Gene: Col18a1

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Name
collagen, type XVIII, alpha 1
MGI ID
MGI:88451
Synonyms
endostatin
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating triglyceride level Col18a1tm1.1(KOMP)Vlcg HOM   Early adult 5.76×10-06
increased circulating free fatty acids level Col18a1tm1.1(KOMP)Vlcg HOM   Early adult 5.86×10-05
abnormal optic disk morphology Col18a1tm1.1(KOMP)Vlcg HOM Early adult 1.78×10-11
abnormal retina morphology Col18a1tm1.1(KOMP)Vlcg HOM Early adult 7.21×10-05
hyperactivity Col18a1tm1.1(KOMP)Vlcg HOM   Early adult 2.64×10-05
abnormal retinal vasculature morphology Col18a1tm1.1(KOMP)Vlcg HOM Early adult 3.19×10-16
abnormal placement of pupils Col18a1tm1.1(KOMP)Vlcg HOM Early adult 4.25×10-05
decreased circulating cholesterol level Col18a1tm1.1(KOMP)Vlcg HOM Early adult 9.33×10-05
increased vertical activity Col18a1tm1.1(KOMP)Vlcg HOM Early adult 8.68×10-07
abnormal lens morphology Col18a1tm1.1(KOMP)Vlcg HOM   Early adult 1.40×10-05
increased fasting circulating glucose level Col18a1tm1.1(KOMP)Vlcg HOM   Early adult 4.32×10-05
irregularly shaped pupil Col18a1tm1.1(KOMP)Vlcg HOM Early adult 1.40×10-07
abnormal retinal blood vessel morphology Col18a1tm1.1(KOMP)Vlcg HOM Early adult 8.25×10-15
abnormal iris pigmentation Col18a1tm1.1(KOMP)Vlcg HOM Early adult 6.02×10-16

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
1 No  (4/583)  (1/1) N/A
1 No  (1/583)  (1/1)  Section images
1 No  (4/583)  (1/1) N/A
1 No  (2/583)  (1/1) N/A
1 No N/A
1 No  (1/583)  (1/1) N/A
1 No  (3/583)  (1/1) N/A
1 No  (2/583)  (1/1) N/A
1 No  (18/132)  (1/1)  Section images
1 No  (7/407)  (1/1)  Section images
1 No  (1/1) N/A
1 No  (2/583) N/A
1 No  (3/583)  (1/1) N/A
1 No  (2/583)  (1/1) N/A
1 No  (21/583)  (1/1) N/A
1 No  (10/583)  (1/1)  Section images
1 No  (1/1) N/A
1 No  (1/583) N/A
1 No  (2/583)  (1/1)  Section images
1 No  (1/583)  (1/1) N/A
1 No N/A
1 No  (1/1) N/A
1 No  (2/583)  (1/1) N/A
1 No  (1/583) N/A
1 No N/A
1 No  (5/583)  (1/1) N/A
1 No  (2/583) N/A
1 No  (1/1)  Section images
1 No  (1/583)  (1/1) N/A
1 No  (12/583) N/A
1 No N/A
1 No  (1/583)  (1/1)  Section images
1 No  (9/583)  (1/1)  Section images
1 No  (3/583)  (1/1) N/A
1 No  (3/583)  (1/1) N/A
1 No  (13/583)  (1/1)  Section images
1 No  (3/583)  (1/1) N/A
1 No  (2/130)  (1/1) N/A
1 No  (6/583)  (1/1)  Section images
1 No  (1/1) N/A
1 No  (1/583)  (1/1)  Section images
1 No  (17/583)  (1/1) N/A
1 No  (3/583)  (1/1) N/A
1 No  (1/1) N/A
1 No N/A
1 No  (1/1)  Section images
1 No N/A
1 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
2  (6/505)  (2/3) N/A
1  (1/60) Image Only N/A
2  (1/505)  (1/3) N/A
2  (1/506)  (2/3)  Wholemount images
2  (1/505)  (2/3) N/A
2  (1/505)  (1/3) N/A
2  (1/505)  (2/3) N/A
2  (1/505)  (2/3) N/A
1  (1/61) Image Only N/A
2  (1/505)  (1/3) N/A
2  (5/505)  (2/3) N/A
2  (1/505) Image Only N/A
2  (6/505)  (2/3) N/A
2  (1/505)  (2/3) N/A
2  (1/503) Image Only N/A
2  (1/503) Image Only N/A
2  (1/505)  (2/3) N/A
2  (1/505)  (2/3) N/A
2  (1/505)  (2/3) N/A
1  (1/75)  (1/2) N/A
2  (1/503)  (1/3) N/A
2  (1/505)  (2/3) N/A
1  (1/72)  (1/2) N/A
2  (1/505)  (2/3) N/A
2  (1/505)  (1/3) N/A

 Associated Images

Eye Morphology: Images Slit Lamp
23 Images
X-ray: XRay Images Skull Lateral Orientation
12 Images
Embryo LacZ: LacZ images wholemount
12 Images
Combined SHIRPA and Dysmorphology
1 Images
X-ray: XRay Images Forepaw
12 Images
Eye Morphology: Images Ophthalmoscopy
21 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
Sleep Wake: Wake state (bmp file)
14 Images
Original Image
Adult LacZ: LacZ Images Section
12 Images
X-ray: XRay Images Whole Body Lateral Orientation
12 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Col18a1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Col18a1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Col18a1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells