Gene Summary

Name:
cellular nucleic acid binding protein
Synonyms:
Znf9

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal embryo size Cnbptm1b(KOMP)Wtsi HOM E18.5 0.00
abnormal embryo size Cnbptm1b(KOMP)Wtsi HOM E12.5 0.00
preweaning lethality, complete penetrance Cnbptm1b(KOMP)Wtsi HOM   Early adult 0.00
embryonic growth retardation Cnbptm1b(KOMP)Wtsi HOM E12.5 0.00
decreased vertical activity Cnbptm1b(KOMP)Wtsi HET   Early adult 5.45×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland  Section images heterozygote 100% (2 of 2)
Aorta  Section images heterozygote 100% (2 of 2)
Bone marrow  Section images heterozygote 100% (2 of 2)
Brain  Section images heterozygote 100% (2 of 2)
Brainstem  Section images heterozygote 100% (2 of 2)
Brown adipose tissue  Section images heterozygote 100% (2 of 2)
Cartilage tissue  Section images heterozygote 100% (2 of 2)
Cerebellum  Section images heterozygote 100% (2 of 2)
Cerebral cortex  Section images heterozygote 100% (2 of 2)
Epididymis  Section images heterozygote 50% (1 of 2)
Esophagus  Section images heterozygote 100% (2 of 2)
Eye  Section images heterozygote 100% (2 of 2)
Heart  Section images heterozygote 100% (2 of 2)
Hippocampus  Section images heterozygote 100% (2 of 2)
Hypothalamus  Section images heterozygote 100% (2 of 2)
Kidney  Section images heterozygote 0.0% (0 of 2)
Large intestine  Section images heterozygote 100% (2 of 2)
Liver  Section images heterozygote 100% (2 of 2)
Lung  Section images heterozygote 100% (2 of 2)
Lymph node  Section images heterozygote 100% (2 of 2)
Mammary gland  Section images heterozygote 50% (1 of 2)
Midbrain  Section images heterozygote 100% (2 of 2)
Olfactory lobe  Section images heterozygote 100% (2 of 2)
Ovary  Section images heterozygote 50% (1 of 2)
Oviduct  Section images heterozygote 50% (1 of 2)
Pancreas  Section images heterozygote 100% (2 of 2)
Peripheral nervous system  Section images heterozygote 100% (2 of 2)
Peyer's patch  Section images heterozygote 100% (2 of 2)
Pituitary gland  Section images heterozygote 100% (2 of 2)
Skeletal muscle  Section images heterozygote 100% (2 of 2)
Skin  Section images heterozygote 100% (2 of 2)
Small intestine  Section images heterozygote 100% (2 of 2)
Spinal cord  Section images heterozygote 100% (2 of 2)
Spleen  Section images heterozygote 100% (2 of 2)
Stomach  Section images heterozygote 100% (2 of 2)
Striatum  Section images heterozygote 100% (2 of 2)
Submandibular gland  Section images heterozygote 100% (2 of 2)
Testis  Section images heterozygote 50% (1 of 2)
Thalamus  Section images heterozygote 100% (2 of 2)
Thymus  Section images heterozygote 100% (2 of 2)
Trachea  Section images heterozygote 100% (2 of 2)
Urinary bladder  Section images heterozygote 100% (2 of 2)
Uterus  Section images heterozygote 50% (1 of 2)
Vascular system  Section images heterozygote 100% (2 of 2)
White adipose tissue  Section images heterozygote 100% (2 of 2)
Lower urinary tract N/A heterozygote Not available
Prostate gland N/A heterozygote Not available
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Vesicular gland N/A heterozygote Not available

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Embryo N/A heterozygote 100% (2 of 2)
Embryo N/A homozygote Ambiguous
Brain N/A heterozygote 100% (2 of 2)
Brain N/A homozygote Ambiguous
Dorsal root ganglion N/A heterozygote Ambiguous
Dorsal root ganglion N/A homozygote Ambiguous
Ear N/A heterozygote 50% (1 of 2)
Ear N/A homozygote Ambiguous
Eye N/A heterozygote 50% (1 of 2)
Eye N/A homozygote Ambiguous
Footplate N/A heterozygote 100% (2 of 2)
Footplate N/A homozygote Ambiguous
Forebrain N/A heterozygote 100% (2 of 2)
Forebrain N/A homozygote Ambiguous
Forelimb N/A heterozygote 100% (2 of 2)
Forelimb N/A homozygote Ambiguous
Fronto-nasal process N/A heterozygote Ambiguous
Fronto-nasal process N/A homozygote Ambiguous
Handplate N/A heterozygote 100% (2 of 2)
Handplate N/A homozygote Ambiguous
Head N/A heterozygote 100% (2 of 2)
Head N/A homozygote Ambiguous
Heart N/A heterozygote 100% (2 of 2)
Heart N/A homozygote Ambiguous
Hindbrain N/A heterozygote 100% (2 of 2)
Hindbrain N/A homozygote Ambiguous
Hindlimb N/A heterozygote 100% (2 of 2)
Hindlimb N/A homozygote Ambiguous
Liver N/A heterozygote 50% (1 of 2)
Liver N/A homozygote Ambiguous
Lung N/A heterozygote Ambiguous
Lung N/A homozygote Ambiguous
Mandibular process N/A heterozygote 100% (2 of 2)
Mandibular process N/A homozygote Ambiguous
Maxillary process N/A heterozygote 100% (2 of 2)
Maxillary process N/A homozygote Ambiguous
Midbrain N/A heterozygote 100% (2 of 2)
Midbrain N/A homozygote Ambiguous
Nose N/A heterozygote 100% (2 of 2)
Nose N/A homozygote Ambiguous
Oral cavity N/A heterozygote Ambiguous
Oral cavity N/A homozygote Ambiguous
Skin N/A heterozygote 100% (2 of 2)
Skin N/A homozygote Ambiguous
Spinal cord N/A heterozygote 100% (2 of 2)
Spinal cord N/A homozygote Ambiguous
Tail somite N/A heterozygote 100% (2 of 2)
Tail somite N/A homozygote Ambiguous
Tail N/A heterozygote 100% (2 of 2)
Tail N/A homozygote Ambiguous

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.68% (4 of 584)
aorta 0.17% (1 of 584)
bone marrow 0.0%
brain 0.68% (4 of 584)
brainstem 0.34% (2 of 584)
brown adipose tissue 0.0%
cartilage tissue 0.17% (1 of 584)
cerebellum 0.51% (3 of 584)
cerebral cortex 0.34% (2 of 584)
epididymis 12.78% (17 of 133)
esophagus 1.72% (7 of 408)
eye 0.0%
heart 0.34% (2 of 584)
hippocampus 0.51% (3 of 584)
hypothalamus 0.34% (2 of 584)
kidney 3.6% (21 of 584)
large intestine 1.71% (10 of 584)
liver 0.0%
lower urinary tract 0.17% (1 of 584)
lung 0.34% (2 of 584)
lymph node 0.17% (1 of 584)
mammary gland 0.0%
midbrain 0.0%
olfactory lobe 0.34% (2 of 584)
ovary 0.17% (1 of 584)
oviduct 0.0%
pancreas 0.86% (5 of 584)
peripheral nervous system 0.34% (2 of 584)
peyers patch 0.0%
pituitary gland 0.17% (1 of 584)
prostate gland 2.05% (12 of 584)
skeletal muscle 0.0%
skin 0.17% (1 of 584)
small intestine 1.54% (9 of 584)
spinal cord 0.51% (3 of 584)
spleen 0.51% (3 of 584)
stomach 2.05% (12 of 584)
striatum 0.51% (3 of 584)
submandibular gland 1.53% (2 of 131)
testis 1.03% (6 of 584)
thalamus 0.0%
thymus 0.17% (1 of 584)
thyroid gland 2.74% (16 of 584)
trachea 0.51% (3 of 584)
urinary bladder 0.0%
uterus 0.0%
vascular system 0.0%
vesicular gland 0.0%
white adipose tissue 0.0%

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
brain 1.18% (6 of 507)
dorsal root ganglion 1.69% (1 of 59)
ear 0.2% (1 of 507)
embryo 0.2% (1 of 508)
eye 0.2% (1 of 507)
footplate 0.2% (1 of 507)
forebrain 0.2% (1 of 507)
forelimb 0.2% (1 of 507)
fronto-nasal process 1.67% (1 of 60)
handplate 0.2% (1 of 507)
head 0.99% (5 of 507)
heart 0.2% (1 of 507)
hindbrain 1.18% (6 of 507)
hindlimb 0.2% (1 of 507)
liver 0.2% (1 of 502)
lung 0.2% (1 of 502)
mandibular process 0.2% (1 of 507)
maxillary process 0.2% (1 of 507)
midbrain 0.2% (1 of 507)
nose 1.3% (1 of 77)
oral cavity 0.2% (1 of 502)
skin 0.2% (1 of 507)
spinal cord 1.41% (1 of 71)
tail 0.2% (1 of 507)
tail somite group 0.2% (1 of 507)

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Adult LacZ

LacZ Images Section

45 Images

Eye Morphology

Images Ophthalmoscopy

6 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

Embryo LacZ

LacZ images wholemount

12 Images

X-ray

XRay Images Forepaw

10 Images

Sleep Wake

Wake state (bmp file)

7 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

Gross Morphology Embryo E18.5

Images

3 Images

Gross Morphology Embryo E12.5

Images

4 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

3 Images

Human diseases caused by Cnbp mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Cnbp by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Myotonic Dystrophy 2
Elevated circulating follicle stimulating hormone level OMIM:602668
Proximal Myotonic Myopathy
ORPHA:606

The table below shows human diseases predicted to be associated to Cnbp by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Attention Deficit-Hyperactivity Disorder
Attention deficit hyperactivity disorder, Hyperactivity OMIM:143465
Mental Retardation, Autosomal Recessive 54
Hyperactivity OMIM:617028
Schizophrenia 15
Hyperactivity OMIM:613950
Finger Locking, Recurrent, With Intrauterine Growth Retardation And Proportionate Short Stature
Intrauterine growth retardation, Short stature OMIM:135950
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome
Microphthalmia, Anophthalmia ORPHA:85275
Microphthalmia, Isolated 1
Microphthalmia, Anophthalmia OMIM:251600
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Microphthalmia, Isolated, With Coloboma 10
Microphthalmia, Anophthalmia OMIM:616428
Microphthalmia, Syndromic 12
Retrognathia, Micrognathia, Microphthalmia, Anophthalmia OMIM:615524
Microphthalmia, Isolated, With Coloboma 5
Microphthalmia, Bilateral microphthalmos, Anophthalmia OMIM:611638
Dextrocardia With Unusual Facies And Microphthalmia
Micrognathia, Microphthalmia, Anophthalmia OMIM:221950
Fryns Microphthalmia Syndrome
Anophthalmia, Microphthalmia, Neural tube defect OMIM:600776
Microphthalmia, Isolated 3
Microphthalmia, Anophthalmia OMIM:611038
Meckel Syndrome, Type 8
Microphthalmia, Anophthalmia OMIM:613885
Oculocerebrocutaneous Syndrome
Microphthalmia, Anophthalmia OMIM:164180
Pulmonary Hypoplasia, Primary
Neonatal death OMIM:265430
Manitoba Oculotrichoanal Syndrome
Microphthalmia, Anophthalmia OMIM:248450
Cockayne Syndrome Type 2
Enamel hypoplasia, Delayed eruption of primary teeth, Hypoplasia of the primary teeth, Mandibular... ORPHA:90322
Trisomy 13
Aplasia/Hypoplasia of the iris, Microphthalmia, Anophthalmia, Intrauterine growth retardation, Ma... ORPHA:3378
Hydrolethalus
Retrognathia, Micrognathia, Microphthalmia, Anophthalmia ORPHA:2189
Hernia, Anterior Diaphragmatic
Neonatal death OMIM:306950
Anophthalmia Plus Syndrome
Spina bifida, Anophthalmia ORPHA:1104
Microphthalmia With Limb Anomalies
Retrognathia, Microphthalmia, Anophthalmia OMIM:206920
Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Anophthalmia ORPHA:411986
Matthew-Wood Syndrome
Intrauterine growth retardation, Microphthalmia, Anophthalmia ORPHA:2470
Oculotrichoanal Syndrome
Microphthalmia, Anophthalmia ORPHA:2717
Cerebrooculonasal Syndrome
Anophthalmia ORPHA:66625
Solitary Median Maxillary Central Incisor
Microphthalmia, Anophthalmia OMIM:147250
Vacterl With Hydrocephalus
Spina bifida, Microphthalmia, Anophthalmia, Intrauterine growth retardation, Retrognathia, Microg... ORPHA:3412
Microphthalmia/Coloboma And Skeletal Dysplasia Syndrome
Microphthalmia, Anophthalmia OMIM:615877
Trisomy 1Q
Microretrognathia, Anophthalmia ORPHA:261344
Microphthalmia With Brain And Digit Anomalies
Microphthalmia, Anophthalmia ORPHA:139471
Microphthalmia, Syndromic 5
Optic nerve hypoplasia, Microphthalmia, Anophthalmia OMIM:610125
Anophthalmia-Megalocornea-Cardiopathy-Skeletal Anomalies Syndrome
Aniridia, Mandibular prognathia, Umbilical hernia, Anophthalmia, Hypoplasia of the maxilla ORPHA:1101
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Microphthalmia, Anophthalmia ORPHA:77298
Cockayne Syndrome Type 1
Enamel hypoplasia, Delayed eruption of primary teeth, Hypoplasia of the primary teeth, Mandibular... ORPHA:90321
Microphthalmia, Syndromic 9
Intrauterine growth retardation, Micrognathia, Bilateral microphthalmos, Anophthalmia OMIM:601186
Microphthalmia, Syndromic 3
Optic nerve hypoplasia, Microphthalmia, Anophthalmia OMIM:206900
Walker-Warburg Syndrome
Microphthalmia, Anophthalmia ORPHA:899
Hemifacial Microsomia
Branchial anomaly, Microphthalmia, Anophthalmia, Micrognathia, Malar flattening, Hypoplasia of th... OMIM:164210
Holoprosencephaly 9
Hypoplasia of the premaxilla, Agenesis of incisor, Optic nerve hypoplasia, Microphthalmia, Anopht... OMIM:610829
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Failure of eruption of permanent teeth, Microphthalmia, Anophthalmia ORPHA:2250
14Q22Q23 Microdeletion Syndrome
Micrognathia, Optic nerve aplasia, Malar flattening, Anophthalmia ORPHA:264200
Holoprosencephaly
Branchial anomaly, Spinal dysraphism, Microphthalmia, Hypoplasia of the zygomatic bone, Anophthalmia ORPHA:2162
Cerebrooculonasal Syndrome
Malar flattening, Anophthalmia OMIM:605627
Fibular Hemimelia
Spina bifida, Anophthalmia ORPHA:93323
Microphthalmia With Linear Skin Defects Syndrome
Mandibular aplasia, Abnormal dental enamel morphology, Microphthalmia, Anophthalmia, Retrognathia... ORPHA:2556
Meckel Syndrome
Micrognathia, Aplasia/Hypoplasia of the iris, Microphthalmia, Anophthalmia ORPHA:564
Microgastria-Limb Reduction Defects Association
Anophthalmia OMIM:156810
Joubert Syndrome 21
Anophthalmia OMIM:615636
Microphthalmia With Limb Anomalies
Hypoplasia of the premaxilla, Death in infancy, Microphthalmia, Micrognathia, True anophthalmia, ... ORPHA:1106
Focal Dermal Hypoplasia
Enamel hypoplasia, Aniridia, Delayed eruption of teeth, Umbilical hernia, Microphthalmia, Spina b... OMIM:305600
Fraser Syndrome
Death in infancy, Umbilical hernia, Microphthalmia, Anophthalmia, Dental malocclusion, Myelomenin... ORPHA:2052
Charge Syndrome
Delayed eruption of teeth, Microphthalmia, Hypoplasia of the zygomatic bone, Anophthalmia, Intrau... ORPHA:138
Microphthalmia, Syndromic 2
Delayed eruption of teeth, Persistence of primary teeth, Umbilical hernia, Microphthalmia, Supern... OMIM:300166
Fraser Syndrome 1
Dental malocclusion, Myelomeningocele, Bilateral microphthalmos, Anophthalmia OMIM:219000
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Microphthalmia, Anophthalmia ORPHA:2526
Microgastria-Limb Reduction Defect Syndrome
Microphthalmia, Anophthalmia ORPHA:2538
Branchiooculofacial Syndrome
Branchial anomaly, Cleft of chin, Microphthalmia, Anophthalmia, Intrauterine growth retardation, ... OMIM:113620
Charge Syndrome
Umbilical hernia, Microphthalmia, Anophthalmia, Micrognathia, Malar flattening OMIM:214800
Microphthalmia, Syndromic 6
Microphthalmia, Anophthalmia, Retrognathia, Micrognathia, Malar flattening OMIM:607932
Saethre-Chotzen Syndrome
Cleft of chin, Buphthalmos, Malar flattening, Hypoplasia of the maxilla OMIM:101400
Microphthalmia, Syndromic 1
Agenesis of maxillary lateral incisor, Microphthalmia, Anophthalmia OMIM:309800
Myotonic Dystrophy 2
Elevated circulating follicle stimulating hormone level OMIM:602668
Proximal Myotonic Myopathy
ORPHA:606

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cnbp

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cnbp.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
CNBP controls IL-12 gene transcription and Th1 immunity. The Journal of experimental medicine (November 2018) Cnbptm1a(KOMP)Wtsi 30442645

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MGI Allele Allele Type Produced
Cnbptm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Cnbptm1e(KOMP)Wtsi Targeted, non-conditional allele Targeting vectors, ES Cells
Cnbptm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Cnbptm3a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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