adult 4.58×10-05
abnormal retinal blood vessel morphology Col18a1tm1.1(KOMP)Vlcg HOM Early adult 1.23×10-14
increased circulating triglyceride level Col18a1tm1.1(KOMP)Vlcg HOM   Early adult 0.00
irregularly shaped pupil Col18a1tm1.1(KOMP)Vlcg HOM Early adult 1.76×10-07
abnormal lens morphology Col18a1tm1.1(KOMP)Vlcg HOM   Early adult 1.70×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590)  (2/2)  Section images
Aorta 2 No  (1/590)  (2/2)  Section images
Brain 2 No  (3/590)  (2/2)  Section images
Brainstem 2 No  (2/590)  (2/2)  Section images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Section images
Cerebellum 2 No  (3/590)  (2/2)  Section images
Cerebral cortex 2 No  (2/590)  (2/2)  Section images
Epididymis 2 No  (18/134)  (1/2)  Section images
Esophagus 2 No  (7/415)  (2/2)  Section images
Eye 2 No  (2/2)  Section images
Heart 2 No  (1/590) N/A
Hippocampus 2 No  (3/590)  (2/2)  Section images
Hypothalamus 2 No  (2/590)  (2/2)  Section images
Kidney 2 No  (20/590)  (2/2)  Section images
Large intestine 2 No  (10/590)  (2/2)  Section images
Liver 2 No  (2/2)  Section images
Lower urinary tract 2 No  (1/590) N/A
Lung 2 No  (1/590)  (2/2)  Section images
Lymph node 2 No  (2/2)  Section images
Mammary gland 2 No  (1/2)  Section images
Midbrain 2 No  (2/2)  Section images
Olfactory lobe 2 No  (2/590)  (2/2)  Section images
Ovary 2 No  (1/590)  (1/2)  Section images
Oviduct 2 No  (1/2)  Section images
Pancreas 2 No  (5/590)  (2/2)  Section images
Peripheral nervous system 2 No  (1/590) N/A
Peyer's patch 2 No  (2/2)  Section images
Pituitary gland 2 No  (1/590)  (2/2)  Section images
Prostate gland 2 No  (12/590) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Section images
Small intestine 2 No  (9/590)  (2/2)  Section images
Spinal cord 2 No  (2/590)  (2/2)  Section images
Spleen 2 No  (2/590)  (2/2)  Section images
Stomach 2 No  (13/590)  (2/2)  Section images
Striatum 2 No  (3/590)  (2/2)  Section images
Submandibular gland 2 No  (2/132)  (2/2)  Section images
Testis 2 No  (5/590)  (1/2)  Section images
Thalamus 2 No  (2/2)  Section images
Thymus 2 No  (2/2)  Section images
Thyroid gland 2 No  (16/590)  (2/2)  Section images
Trachea 2 No  (2/590)  (2/2)  Section images
Urinary bladder 2 No  (2/2)  Section images
Uterus 2 No  (1/2)  Section images
Vascular system 2 No  (2/2)  Section images
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/506)  (2/3) N/A
Dorsal root ganglion 1  (1/61) Image Only N/A
Ear 2  (1/506)  (1/3) N/A
Embryo 2  (1/507)  (2/3)  Wholemount images
Eye 2  (1/506)  (2/3) N/A
Foot 2  (1/506)  (1/3) N/A
Forebrain 2  (1/506)  (2/3) N/A
Forelimb 2  (1/506)  (2/3) N/A
Fronto-nasal process 1  (1/62) Image Only N/A
Hand 2  (1/506)  (1/3) N/A
Head 2  (5/506)  (2/3) N/A
Heart 2  (1/506) Image Only N/A
Hindbrain 2  (6/506)  (2/3) N/A
Hindlimb 2  (1/506)  (2/3) N/A
Liver 2  (1/504) Image Only N/A
Lung 2  (1/504) Image Only N/A
Mandibular process 2  (1/506)  (2/3) N/A
Maxillary process 2  (1/506)  (2/3) N/A
Midbrain 2  (1/506)  (2/3) N/A
Nose 1  (1/76)  (1/2) N/A
Oral cavity 2  (1/504)  (1/3) N/A
Skin 2  (1/506)  (2/3) N/A
Spinal cord 1  (1/73)  (1/2) N/A
Tail 2  (1/506)  (2/3) N/A
Tail somite 2  (1/506)  (1/3) N/A

 Associated Images

X-ray: XRay Images Whole Body Dorso Ventral
12 Images
Eye Morphology: Images Slit Lamp
23 Images
Eye Morphology: Images Ophthalmoscopy
21 Images
X-ray: XRay Images Forepaw
12 Images
X-ray: XRay Images Whole Body Lateral Orientation
12 Images
Original Image
Adult LacZ: LacZ Images Section
40 Images
Embryo LacZ: LacZ images wholemount
12 Images
X-ray: XRay Images Skull Lateral Orientation
12 Images
Sleep Wake: Wake state (bmp file)
14 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images

 Disease Models

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MGI Allele Allele Type Produced
Col18a1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Col18a1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Col18a1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells